WAC_HUMAN - dbPTM
WAC_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID WAC_HUMAN
UniProt AC Q9BTA9
Protein Name WW domain-containing adapter protein with coiled-coil
Gene Name WAC
Organism Homo sapiens (Human).
Sequence Length 647
Subcellular Localization Nucleus speckle . Nucleus . In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes.
Protein Description Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). [PubMed: 21329877 Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription]
Protein Sequence MVMYARKQQRLSDGCHDRRGDSQPYQALKYSSKSHPSSGDHRHEKMRDAGDPSPPNKMLRRSDSPENKYSDSTGHSKAKNVHTHRVRERDGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTSDAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKMAVNSFPKDRDYRREVMQATATSGFASGMEDKHSSDASSLLPQNILSQTSRHNDRDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDKPVSHSCTTPSTSSASGLNPTSAPPTSASAVPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSPRSLQRSSSQRSPSPGPNHTSNSSNASNATVVPQNSSARSTCSLTPALAAHFSENLIKHVQGWPADHAEKQASRLREEAHNMGTIHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure
ASA (%) Reference Orthologous
Protein Cluster
8 (in isoform 2)Phosphorylation-28.2425849741
8 (in isoform 3)Phosphorylation-28.2425849741
12PhosphorylationARKQQRLSDGCHDRR
CCCCCCCCCCCCCCC
33.8623312004
17 (in isoform 2)Phosphorylation-46.15-
19MethylationSDGCHDRRGDSQPYQ
CCCCCCCCCCCCCHH
60.37115919877
19PhosphorylationSDGCHDRRGDSQPYQ
CCCCCCCCCCCCCHH
60.3732645325
19 (in isoform 2)Phosphorylation-60.37-
22PhosphorylationCHDRRGDSQPYQALK
CCCCCCCCCCHHHHH
35.5625159151
25PhosphorylationRRGDSQPYQALKYSS
CCCCCCCHHHHHHHC
9.9725884760
27 (in isoform 2)Phosphorylation-10.52-
29MethylationSQPYQALKYSSKSHP
CCCHHHHHHHCCCCC
46.21115978725
29UbiquitinationSQPYQALKYSSKSHP
CCCHHHHHHHCCCCC
46.2132015554
30PhosphorylationQPYQALKYSSKSHPS
CCHHHHHHHCCCCCC
21.0128555341
53PhosphorylationMRDAGDPSPPNKMLR
HHHCCCCCCCCHHCC
58.7029255136
53 (in isoform 5)Phosphorylation-58.70-
57AcetylationGDPSPPNKMLRRSDS
CCCCCCCHHCCCCCC
45.1225953088
62PhosphorylationPNKMLRRSDSPENKY
CCHHCCCCCCCCCCC
35.6925159151
62 (in isoform 5)Phosphorylation-35.69-
64PhosphorylationKMLRRSDSPENKYSD
HHCCCCCCCCCCCCC
35.0525159151
64 (in isoform 5)Phosphorylation-35.05-
69PhosphorylationSDSPENKYSDSTGHS
CCCCCCCCCCCCCCC
29.3223403867
70PhosphorylationDSPENKYSDSTGHSK
CCCCCCCCCCCCCCC
27.0523403867
72PhosphorylationPENKYSDSTGHSKAK
CCCCCCCCCCCCCCC
30.2823403867
72 (in isoform 5)Phosphorylation-30.28-
73PhosphorylationENKYSDSTGHSKAKN
CCCCCCCCCCCCCCC
43.8523403867
76PhosphorylationYSDSTGHSKAKNVHT
CCCCCCCCCCCCCEE
35.3423403867
93PhosphorylationVRERDGGTSYSPQEN
