THADA_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: THADA_HUMAN
• UniProt AC: Q6YHU6
• Protein Name: Thyroid adenoma-associated protein
• Gene Name: THADA
• Organism: Homo sapiens (Human).
• Sequence Length: 1953
• Protein Sequence: MGVKKKKEMQVAALTICHQDLETLKSFADVEGKNLASLLLHCVQLTDGVSQIHYIKQIVPLLEKADKNGMCDPTIQSCLDILAGIYLSLSLKNPLKKVLASSLNSLPDFFLPEAMHRFTSRLQEELNTTDLYSYRKVTDNISSCMENFNLGRASVNNLLKNVLHFLQKSLIEILEENRKCAGNHIIQTQLMNDLLVGIRVSMMLVQKVQDFQGNLWKTSDSPIWQNMCGLLSIFTKVLSDDDLLQTVQSTSGLAIILFIKTMFHPSEKIPHLISSVLLRSVDCTSVPEWFMSSCRSLCCGDISQSAVLFLCQGTLAMLDWQNGSMGRSGEALLLDTAHVLFTLSSQIKEPTLEMFLSRILASWTNSAIQVLESSSPSLTDSLNGNSSIVGRLLEYVYTHWEHPLDALRHQTKIMFKNLLQMHRLTVEGADFVPDPFFVELTESLLRLEWHIKGKYTCLGCLVECIGVEHILAIDKTIPSQILEVMGDQSLVPYASDLLETMFRNHKSHLKSQTAESSWIDQWHETWVSPLLFILCEGNLDQKSYVIDYYLPKLLSYSPESLQYMVKILQTSIDAKTGQEQSFPSLGSCNSRGALGALMACLRIARAHGHLQSATDTWENLVSDARIKQGLIHQHCQVRIDTLGLLCESNRSTEIVSMEEMQWIQFFITYNLNSQSPGVRQQICSLLKKLFCRIQESSQVLYKLEQSKSKREPENELTKQHPSVSLQQYKNFMSSICNSLFEALFPGSSYSTRFSALTILGSIAEVFHVPEGRIYTVYQLSHDIDVGRFQTLMECFTSTFEDVKILAFDLLMKLSKTAVHFQDSGKLQGLFQAALELSTSTKPYDCVTASYLLNFLIWQDALPSSLSAYLTQQVACDNGDRPAAVVERNTLMVIKCLMENLEEEVSQAENSLLQAAAAFPMYGRVHCITGALQKLSLNSLQLVSEWRPVVEKLLLMSYRLSTVVSPVIQSSSPEGLIPMDTDSESASRLQMILNEIQPRDTNDYFNQAKILKEHDSFDMKDLNASVVNIDTSTEIKGKEVKTCDVTAQMVLVCCWRSMKEVALLLGMLCQLLPMQPVPESSDGLLTVEQVKEIGDYFKQHLLQSRHRGAFELAYTGFVKLTEVLNRCPNVSLQKLPEQWLWSVLEEIKCSDPSSKLCATRRSAGIPFYIQALLASEPKKGRMDLLKITMKELISLAGPTDDIQSTVPQVHALNILRALFRDTRLGENIIPYVADGAKAAILGFTSPVWAVRNSSTLLFSALITRIFGVKRAKDEHSKTNRMTGREFFSRFPELYPFLLKQLETVANTVDSDMGEPNRHPSMFLLLLVLERLYASPMDGTSSALSMGPFVPFIMRCGHSPVYHSREMAARALVPFVMIDHIPNTIRTLLSTLPSCTDQCFRQNHIHGTLLQVFHLLQAYSDSKHGTNSDFQHELTDITVCTKAKLWLAKRQNPCLVTRAVYIDILFLLTCCLNRSAKDNQPVLESLGFWEEVRGIISGSELITGFPWAFKVPGLPQYLQSLTRLAIAAVWAAAAKSGERETNVPISFSQLLESAFPEVRSLTLEALLEKFLAAASGLGEKGVPPLLCNMGEKFLLLAMKENHPECFCKILKILHCMDPGEWLPQTEHCVHLTPKEFLIWTMDIASNERSEIQSVALRLASKVISHHMQTCVENRELIAAELKQWVQLVILSCEDHLPTESRLAVVEVLTSTTPLFLTNPHPILELQDTLALWKCVLTLLQSEEQAVRDAATETVTTAMSQENTCQSTEFAFCQVDASIALALALAVLCDLLQQWDQLAPGLPILLGWLLGESDDLVACVESMHQVEEDYLFEKAEVNFWAETLIFVKYLCKHLFCLLSKSGWRPPSPEMLCHLQRMVSEQCHLLSQFFRELPPAAEFVKTVEFTRLRIQEERTLACLRLLAFLEGKEGEDTLVLSVWDSYAESRQLTLPRTEAAC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
25	Ubiquitination	HQDLETLKSFADVEG HHHHHHHHHHCCCCC	51.45	29967540
64	Ubiquitination	QIVPLLEKADKNGMC HHHHHHHHHCCCCCC	62.95	27667366
77	Phosphorylation	MCDPTIQSCLDILAG CCCHHHHHHHHHHHH	16.88	-
