VP26A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VP26A_HUMAN
• UniProt AC: O75436
• Protein Name: Vacuolar protein sorting-associated protein 26A
• Gene Name: VPS26A
• Organism: Homo sapiens (Human).
• Sequence Length: 327
• Subcellular Localization: Cytoplasm . Endosome membrane ; Peripheral membrane protein . Early endosome . Localizes to tubular profiles adjacent to endosomes (PubMed:15078903). Predominantly found in early not late endosomes (By similarity).
• Protein Description: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins (Probable). The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5 (Probable). Required for retrograde transport of lysosomal enzyme receptor IGF2R. [PubMed: 15078902]
• Protein Sequence: MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQASAEQPEM

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSFLGGFFG ------CCCCCCCCC	29.22	28464451
38	Ubiquitination	TEDGKVEKHYLFYDG CCCCCEEEEEEEECC	40.30	-
40	Phosphorylation	DGKVEKHYLFYDGES CCCEEEEEEEECCCC	15.01	23403867
43	Phosphorylation	VEKHYLFYDGESVSG EEEEEEEECCCCCCC	22.05	23403867
47	Phosphorylation	YLFYDGESVSGKVNL EEEECCCCCCCEEEE	27.41	23403867
49	Phosphorylation	FYDGESVSGKVNLAF EECCCCCCCEEEEEE	42.02	28857561
57	Ubiquitination	GKVNLAFKQPGKRLE CEEEEEECCCCCCCE	50.40	21890473
57	Ubiquitination	GKVNLAFKQPGKRLE CEEEEEECCCCCCCE	50.40	21890473
61	Acetylation	LAFKQPGKRLEHQGI EEECCCCCCCEECCE	61.57	12432335
93	Ubiquitination	HEFVNLVKELALPGE HHHHHHHHHHCCCCC	50.61	21906983
102	Phosphorylation	LALPGELTQSRSYDF HCCCCCCCCCCCCCE	21.87	24043423
104	Phosphorylation	LPGELTQSRSYDFEF CCCCCCCCCCCCEEE	20.26	24043423
112	Sulfoxidation	RSYDFEFMQVEKPYE CCCCEEEEEEECCHH	3.25	28465586
156	Phosphorylation	LIVHQLATYPDVNNS EEEEEHHCCCCCCCC	44.15	28152594
157	Phosphorylation	IVHQLATYPDVNNSI EEEEHHCCCCCCCCE	7.57	28152594
163	Phosphorylation	TYPDVNNSIKMEVGI CCCCCCCCEEEEECC	20.55	27732954
188	Ubiquitination	NKSKYHLKDVIVGKI CCCCCCHHHHHHHHH	36.32	-
213	Ubiquitination	HMELQLIKKEITGIG HHCHHHHHHECCCCC	53.60	-
214	Ubiquitination	MELQLIKKEITGIGP HCHHHHHHECCCCCC	47.56	21906983
214	Malonylation	MELQLIKKEITGIGP HCHHHHHHECCCCCC	47.56	26320211
223	Phosphorylation	ITGIGPSTTTETETI CCCCCCCCCCCCEEE	40.65	22817900
225	Phosphorylation	GIGPSTTTETETIAK CCCCCCCCCCEEEEE	40.78	22817900
233	Phosphorylation	ETETIAKYEIMDGAP CCEEEEEEEEECCCC	11.15	21406692
242	Ubiquitination	IMDGAPVKGESIPIR EECCCCCCCCCCCEE	56.77	21890473
242	Malonylation	IMDGAPVKGESIPIR EECCCCCCCCCCCEE	56.77	26320211
245	Phosphorylation	GAPVKGESIPIRLFL CCCCCCCCCCEEEEE	42.19	21406692
261	Sulfoxidation	GYDPTPTMRDVNKKF CCCCCCCHHHHCHHH	3.47	30846556
269	Phosphorylation	RDVNKKFSVRYFLNL HHHCHHHCCEEEEEE	17.98	-
304	Ubiquitination	KAPEKLRKQRTNFHQ CCHHHHHHHCCCHHH	55.35	-
307	Phosphorylation	EKLRKQRTNFHQRFE HHHHHHCCCHHHHHC	39.48	20201521
315	Phosphorylation	NFHQRFESPESQASA CHHHHHCCHHHHHHH	31.12	23927012
318	Phosphorylation	QRFESPESQASAEQP HHHCCHHHHHHHCCC	34.14	25159151
321	Phosphorylation	ESPESQASAEQPEM- CCHHHHHHHCCCCC-	25.38	23927012
327	Sulfoxidation	ASAEQPEM------- HHHCCCCC-------	9.41	21406390

