UBE2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UBE2B_HUMAN
• UniProt AC: P63146
• Protein Name: Ubiquitin-conjugating enzyme E2 B
• Gene Name: UBE2B
• Organism: Homo sapiens (Human).
• Sequence Length: 152
• Subcellular Localization: Cell membrane . Nucleus . In peripheral neurons, expressed both at the plasma membrane and in nuclei.
• Protein Description: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth..
• Protein Sequence: MSTPARRRLMRDFKRLQEDPPVGVSGAPSENNIMQWNAVIFGPEGTPFEDGTFKLVIEFSEEYPNKPPTVRFLSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNSPANSQAAQLYQENKREYEKRVSAIVEQSWNDS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Acetylation	FSEEYPNKPPTVRFL CCHHCCCCCCCEEHH	48.12	25953088
66	Ubiquitination	FSEEYPNKPPTVRFL CCHHCCCCCCCEEHH	48.12	21963094
69	Phosphorylation	EYPNKPPTVRFLSKM HCCCCCCCEEHHHHH	32.61	-
74	Phosphorylation	PPTVRFLSKMFHPNV CCCEEHHHHHCCCCC	21.25	30387612
75	Ubiquitination	PTVRFLSKMFHPNVY CCEEHHHHHCCCCCC	47.97	21963094
82	Phosphorylation	KMFHPNVYADGSICL HHCCCCCCCCCCCHH	12.96	26074081
86	Phosphorylation	PNVYADGSICLDILQ CCCCCCCCCHHHHHC	15.63	26074081
120	Phosphorylation	LDEPNPNSPANSQAA HCCCCCCCCCHHHHH	27.01	11953320
124	Phosphorylation	NPNSPANSQAAQLYQ CCCCCCHHHHHHHHH	24.25	20068231
130	Phosphorylation	NSQAAQLYQENKREY HHHHHHHHHHHHHHH	11.16	20068231
142	Phosphorylation	REYEKRVSAIVEQSW HHHHHHHHHHHHHHC	19.13	26846344
148	Phosphorylation	VSAIVEQSWNDS--- HHHHHHHHCCCC---	17.84	26846344
152	Phosphorylation	VEQSWNDS------- HHHHCCCC-------	38.62	26846344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UBE2B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UBE2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UBE2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
UBR2_HUMAN	UBR2	physical	14585983
MED31_HUMAN	MED31	physical	16169070
U119A_HUMAN	UNC119	physical	16169070
DPYL1_HUMAN	CRMP1	physical	16169070
UBR1_HUMAN	UBR1	physical	16169070
CDN1B_HUMAN	CDKN1B	physical	19123975
RAD18_HUMAN	RAD18	physical	19549727
UBR3_HUMAN	UBR3	physical	19549727
PCNA_HUMAN	PCNA	physical	20064529
H2A2C_HUMAN	HIST2H2AC	physical	20080676
UBR2_HUMAN	UBR2	physical	20080676
UBR3_HUMAN	UBR3	physical	21816346
BRE1A_HUMAN	RNF20	physical	21443952
PCNA_HUMAN	PCNA	physical	15359278
RAD18_HUMAN	RAD18	physical	15359278
RAD18_HUMAN	RAD18	physical	21549715
RAD18_HUMAN	RAD18	physical	17720710
P53_HUMAN	TP53	physical	22083959
MDM2_HUMAN	MDM2	physical	22083959
CTNB1_HUMAN	CTNNB1	physical	22705350
RL40_HUMAN	UBA52	physical	22939629
UBE2C_HUMAN	UBE2C	physical	22939629
USP9X_HUMAN	USP9X	physical	22939629
UBQL4_HUMAN	UBQLN4	physical	22939629
UBXN7_HUMAN	UBXN7	physical	22939629
UBQL1_HUMAN	UBQLN1	physical	22939629
VATF_HUMAN	ATP6V1F	physical	22939629
UNK_HUMAN	UNK	physical	22939629
ZYX_HUMAN	ZYX	physical	22939629
ANCHR_HUMAN	ZFYVE19	physical	22939629
ZRAB2_HUMAN	ZRANB2	physical	22939629
VATB1_HUMAN	ATP6V1B1	physical	22939629
XPF_HUMAN	ERCC4	physical	22939629
CTNB1_HUMAN	CTNNB1	physical	18339854
UBE2B_HUMAN	UBE2B	physical	20061386
CBX5_HUMAN	CBX5	physical	25384975
H2A2C_HUMAN	HIST2H2AC	physical	23339190
UBE2A_HUMAN	UBE2A	physical	25582440
UBC_HUMAN	UBC	physical	25582440
RAD18_HUMAN	RAD18	physical	25582440
SLF1_HUMAN	ANKRD32	physical	25582440
BRE1A_HUMAN	RNF20	physical	25582440
BRE1B_HUMAN	RNF40	physical	25582440
WAC_HUMAN	WAC	physical	25582440
UBR1_HUMAN	UBR1	physical	25582440
UBR2_HUMAN	UBR2	physical	25582440
UBR3_HUMAN	UBR3	physical	25582440
KCMF1_HUMAN	KCMF1	physical	25582440
UBR4_HUMAN	UBR4	physical	25582440
NIPS1_HUMAN	NIPSNAP1	physical	25582440
NPS3A_HUMAN	NIPSNAP3A	physical	25582440
ABHDA_HUMAN	ABHD10	physical	25582440
SSBP_HUMAN	SSBP1	physical	25582440
SYSM_HUMAN	SARS2	physical	25582440
ACOT9_HUMAN	ACOT9	physical	25582440
UB2L3_HUMAN	UBE2L3	physical	26344197
RAD18_HUMAN	RAD18	physical	28514442
BRE1A_HUMAN	RNF20	physical	28514442
UBE2A_HUMAN	UBE2A	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.