EEECCCCCCCCCCCC
29.9823927012
94PhosphorylationRERDGGTSYSPQENS
EECCCCCCCCCCCCC
27.2123927012
95PhosphorylationERDGGTSYSPQENSH
ECCCCCCCCCCCCCC
24.9830576142
96PhosphorylationRDGGTSYSPQENSHN
CCCCCCCCCCCCCCC
21.6323401153
99UbiquitinationGTSYSPQENSHNHSA
CCCCCCCCCCCCCCC
65.1729967540
101PhosphorylationSYSPQENSHNHSALH
CCCCCCCCCCCCCCC
25.5523927012
105PhosphorylationQENSHNHSALHSSNS
CCCCCCCCCCCCCCC
37.5330576142
109PhosphorylationHNHSALHSSNSHSSN
CCCCCCCCCCCCCCC
31.8723927012
110PhosphorylationNHSALHSSNSHSSNP
CCCCCCCCCCCCCCC
31.4423927012
112PhosphorylationSALHSSNSHSSNPSN
CCCCCCCCCCCCCCC
27.0530576142
114PhosphorylationLHSSNSHSSNPSNNP
CCCCCCCCCCCCCCC
31.4723927012
115PhosphorylationHSSNSHSSNPSNNPS
CCCCCCCCCCCCCCC
47.5423927012
118PhosphorylationNSHSSNPSNNPSKTS
CCCCCCCCCCCCCCC
54.1923927012
122PhosphorylationSNPSNNPSKTSDAPY
CCCCCCCCCCCCCCC
51.1723401153
124PhosphorylationPSNNPSKTSDAPYDS
CCCCCCCCCCCCCCC
35.8629396449
125PhosphorylationSNNPSKTSDAPYDSA
CCCCCCCCCCCCCCC
35.2029396449
129PhosphorylationSKTSDAPYDSADDWS
CCCCCCCCCCCCHHH
25.0130108239
130UbiquitinationKTSDAPYDSADDWSE
CCCCCCCCCCCHHHH
35.9732142685
131PhosphorylationTSDAPYDSADDWSEH
CCCCCCCCCCHHHHH
27.9625159151
136PhosphorylationYDSADDWSEHISSSG
CCCCCHHHHHHHHCC
26.7130108239
140PhosphorylationDDWSEHISSSGKKYY
CHHHHHHHHCCCEEE
21.9930108239
141PhosphorylationDWSEHISSSGKKYYY
HHHHHHHHCCCEEEE
42.3729978859
142PhosphorylationWSEHISSSGKKYYYN
HHHHHHHCCCEEEEE
48.0925159151
144AcetylationEHISSSGKKYYYNCR
HHHHHCCCEEEEECC
39.2826051181
144UbiquitinationEHISSSGKKYYYNCR
HHHHHCCCEEEEECC
39.2829967540
175AcetylationQRQKEANKMAVNSFP
HHHHHHHHHHHHHCC
34.9725953088
175UbiquitinationQRQKEANKMAVNSFP
HHHHHHHHHHHHHCC
34.9732142685
180PhosphorylationANKMAVNSFPKDRDY
HHHHHHHHCCCCHHH
36.01-
183AcetylationMAVNSFPKDRDYRRE
HHHHHCCCCHHHHHH
64.4825953088
187PhosphorylationSFPKDRDYRREVMQA
HCCCCHHHHHHHHHH
16.68-
195PhosphorylationRREVMQATATSGFAS
HHHHHHHHHHCCCCC
17.3622817900
197PhosphorylationEVMQATATSGFASGM
HHHHHHHHCCCCCCC
25.6522817900
198PhosphorylationVMQATATSGFASGME
HHHHHHHCCCCCCCC
29.4722817900
202PhosphorylationTATSGFASGMEDKHS
HHHCCCCCCCCCCCC
36.0922817900
209UbiquitinationSGMEDKHSSDASSLL
CCCCCCCCCCHHHHC
35.3421890473
213PhosphorylationDKHSSDASSLLPQNI
CCCCCCHHHHCCHHH
26.8927080861
222PhosphorylationLLPQNILSQTSRHND
HCCHHHHHHCCCCCC
27.8427080861
224PhosphorylationPQNILSQTSRHNDRD
CHHHHHHCCCCCCCC
25.0927080861
225O-linked_GlycosylationQNILSQTSRHNDRDY
HHHHHHCCCCCCCCC
24.7330059200
225PhosphorylationQNILSQTSRHNDRDY
HHHHHHCCCCCCCCC
24.7320068231
229UbiquitinationSQTSRHNDRDYRLPR
HHCCCCCCCCCCCCC
38.4121890473
