UniProt ID | WAC_HUMAN | |
---|---|---|
UniProt AC | Q9BTA9 | |
Protein Name | WW domain-containing adapter protein with coiled-coil | |
Gene Name | WAC | |
Organism | Homo sapiens (Human). | |
Sequence Length | 647 | |
Subcellular Localization | Nucleus speckle . Nucleus . In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes. | |
Protein Description | Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). [PubMed: 21329877 Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription] | |
Protein Sequence | MVMYARKQQRLSDGCHDRRGDSQPYQALKYSSKSHPSSGDHRHEKMRDAGDPSPPNKMLRRSDSPENKYSDSTGHSKAKNVHTHRVRERDGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTSDAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKMAVNSFPKDRDYRREVMQATATSGFASGMEDKHSSDASSLLPQNILSQTSRHNDRDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDKPVSHSCTTPSTSSASGLNPTSAPPTSASAVPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSPRSLQRSSSQRSPSPGPNHTSNSSNASNATVVPQNSSARSTCSLTPALAAHFSENLIKHVQGWPADHAEKQASRLREEAHNMGTIHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
8 (in isoform 2) | Phosphorylation | - | 28.24 | 25849741 | |
8 (in isoform 3) | Phosphorylation | - | 28.24 | 25849741 | |
12 | Phosphorylation | ARKQQRLSDGCHDRR CCCCCCCCCCCCCCC | 33.86 | 23312004 | |
17 (in isoform 2) | Phosphorylation | - | 46.15 | - | |
19 | Methylation | SDGCHDRRGDSQPYQ CCCCCCCCCCCCCHH | 60.37 | 115919877 | |
19 | Phosphorylation | SDGCHDRRGDSQPYQ CCCCCCCCCCCCCHH | 60.37 | 32645325 | |
19 (in isoform 2) | Phosphorylation | - | 60.37 | - | |
22 | Phosphorylation | CHDRRGDSQPYQALK CCCCCCCCCCHHHHH | 35.56 | 25159151 | |
25 | Phosphorylation | RRGDSQPYQALKYSS CCCCCCCHHHHHHHC | 9.97 | 25884760 | |
27 (in isoform 2) | Phosphorylation | - | 10.52 | - | |
29 | Methylation | SQPYQALKYSSKSHP CCCHHHHHHHCCCCC | 46.21 | 115978725 | |
29 | Ubiquitination | SQPYQALKYSSKSHP CCCHHHHHHHCCCCC | 46.21 | 32015554 | |
30 | Phosphorylation | QPYQALKYSSKSHPS CCHHHHHHHCCCCCC | 21.01 | 28555341 | |
53 | Phosphorylation | MRDAGDPSPPNKMLR HHHCCCCCCCCHHCC | 58.70 | 29255136 | |
53 (in isoform 5) | Phosphorylation | - | 58.70 | - | |
57 | Acetylation | GDPSPPNKMLRRSDS CCCCCCCHHCCCCCC | 45.12 | 25953088 | |
62 | Phosphorylation | PNKMLRRSDSPENKY CCHHCCCCCCCCCCC | 35.69 | 25159151 | |
62 (in isoform 5) | Phosphorylation | - | 35.69 | - | |
64 | Phosphorylation | KMLRRSDSPENKYSD HHCCCCCCCCCCCCC | 35.05 | 25159151 | |
64 (in isoform 5) | Phosphorylation | - | 35.05 | - | |
69 | Phosphorylation | SDSPENKYSDSTGHS CCCCCCCCCCCCCCC | 29.32 | 23403867 | |
70 | Phosphorylation | DSPENKYSDSTGHSK CCCCCCCCCCCCCCC | 27.05 | 23403867 | |
72 | Phosphorylation | PENKYSDSTGHSKAK CCCCCCCCCCCCCCC | 30.28 | 23403867 | |
