dbPTM

WAC_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	WAC_HUMAN
UniProt AC	Q9BTA9
Protein Name	WW domain-containing adapter protein with coiled-coil
Gene Name	WAC
Organism	Homo sapiens (Human).
Sequence Length	647
Subcellular Localization	Nucleus speckle . Nucleus . In distinct nuclear speckles. Colocalizes with pre-mRNA processing complexes.
Protein Description	Acts as a linker between gene transcription and histone H2B monoubiquitination at 'Lys-120' (H2BK120ub1). [PubMed: 21329877 Interacts with the RNA polymerase II transcriptional machinery via its WW domain and with RNF20-RNF40 via its coiled coil region, thereby linking and regulating H2BK120ub1 and gene transcription]
Protein Sequence	MVMYARKQQRLSDGCHDRRGDSQPYQALKYSSKSHPSSGDHRHEKMRDAGDPSPPNKMLRRSDSPENKYSDSTGHSKAKNVHTHRVRERDGGTSYSPQENSHNHSALHSSNSHSSNPSNNPSKTSDAPYDSADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQRQKEANKMAVNSFPKDRDYRREVMQATATSGFASGMEDKHSSDASSLLPQNILSQTSRHNDRDYRLPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDKPVSHSCTTPSTSSASGLNPTSAPPTSASAVPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSPRSLQRSSSQRSPSPGPNHTSNSSNASNATVVPQNSSARSTCSLTPALAAHFSENLIKHVQGWPADHAEKQASRLREEAHNMGTIHMSEICTELKNLRSLVRVCEIQATLREQRILFLRQQIKELEKLKNQNSFMV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8 (in isoform 2)	Phosphorylation	-	28.24	25849741
8 (in isoform 3)	Phosphorylation	-	28.24	25849741
12	Phosphorylation	ARKQQRLSDGCHDRR CCCCCCCCCCCCCCC	33.86	23312004
17 (in isoform 2)	Phosphorylation	-	46.15	-
19	Methylation	SDGCHDRRGDSQPYQ CCCCCCCCCCCCCHH	60.37	115919877
19	Phosphorylation	SDGCHDRRGDSQPYQ CCCCCCCCCCCCCHH	60.37	32645325
19 (in isoform 2)	Phosphorylation	-	60.37	-
22	Phosphorylation	CHDRRGDSQPYQALK CCCCCCCCCCHHHHH	35.56	25159151
25	Phosphorylation	RRGDSQPYQALKYSS CCCCCCCHHHHHHHC	9.97	25884760
27 (in isoform 2)	Phosphorylation	-	10.52	-
29	Methylation	SQPYQALKYSSKSHP CCCHHHHHHHCCCCC	46.21	115978725
29	Ubiquitination	SQPYQALKYSSKSHP CCCHHHHHHHCCCCC	46.21	32015554
30	Phosphorylation	QPYQALKYSSKSHPS CCHHHHHHHCCCCCC	21.01	28555341
53	Phosphorylation	MRDAGDPSPPNKMLR HHHCCCCCCCCHHCC	58.70	29255136
53 (in isoform 5)	Phosphorylation	-	58.70	-
57	Acetylation	GDPSPPNKMLRRSDS CCCCCCCHHCCCCCC	45.12	25953088
62	Phosphorylation	PNKMLRRSDSPENKY CCHHCCCCCCCCCCC	35.69	25159151
62 (in isoform 5)	Phosphorylation	-	35.69	-
