SC24A_HUMAN - dbPTM
SC24A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID SC24A_HUMAN
UniProt AC O95486
Protein Name Protein transport protein Sec24A {ECO:0000305}
Gene Name SEC24A {ECO:0000312|HGNC:HGNC:10703}
Organism Homo sapiens (Human).
Sequence Length 1093
Subcellular Localization Cytoplasmic vesicle, COPII-coated vesicle membrane
Peripheral membrane protein
Cytoplasmic side . Endoplasmic reticulum membrane
Peripheral membrane protein
Cytoplasmic side . Cytoplasm, cytosol .
Protein Description Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. [PubMed: 20427317]
Protein Sequence MSQPGIPASGGAPASLQAQNGAALASGSPYTNGPVQNALLSSQESVSQGYNFQLPGSYPHPIPAKTLNPVSGQSNYGGSQGSGQTLNRPPVASNPVTPSLHSGPAPRMPLPASQNPATTPMPSSSFLPEANLPPPLNWQYNYPSTASQTNHCPRASSQPTVSGNTSLTTNHQYVSSGYPSLQNSFIKSGPSVPPLVNPPLPTTFQPGAPHGPPPAGGPPPVRALTPLTSSYRDVPQPLFNSAVNQEGITSNTNNGSMVVHSSYDEIEGGGLLATPQLTNKNPKMSRSVGYSYPSLPPGYQNTTPPGATGVPPSSLNYPSGPQAFTQTPLGANHLTTSMSGLSLQPEGLRVVNLLQERNMLPSTPLKPPVPNLHEDIQKLNCNPELFRCTLTSIPQTQALLNKAKLPLGLLLHPFKDLVQLPVVTSSTIVRCRSCRTYINPFVSFLDQRRWKCNLCYRVNDVPEEFLYNPLTRVYGEPHRRPEVQNATIEFMAPSEYMLRPPQPPVYLFVFDVSHNAVETGYLNSVCQSLLDNLDLLPGNTRTKIGFITFDSTIHFYGLQESLSQPQMLIVSDIEDVFIPMPENLLVNLNESKELVQDLLKTLPQMFTKTLETQSALGPALQAAFKLMSPTGGRMSVFQTQLPTLGVGALKPREEPNHRSSAKDIHMTPSTDFYKKLALDCSGQQVAVDLFLLSGQYSDLASLGCISRYSAGSVYYYPSYHHQHNPVQVQKLQKELQRYLTRKIGFEAVMRIRCTKGLSIHTFHGNFFVRSTDLLSLPNVNPDAGYAVQMSVEESLTDTQLVSFQSALLYTSSKGERRIRVHTLCLPVVSTLNDVFLGADVQAISGLLANMAVDRSMTASLSDARDALVNAVIDSLSAYRSSVLSNQQPGLMVPFSLRLFPLFVLALLKQKSFQTGTNARLDERIFAMCQVKNQPLVYLMLTTHPSLYRVDNLSDEGALNISDRTIPQPPILQLSVEKLSRDGAFLMDAGSVLMLWVGKNCTQNFLSQVLGVQNYASIPQPMTDLPELDTPESARIIAFISWLREQRPFFPILYVIRDESPMKANFLQNMIEDRTESALSYYEFLLHIQQQVNK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MSQPGIPAS
------CCCCCCCCC		57.28-
88MethylationGSGQTLNRPPVASNP
CCCCCCCCCCCCCCC		39.76115493535
107MethylationLHSGPAPRMPLPASQ
CCCCCCCCCCCCCCC		41.27115493543
156O-linked_GlycosylationTNHCPRASSQPTVSG
CCCCCCCCCCCCCCC		30.6829351928
156PhosphorylationTNHCPRASSQPTVSG
CCCCCCCCCCCCCCC		30.68-
162O-linked_GlycosylationASSQPTVSGNTSLTT
CCCCCCCCCCCCCCC		28.8929351928
165PhosphorylationQPTVSGNTSLTTNHQ
CCCCCCCCCCCCCCC		28.7428796482
165O-linked_GlycosylationQPTVSGNTSLTTNHQ
CCCCCCCCCCCCCCC		28.7429351928
166PhosphorylationPTVSGNTSLTTNHQY
CCCCCCCCCCCCCCH		27.9328796482
168PhosphorylationVSGNTSLTTNHQYVS
CCCCCCCCCCCCHHH		25.8928796482
169PhosphorylationSGNTSLTTNHQYVSS
CCCCCCCCCCCHHHC		35.6828796482
169O-linked_GlycosylationSGNTSLTTNHQYVSS
CCCCCCCCCCCHHHC		35.6829351928
173PhosphorylationSLTTNHQYVSSGYPS
CCCCCCCHHHCCCHH		8.5128796482
175O-linked_GlycosylationTTNHQYVSSGYPSLQ
CCCCCHHHCCCHHHH		17.0829351928
175PhosphorylationTTNHQYVSSGYPSLQ
CCCCCHHHCCCHHHH		17.0828796482
176PhosphorylationTNHQYVSSGYPSLQN
CCCCHHHCCCHHHHH		32.1028796482
178PhosphorylationHQYVSSGYPSLQNSF
CCHHHCCCHHHHHCC		7.5028796482
180PhosphorylationYVSSGYPSLQNSFIK
HHHCCCHHHHHCCCC		33.82-
184PhosphorylationGYPSLQNSFIKSGPS
CCHHHHHCCCCCCCC		18.5224719451
222MethylationAGGPPPVRALTPLTS
CCCCCCCCCCCCCCC		29.65116264829
225PhosphorylationPPPVRALTPLTSSYR