72 (in isoform 5) | Phosphorylation | - | 30.28 | - | |
73 | Phosphorylation | ENKYSDSTGHSKAKN CCCCCCCCCCCCCCC | 43.85 | 23403867 | |
76 | Phosphorylation | YSDSTGHSKAKNVHT CCCCCCCCCCCCCEE | 35.34 | 23403867 | |
93 | Phosphorylation | VRERDGGTSYSPQEN EEECCCCCCCCCCCC | 29.98 | 23927012 | |
94 | Phosphorylation | RERDGGTSYSPQENS EECCCCCCCCCCCCC | 27.21 | 23927012 | |
95 | Phosphorylation | ERDGGTSYSPQENSH ECCCCCCCCCCCCCC | 24.98 | 30576142 | |
96 | Phosphorylation | RDGGTSYSPQENSHN CCCCCCCCCCCCCCC | 21.63 | 23401153 | |
99 | Ubiquitination | GTSYSPQENSHNHSA CCCCCCCCCCCCCCC | 65.17 | 29967540 | |
101 | Phosphorylation | SYSPQENSHNHSALH CCCCCCCCCCCCCCC | 25.55 | 23927012 | |
105 | Phosphorylation | QENSHNHSALHSSNS CCCCCCCCCCCCCCC | 37.53 | 30576142 | |
109 | Phosphorylation | HNHSALHSSNSHSSN CCCCCCCCCCCCCCC | 31.87 | 23927012 | |
110 | Phosphorylation | NHSALHSSNSHSSNP CCCCCCCCCCCCCCC | 31.44 | 23927012 | |
112 | Phosphorylation | SALHSSNSHSSNPSN CCCCCCCCCCCCCCC | 27.05 | 30576142 | |
114 | Phosphorylation | LHSSNSHSSNPSNNP CCCCCCCCCCCCCCC | 31.47 | 23927012 | |
115 | Phosphorylation | HSSNSHSSNPSNNPS CCCCCCCCCCCCCCC | 47.54 | 23927012 | |
118 | Phosphorylation | NSHSSNPSNNPSKTS CCCCCCCCCCCCCCC | 54.19 | 23927012 | |
122 | Phosphorylation | SNPSNNPSKTSDAPY CCCCCCCCCCCCCCC | 51.17 | 23401153 | |
124 | Phosphorylation | PSNNPSKTSDAPYDS CCCCCCCCCCCCCCC | 35.86 | 29396449 | |
125 | Phosphorylation | SNNPSKTSDAPYDSA CCCCCCCCCCCCCCC | 35.20 | 29396449 | |
129 | Phosphorylation | SKTSDAPYDSADDWS CCCCCCCCCCCCHHH | 25.01 | 30108239 | |
130 | Ubiquitination | KTSDAPYDSADDWSE CCCCCCCCCCCHHHH | 35.97 | 32142685 | |
131 | Phosphorylation | TSDAPYDSADDWSEH CCCCCCCCCCHHHHH | 27.96 | 25159151 | |
136 | Phosphorylation | YDSADDWSEHISSSG CCCCCHHHHHHHHCC | 26.71 | 30108239 | |
140 | Phosphorylation | DDWSEHISSSGKKYY CHHHHHHHHCCCEEE | 21.99 | 30108239 | |
141 | Phosphorylation | DWSEHISSSGKKYYY HHHHHHHHCCCEEEE | 42.37 | 29978859 | |
142 | Phosphorylation | WSEHISSSGKKYYYN HHHHHHHCCCEEEEE | 48.09 | 25159151 | |
144 | Acetylation | EHISSSGKKYYYNCR HHHHHCCCEEEEECC | 39.28 | 26051181 | |
144 | Ubiquitination | EHISSSGKKYYYNCR HHHHHCCCEEEEECC | 39.28 | 29967540 | |
175 | Acetylation | QRQKEANKMAVNSFP HHHHHHHHHHHHHCC | 34.97 | 25953088 | |
175 | Ubiquitination | QRQKEANKMAVNSFP HHHHHHHHHHHHHCC | 34.97 | 32142685 | |
180 | Phosphorylation | ANKMAVNSFPKDRDY HHHHHHHHCCCCHHH | 36.01 | - | |
183 | Acetylation | MAVNSFPKDRDYRRE HHHHHCCCCHHHHHH | 64.48 | 25953088 | |
187 | Phosphorylation | SFPKDRDYRREVMQA HCCCCHHHHHHHHHH | 16.68 | - | |
195 | Phosphorylation | RREVMQATATSGFAS HHHHHHHHHHCCCCC | 17.36 | 22817900 | |
197 | Phosphorylation | EVMQATATSGFASGM HHHHHHHHCCCCCCC | 25.65 | 22817900 | |