232UbiquitinationSRHNDRDYRLPRAET
CCCCCCCCCCCCCCC
18.2323000965
233UbiquitinationRHNDRDYRLPRAETH
CCCCCCCCCCCCCCC
42.3723000965
239PhosphorylationYRLPRAETHSSSTPV
CCCCCCCCCCCCCCC
26.5223312004
241PhosphorylationLPRAETHSSSTPVQH
CCCCCCCCCCCCCCC
33.1423312004
242PhosphorylationPRAETHSSSTPVQHP
CCCCCCCCCCCCCCC
30.5423312004
243PhosphorylationRAETHSSSTPVQHPI
CCCCCCCCCCCCCCC
39.4825627689
244PhosphorylationAETHSSSTPVQHPIK
CCCCCCCCCCCCCCC
29.4425159151
248PhosphorylationSSSTPVQHPIKPVVH
CCCCCCCCCCCCCCC
26.7032142685
248 (in isoform 2)Phosphorylation-26.70-
250 (in isoform 2)Phosphorylation-8.06-
251AcetylationTPVQHPIKPVVHPTA
CCCCCCCCCCCCCCC
35.8926051181
257AcetylationIKPVVHPTATPSTVP
CCCCCCCCCCCCCCC
28.4319608861
257PhosphorylationIKPVVHPTATPSTVP
CCCCCCCCCCCCCCC
28.4329978859
257UbiquitinationIKPVVHPTATPSTVP
CCCCCCCCCCCCCCC
28.4332015554
257 (in isoform 2)Acetylation-28.43-
259PhosphorylationPVVHPTATPSTVPSS
CCCCCCCCCCCCCCC
21.9129978859
261PhosphorylationVHPTATPSTVPSSPF
CCCCCCCCCCCCCCC
37.3729978859
262PhosphorylationHPTATPSTVPSSPFT
CCCCCCCCCCCCCCC
37.3229978859
265PhosphorylationATPSTVPSSPFTLQS
CCCCCCCCCCCCCCC
46.4329116813
266PhosphorylationTPSTVPSSPFTLQSD
CCCCCCCCCCCCCCC
20.2625849741
269PhosphorylationTVPSSPFTLQSDHQP
CCCCCCCCCCCCCCC
27.5429978859
270 (in isoform 5)Phosphorylation-4.73-
272PhosphorylationSSPFTLQSDHQPKKS
CCCCCCCCCCCCCCC
39.9229978859
276 (in isoform 5)Phosphorylation-42.49-
277UbiquitinationLQSDHQPKKSFDANG
CCCCCCCCCCCCCCC
55.2523000965
278UbiquitinationQSDHQPKKSFDANGA
CCCCCCCCCCCCCCC
64.1423000965
279PhosphorylationSDHQPKKSFDANGAS
CCCCCCCCCCCCCCC
34.1921815630
286PhosphorylationSFDANGASTLSKLPT
CCCCCCCCHHHCCCC
31.14-
287PhosphorylationFDANGASTLSKLPTP
CCCCCCCHHHCCCCC
34.22-
289PhosphorylationANGASTLSKLPTPTS
CCCCCHHHCCCCCCC
32.03-
292 (in isoform 5)Phosphorylation-39.82-
293PhosphorylationSTLSKLPTPTSSVPA
CHHHCCCCCCCCCCC
50.0330266825
295PhosphorylationLSKLPTPTSSVPAQK
HHCCCCCCCCCCCCC
35.7930266825
296PhosphorylationSKLPTPTSSVPAQKT
HCCCCCCCCCCCCCC
30.4630266825
297PhosphorylationKLPTPTSSVPAQKTE
CCCCCCCCCCCCCCC
34.3030266825
302AcetylationTSSVPAQKTERKEST
CCCCCCCCCCCCCCC
55.2319608861
302UbiquitinationTSSVPAQKTERKEST
CCCCCCCCCCCCCCC
55.2332015554
303O-linked_GlycosylationSSVPAQKTERKESTS
CCCCCCCCCCCCCCC
29.0130059200
303PhosphorylationSSVPAQKTERKESTS
CCCCCCCCCCCCCCC
29.0120068231
308O-linked_GlycosylationQKTERKESTSGDKPV
CCCCCCCCCCCCCCC
30.7930059200
308PhosphorylationQKTERKESTSGDKPV
CCCCCCCCCCCCCCC
30.79-
309PhosphorylationKTERKESTSGDKPVS
CCCCCCCCCCCCCCC
37.51-
310PhosphorylationTERKESTSGDKPVSH
CCCCCCCCCCCCCCC
55.03-
