TLN1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TLN1_HUMAN
• UniProt AC: Q9Y490
• Protein Name: Talin-1
• Gene Name: TLN1
• Organism: Homo sapiens (Human).
• Sequence Length: 2541
• Subcellular Localization: Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell surface . Cell junction, focal adhesion . Colocalizes with LAYN at the membrane ruffles. Localized preferentially in focal adhesions than f
• Protein Description: Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts (By similarity)..
• Protein Sequence: MVALSLKISIGNVVKTMQFEPSTMVYDACRIIRERIPEAPAGPPSDFGLFLSDDDPKKGIWLEAGKALDYYMLRNGDTMEYRKKQRPLKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLVRELMEEKKEEITGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQGVEEHETLLLRRKFFYSDQNVDSRDPVQLNLLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFGPHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHKNCGQMSEIEAKVRYVKLARSLKTYGVSFFLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWAASPKSFTLDFGDYQDGYYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKSTVLQQQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITSGQMHRGHMPPLTSAQQALTGTINSSMQAVQAAQATLDDFDTLPPLGQDAASKAWRKNKMDESKHEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSGRPLLQAAKGLAGAVSELLRSAQPASAEPRQNLLQAAGNVGQASGELLQQIGESDTDPHFQDALMQLAKAVASAAAALVLKAKSVAQRTEDSGLQTQVIAAATQCALSTSQLVACTKVVAPTISSPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQLLRGVGAAATAVTQALNELLQHVKAHATGAGPAGRYDQATDTILTVTENIFSSMGDAGEMVRQARILAQATSDLVNAIKADAEGESDLENSRKLLSAAKILADATAKMVEAAKGAAAHPDSEEQQQRLREAAEGLRMATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAASTPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKMVAAAKASVPTIQDQASAMQLSQCAKNLGTALAELRTAAQKAQEACGPLEMDSALSVVQNLEKDLQEVKAAARDGKLKPLPGETMEKCTQDLGNSTKAVSSAIAQLLGEVAQGNENYAGIAARDVAGGLRSLAQAARGVAALTSDPAVQAIVLDTASDVLDKASSLIEEAKKAAGHPGDPESQQRLAQVAKAVTQALNRCVSCLPGQRDVDNALRAVGDASKRLLSDSLPPSTGTFQEAQSRLNEAAAGLNQAATELVQASRGTPQDLARASGRFGQDFSTFLEAGVEMAGQAPSQEDRAQVVSNLKGISMSSSKLLLAAKALSTDPAAPNLKSQLAAAARAVTDSINQLITMCTQQAPGQKECDNALRELETVRELLENPVQPINDMSYFGCLDSVMENSKVLGEAMTGISQNAKNGNLPEFGDAISTASKALCGFTEAAAQAAYLVGVSDPNSQAGQQGLVEPTQFARANQAIQMACQSLGEPGCTQAQVLSAATIVAKHTSALCNSCRLASARTTNPTAKRQFVQSAKEVANSTANLVKTIKALDGAFTEENRAQCRAATAPLLEAVDNLSAFASNPEFSSIPAQISPEGRAAMEPIVISAKTMLESAGGLIQTARALAVNPRDPPSWSVLAGHSRTVSDSIKKLITSMRDKAPGQLECETAIAALNSCLRDLDQASLAAVSQQLAPREGISQEALHTQMLTAVQEISHLIEPLANAARAEASQLGHKVSQMAQYFEPLTLAAVGAASKTLSHPQQMALLDQTKTLAESALQLLYTAKEAGGNPKQAAHTQEALEEAVQMMTEAVEDLTTTLNEAASAAGVVGGMVDSITQAINQLDEGPMGEPEGSFVDYQTTMVRTAKAIAVTVQEMVTKSNTSPEELGPLANQLTSDYGRLASEAKPAAVAAENEEIGSHIKHRVQELGHGCAALVTKAGALQCSPSDAYTKKELIECARRVSEKVSHVLAALQAGNRGTQACITAASAVSGIIADLDTTIMFATAGTLNREGTETFADHREGILKTAKVLVEDTKVLVQNAAGSQEKLAQAAQSSVATITRLADVVKLGAASLGAEDPETQVVLINAVKDVAKALGDLISATKAAAGKVGDDPAVWQLKNSAKVMVTNVTSLLKTVKAVEDEATKGTRALEATTEHIRQELAVFCSPEPPAKTSTPEDFIRMTKGITMATAKAVAAGNSCRQEDVIATANLSRRAIADMLRACKEAAYHPEVAPDVRLRALHYGRECANGYLELLDHVLLTLQKPSPELKQQLTGHSKRVAGSVTELIQAAEAMKGTEWVDPEDPTVIAENELLGAAAAIEAAAKKLEQLKPRAKPKEADESLNFEEQILEAAKSIAAATSALVKAASAAQRELVAQGKVGAIPANALDDGQWSQGLISAARMVAAATNNLCEAANAAVQGHASQEKLISSAKQVAASTAQLLVACKVKADQDSEAMKRLQAAGNAVKRASDNLVKAAQKAAAFEEQENETVVVKEKMVGGIAQIIAAQEEMLRKERELEEARKKLAQIRQQQYKFLPSELRDEH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MVALSLKISIGN ---CCEEEEEEEECC	20.20	24719451
15	Ubiquitination	ISIGNVVKTMQFEPS EEECCEEECCCCCCC	33.72	32015554
16	Phosphorylation	SIGNVVKTMQFEPST EECCEEECCCCCCCH	12.47	21945579
22	Phosphorylation	KTMQFEPSTMVYDAC ECCCCCCCHHHHHHH	23.18	21945579
23	Phosphorylation	TMQFEPSTMVYDACR CCCCCCCHHHHHHHH	22.75	21945579
26	Phosphorylation	FEPSTMVYDACRIIR CCCCHHHHHHHHHHH	6.23	21945579
29	Glutathionylation	STMVYDACRIIRERI CHHHHHHHHHHHHHC	2.68	22555962
29	S-nitrosylation	STMVYDACRIIRERI CHHHHHHHHHHHHHC	2.68	2212679
35	Methylation	ACRIIRERIPEAPAG HHHHHHHHCCCCCCC	39.66	115389531
45	Phosphorylation	EAPAGPPSDFGLFLS CCCCCCCCCCCEECC	49.02	26657352
52	Phosphorylation	SDFGLFLSDDDPKKG CCCCEECCCCCCCCC	31.49	28060719
57	2-Hydroxyisobutyrylation	FLSDDDPKKGIWLEA ECCCCCCCCCEEEEH	71.30	-