198 | Phosphorylation | VMQATATSGFASGME HHHHHHHCCCCCCCC | 29.47 | 22817900 | |
202 | Phosphorylation | TATSGFASGMEDKHS HHHCCCCCCCCCCCC | 36.09 | 22817900 | |
209 | Ubiquitination | SGMEDKHSSDASSLL CCCCCCCCCCHHHHC | 35.34 | 21890473 | |
213 | Phosphorylation | DKHSSDASSLLPQNI CCCCCCHHHHCCHHH | 26.89 | 27080861 | |
222 | Phosphorylation | LLPQNILSQTSRHND HCCHHHHHHCCCCCC | 27.84 | 27080861 | |
224 | Phosphorylation | PQNILSQTSRHNDRD CHHHHHHCCCCCCCC | 25.09 | 27080861 | |
225 | O-linked_Glycosylation | QNILSQTSRHNDRDY HHHHHHCCCCCCCCC | 24.73 | 30059200 | |
225 | Phosphorylation | QNILSQTSRHNDRDY HHHHHHCCCCCCCCC | 24.73 | 20068231 | |
229 | Ubiquitination | SQTSRHNDRDYRLPR HHCCCCCCCCCCCCC | 38.41 | 21890473 | |
232 | Ubiquitination | SRHNDRDYRLPRAET CCCCCCCCCCCCCCC | 18.23 | 23000965 | |
233 | Ubiquitination | RHNDRDYRLPRAETH CCCCCCCCCCCCCCC | 42.37 | 23000965 | |
239 | Phosphorylation | YRLPRAETHSSSTPV CCCCCCCCCCCCCCC | 26.52 | 23312004 | |
241 | Phosphorylation | LPRAETHSSSTPVQH CCCCCCCCCCCCCCC | 33.14 | 23312004 | |
242 | Phosphorylation | PRAETHSSSTPVQHP CCCCCCCCCCCCCCC | 30.54 | 23312004 | |
243 | Phosphorylation | RAETHSSSTPVQHPI CCCCCCCCCCCCCCC | 39.48 | 25627689 | |
244 | Phosphorylation | AETHSSSTPVQHPIK CCCCCCCCCCCCCCC | 29.44 | 25159151 | |
248 | Phosphorylation | SSSTPVQHPIKPVVH CCCCCCCCCCCCCCC | 26.70 | 32142685 | |
248 (in isoform 2) | Phosphorylation | - | 26.70 | - | |
250 (in isoform 2) | Phosphorylation | - | 8.06 | - | |
251 | Acetylation | TPVQHPIKPVVHPTA CCCCCCCCCCCCCCC | 35.89 | 26051181 | |
257 | Acetylation | IKPVVHPTATPSTVP CCCCCCCCCCCCCCC | 28.43 | 19608861 | |
257 | Phosphorylation | IKPVVHPTATPSTVP CCCCCCCCCCCCCCC | 28.43 | 29978859 | |
257 | Ubiquitination | IKPVVHPTATPSTVP CCCCCCCCCCCCCCC | 28.43 | 32015554 | |
257 (in isoform 2) | Acetylation | - | 28.43 | - | |
259 | Phosphorylation | PVVHPTATPSTVPSS CCCCCCCCCCCCCCC | 21.91 | 29978859 | |
261 | Phosphorylation | VHPTATPSTVPSSPF CCCCCCCCCCCCCCC | 37.37 | 29978859 | |
262 | Phosphorylation | HPTATPSTVPSSPFT CCCCCCCCCCCCCCC | 37.32 | 29978859 | |
265 | Phosphorylation | ATPSTVPSSPFTLQS CCCCCCCCCCCCCCC | 46.43 | 29116813 | |
266 | Phosphorylation | TPSTVPSSPFTLQSD CCCCCCCCCCCCCCC | 20.26 | 25849741 | |
269 | Phosphorylation | TVPSSPFTLQSDHQP CCCCCCCCCCCCCCC | 27.54 | 29978859 | |
270 (in isoform 5) | Phosphorylation | - | 4.73 | - | |
272 | Phosphorylation | SSPFTLQSDHQPKKS CCCCCCCCCCCCCCC | 39.92 | 29978859 | |
276 (in isoform 5) | Phosphorylation | - | 42.49 | - | |
277 | Ubiquitination | LQSDHQPKKSFDANG CCCCCCCCCCCCCCC | 55.25 | 23000965 | |
278 | Ubiquitination | QSDHQPKKSFDANGA CCCCCCCCCCCCCCC | 64.14 | 23000965 | |
279 | Phosphorylation | SDHQPKKSFDANGAS CCCCCCCCCCCCCCC | 34.19 | 21815630 | |