64	Phosphorylation	KMLRRSDSPENKYSD HHCCCCCCCCCCCCC	35.05	25159151
64 (in isoform 5)	Phosphorylation	-	35.05	-
69	Phosphorylation	SDSPENKYSDSTGHS CCCCCCCCCCCCCCC	29.32	23403867
70	Phosphorylation	DSPENKYSDSTGHSK CCCCCCCCCCCCCCC	27.05	23403867
72	Phosphorylation	PENKYSDSTGHSKAK CCCCCCCCCCCCCCC	30.28	23403867
72 (in isoform 5)	Phosphorylation	-	30.28	-
73	Phosphorylation	ENKYSDSTGHSKAKN CCCCCCCCCCCCCCC	43.85	23403867
76	Phosphorylation	YSDSTGHSKAKNVHT CCCCCCCCCCCCCEE	35.34	23403867
93	Phosphorylation	VRERDGGTSYSPQEN EEECCCCCCCCCCCC	29.98	23927012
94	Phosphorylation	RERDGGTSYSPQENS EECCCCCCCCCCCCC	27.21	23927012
95	Phosphorylation	ERDGGTSYSPQENSH ECCCCCCCCCCCCCC	24.98	30576142
96	Phosphorylation	RDGGTSYSPQENSHN CCCCCCCCCCCCCCC	21.63	23401153
99	Ubiquitination	GTSYSPQENSHNHSA CCCCCCCCCCCCCCC	65.17	29967540
101	Phosphorylation	SYSPQENSHNHSALH CCCCCCCCCCCCCCC	25.55	23927012
105	Phosphorylation	QENSHNHSALHSSNS CCCCCCCCCCCCCCC	37.53	30576142
109	Phosphorylation	HNHSALHSSNSHSSN CCCCCCCCCCCCCCC	31.87	23927012
110	Phosphorylation	NHSALHSSNSHSSNP CCCCCCCCCCCCCCC	31.44	23927012
112	Phosphorylation	SALHSSNSHSSNPSN CCCCCCCCCCCCCCC	27.05	30576142
114	Phosphorylation	LHSSNSHSSNPSNNP CCCCCCCCCCCCCCC	31.47	23927012
115	Phosphorylation	HSSNSHSSNPSNNPS CCCCCCCCCCCCCCC	47.54	23927012
118	Phosphorylation	NSHSSNPSNNPSKTS CCCCCCCCCCCCCCC	54.19	23927012
122	Phosphorylation	SNPSNNPSKTSDAPY CCCCCCCCCCCCCCC	51.17	23401153
124	Phosphorylation	PSNNPSKTSDAPYDS CCCCCCCCCCCCCCC	35.86	29396449
125	Phosphorylation	SNNPSKTSDAPYDSA CCCCCCCCCCCCCCC	35.20	29396449
129	Phosphorylation	SKTSDAPYDSADDWS CCCCCCCCCCCCHHH	25.01	30108239
130	Ubiquitination	KTSDAPYDSADDWSE CCCCCCCCCCCHHHH	35.97	32142685
131	Phosphorylation	TSDAPYDSADDWSEH CCCCCCCCCCHHHHH	27.96	25159151
136	Phosphorylation	YDSADDWSEHISSSG CCCCCHHHHHHHHCC	26.71	30108239
140	Phosphorylation	DDWSEHISSSGKKYY CHHHHHHHHCCCEEE	21.99	30108239
141	Phosphorylation	DWSEHISSSGKKYYY HHHHHHHHCCCEEEE	42.37	29978859
142	Phosphorylation	WSEHISSSGKKYYYN HHHHHHHCCCEEEEE	48.09	25159151
144	Acetylation	EHISSSGKKYYYNCR HHHHHCCCEEEEECC	39.28	26051181
144	Ubiquitination	EHISSSGKKYYYNCR HHHHHCCCEEEEECC	39.28	29967540
175	Acetylation	QRQKEANKMAVNSFP HHHHHHHHHHHHHCC	34.97	25953088
175	Ubiquitination	QRQKEANKMAVNSFP HHHHHHHHHHHHHCC	34.97	32142685
180	Phosphorylation	ANKMAVNSFPKDRDY HHHHHHHHCCCCHHH	36.01	-