315 (in isoform 5)Phosphorylation-11.22-
318UbiquitinationGDKPVSHSCTTPSTS
CCCCCCCCCCCCCCC
12.9721890473
328 (in isoform 2)Phosphorylation-45.84-
333 (in isoform 5)Phosphorylation-36.13-
334PhosphorylationASGLNPTSAPPTSAS
CCCCCCCCCCCCCCC
39.7820068231
334 (in isoform 2)Phosphorylation-39.78-
338UbiquitinationNPTSAPPTSASAVPV
CCCCCCCCCCCCCCC
35.5521890473
343 (in isoform 5)Phosphorylation-4.45-
346PhosphorylationSASAVPVSPVPQSPI
CCCCCCCCCCCCCCC
17.70-
349 (in isoform 5)Phosphorylation-32.11-
350 (in isoform 2)Phosphorylation-63.17-
351PhosphorylationPVSPVPQSPIPPLLQ
CCCCCCCCCCCHHHC
20.80-
353PhosphorylationSPVPQSPIPPLLQDP
CCCCCCCCCHHHCCH
7.1232142685
353 (in isoform 5)Phosphorylation-7.12-
354 (in isoform 5)Phosphorylation-19.50-
357 (in isoform 5)Phosphorylation-7.18-
359 (in isoform 5)Phosphorylation-33.74-
363UbiquitinationLLQDPNLLRQLLPAL
HHCCHHHHHHHHHHH
4.1021890473
363UbiquitinationLLQDPNLLRQLLPAL
HHCCHHHHHHHHHHH
4.1021890473
363 (in isoform 5)Ubiquitination-4.1021890473
367 (in isoform 5)Phosphorylation-1.44-
368PhosphorylationNLLRQLLPALQATLQ
HHHHHHHHHHHHHHH
39.2432142685
368 (in isoform 5)Phosphorylation-39.24-
373PhosphorylationLLPALQATLQLNNSN
HHHHHHHHHHHCCCC
11.3220068231
373 (in isoform 2)Phosphorylation-11.32-
376UbiquitinationALQATLQLNNSNVDI
HHHHHHHHCCCCCCH
8.0333845483
379PhosphorylationATLQLNNSNVDISKI
HHHHHCCCCCCHHHH
36.8420068231
379 (in isoform 5)Phosphorylation-36.84-
383UbiquitinationLNNSNVDISKINEVL
HCCCCCCHHHHHHHH
3.8321890473
383UbiquitinationLNNSNVDISKINEVL
HCCCCCCHHHHHHHH
3.8323000965
383 (in isoform 5)Ubiquitination-3.8321890473
384PhosphorylationNNSNVDISKINEVLT
CCCCCCHHHHHHHHH
24.0320068231
391PhosphorylationSKINEVLTAAVTQAS
HHHHHHHHHHHHHHH
20.1120068231
391 (in isoform 2)Phosphorylation-20.11-
395O-linked_GlycosylationEVLTAAVTQASLQSI
HHHHHHHHHHHHHHH
17.4330059200
395PhosphorylationEVLTAAVTQASLQSI
HHHHHHHHHHHHHHH
17.4320068231
398PhosphorylationTAAVTQASLQSIIHK
HHHHHHHHHHHHHHH
19.6820068231
401PhosphorylationVTQASLQSIIHKFLT
HHHHHHHHHHHHHHH
28.8920068231
401 (in isoform 2)Phosphorylation-28.89-
407 (in isoform 2)Phosphorylation-3.70-
408PhosphorylationSIIHKFLTAGPSAFN
HHHHHHHHHCCCHHH
32.4720068231
408 (in isoform 5)Phosphorylation-32.47-
411PhosphorylationHKFLTAGPSAFNITS
HHHHHHCCCHHHHHH
21.7432142685
411 (in isoform 2)Phosphorylation-21.74-
412PhosphorylationKFLTAGPSAFNITSL
HHHHHCCCHHHHHHH
44.5720068231
412 (in isoform 2)Phosphorylation-44.57-
415 (in isoform 2)Phosphorylation-36.02-
417PhosphorylationGPSAFNITSLISQAA
CCCHHHHHHHHHHHH
20.7020068231
417 (in isoform 2)Phosphorylation-20.70-
418PhosphorylationPSAFNITSLISQAAQ
CCHHHHHHHHHHHHH