88	Phosphorylation	ILAGIYLSLSLKNPL HHHHHHHHHHCCCHH	10.03	24719451
90	Phosphorylation	AGIYLSLSLKNPLKK HHHHHHHHCCCHHHH	33.64	24719451
112	Ubiquitination	SLPDFFLPEAMHRFT CCCCCCCHHHHHHHH	23.34	21890473
115	Ubiquitination	DFFLPEAMHRFTSRL CCCCHHHHHHHHHHH	1.91	22817900
123	Ubiquitination	HRFTSRLQEELNTTD HHHHHHHHHHHCCCC	40.79	23503661
133	Phosphorylation	LNTTDLYSYRKVTDN HCCCCCHHHHHHHCC	26.26	24719451
136	Ubiquitination	TDLYSYRKVTDNISS CCCHHHHHHHCCHHH	41.05	-
191	Ubiquitination	HIIQTQLMNDLLVGI HHHHHHHHHHHHHHH	2.36	21890473
194	Ubiquitination	QTQLMNDLLVGIRVS HHHHHHHHHHHHHHH	3.38	22817900
202	Ubiquitination	LVGIRVSMMLVQKVQ HHHHHHHHHHHHHHH	1.89	23503661
258	Ubiquitination	SGLAIILFIKTMFHP CHHHHHHHHHHHCCC	3.66	21963094
285	Phosphorylation	LRSVDCTSVPEWFMS HHCCCCCCCCHHHHH	41.84	-
337	Ubiquitination	EALLLDTAHVLFTLS CEEHHHHHHHHHHHC	7.17	21963094
344	Phosphorylation	AHVLFTLSSQIKEPT HHHHHHHCCCCCCHH	19.69	24719451
386	Phosphorylation	TDSLNGNSSIVGRLL CHHCCCCCHHHHHHH	23.88	30266825
387	Phosphorylation	DSLNGNSSIVGRLLE HHCCCCCHHHHHHHH	25.87	30266825
412 (in isoform 2)	Ubiquitination	-	26.13	21890473
441	Phosphorylation	DPFFVELTESLLRLE CHHHHHHHHHHHHHH	15.26	20068231
454	Ubiquitination	LEWHIKGKYTCLGCL HHHHHCCCCCHHHHH	32.17	-
455	Phosphorylation	EWHIKGKYTCLGCLV HHHHCCCCCHHHHHH	16.02	28111955
456	Phosphorylation	WHIKGKYTCLGCLVE HHHCCCCCHHHHHHH	12.53	28111955
511	Phosphorylation	NHKSHLKSQTAESSW HCHHHHHHCCCCCCH	38.84	29978859
513	Phosphorylation	KSHLKSQTAESSWID HHHHHHCCCCCCHHH	39.21	29978859
516	Phosphorylation	LKSQTAESSWIDQWH HHHCCCCCCHHHHHH	28.63	29978859
517	Phosphorylation	KSQTAESSWIDQWHE HHCCCCCCHHHHHHH	21.40	29978859
525	Phosphorylation	WIDQWHETWVSPLLF HHHHHHHHCHHHHHH	20.48	29978859
528	Phosphorylation	QWHETWVSPLLFILC HHHHHCHHHHHHHHH	11.03	29978859
535	Ubiquitination	SPLLFILCEGNLDQK HHHHHHHHCCCCCCC	5.56	21963094
543	Phosphorylation	EGNLDQKSYVIDYYL CCCCCCCCHHHHHHH	20.99	25262027
544	Phosphorylation	GNLDQKSYVIDYYLP CCCCCCCHHHHHHHH	14.41	25262027
548	Phosphorylation	QKSYVIDYYLPKLLS CCCHHHHHHHHHHHH	8.86	25262027
549	Phosphorylation	KSYVIDYYLPKLLSY CCHHHHHHHHHHHHC	16.87	25262027
560	Phosphorylation	LLSYSPESLQYMVKI HHHCCHHHHHHHHHH	24.94	28509920
563	Phosphorylation	YSPESLQYMVKILQT CCHHHHHHHHHHHHH	14.79	28509920
566	Ubiquitination	ESLQYMVKILQTSID HHHHHHHHHHHHCCC	22.59	-
570	Phosphorylation	YMVKILQTSIDAKTG HHHHHHHHCCCCCCC	24.97	21406692
571	Phosphorylation	MVKILQTSIDAKTGQ HHHHHHHCCCCCCCC	12.90	21406692
575	Ubiquitination	LQTSIDAKTGQEQSF HHHCCCCCCCCCCCC	49.82	21963094
