SMUF1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SMUF1_HUMAN
• UniProt AC: Q9HCE7
• Protein Name: E3 ubiquitin-protein ligase SMURF1
• Gene Name: SMURF1
• Organism: Homo sapiens (Human).
• Sequence Length: 757
• Subcellular Localization: Cytoplasm . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side .
• Protein Description: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS. [PubMed: 23087404 Plays a role in dendrite formation by melanocytes]
• Protein Sequence: MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Ubiquitination	RLTVLCAKNLAKKDF HHHHHHHHHHCCCCC	52.04	33845483
66	Phosphorylation	DPKWNQHYDLYVGKT CCCHHHCEEEEEECC	9.62	-
69	Phosphorylation	WNQHYDLYVGKTDSI HHHCEEEEEECCCEE	12.31	-
145	Phosphorylation	QTRDRIGTGGSVVDC ECCCCCCCCCCEEEC	35.68	24719451
148	Phosphorylation	DRIGTGGSVVDCRGL CCCCCCCCEEECCHH	21.95	28857561
163	Phosphorylation	LENEGTVYEDSGPGR HCCCCCEEECCCCCC	17.54	27642862
200	Phosphorylation	GNCRFVESPSQDQRL CCCEECCCCCHHHHH	25.26	29255136
202	Phosphorylation	CRFVESPSQDQRLQA CEECCCCCHHHHHHH	56.52	22210691
223	Phosphorylation	DVRGSLQTPQNRPHG CCCCCCCCCCCCCCC	31.94	28555341
233	Phosphorylation	NRPHGHQSPELPEGY CCCCCCCCCCCCCCC	18.05	28985074
251	Phosphorylation	TTVQGQVYFLHTQTG EEEEEEEEEEEECCC	7.79	-
260	Phosphorylation	LHTQTGVSTWHDPRI EEECCCCCCCCCCCC	27.42	-
324	Ubiquitination	TVSGRIYFVDHNNRT EEECEEEEEECCCCE	4.91	21963094
332	Phosphorylation	VDHNNRTTQFTDPRL EECCCCEEEECCHHH	20.60	-
350	Ubiquitination	MNHQCQLKEPSQPLP HCCCCCCCCCCCCCC	41.52	PubMed
355	Ubiquitination	QLKEPSQPLPLPSEG CCCCCCCCCCCCCCC	40.04	29967540
360	Phosphorylation	SQPLPLPSEGSLEDE CCCCCCCCCCCCCCC	63.37	28348404
363	Phosphorylation	LPLPSEGSLEDEELP CCCCCCCCCCCCCCC	25.24	28348404
381	Ubiquitination	YERDLVQKLKVLRHE HHHHHHHHHHHHHHH	42.68	21572392
383	Ubiquitination	RDLVQKLKVLRHELS HHHHHHHHHHHHHHC	46.38	21572392
390	Phosphorylation	KVLRHELSLQQPQAG HHHHHHHCCCCCCCC	22.58	22210691
392	Ubiquitination	LRHELSLQQPQAGHC HHHHHCCCCCCCCCC	49.92	25015289
404	Phosphorylation	GHCRIEVSREEIFEE CCCEEEECHHHHHHH	22.60	22210691
412	Phosphorylation	REEIFEESYRQIMKM HHHHHHHHHHHHHHC	20.58	22210691
413	Phosphorylation	EEIFEESYRQIMKMR HHHHHHHHHHHHHCC	15.15	22210691
418	Ubiquitination	ESYRQIMKMRPKDLK HHHHHHHHCCHHHHH	33.13	25015289
440	Phosphorylation	RGEEGLDYGGVAREW CCCCCCCCCHHHHHH	22.33	-
495	Ubiquitination	YFHFVGRIMGLAVFH HHHHHHHHHHHEEEE	1.80	29967540
521	Ubiquitination	FYKQLLGKPIQLSDL HHHHHHCCCEEHHHH	38.63	29967540
526	Phosphorylation	LGKPIQLSDLESVDP HCCCEEHHHHHHCCH	24.63	18452278