57	Acetylation	FLSDDDPKKGIWLEA ECCCCCCCCCEEEEH	71.30	15605901
70	Phosphorylation	EAGKALDYYMLRNGD EHHHHHHEEEHHCCC	7.51	25159151
71	Phosphorylation	AGKALDYYMLRNGDT HHHHHHEEEHHCCCC	6.85	21945579
74	Methylation	ALDYYMLRNGDTMEY HHHEEEHHCCCCCHH	28.67	115918161
78	Phosphorylation	YMLRNGDTMEYRKKQ EEHHCCCCCHHHHHC	17.19	28857561
81	Phosphorylation	RNGDTMEYRKKQRPL HCCCCCHHHHHCCCC	19.53	-
83	Ubiquitination	GDTMEYRKKQRPLKI CCCCHHHHHCCCCEE	52.97	23503661
84	Ubiquitination	DTMEYRKKQRPLKIR CCCHHHHHCCCCEEE	42.41	23503661
89	Ubiquitination	RKKQRPLKIRMLDGT HHHCCCCEEEECCCC	30.83	23503661
96	Phosphorylation	KIRMLDGTVKTIMVD EEEECCCCEEEEEEC	20.63	28060719
98	Acetylation	RMLDGTVKTIMVDDS EECCCCEEEEEECCC	31.97	23236377
98	Malonylation	RMLDGTVKTIMVDDS EECCCCEEEEEECCC	31.97	26320211
99	Phosphorylation	MLDGTVKTIMVDDSK ECCCCEEEEEECCCH	15.23	28857561
101	Sulfoxidation	DGTVKTIMVDDSKTV CCCEEEEEECCCHHH	3.07	30846556
105	Phosphorylation	KTIMVDDSKTVTDML EEEEECCCHHHHHHH	26.26	-
114	Phosphorylation	TVTDMLMTICARIGI HHHHHHHHHHHHHCC	14.67	-
116	Glutathionylation	TDMLMTICARIGITN HHHHHHHHHHHCCCC	1.21	22555962
122	Phosphorylation	ICARIGITNHDEYSL HHHHHCCCCCHHHHH	22.68	26356563
127	Phosphorylation	GITNHDEYSLVRELM CCCCCHHHHHHHHHH	17.23	21082442
128	Phosphorylation	ITNHDEYSLVRELME CCCCHHHHHHHHHHH	20.52	28796482
134	Sulfoxidation	YSLVRELMEEKKEEI HHHHHHHHHHHHHHH	5.53	30846556
137	2-Hydroxyisobutyrylation	VRELMEEKKEEITGT HHHHHHHHHHHHHCC	52.78	-
138	Ubiquitination	RELMEEKKEEITGTL HHHHHHHHHHHHCCH	64.95	24816145
142	Phosphorylation	EEKKEEITGTLRKDK HHHHHHHHCCHHCCC	27.65	24706070
144	Phosphorylation	KKEEITGTLRKDKTL HHHHHHCCHHCCCHH	18.10	23401153
146	Methylation	EEITGTLRKDKTLLR HHHHCCHHCCCHHHC	44.99	115918145
149	Ubiquitination	TGTLRKDKTLLRDEK HCCHHCCCHHHCCHH	44.07	24816145
150	Phosphorylation	GTLRKDKTLLRDEKK CCHHCCCHHHCCHHH	40.95	23403867
156	Acetylation	KTLLRDEKKMEKLKQ CHHHCCHHHHHHHHH	62.80	25953088
164	Ubiquitination	KMEKLKQKLHTDDEL HHHHHHHHCCCCCCC	40.42	29967540
167	O-linked_Glycosylation	KLKQKLHTDDELNWL HHHHHCCCCCCCHHH	56.43	28657654
167	Phosphorylation	KLKQKLHTDDELNWL HHHHHCCCCCCCHHH	56.43	25159151
179	O-linked_Glycosylation	NWLDHGRTLREQGVE HHHHHCCHHHHCCHH	34.46	28657654
179	Phosphorylation	NWLDHGRTLREQGVE HHHHHCCHHHHCCHH	34.46	26074081
190	Phosphorylation	QGVEEHETLLLRRKF CCHHHHHHHHHHCHH	25.31	29255136
196	Acetylation	ETLLLRRKFFYSDQN HHHHHHCHHHCCCCC	33.13	27452117
196	Malonylation	ETLLLRRKFFYSDQN HHHHHHCHHHCCCCC	33.13	26320211
199	Phosphorylation	LLRRKFFYSDQNVDS HHHCHHHCCCCCCCC	17.92	26074081
200	Phosphorylation	LRRKFFYSDQNVDSR HHCHHHCCCCCCCCC	27.80	26074081
254	Acetylation	FGPHNEQKHKAGFLD ECCCCHHHCCCCCCC	40.68	26822725
254	Ubiquitination	FGPHNEQKHKAGFLD ECCCCHHHCCCCCCC	40.68	32015554
256	Malonylation	PHNEQKHKAGFLDLK CCCHHHCCCCCCCHH	58.18	26320211
256	Ubiquitination	PHNEQKHKAGFLDLK CCCHHHCCCCCCCHH	58.18	33845483
263	Ubiquitination	KAGFLDLKDFLPKEY CCCCCCHHHHCCHHH	46.21	32015554
268	Ubiquitination	DLKDFLPKEYVKQKG CHHHHCCHHHHHHHC	64.92	29967540
270	Phosphorylation	KDFLPKEYVKQKGER HHHCCHHHHHHHCCH	21.05	22210691
272	Ubiquitination	FLPKEYVKQKGERKI HCCHHHHHHHCCHHH	45.44	23503661
274	Ubiquitination	PKEYVKQKGERKIFQ CHHHHHHHCCHHHHH	57.95	23503661
278	Ubiquitination	VKQKGERKIFQAHKN HHHHCCHHHHHHHCC	43.50	23503661
284	Acetylation	RKIFQAHKNCGQMSE HHHHHHHCCCCCHHH	57.88	25953088
284	Ubiquitination	RKIFQAHKNCGQMSE HHHHHHHCCCCCHHH	57.88	23503661
286	S-nitrosylation	IFQAHKNCGQMSEIE HHHHHCCCCCHHHHH	4.83	2212679
290	Phosphorylation	HKNCGQMSEIEAKVR HCCCCCHHHHHHHHH	27.77	28857561
295	Ubiquitination	QMSEIEAKVRYVKLA CHHHHHHHHHHHHHH	17.91	29967540
300	Ubiquitination	EAKVRYVKLARSLKT HHHHHHHHHHHHHHH	27.74	27667366
307	Phosphorylation	KLARSLKTYGVSFFL HHHHHHHHHCCEEEE	30.70	23882029
324	Ubiquitination	EKMKGKNKLVPRLLG HHHCCCCCCHHHHHC	55.11	27667366
334	Malonylation	PRLLGITKECVMRVD HHHHCCCHHHHHCCC	47.39	26320211
334	Ubiquitination	PRLLGITKECVMRVD HHHHCCCHHHHHCCC	47.39	22817900
354	Phosphorylation	VIQEWNLTNIKRWAA HHHHCCCCCHHHHCC	31.52	28270605
357	2-Hydroxyisobutyrylation	EWNLTNIKRWAASPK HCCCCCHHHHCCCCC	43.91	-
357	Malonylation	EWNLTNIKRWAASPK HCCCCCHHHHCCCCC	43.91	26320211