576	Phosphorylation	QTSIDAKTGQEQSFP HHCCCCCCCCCCCCC	45.90	28387310
581	Phosphorylation	AKTGQEQSFPSLGSC CCCCCCCCCCCCCCC	38.07	-
584	Phosphorylation	GQEQSFPSLGSCNSR CCCCCCCCCCCCCHH	43.27	28387310
587	Ubiquitination	QSFPSLGSCNSRGAL CCCCCCCCCCHHHHH	18.54	21963094
590	Phosphorylation	PSLGSCNSRGALGAL CCCCCCCHHHHHHHH	36.10	28387310
627	Ubiquitination	LVSDARIKQGLIHQH HHCHHHHHHCHHHCC	32.53	21963094
647	Ubiquitination	DTLGLLCESNRSTEI HHHHHHCCCCCCCEE	51.52	27667366
662	Ubiquitination	VSMEEMQWIQFFITY EEHHHHHEEEHHHHC	5.76	21890473
667	Ubiquitination	MQWIQFFITYNLNSQ HHEEEHHHHCCCCCC	4.16	22817900
678	Ubiquitination	LNSQSPGVRQQICSL CCCCCHHHHHHHHHH	5.92	29967540
684	Phosphorylation	GVRQQICSLLKKLFC HHHHHHHHHHHHHHH	38.06	24719451
687	Ubiquitination	QQICSLLKKLFCRIQ HHHHHHHHHHHHHHH	53.36	27667366
696	Phosphorylation	LFCRIQESSQVLYKL HHHHHHHHHHHHHHH	15.08	29052541
697	Phosphorylation	FCRIQESSQVLYKLE HHHHHHHHHHHHHHH	24.45	29052541
701	Phosphorylation	QESSQVLYKLEQSKS HHHHHHHHHHHHCCC	18.05	29052541
702	Ubiquitination	ESSQVLYKLEQSKSK HHHHHHHHHHHCCCC	41.19	21963094
702 (in isoform 3)	Ubiquitination	-	41.19	21890473
702 (in isoform 5)	Ubiquitination	-	41.19	21890473
702	Ubiquitination	ESSQVLYKLEQSKSK HHHHHHHHHHHCCCC	41.19	21890473
707	Ubiquitination	LYKLEQSKSKREPEN HHHHHHCCCCCCCCC	60.74	22817900
709	Ubiquitination	KLEQSKSKREPENEL HHHHCCCCCCCCCCC	65.60	-
718	Ubiquitination	EPENELTKQHPSVSL CCCCCCCCCCCCCCH	60.27	29967540
718 (in isoform 2)	Ubiquitination	-	60.27	21890473
721 (in isoform 2)	Ubiquitination	-	33.65	-
729 (in isoform 2)	Ubiquitination	-	39.09	-
734	Phosphorylation	QYKNFMSSICNSLFE HHHHHHHHHHHHHHH	21.26	20068231
886	Ubiquitination	DRPAAVVERNTLMVI CCCEEEEEHHHHHHH	33.35	21890473
887	Ubiquitination	RPAAVVERNTLMVIK CCEEEEEHHHHHHHH	29.80	21890473
889	Ubiquitination	AAVVERNTLMVIKCL EEEEEHHHHHHHHHH	23.58	22817900
890	Ubiquitination	AVVERNTLMVIKCLM EEEEHHHHHHHHHHH	2.70	22817900
897	Ubiquitination	LMVIKCLMENLEEEV HHHHHHHHHCHHHHH	4.50	23503661
898	Ubiquitination	MVIKCLMENLEEEVS HHHHHHHHCHHHHHH	45.79	23503661
935	Phosphorylation	TGALQKLSLNSLQLV HHHHHHHCCCHHHHH	32.32	20068231
938	Phosphorylation	LQKLSLNSLQLVSEW HHHHCCCHHHHHHHH	23.84	27499020
943	Phosphorylation	LNSLQLVSEWRPVVE CCHHHHHHHHHHHHH	39.78	20068231
964	Phosphorylation	YRLSTVVSPVIQSSS HHHHHCCCHHHCCCC	14.76	-
967	Ubiquitination	STVVSPVIQSSSPEG HHCCCHHHCCCCCCC	3.59	33845483
968	Ubiquitination	TVVSPVIQSSSPEGL HCCCHHHCCCCCCCC	37.18	21890473