656	Phosphorylation	LKHCVADSNIVRWFW HHHHHCCHHHHHHHH	20.79	23312004
667	Ubiquitination	RWFWQAVETFDEERR HHHHHHHHHCCHHHH	46.93	27667366
693	Ubiquitination	RVPLQGFKALQGSTG CCCCCCHHHHCCCCC	55.82	27667366
739	Ubiquitination	PPYESYEKLYEKLLT CCHHHHHHHHHHHHH	48.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	FBXL15	Q9H469	PMID:21572392
-	K	Ubiquitination	E3 ubiquitin ligase	FBXO3	Q9UK99	PMID:25721664
-	K	Ubiquitination	E3 ubiquitin ligase	SMURF2	Q9HAU4	PMID:16373342

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
381	K	ubiquitylation	Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome.	21572392
383	K	ubiquitylation	Lys-383 is the primary ubiquitination site.	21572392
383	K	ubiquitylation	Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome.	21572392

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SMUF1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RHBT1_MOUSE	Rhobtb1	physical	15761153
ARL4D_MOUSE	Arl4d	physical	15761153
GBG11_MOUSE	Gng11	physical	15761153
RGL3_MOUSE	Rgl3	physical	15761153
ARHG1_MOUSE	Arhgef1	physical	15761153
UBB_MOUSE	Ubb	physical	15761153
RS27A_MOUSE	Rps27a	physical	15761153
UBP45_MOUSE	Usp45	physical	15761153
FBX24_MOUSE	Fbxo24	physical	15761153
SQSTM_MOUSE	Sqstm1	physical	15761153
TBL2_MOUSE	Tbl2	physical	15761153
PRP17_MOUSE	Cdc40	physical	15761153
WDR61_MOUSE	Wdr61	physical	15761153
PK1IP_MOUSE	Pak1ip1	physical	15761153
PWP1_MOUSE	Pwp1	physical	15761153
U3IP2_MOUSE	Rrp9	physical	15761153
CSK22_MOUSE	Csnk2a2	physical	15761153
CDKL1_MOUSE	Cdkl1	physical	15761153
UHMK1_MOUSE	Uhmk1	physical	15761153
IRAK2_MOUSE	Irak2	physical	15761153
M3K7_MOUSE	Map3k7	physical	15761153
APC5_MOUSE	Anapc5	physical	15761153
OSBL3_MOUSE	Osbpl3	physical	15761153
RHG15_MOUSE	Arhgap15	physical	15761153
LHX9_MOUSE	Lhx9	physical	15761153
RNF14_MOUSE	Rnf14	physical	15761153
RNF12_MOUSE	Rlim	physical	15761153
ELP3_MOUSE	Elp3	physical	15761153
NAA20_MOUSE	Naa20	physical	15761153
ING2_MOUSE	Ing2	physical	15761153
CXXC1_MOUSE	Cxxc1	physical	15761153
GAR1_MOUSE	Gar1	physical	15761153
ETV6_MOUSE	Etv6	physical	15761153
SRSF5_MOUSE	Srsf5	physical	15761153
AVEN_MOUSE	Aven	physical	15761153
ASH2L_MOUSE	Ash2l	physical	15761153
HDGR3_MOUSE	Hdgfrp3	physical	15761153
ECSIT_MOUSE	Ecsit	physical	15761153
RIT1_MOUSE	Rit1	physical	15761153
RHES_MOUSE	Rasd2	physical	15761153
I5P2_MOUSE	Inpp5b	physical	15761153
ARHG7_MOUSE	Arhgef7	physical	15761153
SF3A1_MOUSE	Sf3a1	physical	15761153
FBX3_MOUSE	Fbxo3	physical	15761153
CUL5_MOUSE	Cul5	physical	15761153