357	Ubiquitination	EWNLTNIKRWAASPK HCCCCCHHHHCCCCC	43.91	22817900
362	Phosphorylation	NIKRWAASPKSFTLD CHHHHCCCCCEEEEE	25.72	24719451
405	Phosphorylation	IILKKKKSKDHFGLE HHCCCCCCCCCCCCC	52.80	23927012
406	Malonylation	ILKKKKSKDHFGLEG HCCCCCCCCCCCCCC	65.19	26320211
406	Ubiquitination	ILKKKKSKDHFGLEG HCCCCCCCCCCCCCC	65.19	29967540
417	Phosphorylation	GLEGDEESTMLEDSV CCCCCHHHCCCCCCC	19.64	23927012
418	Phosphorylation	LEGDEESTMLEDSVS CCCCHHHCCCCCCCC	29.11	23927012
419	Sulfoxidation	EGDEESTMLEDSVSP CCCHHHCCCCCCCCC	5.55	30846556
423	Phosphorylation	ESTMLEDSVSPKKST HHCCCCCCCCCCHHH	18.34	29255136
425	Phosphorylation	TMLEDSVSPKKSTVL CCCCCCCCCCHHHHH	34.65	29255136
427	2-Hydroxyisobutyrylation	LEDSVSPKKSTVLQQ CCCCCCCCHHHHHHH	52.42	-
428	Methylation	EDSVSPKKSTVLQQQ CCCCCCCHHHHHHHH	55.53	83364225
428	Ubiquitination	EDSVSPKKSTVLQQQ CCCCCCCHHHHHHHH	55.53	29967540
429	Phosphorylation	DSVSPKKSTVLQQQY CCCCCCHHHHHHHHH	29.85	21945579
430	Phosphorylation	SVSPKKSTVLQQQYN CCCCCHHHHHHHHHH	33.83	21945579
436	Phosphorylation	STVLQQQYNRVGKVE HHHHHHHHHCCCCCC	10.70	21945579
441	Malonylation	QQYNRVGKVEHGSVA HHHHCCCCCCCCCCH	41.41	26320211
441	Ubiquitination	QQYNRVGKVEHGSVA HHHHCCCCCCCCCCH	41.41	23000965
446	Phosphorylation	VGKVEHGSVALPAIM CCCCCCCCCHHHHHH	13.21	26657352
453	Sulfoxidation	SVALPAIMRSGASGP CCHHHHHHCCCCCCC	2.79	30846556
455	Phosphorylation	ALPAIMRSGASGPEN HHHHHHCCCCCCCCC	22.72	28270605
458	Phosphorylation	AIMRSGASGPENFQV HHHCCCCCCCCCCCC	59.41	28270605
467	Phosphorylation	PENFQVGSMPPAQQQ CCCCCCCCCCHHHHC	29.29	23312004
468	Sulfoxidation	ENFQVGSMPPAQQQI CCCCCCCCCHHHHCC	3.66	30846556
477	Phosphorylation	PAQQQITSGQMHRGH HHHHCCCCCCCCCCC	28.76	28555341
480	Sulfoxidation	QQITSGQMHRGHMPP HCCCCCCCCCCCCCC	2.38	30846556
482	Methylation	ITSGQMHRGHMPPLT CCCCCCCCCCCCCCC	31.22	115389539
539	Phosphorylation	RKNKMDESKHEIHSQ HHHCCCHHHHHHHHH	34.74	29759185
568	Phosphorylation	TAGDPAETDYTAVGC CCCCCCCCCCCEEEE	36.09	-
570	Phosphorylation	GDPAETDYTAVGCAV CCCCCCCCCEEEEEE	12.20	22817900
571	Phosphorylation	DPAETDYTAVGCAVT CCCCCCCCEEEEEEH	20.06	-
585	Phosphorylation	TTISSNLTEMSRGVK HHHHCCHHHHHHHHH	33.61	23879269
588	Phosphorylation	SSNLTEMSRGVKLLA HCCHHHHHHHHHHHH	21.46	23879269
604	Phosphorylation	LLEDEGGSGRPLLQA HHHCCCCCCHHHHHH	42.35	28060719
620	Phosphorylation	KGLAGAVSELLRSAQ HHHHHHHHHHHHHCC	23.22	30266825
625	Phosphorylation	AVSELLRSAQPASAE HHHHHHHHCCCCCCC	31.09	-
648	Phosphorylation	AGNVGQASGELLQQI HHCHHHHHHHHHHHH	25.55	22199227
658	Phosphorylation	LLQQIGESDTDPHFQ HHHHHCCCCCCHHHH	40.37	29523821
660	Phosphorylation	QQIGESDTDPHFQDA HHHCCCCCCHHHHHH	61.79	29523821
677	Phosphorylation	QLAKAVASAAAALVL HHHHHHHHHHHHHHH	16.31	26699800
685	Malonylation	AAAALVLKAKSVAQR HHHHHHHHHHHHHHH	46.41	26320211
685	Ubiquitination	AAAALVLKAKSVAQR HHHHHHHHHHHHHHH	46.41	32015554
707	Phosphorylation	TQVIAAATQCALSTS HHHHHHHHHHHHCHH	21.32	28348404
712	Phosphorylation	AATQCALSTSQLVAC HHHHHHHCHHHHHHH	13.90	28348404
713	Phosphorylation	ATQCALSTSQLVACT HHHHHHCHHHHHHHC	22.72	28348404
714	Phosphorylation	TQCALSTSQLVACTK HHHHHCHHHHHHHCE	20.38	28348404
726	Phosphorylation	CTKVVAPTISSPVCQ HCEEECCCCCCCCHH	24.61	30266825
728	Phosphorylation	KVVAPTISSPVCQEQ EEECCCCCCCCHHHH	30.94	30266825
729	Phosphorylation	VVAPTISSPVCQEQL EECCCCCCCCHHHHH	19.94	30266825
732	Glutathionylation	PTISSPVCQEQLVEA CCCCCCCHHHHHHHH	4.12	22555962
745	Acetylation	EAGRLVAKAVEGCVS HHHHHHHHHHHHHCC	45.55	26051181
816	Sulfoxidation	TENIFSSMGDAGEMV HHHHHHCCCCHHHHH	5.66	30846556
822	Sulfoxidation	SMGDAGEMVRQARIL CCCCHHHHHHHHHHH	2.70	30846556
833	Phosphorylation	ARILAQATSDLVNAI HHHHHHHHHHHHHHH	15.64	28857561
834	Phosphorylation	RILAQATSDLVNAIK HHHHHHHHHHHHHHH	31.78	28857561
841	Ubiquitination	SDLVNAIKADAEGES HHHHHHHHHCCCCCC	37.49	23503661
848	Phosphorylation	KADAEGESDLENSRK HHCCCCCCCCHHHHH	59.35	29449344
853	Phosphorylation	GESDLENSRKLLSAA CCCCCHHHHHHHHHH	22.78	28060719
855	Ubiquitination	SDLENSRKLLSAAKI CCCHHHHHHHHHHHH	54.31	23000965
858	Phosphorylation	ENSRKLLSAAKILAD HHHHHHHHHHHHHHH	36.29	28857561
861	Acetylation	RKLLSAAKILADATA HHHHHHHHHHHHHHH	37.66	25953088