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VP26A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VP26A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VP26A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EHD1_HUMAN	EHD1	physical	22284051
VPS29_HUMAN	VPS29	physical	22939629
VPS35_HUMAN	VPS35	physical	22939629
VPS36_HUMAN	VPS36	physical	22939629
ZPR1_HUMAN	ZPR1	physical	22939629
VPS25_HUMAN	VPS25	physical	22939629
VPS4B_HUMAN	VPS4B	physical	22939629
XPF_HUMAN	ERCC4	physical	22939629
VP26A_HUMAN	VPS26A	physical	23452853
ACPH_HUMAN	APEH	physical	22863883
COR1B_HUMAN	CORO1B	physical	22863883
COR1C_HUMAN	CORO1C	physical	22863883
ERF1_HUMAN	ETF1	physical	22863883
NIBL1_HUMAN	FAM129B	physical	22863883
H33_HUMAN	H3F3A	physical	22863883
JMJD6_HUMAN	JMJD6	physical	22863883
NMI_HUMAN	NMI	physical	22863883
NUDC_HUMAN	NUDC	physical	22863883
PSMG3_HUMAN	PSMG3	physical	22863883
SC24A_HUMAN	SEC24A	physical	22863883
SYTC_HUMAN	TARS	physical	22863883
VPS35_HUMAN	VPS35	physical	22863883
VPS29_HUMAN	VPS29	physical	26186194
VPS35_HUMAN	VPS35	physical	26186194
TBCD5_HUMAN	TBC1D5	physical	26186194
VP26B_HUMAN	VPS26B	physical	26186194
VPS29_HUMAN	VPS29	physical	26344197
VPS35_HUMAN	VPS35	physical	26344197
BCS1_HUMAN	BCS1L	physical	26496610
CAPZB_HUMAN	CAPZB	physical	26496610
CX6B1_HUMAN	COX6B1	physical	26496610
MIF_HUMAN	MIF	physical	26496610
NFKB1_HUMAN	NFKB1	physical	26496610
RBM4_HUMAN	RBM4	physical	26496610
BAG6_HUMAN	BAG6	physical	26496610
SYMPK_HUMAN	SYMPK	physical	26496610
UBL4A_HUMAN	UBL4A	physical	26496610
MPDZ_HUMAN	MPDZ	physical	26496610
NOLC1_HUMAN	NOLC1	physical	26496610
TBCD5_HUMAN	TBC1D5	physical	26496610
TYW4_HUMAN	LCMT2	physical	26496610
WASC5_HUMAN	KIAA0196	physical	26496610
ZER1_HUMAN	ZER1	physical	26496610
CRTAP_HUMAN	CRTAP	physical	26496610
CELF1_HUMAN	CELF1	physical	26496610
SDCG3_HUMAN	SDCCAG3	physical	26496610
CPSF6_HUMAN	CPSF6	physical	26496610
FKB15_HUMAN	FKBP15	physical	26496610
WASC4_HUMAN	KIAA1033	physical	26496610
INT7_HUMAN	INTS7	physical	26496610
RAI14_HUMAN	RAI14	physical	26496610
VPS29_HUMAN	VPS29	physical	26496610
VPS35_HUMAN	VPS35	physical	26496610
RBM26_HUMAN	RBM26	physical	26496610
P3H1_HUMAN	P3H1	physical	26496610
BHE41_HUMAN	BHLHE41	physical	26496610
C99L2_HUMAN	CD99L2	physical	26496610
ANR27_HUMAN	ANKRD27	physical	26496610
UTP4_HUMAN	CIRH1A	physical	26496610
CB069_HUMAN	C2orf69	physical	26496610
WAC2C_HUMAN	FAM21C	physical	26496610
F102B_HUMAN	FAM102B	physical	26496610
WAC2A_HUMAN	FAM21A	physical	26496610
VP26B_HUMAN	VPS26B	physical	28514442
VPS29_HUMAN	VPS29	physical	28514442
TBCD5_HUMAN	TBC1D5	physical	28514442
VPS35_HUMAN	VPS35	physical	28514442
WAC2C_HUMAN	FAM21C	physical	24819384
FKB15_HUMAN	FKBP15	physical	24819384
WASC5_HUMAN	KIAA0196	physical	24819384
WASH1_HUMAN	WASH1	physical	24819384
VPS29_HUMAN	VPS29	physical	24819384
VPS35_HUMAN	VPS35	physical	24819384
VPS35_MOUSE	Vps35	physical	24819384

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.