286 | Phosphorylation | SFDANGASTLSKLPT CCCCCCCCHHHCCCC | 31.14 | - | |
287 | Phosphorylation | FDANGASTLSKLPTP CCCCCCCHHHCCCCC | 34.22 | - | |
289 | Phosphorylation | ANGASTLSKLPTPTS CCCCCHHHCCCCCCC | 32.03 | - | |
292 (in isoform 5) | Phosphorylation | - | 39.82 | - | |
293 | Phosphorylation | STLSKLPTPTSSVPA CHHHCCCCCCCCCCC | 50.03 | 30266825 | |
295 | Phosphorylation | LSKLPTPTSSVPAQK HHCCCCCCCCCCCCC | 35.79 | 30266825 | |
296 | Phosphorylation | SKLPTPTSSVPAQKT HCCCCCCCCCCCCCC | 30.46 | 30266825 | |
297 | Phosphorylation | KLPTPTSSVPAQKTE CCCCCCCCCCCCCCC | 34.30 | 30266825 | |
302 | Acetylation | TSSVPAQKTERKEST CCCCCCCCCCCCCCC | 55.23 | 19608861 | |
302 | Ubiquitination | TSSVPAQKTERKEST CCCCCCCCCCCCCCC | 55.23 | 32015554 | |
303 | O-linked_Glycosylation | SSVPAQKTERKESTS CCCCCCCCCCCCCCC | 29.01 | 30059200 | |
303 | Phosphorylation | SSVPAQKTERKESTS CCCCCCCCCCCCCCC | 29.01 | 20068231 | |
308 | O-linked_Glycosylation | QKTERKESTSGDKPV CCCCCCCCCCCCCCC | 30.79 | 30059200 | |
308 | Phosphorylation | QKTERKESTSGDKPV CCCCCCCCCCCCCCC | 30.79 | - | |
309 | Phosphorylation | KTERKESTSGDKPVS CCCCCCCCCCCCCCC | 37.51 | - | |
310 | Phosphorylation | TERKESTSGDKPVSH CCCCCCCCCCCCCCC | 55.03 | - | |
315 (in isoform 5) | Phosphorylation | - | 11.22 | - | |
318 | Ubiquitination | GDKPVSHSCTTPSTS CCCCCCCCCCCCCCC | 12.97 | 21890473 | |
328 (in isoform 2) | Phosphorylation | - | 45.84 | - | |
333 (in isoform 5) | Phosphorylation | - | 36.13 | - | |
334 | Phosphorylation | ASGLNPTSAPPTSAS CCCCCCCCCCCCCCC | 39.78 | 20068231 | |
334 (in isoform 2) | Phosphorylation | - | 39.78 | - | |
338 | Ubiquitination | NPTSAPPTSASAVPV CCCCCCCCCCCCCCC | 35.55 | 21890473 | |
343 (in isoform 5) | Phosphorylation | - | 4.45 | - | |
346 | Phosphorylation | SASAVPVSPVPQSPI CCCCCCCCCCCCCCC | 17.70 | - | |
349 (in isoform 5) | Phosphorylation | - | 32.11 | - | |
350 (in isoform 2) | Phosphorylation | - | 63.17 | - | |
351 | Phosphorylation | PVSPVPQSPIPPLLQ CCCCCCCCCCCHHHC | 20.80 | - | |
353 | Phosphorylation | SPVPQSPIPPLLQDP CCCCCCCCCHHHCCH | 7.12 | 32142685 | |
353 (in isoform 5) | Phosphorylation | - | 7.12 | - | |
354 (in isoform 5) | Phosphorylation | - | 19.50 | - | |
357 (in isoform 5) | Phosphorylation | - | 7.18 | - | |
359 (in isoform 5) | Phosphorylation | - | 33.74 | - | |
363 | Ubiquitination | LLQDPNLLRQLLPAL HHCCHHHHHHHHHHH | 4.10 | 21890473 | |
363 | Ubiquitination | LLQDPNLLRQLLPAL HHCCHHHHHHHHHHH | 4.10 | 21890473 | |
363 (in isoform 5) | Ubiquitination | - | 4.10 | 21890473 | |
367 (in isoform 5) | Phosphorylation | - | 1.44 | - | |
368 | Phosphorylation | NLLRQLLPALQATLQ HHHHHHHHHHHHHHH | 39.24 | 32142685 | |