183	Acetylation	MAVNSFPKDRDYRRE HHHHHCCCCHHHHHH	64.48	25953088
187	Phosphorylation	SFPKDRDYRREVMQA HCCCCHHHHHHHHHH	16.68	-
195	Phosphorylation	RREVMQATATSGFAS HHHHHHHHHHCCCCC	17.36	22817900
197	Phosphorylation	EVMQATATSGFASGM HHHHHHHHCCCCCCC	25.65	22817900
198	Phosphorylation	VMQATATSGFASGME HHHHHHHCCCCCCCC	29.47	22817900
202	Phosphorylation	TATSGFASGMEDKHS HHHCCCCCCCCCCCC	36.09	22817900
209	Ubiquitination	SGMEDKHSSDASSLL CCCCCCCCCCHHHHC	35.34	21890473
213	Phosphorylation	DKHSSDASSLLPQNI CCCCCCHHHHCCHHH	26.89	27080861
222	Phosphorylation	LLPQNILSQTSRHND HCCHHHHHHCCCCCC	27.84	27080861
224	Phosphorylation	PQNILSQTSRHNDRD CHHHHHHCCCCCCCC	25.09	27080861
225	O-linked_Glycosylation	QNILSQTSRHNDRDY HHHHHHCCCCCCCCC	24.73	30059200
225	Phosphorylation	QNILSQTSRHNDRDY HHHHHHCCCCCCCCC	24.73	20068231
229	Ubiquitination	SQTSRHNDRDYRLPR HHCCCCCCCCCCCCC	38.41	21890473
232	Ubiquitination	SRHNDRDYRLPRAET CCCCCCCCCCCCCCC	18.23	23000965
233	Ubiquitination	RHNDRDYRLPRAETH CCCCCCCCCCCCCCC	42.37	23000965
239	Phosphorylation	YRLPRAETHSSSTPV CCCCCCCCCCCCCCC	26.52	23312004
241	Phosphorylation	LPRAETHSSSTPVQH CCCCCCCCCCCCCCC	33.14	23312004
242	Phosphorylation	PRAETHSSSTPVQHP CCCCCCCCCCCCCCC	30.54	23312004
243	Phosphorylation	RAETHSSSTPVQHPI CCCCCCCCCCCCCCC	39.48	25627689
244	Phosphorylation	AETHSSSTPVQHPIK CCCCCCCCCCCCCCC	29.44	25159151
248	Phosphorylation	SSSTPVQHPIKPVVH CCCCCCCCCCCCCCC	26.70	32142685
248 (in isoform 2)	Phosphorylation	-	26.70	-
250 (in isoform 2)	Phosphorylation	-	8.06	-
251	Acetylation	TPVQHPIKPVVHPTA CCCCCCCCCCCCCCC	35.89	26051181
257	Acetylation	IKPVVHPTATPSTVP CCCCCCCCCCCCCCC	28.43	19608861
257	Phosphorylation	IKPVVHPTATPSTVP CCCCCCCCCCCCCCC	28.43	29978859
257	Ubiquitination	IKPVVHPTATPSTVP CCCCCCCCCCCCCCC	28.43	32015554
257 (in isoform 2)	Acetylation	-	28.43	-
259	Phosphorylation	PVVHPTATPSTVPSS CCCCCCCCCCCCCCC	21.91	29978859
261	Phosphorylation	VHPTATPSTVPSSPF CCCCCCCCCCCCCCC	37.37	29978859
262	Phosphorylation	HPTATPSTVPSSPFT CCCCCCCCCCCCCCC	37.32	29978859
265	Phosphorylation	ATPSTVPSSPFTLQS CCCCCCCCCCCCCCC	46.43	29116813
266	Phosphorylation	TPSTVPSSPFTLQSD CCCCCCCCCCCCCCC	20.26	25849741
269	Phosphorylation	TVPSSPFTLQSDHQP CCCCCCCCCCCCCCC	27.54	29978859
270 (in isoform 5)	Phosphorylation	-	4.73	-
272	Phosphorylation	SSPFTLQSDHQPKKS CCCCCCCCCCCCCCC	39.92	29978859