861	Ubiquitination	RKLLSAAKILADATA HHHHHHHHHHHHHHH	37.66	23000965
869	2-Hydroxyisobutyrylation	ILADATAKMVEAAKG HHHHHHHHHHHHHHH	38.84	-
869	Acetylation	ILADATAKMVEAAKG HHHHHHHHHHHHHHH	38.84	25953088
869	Malonylation	ILADATAKMVEAAKG HHHHHHHHHHHHHHH	38.84	26320211
869	Ubiquitination	ILADATAKMVEAAKG HHHHHHHHHHHHHHH	38.84	23000965
875	2-Hydroxyisobutyrylation	AKMVEAAKGAAAHPD HHHHHHHHHHHCCCC	57.01	-
875	Acetylation	AKMVEAAKGAAAHPD HHHHHHHHHHHCCCC	57.01	26051181
875	Ubiquitination	AKMVEAAKGAAAHPD HHHHHHHHHHHCCCC	57.01	23000965
883	Phosphorylation	GAAAHPDSEEQQQRL HHHCCCCCHHHHHHH	47.70	28102081
889	Methylation	DSEEQQQRLREAAEG CCHHHHHHHHHHHHH	31.23	115389547
898	Methylation	REAAEGLRMATNAAA HHHHHHHHHHHHHHH	24.44	115918165
899	Sulfoxidation	EAAEGLRMATNAAAQ HHHHHHHHHHHHHHH	6.93	21406390
910	2-Hydroxyisobutyrylation	AAAQNAIKKKLVQRL HHHHHHHHHHHHHHH	41.25	-
910	Acetylation	AAAQNAIKKKLVQRL HHHHHHHHHHHHHHH	41.25	25953088
912	Ubiquitination	AQNAIKKKLVQRLEH HHHHHHHHHHHHHHH	49.22	24816145
927	Phosphorylation	AAKQAAASATQTIAA HHHHHHHHHHHHHHH	27.42	28060719
929	Phosphorylation	KQAAASATQTIAAAQ HHHHHHHHHHHHHHH	24.61	28060719
931	Phosphorylation	AAASATQTIAAAQHA HHHHHHHHHHHHHHH	14.29	25159151
940	Phosphorylation	AAAQHAASTPKASAG HHHHHHHCCCCCCCC	46.13	22199227
941	Phosphorylation	AAQHAASTPKASAGP HHHHHHCCCCCCCCC	24.87	25159151
945	Phosphorylation	AASTPKASAGPQPLL HHCCCCCCCCCCCCH	39.63	28857561
955	Phosphorylation	PQPLLVQSCKAVAEQ CCCCHHHHHHHHHHH	15.31	-
973	Phosphorylation	LVQGVRGSQAQPDSP HHHCCCCCCCCCCCH	16.27	29255136
979	Phosphorylation	GSQAQPDSPSAQLAL CCCCCCCCHHHHHHH	27.69	29255136
981	Phosphorylation	QAQPDSPSAQLALIA CCCCCCHHHHHHHHH	32.38	29255136
990	Phosphorylation	QLALIAASQSFLQPG HHHHHHHCHHHCCCC	19.82	23403867
992	Phosphorylation	ALIAASQSFLQPGGK HHHHHCHHHCCCCCE	25.98	23403867
1007	Phosphorylation	MVAAAKASVPTIQDQ EHHHHHCCCCCHHHH	28.11	28060719
1010	Phosphorylation	AAKASVPTIQDQASA HHHCCCCCHHHHHHH	29.16	28060719
1016	Phosphorylation	PTIQDQASAMQLSQC CCHHHHHHHHHHHHH	20.74	28060719
1018	Sulfoxidation	IQDQASAMQLSQCAK HHHHHHHHHHHHHHH	3.69	21406390
1021	Phosphorylation	QASAMQLSQCAKNLG HHHHHHHHHHHHHHH	13.30	26657352
1023	Glutathionylation	SAMQLSQCAKNLGTA HHHHHHHHHHHHHHH	5.38	22555962
1029	Phosphorylation	QCAKNLGTALAELRT HHHHHHHHHHHHHHH	22.97	20068231
1035	Methylation	GTALAELRTAAQKAQ HHHHHHHHHHHHHHH	17.52	115918141
1045	Glutathionylation	AQKAQEACGPLEMDS HHHHHHHHCCCCHHH	5.92	22555962
1050	Sulfoxidation	EACGPLEMDSALSVV HHHCCCCHHHHHHHH	6.94	21406390
1052	Phosphorylation	CGPLEMDSALSVVQN HCCCCHHHHHHHHHH	29.78	28060719
1055	Phosphorylation	LEMDSALSVVQNLEK CCHHHHHHHHHHHHH	21.69	28060719
1068	Malonylation	EKDLQEVKAAARDGK HHHHHHHHHHHHCCC	31.39	26320211
1083	Phosphorylation	LKPLPGETMEKCTQD CCCCCCCHHHHHHHH	36.22	29514088
1084	Sulfoxidation	KPLPGETMEKCTQDL CCCCCCHHHHHHHHC	3.94	21406390
1116	Phosphorylation	VAQGNENYAGIAARD HHCCCCCCCHHHHHH	10.46	21082442
1130	Phosphorylation	DVAGGLRSLAQAARG HHHHHHHHHHHHHHH	32.85	28176443
1142	Phosphorylation	ARGVAALTSDPAVQA HHHHHHHCCCHHHHH	26.76	28176443
1143	Phosphorylation	RGVAALTSDPAVQAI HHHHHHCCCHHHHHH	42.31	28176443
1154	Phosphorylation	VQAIVLDTASDVLDK HHHHEEECHHHHHHH	24.73	28176443
1156	Phosphorylation	AIVLDTASDVLDKAS HHEEECHHHHHHHHH	30.28	22199227
1163	Phosphorylation	SDVLDKASSLIEEAK HHHHHHHHHHHHHHH	31.27	25850435
1164	Phosphorylation	DVLDKASSLIEEAKK HHHHHHHHHHHHHHH	37.92	29255136
1170	2-Hydroxyisobutyrylation	SSLIEEAKKAAGHPG HHHHHHHHHHHCCCC	46.34	-
1170	Malonylation	SSLIEEAKKAAGHPG HHHHHHHHHHHCCCC	46.34	26320211
1190	Acetylation	QRLAQVAKAVTQALN HHHHHHHHHHHHHHH	44.53	25953088
1190	Malonylation	QRLAQVAKAVTQALN HHHHHHHHHHHHHHH	44.53	26320211
1190	Ubiquitination	QRLAQVAKAVTQALN HHHHHHHHHHHHHHH	44.53	32015554
1201	Phosphorylation	QALNRCVSCLPGQRD HHHHHHHHCCCCCCC	17.35	24670416
1220	Phosphorylation	LRAVGDASKRLLSDS HHHHHHHHHHHHHCC	24.05	26657352
1225	Phosphorylation	DASKRLLSDSLPPST HHHHHHHHCCCCCCC	29.73	30266825
1227	Phosphorylation	SKRLLSDSLPPSTGT HHHHHHCCCCCCCCH	39.12	30266825
1231	Phosphorylation	LSDSLPPSTGTFQEA HHCCCCCCCCHHHHH	37.21	29632367