368 (in isoform 5) | Phosphorylation | - | 39.24 | - | |
373 | Phosphorylation | LLPALQATLQLNNSN HHHHHHHHHHHCCCC | 11.32 | 20068231 | |
373 (in isoform 2) | Phosphorylation | - | 11.32 | - | |
376 | Ubiquitination | ALQATLQLNNSNVDI HHHHHHHHCCCCCCH | 8.03 | 33845483 | |
379 | Phosphorylation | ATLQLNNSNVDISKI HHHHHCCCCCCHHHH | 36.84 | 20068231 | |
379 (in isoform 5) | Phosphorylation | - | 36.84 | - | |
383 | Ubiquitination | LNNSNVDISKINEVL HCCCCCCHHHHHHHH | 3.83 | 21890473 | |
383 | Ubiquitination | LNNSNVDISKINEVL HCCCCCCHHHHHHHH | 3.83 | 23000965 | |
383 (in isoform 5) | Ubiquitination | - | 3.83 | 21890473 | |
384 | Phosphorylation | NNSNVDISKINEVLT CCCCCCHHHHHHHHH | 24.03 | 20068231 | |
391 | Phosphorylation | SKINEVLTAAVTQAS HHHHHHHHHHHHHHH | 20.11 | 20068231 | |
391 (in isoform 2) | Phosphorylation | - | 20.11 | - | |
395 | O-linked_Glycosylation | EVLTAAVTQASLQSI HHHHHHHHHHHHHHH | 17.43 | 30059200 | |
395 | Phosphorylation | EVLTAAVTQASLQSI HHHHHHHHHHHHHHH | 17.43 | 20068231 | |
398 | Phosphorylation | TAAVTQASLQSIIHK HHHHHHHHHHHHHHH | 19.68 | 20068231 | |
401 | Phosphorylation | VTQASLQSIIHKFLT HHHHHHHHHHHHHHH | 28.89 | 20068231 | |
401 (in isoform 2) | Phosphorylation | - | 28.89 | - | |
407 (in isoform 2) | Phosphorylation | - | 3.70 | - | |
408 | Phosphorylation | SIIHKFLTAGPSAFN HHHHHHHHHCCCHHH | 32.47 | 20068231 | |
408 (in isoform 5) | Phosphorylation | - | 32.47 | - | |
411 | Phosphorylation | HKFLTAGPSAFNITS HHHHHHCCCHHHHHH | 21.74 | 32142685 | |
411 (in isoform 2) | Phosphorylation | - | 21.74 | - | |
412 | Phosphorylation | KFLTAGPSAFNITSL HHHHHCCCHHHHHHH | 44.57 | 20068231 | |
412 (in isoform 2) | Phosphorylation | - | 44.57 | - | |
415 (in isoform 2) | Phosphorylation | - | 36.02 | - | |
417 | Phosphorylation | GPSAFNITSLISQAA CCCHHHHHHHHHHHH | 20.70 | 20068231 | |
417 (in isoform 2) | Phosphorylation | - | 20.70 | - | |
418 | Phosphorylation | PSAFNITSLISQAAQ CCHHHHHHHHHHHHH | 21.65 | 20068231 | |
420 (in isoform 5) | Phosphorylation | - | 2.62 | - | |
421 | Phosphorylation | FNITSLISQAAQLST HHHHHHHHHHHHHHH | 21.04 | 30177828 | |
421 | Ubiquitination | FNITSLISQAAQLST HHHHHHHHHHHHHHH | 21.04 | 21890473 | |
421 (in isoform 2) | Ubiquitination | - | 21.04 | 21890473 | |
422 | Phosphorylation | NITSLISQAAQLSTQ HHHHHHHHHHHHHHH | 33.45 | 33259812 | |
422 (in isoform 5) | Phosphorylation | - | 33.45 | - | |
425 (in isoform 2) | Phosphorylation | - | 38.67 | - | |
426 | Phosphorylation | LISQAAQLSTQAQPS HHHHHHHHHHHCCCC | 5.26 | 32142685 | |
426 (in isoform 2) | Phosphorylation | - | 5.26 | - | |
427 | Phosphorylation | ISQAAQLSTQAQPSN HHHHHHHHHHCCCCC | 13.34 | 30177828 | |
428 | Phosphorylation | SQAAQLSTQAQPSNQ HHHHHHHHHCCCCCC | 36.19 | 28450419 | |