21.6520068231
420 (in isoform 5)Phosphorylation-2.62-
421PhosphorylationFNITSLISQAAQLST
HHHHHHHHHHHHHHH
21.0430177828
421UbiquitinationFNITSLISQAAQLST
HHHHHHHHHHHHHHH
21.0421890473
421 (in isoform 2)Ubiquitination-21.0421890473
422PhosphorylationNITSLISQAAQLSTQ
HHHHHHHHHHHHHHH
33.4533259812
422 (in isoform 5)Phosphorylation-33.45-
425 (in isoform 2)Phosphorylation-38.67-
426PhosphorylationLISQAAQLSTQAQPS
HHHHHHHHHHHCCCC
5.2632142685
426 (in isoform 2)Phosphorylation-5.26-
427PhosphorylationISQAAQLSTQAQPSN
HHHHHHHHHHCCCCC
13.3430177828
428PhosphorylationSQAAQLSTQAQPSNQ
HHHHHHHHHCCCCCC
36.1928450419
429 (in isoform 5)Phosphorylation-34.32-
431 (in isoform 5)Phosphorylation-31.94-
433PhosphorylationLSTQAQPSNQSPMSL
HHHHCCCCCCCCCCC
35.1128450419
434UbiquitinationSTQAQPSNQSPMSLT
HHHCCCCCCCCCCCC
53.7033845483
436PhosphorylationQAQPSNQSPMSLTSD
HCCCCCCCCCCCCCC
27.1628450419
437 (in isoform 2)Phosphorylation-13.45-
439PhosphorylationPSNQSPMSLTSDASS
CCCCCCCCCCCCCCC
31.7028450419
441PhosphorylationNQSPMSLTSDASSPR
CCCCCCCCCCCCCCC
19.7728450419
441UbiquitinationNQSPMSLTSDASSPR
CCCCCCCCCCCCCCC
19.7723000965
441 (in isoform 2)Ubiquitination-19.7721890473
442PhosphorylationQSPMSLTSDASSPRS
CCCCCCCCCCCCCCC
36.1528450419
445PhosphorylationMSLTSDASSPRSYVS
CCCCCCCCCCCCCCC
45.9628464451
446PhosphorylationSLTSDASSPRSYVSP
CCCCCCCCCCCCCCC
26.5025159151
449PhosphorylationSDASSPRSYVSPRIS
CCCCCCCCCCCCCCC
33.0226074081
450PhosphorylationDASSPRSYVSPRIST
CCCCCCCCCCCCCCC
13.2623403867
452PhosphorylationSSPRSYVSPRISTPQ
CCCCCCCCCCCCCCC
10.5430183078
456O-linked_GlycosylationSYVSPRISTPQTNTV
CCCCCCCCCCCCCCC
35.0030059200
456PhosphorylationSYVSPRISTPQTNTV
CCCCCCCCCCCCCCC
35.0025159151
457PhosphorylationYVSPRISTPQTNTVP
CCCCCCCCCCCCCCC
19.6223401153
460PhosphorylationPRISTPQTNTVPIKP
CCCCCCCCCCCCCCC
33.7821712546
462PhosphorylationISTPQTNTVPIKPLI
CCCCCCCCCCCCCCC
30.9222115753
466AcetylationQTNTVPIKPLISTPP
CCCCCCCCCCCCCCC
27.9223954790
466UbiquitinationQTNTVPIKPLISTPP
CCCCCCCCCCCCCCC
27.9223000965
466 (in isoform 1)Ubiquitination-27.9221890473
466 (in isoform 2)Phosphorylation-27.92-
470PhosphorylationVPIKPLISTPPVSSQ
CCCCCCCCCCCCCCC
42.4123401153
471PhosphorylationPIKPLISTPPVSSQP
CCCCCCCCCCCCCCC
25.3125159151
475O-linked_GlycosylationLISTPPVSSQPKVST
CCCCCCCCCCCCCCC
29.0930059200
475PhosphorylationLISTPPVSSQPKVST
CCCCCCCCCCCCCCC
29.0921082442
476PhosphorylationISTPPVSSQPKVSTP
CCCCCCCCCCCCCCC
51.2221712546
478UbiquitinationTPPVSSQPKVSTPVV
CCCCCCCCCCCCCCE
40.7529967540
478 (in isoform 2)Phosphorylation-40.75-
479UbiquitinationPPVSSQPKVSTPVVK
CCCCCCCCCCCCCEE