970	Ubiquitination	VSPVIQSSSPEGLIP CCHHHCCCCCCCCCC	33.27	22817900
971	Ubiquitination	SPVIQSSSPEGLIPM CHHHCCCCCCCCCCC	32.02	22817900
978	Ubiquitination	SPEGLIPMDTDSESA CCCCCCCCCCCCHHH	7.40	23503661
979	Ubiquitination	PEGLIPMDTDSESAS CCCCCCCCCCCHHHH	41.84	23503661
980	Phosphorylation	EGLIPMDTDSESASR CCCCCCCCCCHHHHH	34.86	-
994	Ubiquitination	RLQMILNEIQPRDTN HHHHHHHHCCCCCCC	39.29	29967540
1001	Ubiquitination	EIQPRDTNDYFNQAK HCCCCCCCCCCHHHH	46.39	23503661
1003	Phosphorylation	QPRDTNDYFNQAKIL CCCCCCCCCHHHHHH	13.39	28796482
1007	Ubiquitination	TNDYFNQAKILKEHD CCCCCHHHHHHHHCC	11.27	33845483
1008	Ubiquitination	NDYFNQAKILKEHDS CCCCHHHHHHHHCCC	38.52	21906983
1008 (in isoform 3)	Ubiquitination	-	38.52	21890473
1009 (in isoform 1)	Ubiquitination	-	8.13	21890473
1010	Ubiquitination	YFNQAKILKEHDSFD CCHHHHHHHHCCCCC	5.40	22817900
1011	Ubiquitination	FNQAKILKEHDSFDM CHHHHHHHHCCCCCH	57.38	22817900
1015	Phosphorylation	KILKEHDSFDMKDLN HHHHHCCCCCHHHCC	25.67	29255136
1018	Ubiquitination	KEHDSFDMKDLNASV HHCCCCCHHHCCCEE	3.24	23503661
1019	Ubiquitination	EHDSFDMKDLNASVV HCCCCCHHHCCCEEE	61.99	23503661
1024	Phosphorylation	DMKDLNASVVNIDTS CHHHCCCEEEEECCC	26.06	20068231
1030	Phosphorylation	ASVVNIDTSTEIKGK CEEEEECCCCCCCCE	33.48	25627689
1031	Phosphorylation	SVVNIDTSTEIKGKE EEEEECCCCCCCCEE	21.94	17192257
1032	Phosphorylation	VVNIDTSTEIKGKEV EEEECCCCCCCCEEE	43.77	25627689
1032	Ubiquitination	VVNIDTSTEIKGKEV EEEECCCCCCCCEEE	43.77	21963094
1033	Ubiquitination	VNIDTSTEIKGKEVK EEECCCCCCCCEEEE	42.33	21963094
1034	Ubiquitination	NIDTSTEIKGKEVKT EECCCCCCCCEEEEC	7.84	29967540
1035	Ubiquitination	IDTSTEIKGKEVKTC ECCCCCCCCEEEECC	58.67	29967540
1037	Acetylation	TSTEIKGKEVKTCDV CCCCCCCEEEECCCC	55.09	19810329
1040	Acetylation	EIKGKEVKTCDVTAQ CCCCEEEECCCCHHH	44.52	19810337
1080	Ubiquitination	MQPVPESSDGLLTVE CCCCCCCCCCCEEHH	33.75	23503661
1113	Ubiquitination	RGAFELAYTGFVKLT CCHHHHHHHCHHHHH	21.74	21963094
1114	Phosphorylation	GAFELAYTGFVKLTE CHHHHHHHCHHHHHH	20.66	24719451
1114	Ubiquitination	GAFELAYTGFVKLTE CHHHHHHHCHHHHHH	20.66	21963094
1153	Ubiquitination	IKCSDPSSKLCATRR CCCCCCCCCCCCHHH	34.73	21963094
1154	Ubiquitination	KCSDPSSKLCATRRS CCCCCCCCCCCHHHH	52.50	21963094
1161	Phosphorylation	KLCATRRSAGIPFYI CCCCHHHHCCCCHHH	27.79	11214970
1167	Phosphorylation	RSAGIPFYIQALLAS HHCCCCHHHHHHHHC	6.18	22199227
1174	Phosphorylation	YIQALLASEPKKGRM HHHHHHHCCCCCCCC	55.17	20068231
1221	Phosphorylation	LRALFRDTRLGENII HHHHHCCCCCCCCCH	24.44	20068231