429 (in isoform 5) | Phosphorylation | - | 34.32 | - | |
431 (in isoform 5) | Phosphorylation | - | 31.94 | - | |
433 | Phosphorylation | LSTQAQPSNQSPMSL HHHHCCCCCCCCCCC | 35.11 | 28450419 | |
434 | Ubiquitination | STQAQPSNQSPMSLT HHHCCCCCCCCCCCC | 53.70 | 33845483 | |
436 | Phosphorylation | QAQPSNQSPMSLTSD HCCCCCCCCCCCCCC | 27.16 | 28450419 | |
437 (in isoform 2) | Phosphorylation | - | 13.45 | - | |
439 | Phosphorylation | PSNQSPMSLTSDASS CCCCCCCCCCCCCCC | 31.70 | 28450419 | |
441 | Phosphorylation | NQSPMSLTSDASSPR CCCCCCCCCCCCCCC | 19.77 | 28450419 | |
441 | Ubiquitination | NQSPMSLTSDASSPR CCCCCCCCCCCCCCC | 19.77 | 23000965 | |
441 (in isoform 2) | Ubiquitination | - | 19.77 | 21890473 | |
442 | Phosphorylation | QSPMSLTSDASSPRS CCCCCCCCCCCCCCC | 36.15 | 28450419 | |
445 | Phosphorylation | MSLTSDASSPRSYVS CCCCCCCCCCCCCCC | 45.96 | 28464451 | |
446 | Phosphorylation | SLTSDASSPRSYVSP CCCCCCCCCCCCCCC | 26.50 | 25159151 | |
449 | Phosphorylation | SDASSPRSYVSPRIS CCCCCCCCCCCCCCC | 33.02 | 26074081 | |
450 | Phosphorylation | DASSPRSYVSPRIST CCCCCCCCCCCCCCC | 13.26 | 23403867 | |
452 | Phosphorylation | SSPRSYVSPRISTPQ CCCCCCCCCCCCCCC | 10.54 | 30183078 | |
456 | O-linked_Glycosylation | SYVSPRISTPQTNTV CCCCCCCCCCCCCCC | 35.00 | 30059200 | |
456 | Phosphorylation | SYVSPRISTPQTNTV CCCCCCCCCCCCCCC | 35.00 | 25159151 | |
457 | Phosphorylation | YVSPRISTPQTNTVP CCCCCCCCCCCCCCC | 19.62 | 23401153 | |
460 | Phosphorylation | PRISTPQTNTVPIKP CCCCCCCCCCCCCCC | 33.78 | 21712546 | |
462 | Phosphorylation | ISTPQTNTVPIKPLI CCCCCCCCCCCCCCC | 30.92 | 22115753 | |
466 | Acetylation | QTNTVPIKPLISTPP CCCCCCCCCCCCCCC | 27.92 | 23954790 | |
466 | Ubiquitination | QTNTVPIKPLISTPP CCCCCCCCCCCCCCC | 27.92 | 23000965 | |
466 (in isoform 1) | Ubiquitination | - | 27.92 | 21890473 | |
466 (in isoform 2) | Phosphorylation | - | 27.92 | - | |
470 | Phosphorylation | VPIKPLISTPPVSSQ CCCCCCCCCCCCCCC | 42.41 | 23401153 | |
471 | Phosphorylation | PIKPLISTPPVSSQP CCCCCCCCCCCCCCC | 25.31 | 25159151 | |
475 | O-linked_Glycosylation | LISTPPVSSQPKVST CCCCCCCCCCCCCCC | 29.09 | 30059200 | |
475 | Phosphorylation | LISTPPVSSQPKVST CCCCCCCCCCCCCCC | 29.09 | 21082442 | |
476 | Phosphorylation | ISTPPVSSQPKVSTP CCCCCCCCCCCCCCC | 51.22 | 21712546 | |
478 | Ubiquitination | TPPVSSQPKVSTPVV CCCCCCCCCCCCCCE | 40.75 | 29967540 | |
478 (in isoform 2) | Phosphorylation | - | 40.75 | - | |
479 | Ubiquitination | PPVSSQPKVSTPVVK CCCCCCCCCCCCCEE | 40.98 | 33845483 | |
480 | Phosphorylation | PVSSQPKVSTPVVKQ CCCCCCCCCCCCEEC | 11.09 | 33259812 | |
480 (in isoform 2) | Phosphorylation | - | 11.09 | - | |
481 | Phosphorylation | VSSQPKVSTPVVKQG CCCCCCCCCCCEECC | 32.87 | 20068231 | |