276 (in isoform 5)	Phosphorylation	-	42.49	-
277	Ubiquitination	LQSDHQPKKSFDANG CCCCCCCCCCCCCCC	55.25	23000965
278	Ubiquitination	QSDHQPKKSFDANGA CCCCCCCCCCCCCCC	64.14	23000965
279	Phosphorylation	SDHQPKKSFDANGAS CCCCCCCCCCCCCCC	34.19	21815630
286	Phosphorylation	SFDANGASTLSKLPT CCCCCCCCHHHCCCC	31.14	-
287	Phosphorylation	FDANGASTLSKLPTP CCCCCCCHHHCCCCC	34.22	-
289	Phosphorylation	ANGASTLSKLPTPTS CCCCCHHHCCCCCCC	32.03	-
292 (in isoform 5)	Phosphorylation	-	39.82	-
293	Phosphorylation	STLSKLPTPTSSVPA CHHHCCCCCCCCCCC	50.03	30266825
295	Phosphorylation	LSKLPTPTSSVPAQK HHCCCCCCCCCCCCC	35.79	30266825
296	Phosphorylation	SKLPTPTSSVPAQKT HCCCCCCCCCCCCCC	30.46	30266825
297	Phosphorylation	KLPTPTSSVPAQKTE CCCCCCCCCCCCCCC	34.30	30266825
302	Acetylation	TSSVPAQKTERKEST CCCCCCCCCCCCCCC	55.23	19608861
302	Ubiquitination	TSSVPAQKTERKEST CCCCCCCCCCCCCCC	55.23	32015554
303	O-linked_Glycosylation	SSVPAQKTERKESTS CCCCCCCCCCCCCCC	29.01	30059200
303	Phosphorylation	SSVPAQKTERKESTS CCCCCCCCCCCCCCC	29.01	20068231
308	O-linked_Glycosylation	QKTERKESTSGDKPV CCCCCCCCCCCCCCC	30.79	30059200
308	Phosphorylation	QKTERKESTSGDKPV CCCCCCCCCCCCCCC	30.79	-
309	Phosphorylation	KTERKESTSGDKPVS CCCCCCCCCCCCCCC	37.51	-
310	Phosphorylation	TERKESTSGDKPVSH CCCCCCCCCCCCCCC	55.03	-
315 (in isoform 5)	Phosphorylation	-	11.22	-
318	Ubiquitination	GDKPVSHSCTTPSTS CCCCCCCCCCCCCCC	12.97	21890473
328 (in isoform 2)	Phosphorylation	-	45.84	-
333 (in isoform 5)	Phosphorylation	-	36.13	-
334	Phosphorylation	ASGLNPTSAPPTSAS CCCCCCCCCCCCCCC	39.78	20068231
334 (in isoform 2)	Phosphorylation	-	39.78	-
338	Ubiquitination	NPTSAPPTSASAVPV CCCCCCCCCCCCCCC	35.55	21890473
343 (in isoform 5)	Phosphorylation	-	4.45	-
346	Phosphorylation	SASAVPVSPVPQSPI CCCCCCCCCCCCCCC	17.70	-
349 (in isoform 5)	Phosphorylation	-	32.11	-
350 (in isoform 2)	Phosphorylation	-	63.17	-
351	Phosphorylation	PVSPVPQSPIPPLLQ CCCCCCCCCCCHHHC	20.80	-
353	Phosphorylation	SPVPQSPIPPLLQDP CCCCCCCCCHHHCCH	7.12	32142685
353 (in isoform 5)	Phosphorylation	-	7.12	-
354 (in isoform 5)	Phosphorylation	-	19.50	-
357 (in isoform 5)	Phosphorylation	-	7.18	-
359 (in isoform 5)	Phosphorylation	-	33.74	-
363	Ubiquitination	LLQDPNLLRQLLPAL HHCCHHHHHHHHHHH	4.10	21890473
363	Ubiquitination	LLQDPNLLRQLLPAL HHCCHHHHHHHHHHH	4.10	21890473
363 (in isoform 5)	Ubiquitination	-	4.10	21890473