1232	Phosphorylation	SDSLPPSTGTFQEAQ HCCCCCCCCHHHHHH	46.12	29632367
1234	Phosphorylation	SLPPSTGTFQEAQSR CCCCCCCHHHHHHHH	23.41	29632367
1254	Phosphorylation	AGLNQAATELVQASR HHHHHHHHHHHHHCC	32.63	22199227
1260	Phosphorylation	ATELVQASRGTPQDL HHHHHHHCCCCHHHH	17.72	26846344
1263	Phosphorylation	LVQASRGTPQDLARA HHHHCCCCHHHHHHH	19.37	26846344
1271	Phosphorylation	PQDLARASGRFGQDF HHHHHHHCCCCCCCH	25.58	24719451
1288	Sulfoxidation	FLEAGVEMAGQAPSQ HHHHHHHCCCCCCCH	4.76	30846556
1303	Phosphorylation	EDRAQVVSNLKGISM HHHHHHHHHHCCCCC	37.27	26434552
1306	Malonylation	AQVVSNLKGISMSSS HHHHHHHCCCCCCHH	59.45	26320211
1306	Ubiquitination	AQVVSNLKGISMSSS HHHHHHHCCCCCCHH	59.45	23503661
1309	Phosphorylation	VSNLKGISMSSSKLL HHHHCCCCCCHHHHH	22.68	27251275
1311	Phosphorylation	NLKGISMSSSKLLLA HHCCCCCCHHHHHHH	25.35	24505115
1312	Phosphorylation	LKGISMSSSKLLLAA HCCCCCCHHHHHHHH	23.89	28857561
1313	Phosphorylation	KGISMSSSKLLLAAK CCCCCCHHHHHHHHH	21.73	28857561
1314	Acetylation	GISMSSSKLLLAAKA CCCCCHHHHHHHHHH	45.14	25953088
1314	Malonylation	GISMSSSKLLLAAKA CCCCCHHHHHHHHHH	45.14	26320211
1323	Phosphorylation	LLAAKALSTDPAAPN HHHHHHHCCCCCCCC	35.31	26657352
1324	Phosphorylation	LAAKALSTDPAAPNL HHHHHHCCCCCCCCH	47.02	29978859
1332	Malonylation	DPAAPNLKSQLAAAA CCCCCCHHHHHHHHH	42.68	26320211
1343	Phosphorylation	AAAARAVTDSINQLI HHHHHHHHHHHHHHH	24.04	-
1352	Sulfoxidation	SINQLITMCTQQAPG HHHHHHHHHHCCCCC	1.52	30846556
1387	Sulfoxidation	PVQPINDMSYFGCLD CCCCCCCCCCCCCHH	2.79	30846556
1392	Glutathionylation	NDMSYFGCLDSVMEN CCCCCCCCHHHHHHC	2.46	22555962
1397	Sulfoxidation	FGCLDSVMENSKVLG CCCHHHHHHCCHHHH	4.70	30846556
1400	Phosphorylation	LDSVMENSKVLGEAM HHHHHHCCHHHHHHH	15.72	23401153
1407	Sulfoxidation	SKVLGEAMTGISQNA CHHHHHHHHHCCCCC	2.83	21406390
1411	Phosphorylation	GEAMTGISQNAKNGN HHHHHHCCCCCCCCC	20.80	23911959
1415	Acetylation	TGISQNAKNGNLPEF HHCCCCCCCCCCCCH	73.30	26051181
1415	Malonylation	TGISQNAKNGNLPEF HHCCCCCCCCCCCCH	73.30	26320211
1415	Ubiquitination	TGISQNAKNGNLPEF HHCCCCCCCCCCCCH	73.30	32015554
1445	Phosphorylation	EAAAQAAYLVGVSDP HHHHHHHHHHCCCCC	12.63	-
1476	Sulfoxidation	RANQAIQMACQSLGE HHHHHHHHHHHHHCC	3.09	30846556
1480	Phosphorylation	AIQMACQSLGEPGCT HHHHHHHHHCCCCCC	37.92	28857561
1487	Phosphorylation	SLGEPGCTQAQVLSA HHCCCCCCHHHHHHH	32.62	28857561
1502	Phosphorylation	ATIVAKHTSALCNSC HHHHHHHHHHHHHHC	18.26	27732954
1503	Phosphorylation	TIVAKHTSALCNSCR HHHHHHHHHHHHHCH	20.97	28857561
1508	Phosphorylation	HTSALCNSCRLASAR HHHHHHHHCHHCCCC	10.30	28857561
1517	Phosphorylation	RLASARTTNPTAKRQ HHCCCCCCCHHHHHH	33.38	22210691
1520	Phosphorylation	SARTTNPTAKRQFVQ CCCCCCHHHHHHHHH	47.05	22210691
1522	2-Hydroxyisobutyrylation	RTTNPTAKRQFVQSA CCCCHHHHHHHHHHH	49.57	-
1522	Acetylation	RTTNPTAKRQFVQSA CCCCHHHHHHHHHHH	49.57	25953088
1528	Phosphorylation	AKRQFVQSAKEVANS HHHHHHHHHHHHHHH	35.69	21712546
1530	Malonylation	RQFVQSAKEVANSTA HHHHHHHHHHHHHHH	58.95	26320211
1530	Ubiquitination	RQFVQSAKEVANSTA HHHHHHHHHHHHHHH	58.95	23503661
1535	Phosphorylation	SAKEVANSTANLVKT HHHHHHHHHHHHHHH	21.11	21712546
1541	Acetylation	NSTANLVKTIKALDG HHHHHHHHHHHHHCC	47.93	23236377
1541	Malonylation	NSTANLVKTIKALDG HHHHHHHHHHHHHCC	47.93	26320211
1541	Ubiquitination	NSTANLVKTIKALDG HHHHHHHHHHHHHCC	47.93	23000965
1544	Acetylation	ANLVKTIKALDGAFT HHHHHHHHHHCCCCC	48.40	23954790
1544	Malonylation	ANLVKTIKALDGAFT HHHHHHHHHHCCCCC	48.40	26320211
1544	Ubiquitination	ANLVKTIKALDGAFT HHHHHHHHHHCCCCC	48.40	23000965
1573	Phosphorylation	LEAVDNLSAFASNPE HHHHHHHHHHHCCCC	27.82	27251275
1577	Phosphorylation	DNLSAFASNPEFSSI HHHHHHHCCCCHHCC	46.60	27251275
1582	Phosphorylation	FASNPEFSSIPAQIS HHCCCCHHCCCCCCC	26.20	28270605
1583	Phosphorylation	ASNPEFSSIPAQISP HCCCCHHCCCCCCCC	37.60	28270605
1589	Phosphorylation	SSIPAQISPEGRAAM HCCCCCCCCCCHHCC	12.57	26657352
1596	Sulfoxidation	SPEGRAAMEPIVISA CCCCHHCCCCEEEEH	6.50	21406390
1602	Phosphorylation	AMEPIVISAKTMLES CCCCEEEEHHHHHHH	16.90	20068231
1605	Phosphorylation	PIVISAKTMLESAGG CEEEEHHHHHHHCCH	27.06	28270605
1606	Sulfoxidation	IVISAKTMLESAGGL EEEEHHHHHHHCCHH	3.73	30846556
1609	Phosphorylation	SAKTMLESAGGLIQT EHHHHHHHCCHHHHH	28.40	28270605