482 | Phosphorylation | SSQPKVSTPVVKQGP CCCCCCCCCCEECCC | 24.08 | 16964243 | |
485 | Ubiquitination | PKVSTPVVKQGPVSQ CCCCCCCEECCCCCC | 3.95 | 23000965 | |
486 | Acetylation | KVSTPVVKQGPVSQS CCCCCCEECCCCCCC | 50.17 | 25953088 | |
486 | Phosphorylation | KVSTPVVKQGPVSQS CCCCCCEECCCCCCC | 50.17 | 32142685 | |
486 | Ubiquitination | KVSTPVVKQGPVSQS CCCCCCEECCCCCCC | 50.17 | 23000965 | |
486 (in isoform 1) | Ubiquitination | - | 50.17 | 21890473 | |
487 (in isoform 2) | Phosphorylation | - | 50.22 | - | |
489 | Ubiquitination | TPVVKQGPVSQSATQ CCCEECCCCCCCCCC | 21.79 | 23000965 | |
489 (in isoform 2) | Phosphorylation | - | 21.79 | - | |
490 | Ubiquitination | PVVKQGPVSQSATQQ CCEECCCCCCCCCCC | 11.84 | 23000965 | |
491 | Phosphorylation | VVKQGPVSQSATQQP CEECCCCCCCCCCCC | 22.88 | 23927012 | |
491 | Ubiquitination | VVKQGPVSQSATQQP CEECCCCCCCCCCCC | 22.88 | 23000965 | |
492 | Ubiquitination | VKQGPVSQSATQQPV EECCCCCCCCCCCCC | 37.00 | 23000965 | |
493 | Phosphorylation | KQGPVSQSATQQPVT ECCCCCCCCCCCCCC | 26.27 | 23927012 | |
495 | Phosphorylation | GPVSQSATQQPVTAD CCCCCCCCCCCCCCC | 32.74 | 23927012 | |
500 | Phosphorylation | SATQQPVTADKQQGH CCCCCCCCCCCCCCC | 35.50 | 23927012 | |
503 | Acetylation | QQPVTADKQQGHEPV CCCCCCCCCCCCCCC | 41.90 | 26051181 | |
511 | Phosphorylation | QQGHEPVSPRSLQRS CCCCCCCCHHHHHCC | 25.88 | 29255136 | |
514 | Phosphorylation | HEPVSPRSLQRSSSQ CCCCCHHHHHCCCCC | 32.03 | 28111955 | |
518 | Phosphorylation | SPRSLQRSSSQRSPS CHHHHHCCCCCCCCC | 22.75 | 30278072 | |
519 | Phosphorylation | PRSLQRSSSQRSPSP HHHHHCCCCCCCCCC | 32.45 | 30278072 | |
520 | Phosphorylation | RSLQRSSSQRSPSPG HHHHCCCCCCCCCCC | 30.75 | 30278072 | |
523 | Phosphorylation | QRSSSQRSPSPGPNH HCCCCCCCCCCCCCC | 23.30 | 25159151 | |
525 | Phosphorylation | SSSQRSPSPGPNHTS CCCCCCCCCCCCCCC | 43.67 | 25159151 | |
531 | Phosphorylation | PSPGPNHTSNSSNAS CCCCCCCCCCCCCCC | 35.92 | 26503892 | |
531 | Ubiquitination | PSPGPNHTSNSSNAS CCCCCCCCCCCCCCC | 35.92 | 23000965 | |
532 | Phosphorylation | SPGPNHTSNSSNASN CCCCCCCCCCCCCCC | 27.45 | 30278072 | |
534 | Phosphorylation | GPNHTSNSSNASNAT CCCCCCCCCCCCCCE | 25.41 | 23401153 | |
535 | Phosphorylation | PNHTSNSSNASNATV CCCCCCCCCCCCCEE | 40.44 | 30278072 | |
535 | Ubiquitination | PNHTSNSSNASNATV CCCCCCCCCCCCCEE | 40.44 | 23000965 | |
536 | Ubiquitination | NHTSNSSNASNATVV CCCCCCCCCCCCEEC | 47.40 | 29967540 | |
537 | Ubiquitination | HTSNSSNASNATVVP CCCCCCCCCCCEECC | 13.20 | 23000965 | |
538 | Phosphorylation | TSNSSNASNATVVPQ CCCCCCCCCCEECCC | 31.11 | 30278072 | |
541 | Phosphorylation | SSNASNATVVPQNSS CCCCCCCEECCCCCC | 26.70 | 23927012 | |
547 | Phosphorylation | ATVVPQNSSARSTCS CEECCCCCCCHHHHC | 21.81 | 23927012 | |