40.9833845483
480PhosphorylationPVSSQPKVSTPVVKQ
CCCCCCCCCCCCEEC
11.0933259812
480 (in isoform 2)Phosphorylation-11.09-
481PhosphorylationVSSQPKVSTPVVKQG
CCCCCCCCCCCEECC
32.8720068231
482PhosphorylationSSQPKVSTPVVKQGP
CCCCCCCCCCEECCC
24.0816964243
485UbiquitinationPKVSTPVVKQGPVSQ
CCCCCCCEECCCCCC
3.9523000965
486AcetylationKVSTPVVKQGPVSQS
CCCCCCEECCCCCCC
50.1725953088
486PhosphorylationKVSTPVVKQGPVSQS
CCCCCCEECCCCCCC
50.1732142685
486UbiquitinationKVSTPVVKQGPVSQS
CCCCCCEECCCCCCC
50.1723000965
486 (in isoform 1)Ubiquitination-50.1721890473
487 (in isoform 2)Phosphorylation-50.22-
489UbiquitinationTPVVKQGPVSQSATQ
CCCEECCCCCCCCCC
21.7923000965
489 (in isoform 2)Phosphorylation-21.79-
490UbiquitinationPVVKQGPVSQSATQQ
CCEECCCCCCCCCCC
11.8423000965
491PhosphorylationVVKQGPVSQSATQQP
CEECCCCCCCCCCCC
22.8823927012
491UbiquitinationVVKQGPVSQSATQQP
CEECCCCCCCCCCCC
22.8823000965
492UbiquitinationVKQGPVSQSATQQPV
EECCCCCCCCCCCCC
37.0023000965
493PhosphorylationKQGPVSQSATQQPVT
ECCCCCCCCCCCCCC
26.2723927012
495PhosphorylationGPVSQSATQQPVTAD
CCCCCCCCCCCCCCC
32.7423927012
500PhosphorylationSATQQPVTADKQQGH
CCCCCCCCCCCCCCC
35.5023927012
503AcetylationQQPVTADKQQGHEPV
CCCCCCCCCCCCCCC
41.9026051181
511PhosphorylationQQGHEPVSPRSLQRS
CCCCCCCCHHHHHCC
25.8829255136
514PhosphorylationHEPVSPRSLQRSSSQ
CCCCCHHHHHCCCCC
32.0328111955
518PhosphorylationSPRSLQRSSSQRSPS
CHHHHHCCCCCCCCC
22.7530278072
519PhosphorylationPRSLQRSSSQRSPSP
HHHHHCCCCCCCCCC
32.4530278072
520PhosphorylationRSLQRSSSQRSPSPG
HHHHCCCCCCCCCCC
30.7530278072
523PhosphorylationQRSSSQRSPSPGPNH
HCCCCCCCCCCCCCC
23.3025159151
525PhosphorylationSSSQRSPSPGPNHTS
CCCCCCCCCCCCCCC
43.6725159151
531PhosphorylationPSPGPNHTSNSSNAS
CCCCCCCCCCCCCCC
35.9226503892
531UbiquitinationPSPGPNHTSNSSNAS
CCCCCCCCCCCCCCC
35.9223000965
532PhosphorylationSPGPNHTSNSSNASN
CCCCCCCCCCCCCCC
27.4530278072
534PhosphorylationGPNHTSNSSNASNAT
CCCCCCCCCCCCCCE
25.4123401153
535PhosphorylationPNHTSNSSNASNATV
CCCCCCCCCCCCCEE
40.4430278072
535UbiquitinationPNHTSNSSNASNATV
CCCCCCCCCCCCCEE
40.4423000965
536UbiquitinationNHTSNSSNASNATVV
CCCCCCCCCCCCEEC
47.4029967540
537UbiquitinationHTSNSSNASNATVVP
CCCCCCCCCCCEECC
13.2023000965
538PhosphorylationTSNSSNASNATVVPQ
CCCCCCCCCCEECCC
31.1130278072
541PhosphorylationSSNASNATVVPQNSS
CCCCCCCEECCCCCC
26.7023927012
547PhosphorylationATVVPQNSSARSTCS
CEECCCCCCCHHHHC
21.8123927012
548PhosphorylationTVVPQNSSARSTCSL
EECCCCCCCHHHHCC
34.9423927012
556PhosphorylationARSTCSLTPALAAHF
CHHHHCCCHHHHHHH
7.10-
581UbiquitinationWPADHAEKQASRLRE
CCHHHHHHHHHHHHH
52.5329967540
588UbiquitinationKQASRLREEAHNMGT
HHHHHHHHHHHHHCC