1230	Phosphorylation	LGENIIPYVADGAKA CCCCCHHHHHCCCCH	9.62	20068231
1258	Phosphorylation	NSSTLLFSALITRIF CCHHHHHHHHHHHHH	23.33	-
1262	Phosphorylation	LLFSALITRIFGVKR HHHHHHHHHHHCCCC	20.68	-
1275	Phosphorylation	KRAKDEHSKTNRMTG CCCCCCCCHHCCCCH	38.84	-
1319	Phosphorylation	GEPNRHPSMFLLLLV CCCCCCHHHHHHHHH	18.95	20068231
1331	Phosphorylation	LLVLERLYASPMDGT HHHHHHHHCCCCCCC	15.97	20068231
1333	Phosphorylation	VLERLYASPMDGTSS HHHHHHCCCCCCCCH	13.75	20068231
1338	Phosphorylation	YASPMDGTSSALSMG HCCCCCCCCHHHHCC	18.42	20068231
1339	Phosphorylation	ASPMDGTSSALSMGP CCCCCCCCHHHHCCC	21.10	20068231
1340	Phosphorylation	SPMDGTSSALSMGPF CCCCCCCHHHHCCCC	32.82	20068231
1343	Phosphorylation	DGTSSALSMGPFVPF CCCCHHHHCCCCHHH	22.78	20068231
1399	Ubiquitination	SCTDQCFRQNHIHGT CCHHHHHHCCCHHHH	43.98	29967540
1439	Ubiquitination	LTDITVCTKAKLWLA HHHCHHHHHHHHHHH	29.69	29967540
1440	Ubiquitination	TDITVCTKAKLWLAK HHCHHHHHHHHHHHH	38.10	29967540
1537	Ubiquitination	AAAKSGERETNVPIS HHHHCCCCCCCCCCC	60.61	29967540
1576 (in isoform 2)	Ubiquitination	-	37.79	-
1577	Ubiquitination	AAASGLGEKGVPPLL HHHCCCCCCCCCCEE	52.24	29967540
1578	Ubiquitination	AASGLGEKGVPPLLC HHCCCCCCCCCCEEC	64.51	29967540
1659	Ubiquitination	VALRLASKVISHHMQ HHHHHHHHHHHHHHH	37.67	-
1667	Phosphorylation	VISHHMQTCVENREL HHHHHHHHHHHCHHH	15.79	-
1775	Ubiquitination	AFCQVDASIALALAL CCCCCHHHHHHHHHH	12.16	23503661
1776	Ubiquitination	FCQVDASIALALALA CCCCHHHHHHHHHHH	3.79	23503661
1823	Ubiquitination	CVESMHQVEEDYLFE HHHHHHHHCHHHHHH	5.45	23503661
1853	Ubiquitination	YLCKHLFCLLSKSGW HHHHHHHHHHHCCCC	4.74	23503661
1856	Ubiquitination	KHLFCLLSKSGWRPP HHHHHHHHCCCCCCC	16.30	23503661
1857	Ubiquitination	HLFCLLSKSGWRPPS HHHHHHHCCCCCCCC	53.62	23503661
1896	Ubiquitination	LPPAAEFVKTVEFTR CCCHHHHHHEEEEEE	3.70	23503661
1897	Ubiquitination	PPAAEFVKTVEFTRL CCHHHHHHEEEEEEC	52.77	23503661
1945	Phosphorylation	YAESRQLTLPRTEAA HHHHCCCCCCCCCCC	26.78	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of THADA_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of THADA_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of THADA_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
USBP1_HUMAN	USHBP1	physical	25416956
NAA10_HUMAN	NAA10	physical	28514442
LST8_HUMAN	MLST8	physical	27173435

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle.";
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.;
Mol. Cell 31:438-448(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1031 AND SER-1161, ANDMASS SPECTROMETRY.
PubMed: 18691976