367 (in isoform 5)	Phosphorylation	-	1.44	-
368	Phosphorylation	NLLRQLLPALQATLQ HHHHHHHHHHHHHHH	39.24	32142685
368 (in isoform 5)	Phosphorylation	-	39.24	-
373	Phosphorylation	LLPALQATLQLNNSN HHHHHHHHHHHCCCC	11.32	20068231
373 (in isoform 2)	Phosphorylation	-	11.32	-
376	Ubiquitination	ALQATLQLNNSNVDI HHHHHHHHCCCCCCH	8.03	33845483
379	Phosphorylation	ATLQLNNSNVDISKI HHHHHCCCCCCHHHH	36.84	20068231
379 (in isoform 5)	Phosphorylation	-	36.84	-
383	Ubiquitination	LNNSNVDISKINEVL HCCCCCCHHHHHHHH	3.83	21890473
383	Ubiquitination	LNNSNVDISKINEVL HCCCCCCHHHHHHHH	3.83	23000965
383 (in isoform 5)	Ubiquitination	-	3.83	21890473
384	Phosphorylation	NNSNVDISKINEVLT CCCCCCHHHHHHHHH	24.03	20068231
391	Phosphorylation	SKINEVLTAAVTQAS HHHHHHHHHHHHHHH	20.11	20068231
391 (in isoform 2)	Phosphorylation	-	20.11	-
395	O-linked_Glycosylation	EVLTAAVTQASLQSI HHHHHHHHHHHHHHH	17.43	30059200
395	Phosphorylation	EVLTAAVTQASLQSI HHHHHHHHHHHHHHH	17.43	20068231
398	Phosphorylation	TAAVTQASLQSIIHK HHHHHHHHHHHHHHH	19.68	20068231
401	Phosphorylation	VTQASLQSIIHKFLT HHHHHHHHHHHHHHH	28.89	20068231
401 (in isoform 2)	Phosphorylation	-	28.89	-
407 (in isoform 2)	Phosphorylation	-	3.70	-
408	Phosphorylation	SIIHKFLTAGPSAFN HHHHHHHHHCCCHHH	32.47	20068231
408 (in isoform 5)	Phosphorylation	-	32.47	-
411	Phosphorylation	HKFLTAGPSAFNITS HHHHHHCCCHHHHHH	21.74	32142685
411 (in isoform 2)	Phosphorylation	-	21.74	-
412	Phosphorylation	KFLTAGPSAFNITSL HHHHHCCCHHHHHHH	44.57	20068231
412 (in isoform 2)	Phosphorylation	-	44.57	-
415 (in isoform 2)	Phosphorylation	-	36.02	-
417	Phosphorylation	GPSAFNITSLISQAA CCCHHHHHHHHHHHH	20.70	20068231
417 (in isoform 2)	Phosphorylation	-	20.70	-
418	Phosphorylation	PSAFNITSLISQAAQ CCHHHHHHHHHHHHH	21.65	20068231
420 (in isoform 5)	Phosphorylation	-	2.62	-
421	Phosphorylation	FNITSLISQAAQLST HHHHHHHHHHHHHHH	21.04	30177828
421	Ubiquitination	FNITSLISQAAQLST HHHHHHHHHHHHHHH	21.04	21890473
421 (in isoform 2)	Ubiquitination	-	21.04	21890473
422	Phosphorylation	NITSLISQAAQLSTQ HHHHHHHHHHHHHHH	33.45	33259812
422 (in isoform 5)	Phosphorylation	-	33.45	-
425 (in isoform 2)	Phosphorylation	-	38.67	-
426	Phosphorylation	LISQAAQLSTQAQPS HHHHHHHHHHHCCCC	5.26	32142685
426 (in isoform 2)	Phosphorylation	-	5.26	-
427	Phosphorylation	ISQAAQLSTQAQPSN HHHHHHHHHHCCCCC	13.34	30177828
428	Phosphorylation	SQAAQLSTQAQPSNQ HHHHHHHHHCCCCCC	36.19	28450419