548 | Phosphorylation | TVVPQNSSARSTCSL EECCCCCCCHHHHCC | 34.94 | 23927012 | |
556 | Phosphorylation | ARSTCSLTPALAAHF CHHHHCCCHHHHHHH | 7.10 | - | |
581 | Ubiquitination | WPADHAEKQASRLRE CCHHHHHHHHHHHHH | 52.53 | 29967540 | |
588 | Ubiquitination | KQASRLREEAHNMGT HHHHHHHHHHHHHCC | 65.22 | 23000965 | |
589 | Ubiquitination | QASRLREEAHNMGTI HHHHHHHHHHHHCCC | 49.12 | 23000965 | |
592 | Ubiquitination | RLREEAHNMGTIHMS HHHHHHHHHCCCCHH | 37.31 | 23000965 | |
593 | Ubiquitination | LREEAHNMGTIHMSE HHHHHHHHCCCCHHH | 3.44 | 23000965 | |
594 | Ubiquitination | REEAHNMGTIHMSEI HHHHHHHCCCCHHHH | 27.17 | 23000965 | |
595 | Ubiquitination | EEAHNMGTIHMSEIC HHHHHHCCCCHHHHH | 9.28 | 23000965 | |
606 | Acetylation | SEICTELKNLRSLVR HHHHHHHHHHHHHHH | 47.94 | 26051181 | |
634 | Ubiquitination | LFLRQQIKELEKLKN HHHHHHHHHHHHHHH | 52.49 | 23000965 | |
638 | Ubiquitination | QQIKELEKLKNQNSF HHHHHHHHHHHCCCC | 76.90 | 23000965 | |
640 | Ubiquitination | IKELEKLKNQNSFMV HHHHHHHHHCCCCCC | 68.50 | 23000965 |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of WAC_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of WAC_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
BRE1B_HUMAN | RNF40 | physical | 21329877 | |
BRE1A_HUMAN | RNF20 | physical | 21329877 | |
RPB1_HUMAN | POLR2A | physical | 21329877 | |
VCIP1_HUMAN | VCPIP1 | physical | 21811234 | |
TERA_HUMAN | VCP | physical | 21811234 | |
A4_HUMAN | APP | physical | 21832049 | |
WAC_HUMAN | WAC | physical | 25416956 | |
T3JAM_HUMAN | TRAF3IP3 | physical | 25416956 | |
SYTL5_HUMAN | SYTL5 | physical | 25416956 | |
DYDC1_HUMAN | DYDC1 | physical | 25416956 | |
KLC3_HUMAN | KLC3 | physical | 25416956 | |
TLN1_HUMAN | TLN1 | physical | 26344197 | |
BRE1A_HUMAN | RNF20 | physical | 28514442 | |
BRE1B_HUMAN | RNF40 | physical | 28514442 | |
TPM2_HUMAN | TPM2 | physical | 28514442 |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Acetylation | |
Reference | PubMed |
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-302, AND MASS SPECTROMETRY. | |
Phosphorylation | |
Reference | PubMed |
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-471; SER-523 ANDSER-525, AND MASS SPECTROMETRY. | |
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-293; SER-456; SER-476AND THR-482, AND MASS SPECTROMETRY. | |
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525, AND MASSSPECTROMETRY. | |
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53; THR-293 AND THR-482,AND MASS SPECTROMETRY. | |
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53; SER-64; SER-511;SER-523 AND SER-525, AND MASS SPECTROMETRY. | |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-293, AND MASSSPECTROMETRY. |