65.2223000965
589UbiquitinationQASRLREEAHNMGTI
HHHHHHHHHHHHCCC
49.1223000965
592UbiquitinationRLREEAHNMGTIHMS
HHHHHHHHHCCCCHH
37.3123000965
593UbiquitinationLREEAHNMGTIHMSE
HHHHHHHHCCCCHHH
3.4423000965
594UbiquitinationREEAHNMGTIHMSEI
HHHHHHHCCCCHHHH
27.1723000965
595UbiquitinationEEAHNMGTIHMSEIC
HHHHHHCCCCHHHHH
9.2823000965
606AcetylationSEICTELKNLRSLVR
HHHHHHHHHHHHHHH
47.9426051181
634UbiquitinationLFLRQQIKELEKLKN
HHHHHHHHHHHHHHH
52.4923000965
638UbiquitinationQQIKELEKLKNQNSF
HHHHHHHHHHHCCCC
76.9023000965
640UbiquitinationIKELEKLKNQNSFMV
HHHHHHHHHCCCCCC
68.5023000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
244TPhosphorylationKinaseCDK1P06493
PSP
457TPhosphorylationKinaseCDK1P06493
PSP
471TPhosphorylationKinaseCDK1P06493
PSP
482TPhosphorylationKinaseCDK1P06493
PSP

Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of WAC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10)
Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of WAC_HUMAN !!

Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
BRE1B_HUMANRNF40physical
21329877
BRE1A_HUMANRNF20physical
21329877
RPB1_HUMANPOLR2Aphysical
21329877
VCIP1_HUMANVCPIP1physical
21811234
TERA_HUMANVCPphysical
21811234
A4_HUMANAPPphysical
21832049
WAC_HUMANWACphysical
25416956
T3JAM_HUMANTRAF3IP3physical
25416956
SYTL5_HUMANSYTL5physical
25416956
DYDC1_HUMANDYDC1physical
25416956
KLC3_HUMANKLC3physical
25416956
TLN1_HUMANTLN1physical
26344197
BRE1A_HUMANRNF20physical
28514442
BRE1B_HUMANRNF40physical
28514442
TPM2_HUMANTPM2physical
28514442

Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of WAC_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-302, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-471; SER-523 ANDSER-525, AND MASS SPECTROMETRY.
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-293; SER-456; SER-476AND THR-482, AND MASS SPECTROMETRY.
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525, AND MASSSPECTROMETRY.
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization.";
Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.;
Nat. Biotechnol. 24:1285-1292(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53; THR-293 AND THR-482,AND MASS SPECTROMETRY.
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks.";
Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.;
Cell 127:635-648(2006).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53; SER-64; SER-511;SER-523 AND SER-525, AND MASS SPECTROMETRY.
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-293, AND MASSSPECTROMETRY.

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