429 (in isoform 5)	Phosphorylation	-	34.32	-
431 (in isoform 5)	Phosphorylation	-	31.94	-
433	Phosphorylation	LSTQAQPSNQSPMSL HHHHCCCCCCCCCCC	35.11	28450419
434	Ubiquitination	STQAQPSNQSPMSLT HHHCCCCCCCCCCCC	53.70	33845483
436	Phosphorylation	QAQPSNQSPMSLTSD HCCCCCCCCCCCCCC	27.16	28450419
437 (in isoform 2)	Phosphorylation	-	13.45	-
439	Phosphorylation	PSNQSPMSLTSDASS CCCCCCCCCCCCCCC	31.70	28450419
441	Phosphorylation	NQSPMSLTSDASSPR CCCCCCCCCCCCCCC	19.77	28450419
441	Ubiquitination	NQSPMSLTSDASSPR CCCCCCCCCCCCCCC	19.77	23000965
441 (in isoform 2)	Ubiquitination	-	19.77	21890473
442	Phosphorylation	QSPMSLTSDASSPRS CCCCCCCCCCCCCCC	36.15	28450419
445	Phosphorylation	MSLTSDASSPRSYVS CCCCCCCCCCCCCCC	45.96	28464451
446	Phosphorylation	SLTSDASSPRSYVSP CCCCCCCCCCCCCCC	26.50	25159151
449	Phosphorylation	SDASSPRSYVSPRIS CCCCCCCCCCCCCCC	33.02	26074081
450	Phosphorylation	DASSPRSYVSPRIST CCCCCCCCCCCCCCC	13.26	23403867
452	Phosphorylation	SSPRSYVSPRISTPQ CCCCCCCCCCCCCCC	10.54	30183078
456	O-linked_Glycosylation	SYVSPRISTPQTNTV CCCCCCCCCCCCCCC	35.00	30059200
456	Phosphorylation	SYVSPRISTPQTNTV CCCCCCCCCCCCCCC	35.00	25159151
457	Phosphorylation	YVSPRISTPQTNTVP CCCCCCCCCCCCCCC	19.62	23401153
460	Phosphorylation	PRISTPQTNTVPIKP CCCCCCCCCCCCCCC	33.78	21712546
462	Phosphorylation	ISTPQTNTVPIKPLI CCCCCCCCCCCCCCC	30.92	22115753
466	Acetylation	QTNTVPIKPLISTPP CCCCCCCCCCCCCCC	27.92	23954790
466	Ubiquitination	QTNTVPIKPLISTPP CCCCCCCCCCCCCCC	27.92	23000965
466 (in isoform 1)	Ubiquitination	-	27.92	21890473
466 (in isoform 2)	Phosphorylation	-	27.92	-
470	Phosphorylation	VPIKPLISTPPVSSQ CCCCCCCCCCCCCCC	42.41	23401153
471	Phosphorylation	PIKPLISTPPVSSQP CCCCCCCCCCCCCCC	25.31	25159151
475	O-linked_Glycosylation	LISTPPVSSQPKVST CCCCCCCCCCCCCCC	29.09	30059200
475	Phosphorylation	LISTPPVSSQPKVST CCCCCCCCCCCCCCC	29.09	21082442
476	Phosphorylation	ISTPPVSSQPKVSTP CCCCCCCCCCCCCCC	51.22	21712546
478	Ubiquitination	TPPVSSQPKVSTPVV CCCCCCCCCCCCCCE	40.75	29967540
478 (in isoform 2)	Phosphorylation	-	40.75	-
479	Ubiquitination	PPVSSQPKVSTPVVK CCCCCCCCCCCCCEE	40.98	33845483
480	Phosphorylation	PVSSQPKVSTPVVKQ CCCCCCCCCCCCEEC	11.09	33259812
480 (in isoform 2)	Phosphorylation	-	11.09	-
481	Phosphorylation	VSSQPKVSTPVVKQG CCCCCCCCCCCEECC	32.87	20068231
482	Phosphorylation	SSQPKVSTPVVKQGP CCCCCCCCCCEECCC	24.08	16964243