CCCCCCCCCCCCCCC		18.4423312004
228PhosphorylationVRALTPLTSSYRDVP
CCCCCCCCCCCCCCC		19.4828985074
232MethylationTPLTSSYRDVPQPLF
CCCCCCCCCCCHHHH		40.16116264827
263PhosphorylationSMVVHSSYDEIEGGG
CEEEECCCCEECCCC		22.17-
314O-linked_GlycosylationATGVPPSSLNYPSGP
CCCCCCHHCCCCCCC		26.8029351928
336PhosphorylationLGANHLTTSMSGLSL
CCCCCCCCCCCCCCC		28.8826657352
339PhosphorylationNHLTTSMSGLSLQPE
CCCCCCCCCCCCCCC		36.0326657352
362PhosphorylationQERNMLPSTPLKPPV
HHHCCCCCCCCCCCC		38.4020873877
363PhosphorylationERNMLPSTPLKPPVP
HHCCCCCCCCCCCCC		30.6020873877
366UbiquitinationMLPSTPLKPPVPNLH
CCCCCCCCCCCCCHH		48.78-
389PhosphorylationNPELFRCTLTSIPQT
CHHHHHCEECCCHHH		28.90-
391PhosphorylationELFRCTLTSIPQTQA
HHHHCEECCCHHHHH		13.37-
392PhosphorylationLFRCTLTSIPQTQAL
HHHCEECCCHHHHHH		35.07-
396PhosphorylationTLTSIPQTQALLNKA
EECCCHHHHHHHHHC		15.51-
402UbiquitinationQTQALLNKAKLPLGL
HHHHHHHHCCCCHHH		47.03-
404UbiquitinationQALLNKAKLPLGLLL
HHHHHHCCCCHHHHH		52.85-
426PhosphorylationQLPVVTSSTIVRCRS
CCCCCCCCCEEEECC		16.88-
451UbiquitinationFLDQRRWKCNLCYRV
HHHHCCEECCEEEEE		16.07-
643PhosphorylationVFQTQLPTLGVGALK
EEEECCCCCCCCCCC		44.7425599653
650 (in isoform 1)Ubiquitination-41.3021890473
650UbiquitinationTLGVGALKPREEPNH
CCCCCCCCCCCCCCC		41.3021890473
662UbiquitinationPNHRSSAKDIHMTPS
CCCCCCCCCCCCCCC		60.20-
708PhosphorylationSLGCISRYSAGSVYY
HHCCEECCCCCCEEE		8.97-
733UbiquitinationVQVQKLQKELQRYLT
HHHHHHHHHHHHHHH		71.48-
742UbiquitinationLQRYLTRKIGFEAVM
HHHHHHHHHCHHHHH		41.78-
813AcetylationALLYTSSKGERRIRV
EEHHHCCCCCCEEEE		65.6430592279
856SulfoxidationNMAVDRSMTASLSDA
HHHHCHHHCCCHHHH		3.6521406390
874PhosphorylationLVNAVIDSLSAYRSS
HHHHHHHHHHHHHHH		17.0720068231
916PhosphorylationQKSFQTGTNARLDER
CCCCCCCCCCCHHHH		29.1417322306
1053PhosphorylationRPFFPILYVIRDESP
CCCCEEEEEECCCCC		8.4422817900
1062UbiquitinationIRDESPMKANFLQNM
ECCCCCCCCHHHHHH		43.4921906983
1062 (in isoform 1)Ubiquitination-43.4921890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of SC24A_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of SC24A_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of SC24A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
SC24C_HUMANSEC24Cphysical
22939629
SC24D_HUMANSEC24Dphysical
22939629
SC24B_HUMANSEC24Bphysical
22939629
SPS2_HUMANSEPHS2physical
22939629
SSA27_HUMANSSSCA1physical
22939629
THADA_HUMANTHADAphysical
22939629
SHOT1_HUMANKIAA1598physical
22939629
STAT6_HUMANSTAT6physical
22939629
UBE2C_HUMANUBE2Cphysical
22939629
STMN2_HUMANSTMN2physical
22939629
UBE2B_HUMANUBE2Bphysical
22939629
TBB6_HUMANTUBB6physical
22939629
TLE3_HUMANTLE3physical
22939629
TTC1_HUMANTTC1physical
22939629
TTC9C_HUMANTTC9Cphysical
22939629
UBP34_HUMANUSP34physical
22939629
UNK_HUMANUNKphysical
22939629
CHIP_HUMANSTUB1physical
22939629
TACC3_HUMANTACC3physical
22939629
JMJD6_HUMANJMJD6physical
22863883
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of SC24A_HUMAN

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Related Literatures of Post-Translational Modification

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