| UniProt ID | SPS2_HUMAN | |
|---|---|---|
| UniProt AC | Q99611 | |
| Protein Name | Selenide, water dikinase 2 | |
| Gene Name | SEPHS2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 448 | |
| Subcellular Localization | ||
| Protein Description | Synthesizes selenophosphate from selenide and ATP.. | |
| Protein Sequence | MAEASATGACGEAMAAAEGSSGPAGLTLGRSFSNYRPFEPQALGLSPSWRLTGFSGMKGUGCKVPQEALLKLLAGLTRPDVRPPLGRGLVGGQEEASQEAGLPAGAGPSPTFPALGIGMDSCVIPLRHGGLSLVQTTDFFYPLVEDPYMMGRIACANVLSDLYAMGITECDNMLMLLSVSQSMSEEEREKVTPLMVKGFRDAAEEGGTAVTGGQTVVNPWIIIGGVATVVCQPNEFIMPDSAVVGDVLVLTKPLGTQVAVNAHQWLDNPERWNKVKMVVSREEVELAYQEAMFNMATLNRTAAGLMHTFNAHAATDITGFGILGHSQNLAKQQRNEVSFVIHNLPIIAKMAAVSKASGRFGLLQGTSAETSGGLLICLPREQAARFCSEIKSSKYGEGHQAWIVGIVEKGNRTARIIDKPRVIEVLPRGATAAVLAPDSSNASSEPSS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 2 | Acetylation | ------MAEASATGA ------CCCCCCCCH | 22.51 | 22814378 | |
| 31 | Phosphorylation | AGLTLGRSFSNYRPF CCCCCCCCCCCCCCC | 31.09 | 28450419 | |
| 33 | Phosphorylation | LTLGRSFSNYRPFEP CCCCCCCCCCCCCCC | 33.91 | 28450419 | |
| 35 | Phosphorylation | LGRSFSNYRPFEPQA CCCCCCCCCCCCCCC | 20.61 | 28857561 | |
| 46 | Phosphorylation | EPQALGLSPSWRLTG CCCCCCCCCCCCCCC | 18.32 | 25159151 | |
| 48 | Phosphorylation | QALGLSPSWRLTGFS CCCCCCCCCCCCCCC | 22.81 | 28450419 | |
| 97 | Phosphorylation | VGGQEEASQEAGLPA CCCCHHHHHHCCCCC | 31.65 | 28464451 | |
| 109 | Phosphorylation | LPAGAGPSPTFPALG CCCCCCCCCCCCCCC | 35.34 | 26657352 | |
| 111 | Phosphorylation | AGAGPSPTFPALGIG CCCCCCCCCCCCCCC | 46.73 | 26657352 | |
| 121 | Phosphorylation | ALGIGMDSCVIPLRH CCCCCCCCEEEEECC | 11.03 | 27080861 | |
| 197 | Ubiquitination | KVTPLMVKGFRDAAE CCHHHHHHCHHHHHH | 38.06 | 24816145 | |
| 276 | Acetylation | PERWNKVKMVVSREE HHHHHCCEEEECHHH | 27.82 | 18530709 | |
| 355 | Ubiquitination | AKMAAVSKASGRFGL HHHHHHHHHCCCCCC | 39.72 | 29967540 | |
| 391 | Acetylation | ARFCSEIKSSKYGEG HHHHHHHHHCCCCCC | 44.62 | 25953088 | |
| 447 | Phosphorylation | SNASSEPSS------ CCCCCCCCC------ | 44.63 | 28348404 | |
| 448 | Phosphorylation | NASSEPSS------- CCCCCCCC------- | 55.76 | 28348404 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SPS2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SPS2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SPS2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of SPS2_HUMAN !! | ||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY. | |