485	Ubiquitination	PKVSTPVVKQGPVSQ CCCCCCCEECCCCCC	3.95	23000965
486	Acetylation	KVSTPVVKQGPVSQS CCCCCCEECCCCCCC	50.17	25953088
486	Phosphorylation	KVSTPVVKQGPVSQS CCCCCCEECCCCCCC	50.17	32142685
486	Ubiquitination	KVSTPVVKQGPVSQS CCCCCCEECCCCCCC	50.17	23000965
486 (in isoform 1)	Ubiquitination	-	50.17	21890473
487 (in isoform 2)	Phosphorylation	-	50.22	-
489	Ubiquitination	TPVVKQGPVSQSATQ CCCEECCCCCCCCCC	21.79	23000965
489 (in isoform 2)	Phosphorylation	-	21.79	-
490	Ubiquitination	PVVKQGPVSQSATQQ CCEECCCCCCCCCCC	11.84	23000965
491	Phosphorylation	VVKQGPVSQSATQQP CEECCCCCCCCCCCC	22.88	23927012
491	Ubiquitination	VVKQGPVSQSATQQP CEECCCCCCCCCCCC	22.88	23000965
492	Ubiquitination	VKQGPVSQSATQQPV EECCCCCCCCCCCCC	37.00	23000965
493	Phosphorylation	KQGPVSQSATQQPVT ECCCCCCCCCCCCCC	26.27	23927012
495	Phosphorylation	GPVSQSATQQPVTAD CCCCCCCCCCCCCCC	32.74	23927012
500	Phosphorylation	SATQQPVTADKQQGH CCCCCCCCCCCCCCC	35.50	23927012
503	Acetylation	QQPVTADKQQGHEPV CCCCCCCCCCCCCCC	41.90	26051181
511	Phosphorylation	QQGHEPVSPRSLQRS CCCCCCCCHHHHHCC	25.88	29255136
514	Phosphorylation	HEPVSPRSLQRSSSQ CCCCCHHHHHCCCCC	32.03	28111955
518	Phosphorylation	SPRSLQRSSSQRSPS CHHHHHCCCCCCCCC	22.75	30278072
519	Phosphorylation	PRSLQRSSSQRSPSP HHHHHCCCCCCCCCC	32.45	30278072
520	Phosphorylation	RSLQRSSSQRSPSPG HHHHCCCCCCCCCCC	30.75	30278072
523	Phosphorylation	QRSSSQRSPSPGPNH HCCCCCCCCCCCCCC	23.30	25159151
525	Phosphorylation	SSSQRSPSPGPNHTS CCCCCCCCCCCCCCC	43.67	25159151
531	Phosphorylation	PSPGPNHTSNSSNAS CCCCCCCCCCCCCCC	35.92	26503892
531	Ubiquitination	PSPGPNHTSNSSNAS CCCCCCCCCCCCCCC	35.92	23000965
532	Phosphorylation	SPGPNHTSNSSNASN CCCCCCCCCCCCCCC	27.45	30278072
534	Phosphorylation	GPNHTSNSSNASNAT CCCCCCCCCCCCCCE	25.41	23401153
535	Phosphorylation	PNHTSNSSNASNATV CCCCCCCCCCCCCEE	40.44	30278072
535	Ubiquitination	PNHTSNSSNASNATV CCCCCCCCCCCCCEE	40.44	23000965
536	Ubiquitination	NHTSNSSNASNATVV CCCCCCCCCCCCEEC	47.40	29967540
537	Ubiquitination	HTSNSSNASNATVVP CCCCCCCCCCCEECC	13.20	23000965
538	Phosphorylation	TSNSSNASNATVVPQ CCCCCCCCCCEECCC	31.11	30278072
541	Phosphorylation	SSNASNATVVPQNSS CCCCCCCEECCCCCC	26.70	23927012
547	Phosphorylation	ATVVPQNSSARSTCS CEECCCCCCCHHHHC	21.81	23927012
548	Phosphorylation	TVVPQNSSARSTCSL EECCCCCCCHHHHCC	34.94	23927012
556	Phosphorylation	ARSTCSLTPALAAHF CHHHHCCCHHHHHHH	7.10	-