1616	Phosphorylation	SAGGLIQTARALAVN HCCHHHHHHHHHHCC	15.89	20068231
1629	Phosphorylation	VNPRDPPSWSVLAGH CCCCCCCCCHHHHCC	37.05	29514088
1631	Phosphorylation	PRDPPSWSVLAGHSR CCCCCCCHHHHCCCC	16.16	29514088
1637	Phosphorylation	WSVLAGHSRTVSDSI CHHHHCCCCCHHHHH	28.82	29514088
1639	Phosphorylation	VLAGHSRTVSDSIKK HHHCCCCCHHHHHHH	27.63	23403867
1641	Phosphorylation	AGHSRTVSDSIKKLI HCCCCCHHHHHHHHH	25.65	28355574
1643	Phosphorylation	HSRTVSDSIKKLITS CCCCHHHHHHHHHHH	28.89	23403867
1645	Acetylation	RTVSDSIKKLITSMR CCHHHHHHHHHHHHH	45.54	25953088
1646	Malonylation	TVSDSIKKLITSMRD CHHHHHHHHHHHHHC	43.37	26320211
1646	Ubiquitination	TVSDSIKKLITSMRD CHHHHHHHHHHHHHC	43.37	24816145
1649	Phosphorylation	DSIKKLITSMRDKAP HHHHHHHHHHHCCCC	27.23	29759185
1650	Phosphorylation	SIKKLITSMRDKAPG HHHHHHHHHHCCCCC	12.58	29759185
1654	Acetylation	LITSMRDKAPGQLEC HHHHHHCCCCCCCHH	46.22	25953088
1670	Phosphorylation	TAIAALNSCLRDLDQ HHHHHHHHHHHCHHH	18.51	-
1679	Phosphorylation	LRDLDQASLAAVSQQ HHCHHHHHHHHHHHH	16.95	28857561
1694	Phosphorylation	LAPREGISQEALHTQ HCCCCCCCHHHHHHH	32.59	24719451
1700	Phosphorylation	ISQEALHTQMLTAVQ CCHHHHHHHHHHHHH	19.27	27251275
1702	Sulfoxidation	QEALHTQMLTAVQEI HHHHHHHHHHHHHHH	3.64	30846556
1732	Phosphorylation	SQLGHKVSQMAQYFE HHHHHHHHHHHHHHH	21.02	21712546
1737	Phosphorylation	KVSQMAQYFEPLTLA HHHHHHHHHHHHHHH	10.60	27259358
1750	Phosphorylation	LAAVGAASKTLSHPQ HHHHHHHHHCCCCHH	26.16	21712546
1759	Sulfoxidation	TLSHPQQMALLDQTK CCCCHHHHHHHHHHH	2.09	21406390
1766	Ubiquitination	MALLDQTKTLAESAL HHHHHHHHHHHHHHH	35.59	32015554
1767	Phosphorylation	ALLDQTKTLAESALQ HHHHHHHHHHHHHHH	34.29	21712546
1777	Phosphorylation	ESALQLLYTAKEAGG HHHHHHHHHHHHCCC	17.16	27259358
1778	Phosphorylation	SALQLLYTAKEAGGN HHHHHHHHHHHCCCC	31.09	30108239
1849	Phosphorylation	PMGEPEGSFVDYQTT CCCCCCCCCCCCHHH	22.04	24275569
1855	Phosphorylation	GSFVDYQTTMVRTAK CCCCCCHHHHHHHHH	15.61	24275569
1871	Sulfoxidation	IAVTVQEMVTKSNTS HHHHHHHHHHCCCCC	2.31	30846556
1875	Phosphorylation	VQEMVTKSNTSPEEL HHHHHHCCCCCHHHH	35.65	21406692
1877	Phosphorylation	EMVTKSNTSPEELGP HHHHCCCCCHHHHHH	53.39	26657352
1878	Phosphorylation	MVTKSNTSPEELGPL HHHCCCCCHHHHHHH	34.27	26657352
1890	Phosphorylation	GPLANQLTSDYGRLA HHHHHHHHHHHHHHH	15.13	21406692
1891	Phosphorylation	PLANQLTSDYGRLAS HHHHHHHHHHHHHHH	37.11	21406692
1893	Phosphorylation	ANQLTSDYGRLASEA HHHHHHHHHHHHHHC	12.15	21406692
1898	Phosphorylation	SDYGRLASEAKPAAV HHHHHHHHHCCCHHH	42.55	28857561
1901	Ubiquitination	GRLASEAKPAAVAAE HHHHHHCCCHHHHHC	31.01	24816145
1914	Phosphorylation	AENEEIGSHIKHRVQ HCCCHHHHHHHHHHH	27.92	28270605
1917	Acetylation	EEIGSHIKHRVQELG CHHHHHHHHHHHHHC	21.67	21466224
1917	Ubiquitination	EEIGSHIKHRVQELG CHHHHHHHHHHHHHC	21.67	29967540
1927	Glutathionylation	VQELGHGCAALVTKA HHHHCCCHHHHHHHC	1.34	22555962
1933	2-Hydroxyisobutyrylation	GCAALVTKAGALQCS CHHHHHHHCCCCCCC	37.03	-
1933	Malonylation	GCAALVTKAGALQCS CHHHHHHHCCCCCCC	37.03	26320211
1939	S-nitrosylation	TKAGALQCSPSDAYT HHCCCCCCCCCCCCC	7.22	22178444
1940	Phosphorylation	KAGALQCSPSDAYTK HCCCCCCCCCCCCCH	17.93	26657352
1942	Phosphorylation	GALQCSPSDAYTKKE CCCCCCCCCCCCHHH	20.69	28857561
1945	Phosphorylation	QCSPSDAYTKKELIE CCCCCCCCCHHHHHH	24.88	28152594
1946	Phosphorylation	CSPSDAYTKKELIEC CCCCCCCCHHHHHHH	37.04	28152594
1947	2-Hydroxyisobutyrylation	SPSDAYTKKELIECA CCCCCCCHHHHHHHH	31.41	-
1947	Acetylation	SPSDAYTKKELIECA CCCCCCCHHHHHHHH	31.41	25953088
1947	Ubiquitination	SPSDAYTKKELIECA CCCCCCCHHHHHHHH	31.41	33845483
1948	Malonylation	PSDAYTKKELIECAR CCCCCCHHHHHHHHH	50.37	26320211
1948	Ubiquitination	PSDAYTKKELIECAR CCCCCCHHHHHHHHH	50.37	29967540
1960	Acetylation	CARRVSEKVSHVLAA HHHHHHHHHHHHHHH	41.34	25953088
1960	Malonylation	CARRVSEKVSHVLAA HHHHHHHHHHHHHHH	41.34	26320211
1960	Ubiquitination	CARRVSEKVSHVLAA HHHHHHHHHHHHHHH	41.34	23503661
1962	Phosphorylation	RRVSEKVSHVLAALQ HHHHHHHHHHHHHHH	20.95	24719451
1997	Sulfoxidation	ADLDTTIMFATAGTL CCCCCEEEEEECCCC	1.43	30846556
2009	Phosphorylation	GTLNREGTETFADHR CCCCCCCCCHHHHHH	27.40	26699800
2011	Phosphorylation	LNREGTETFADHREG CCCCCCCHHHHHHCH	24.78	23312004
2021	Acetylation	DHREGILKTAKVLVE HHHCHHHHHHHHHHC	44.51	25953088
2021	Malonylation	DHREGILKTAKVLVE HHHCHHHHHHHHHHC	44.51	26320211
2021	Ubiquitination	DHREGILKTAKVLVE HHHCHHHHHHHHHHC	44.51	27667366
2024	2-Hydroxyisobutyrylation	EGILKTAKVLVEDTK CHHHHHHHHHHCCHH	41.14	-
2024	Acetylation	EGILKTAKVLVEDTK CHHHHHHHHHHCCHH	41.14	23749302
2024	Malonylation	EGILKTAKVLVEDTK CHHHHHHHHHHCCHH	41.14	26320211
2024	Ubiquitination	EGILKTAKVLVEDTK CHHHHHHHHHHCCHH	41.14	23503661
2030	Phosphorylation	AKVLVEDTKVLVQNA HHHHHCCHHHHHHCC	15.00	-
2031	Acetylation	KVLVEDTKVLVQNAA HHHHCCHHHHHHCCC	45.99	19608861
2031	Malonylation	KVLVEDTKVLVQNAA HHHHCCHHHHHHCCC	45.99	26320211
2031	Ubiquitination	KVLVEDTKVLVQNAA HHHHCCHHHHHHCCC	45.99	23503661
2040	Phosphorylation	LVQNAAGSQEKLAQA HHHCCCCCHHHHHHH	30.36	30266825
2043	Acetylation	NAAGSQEKLAQAAQS CCCCCHHHHHHHHHH	41.30	23236377
2050	Phosphorylation	KLAQAAQSSVATITR HHHHHHHHHHHHHHH	23.27	23927012
2051	Phosphorylation	LAQAAQSSVATITRL HHHHHHHHHHHHHHH	12.05	23927012
2063	2-Hydroxyisobutyrylation	TRLADVVKLGAASLG HHHHHHHHHCHHHCC	40.84	-
2068	Phosphorylation	VVKLGAASLGAEDPE HHHHCHHHCCCCCCC	27.14	21712546
2089	Acetylation	NAVKDVAKALGDLIS HHHHHHHHHHHHHHH	43.95	7675735
2096	Phosphorylation	KALGDLISATKAAAG HHHHHHHHHHHHHCC	36.86	28060719
2098	Phosphorylation	LGDLISATKAAAGKV HHHHHHHHHHHCCCC	17.90	28060719
2099	2-Hydroxyisobutyrylation	GDLISATKAAAGKVG HHHHHHHHHHCCCCC	35.43	-
2099	Acetylation	GDLISATKAAAGKVG HHHHHHHHHHCCCCC	35.43	25953088
2099	Malonylation	GDLISATKAAAGKVG HHHHHHHHHHCCCCC	35.43	26320211
2099	Ubiquitination	GDLISATKAAAGKVG HHHHHHHHHHCCCCC	35.43	33845483
2115	Acetylation	DPAVWQLKNSAKVMV CHHHHHCCCCCEEEE	33.48	19608861
2115	Malonylation	DPAVWQLKNSAKVMV CHHHHHCCCCCEEEE	33.48	26320211
2115	Methylation	DPAVWQLKNSAKVMV CHHHHHCCCCCEEEE	33.48	19608861
2115	Ubiquitination	DPAVWQLKNSAKVMV CHHHHHCCCCCEEEE	33.48	32015554
2119	Acetylation	WQLKNSAKVMVTNVT HHCCCCCEEEEEEHH	30.59	25953088
2119	Malonylation	WQLKNSAKVMVTNVT HHCCCCCEEEEEEHH	30.59	26320211
2121	Sulfoxidation	LKNSAKVMVTNVTSL CCCCCEEEEEEHHHH	2.79	30846556
2123	Phosphorylation	NSAKVMVTNVTSLLK CCCEEEEEEHHHHHH	13.08	24117733
2126	Phosphorylation	KVMVTNVTSLLKTVK EEEEEEHHHHHHHHH	18.74	22199227
2127	Phosphorylation	VMVTNVTSLLKTVKA EEEEEHHHHHHHHHH	27.67	28355574
2130	Acetylation	TNVTSLLKTVKAVED EEHHHHHHHHHHHHH	57.47	25953088
2130	Ubiquitination	TNVTSLLKTVKAVED EEHHHHHHHHHHHHH	57.47	23000965
2131	Phosphorylation	NVTSLLKTVKAVEDE EHHHHHHHHHHHHHH	27.49	25599653
2133	Acetylation	TSLLKTVKAVEDEAT HHHHHHHHHHHHHCH	52.53	23749302
2133	Malonylation	TSLLKTVKAVEDEAT HHHHHHHHHHHHHCH	52.53	26320211
2133	Ubiquitination	TSLLKTVKAVEDEAT HHHHHHHHHHHHHCH	52.53	23000965
2162	Phosphorylation	QELAVFCSPEPPAKT HHHHHHCCCCCCCCC	22.34	27422710
2168	Ubiquitination	CSPEPPAKTSTPEDF CCCCCCCCCCCHHHH	49.10	24816145
2169	Phosphorylation	SPEPPAKTSTPEDFI CCCCCCCCCCHHHHH	39.68	28857561
2170	Phosphorylation	PEPPAKTSTPEDFIR CCCCCCCCCHHHHHH	41.06	28857561
2171	Phosphorylation	EPPAKTSTPEDFIRM CCCCCCCCHHHHHHH	35.61	22199227
2179	Phosphorylation	PEDFIRMTKGITMAT HHHHHHHCCCCHHHH	19.10	26074081
2180	Malonylation	EDFIRMTKGITMATA HHHHHHCCCCHHHHH	38.68	26320211
2180	Ubiquitination	EDFIRMTKGITMATA HHHHHHCCCCHHHHH	38.68	29967540
2183	Phosphorylation	IRMTKGITMATAKAV HHHCCCCHHHHHHHH	14.93	26074081
2184	Sulfoxidation	RMTKGITMATAKAVA HHCCCCHHHHHHHHH	2.70	30846556
2186	Phosphorylation	TKGITMATAKAVAAG CCCCHHHHHHHHHCC	20.19	26074081
2188	Malonylation	GITMATAKAVAAGNS CCHHHHHHHHHCCCC	38.75	26320211
2188	Ubiquitination	GITMATAKAVAAGNS CCHHHHHHHHHCCCC	38.75	24816145
2195	Phosphorylation	KAVAAGNSCRQEDVI HHHHCCCCCCHHHHH	15.12	26074081
2197	Methylation	VAAGNSCRQEDVIAT HHCCCCCCHHHHHHH	42.62	-
2215	Sulfoxidation	SRRAIADMLRACKEA CHHHHHHHHHHHHHH	1.70	21406390
2220	Ubiquitination	ADMLRACKEAAYHPE HHHHHHHHHHHCCCC	49.78	24816145
2224	Phosphorylation	RACKEAAYHPEVAPD HHHHHHHCCCCCCCC	25.59	22817900
2233	Methylation	PEVAPDVRLRALHYG CCCCCCHHHHHHHHC	26.32	115918153
2239	Phosphorylation	VRLRALHYGRECANG HHHHHHHHCHHHHHH	20.80	-
2262	Phosphorylation	LLTLQKPSPELKQQL HHHCCCCCHHHHHHH	37.73	24719451