581	Ubiquitination	WPADHAEKQASRLRE CCHHHHHHHHHHHHH	52.53	29967540
588	Ubiquitination	KQASRLREEAHNMGT HHHHHHHHHHHHHCC	65.22	23000965
589	Ubiquitination	QASRLREEAHNMGTI HHHHHHHHHHHHCCC	49.12	23000965
592	Ubiquitination	RLREEAHNMGTIHMS HHHHHHHHHCCCCHH	37.31	23000965
593	Ubiquitination	LREEAHNMGTIHMSE HHHHHHHHCCCCHHH	3.44	23000965
594	Ubiquitination	REEAHNMGTIHMSEI HHHHHHHCCCCHHHH	27.17	23000965
595	Ubiquitination	EEAHNMGTIHMSEIC HHHHHHCCCCHHHHH	9.28	23000965
606	Acetylation	SEICTELKNLRSLVR HHHHHHHHHHHHHHH	47.94	26051181
634	Ubiquitination	LFLRQQIKELEKLKN HHHHHHHHHHHHHHH	52.49	23000965
638	Ubiquitination	QQIKELEKLKNQNSF HHHHHHHHHHHCCCC	76.90	23000965
640	Ubiquitination	IKELEKLKNQNSFMV HHHHHHHHHCCCCCC	68.50	23000965

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
244	T	Phosphorylation	Kinase	CDK1	P06493	PSP
457	T	Phosphorylation	Kinase	CDK1	P06493	PSP
471	T	Phosphorylation	Kinase	CDK1	P06493	PSP
482	T	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of WAC_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of WAC_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BRE1B_HUMAN	RNF40	physical	21329877
BRE1A_HUMAN	RNF20	physical	21329877
RPB1_HUMAN	POLR2A	physical	21329877
VCIP1_HUMAN	VCPIP1	physical	21811234
TERA_HUMAN	VCP	physical	21811234
A4_HUMAN	APP	physical	21832049
WAC_HUMAN	WAC	physical	25416956
T3JAM_HUMAN	TRAF3IP3	physical	25416956
SYTL5_HUMAN	SYTL5	physical	25416956
DYDC1_HUMAN	DYDC1	physical	25416956
KLC3_HUMAN	KLC3	physical	25416956
TLN1_HUMAN	TLN1	physical	26344197
BRE1A_HUMAN	RNF20	physical	28514442
BRE1B_HUMAN	RNF40	physical	28514442
TPM2_HUMAN	TPM2	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of WAC_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-302, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-471; SER-523 ANDSER-525, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-293; SER-456; SER-476AND THR-482, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525, AND MASSSPECTROMETRY.	18220336 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53; THR-293 AND THR-482,AND MASS SPECTROMETRY.	16964243 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-53; SER-64; SER-511;SER-523 AND SER-525, AND MASS SPECTROMETRY.	17081983 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-293, AND MASSSPECTROMETRY.	18669648 [Abstract]