2270	Phosphorylation	PELKQQLTGHSKRVA HHHHHHHHCCCHHHH	28.63	26699800
2279	Phosphorylation	HSKRVAGSVTELIQA CCHHHHHHHHHHHHH	19.01	26657352
2281	Phosphorylation	KRVAGSVTELIQAAE HHHHHHHHHHHHHHH	27.11	27251275
2290	Sulfoxidation	LIQAAEAMKGTEWVD HHHHHHHHCCCCCCC	2.87	30846556
2338	Phosphorylation	KPKEADESLNFEEQI CCCCCCCCCCHHHHH	29.21	21712546
2351	Phosphorylation	QILEAAKSIAAATSA HHHHHHHHHHHHHHH	16.84	22199227
2356	Phosphorylation	AKSIAAATSALVKAA HHHHHHHHHHHHHHH	15.14	28060719
2357	Phosphorylation	KSIAAATSALVKAAS HHHHHHHHHHHHHHH	18.19	20068231
2361	Acetylation	AATSALVKAASAAQR HHHHHHHHHHHHHHH	38.80	25953088
2361	Ubiquitination	AATSALVKAASAAQR HHHHHHHHHHHHHHH	38.80	23000965
2390	Phosphorylation	ALDDGQWSQGLISAA CCCCCCCHHHHHHHH	13.39	21712546
2404	Phosphorylation	ARMVAAATNNLCEAA HHHHHHHHCCHHHHH	21.66	-
2426	Phosphorylation	ASQEKLISSAKQVAA CCHHHHHHHHHHHHH	34.38	28060719
2427	Phosphorylation	SQEKLISSAKQVAAS CHHHHHHHHHHHHHH	32.27	-
2429	Acetylation	EKLISSAKQVAASTA HHHHHHHHHHHHHHH	47.45	25953088
2453	Sulfoxidation	ADQDSEAMKRLQAAG CCCCHHHHHHHHHHH	1.97	30846556
2464	Acetylation	QAAGNAVKRASDNLV HHHHHHHHHHHHHHH	39.58	25953088
2464	Ubiquitination	QAAGNAVKRASDNLV HHHHHHHHHHHHHHH	39.58	24816145
2476	Acetylation	NLVKAAQKAAAFEEQ HHHHHHHHHHHHHHH	34.95	27178108
2491	Ubiquitination	ENETVVVKEKMVGGI CCCEEEEEEEHHHHH	39.75	33845483
2494	Sulfoxidation	TVVVKEKMVGGIAQI EEEEEEEHHHHHHHH	3.38	30846556
2508	Sulfoxidation	IIAAQEEMLRKEREL HHHHHHHHHHHHHHH	4.28	30846556
2521	Ubiquitination	ELEEARKKLAQIRQQ HHHHHHHHHHHHHHH	43.43	24816145
2530	Phosphorylation	AQIRQQQYKFLPSEL HHHHHHHHCCCCHHH	10.20	19534553
2531	Acetylation	QIRQQQYKFLPSELR HHHHHHHCCCCHHHC	35.77	25953088
2531	Ubiquitination	QIRQQQYKFLPSELR HHHHHHHCCCCHHHC	35.77	22817900
2535	Phosphorylation	QQYKFLPSELRDEH- HHHCCCCHHHCCCC-	51.95	28857561
2538	Methylation	KFLPSELRDEH---- CCCCHHHCCCC----	43.13	115918157

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
425	S	Phosphorylation	Kinase	CDK5	Q00535	PSP
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF1	Q9HCE7	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TLN1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TLN1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ITB3_HUMAN	ITGB3	physical	10497223
FAK1_HUMAN	PTK2	physical	7622520
ITB3_HUMAN	ITGB3	physical	11932255
SMUF1_HUMAN	SMURF1	physical	19363486
DAG1_HUMAN	DAG1	physical	18341635
TBA1A_HUMAN	TUBA1A	physical	18341635
UBA1_HUMAN	UBA1	physical	22939629
TRIP6_HUMAN	TRIP6	physical	22939629
UBP19_HUMAN	USP19	physical	22939629
TXLNG_HUMAN	TXLNG	physical	22939629
TXD12_HUMAN	TXNDC12	physical	22939629
NXP20_HUMAN	FAM114A1	physical	22863883
NMD3_HUMAN	NMD3	physical	26344197
RNH2C_HUMAN	RNASEH2C	physical	26344197
ITB1_HUMAN	ITGB1	physical	19843520
ITB3_HUMAN	ITGB3	physical	19843520
ITB7_HUMAN	ITGB7	physical	19843520
ITB3_HUMAN	ITGB3	physical	11412103
ITA5_HUMAN	ITGA5	physical	28263956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-2031 AND LYS-2115, AND MASSSPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, AND MASSSPECTROMETRY.
PubMed: 19690332

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-167; SER-425 ANDSER-2338, AND MASS SPECTROMETRY.
PubMed: 18669648

"Phosphoproteome of resting human platelets.";
Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.;
J. Proteome Res. 7:526-534(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-425, AND MASSSPECTROMETRY.
PubMed: 18088087

"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells.";
Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.;
J. Proteome Res. 8:3852-3861(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-26; TYR-70 AND TYR-2530,AND MASS SPECTROMETRY.
PubMed: 19534553

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-26; TYR-70; TYR-436;TYR-1116 AND TYR-1945, AND MASS SPECTROMETRY.
PubMed: 18083107

"Immunoaffinity profiling of tyrosine phosphorylation in cancercells.";
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.;
Nat. Biotechnol. 23:94-101(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-70, AND MASSSPECTROMETRY.
PubMed: 15592455