2ABD_MOUSE	Ppp2r2d	physical	15761153
TSSK5_MOUSE	Tssk5	physical	15761153
RIPK2_MOUSE	Ripk2	physical	15761153
MP2K3_MOUSE	Map2k3	physical	15761153
WEE1_MOUSE	Wee1	physical	15761153
CDK14_MOUSE	Cdk14	physical	15761153
CHIP_MOUSE	Stub1	physical	15761153
DNJC7_MOUSE	Dnajc7	physical	15761153
RAPSN_MOUSE	Rapsn	physical	15761153
LONF3_MOUSE	Lonrf3	physical	15761153
ZBT8B_MOUSE	Zbtb8b	physical	15761153
PP1B_MOUSE	Ppp1cb	physical	15761153
TRI35_MOUSE	Trim35	physical	15761153
RN141_MOUSE	Rnf141	physical	15761153
RN138_MOUSE	Rnf138	physical	15761153
AP2B1_MOUSE	Ap2b1	physical	15761153
SMAD3_MOUSE	Smad3	physical	15761153
SMAD6_MOUSE	Smad6	physical	15761153
SMAD7_MOUSE	Smad7	physical	15761153
RHPN2_MOUSE	Rhpn2	physical	15761153
RTKN_MOUSE	Rtkn	physical	15761153
OCLN_MOUSE	Ocln	physical	15761153
APBB2_MOUSE	Apbb2	physical	15761153
STRAP_MOUSE	Strap	physical	15761153
FCHO1_MOUSE	Fcho1	physical	15761153
SMUF2_HUMAN	SMURF2	physical	18927080
PKHO1_HUMAN	PLEKHO1	physical	18641638
ARHG9_HUMAN	ARHGEF9	physical	18208356
PDLI7_HUMAN	PDLIM7	physical	16611643
SMAD1_HUMAN	SMAD1	physical	16611643
TRAF4_HUMAN	TRAF4	physical	19937093
SMAD5_HUMAN	SMAD5	physical	11278251
SMAD6_HUMAN	SMAD6	physical	11278251
SMAD7_HUMAN	SMAD7	physical	11278251
TGFR1_HUMAN	TGFBR1	physical	11278251
TGFR2_HUMAN	TGFBR2	physical	11278251
KLF2_HUMAN	KLF2	physical	21382345
WFS1_HUMAN	WFS1	physical	21454619
RHOA_HUMAN	RHOA	physical	21708152
SMAD1_HUMAN	SMAD1	physical	21708152
SMAD1_HUMAN	SMAD1	physical	17289590
JUNB_HUMAN	JUNB	physical	20200942
ESR1_HUMAN	ESR1	physical	20207742
ACK1_HUMAN	TNK2	physical	19144635
PSME3_HUMAN	PSME3	physical	20580715
TLN1_HUMAN	TLN1	physical	19363486
ING2_HUMAN	ING2	physical	20621832
SMAD5_HUMAN	SMAD5	physical	20484049
MDM2_HUMAN	MDM2	physical	20484049
P53_HUMAN	TP53	physical	20484049
NFIC_HUMAN	NFIC	physical	22195013
PAR6A_RAT	Pard6a	physical	21262463
PAR6A_HUMAN	PARD6A	physical	21262463
RHOA_MOUSE	Rhoa	physical	21262463
SMAD1_HUMAN	SMAD1	physical	19914168
SMAD5_HUMAN	SMAD5	physical	19914168
STAT1_HUMAN	STAT1	physical	22474288
SMAD1_HUMAN	SMAD1	physical	21685363
PDLI7_HUMAN	PDLIM7	physical	17510966
SMAD1_HUMAN	SMAD1	physical	22670624
SMAD5_HUMAN	SMAD5	physical	22670624
CCM2_HUMAN	CCM2	physical	19318350
SMUF1_HUMAN	SMURF1	physical	19318350
M3K3_HUMAN	MAP3K3	physical	19318350
SMUF1_HUMAN	SMURF1	physical	22921829
SMAD7_HUMAN	SMAD7	physical	12519765
XPO1_HUMAN	XPO1	physical	12519765
SMAD1_HUMAN	SMAD1	physical	17676934
SMAD5_HUMAN	SMAD5	physical	17676934
SMAD6_HUMAN	SMAD6	physical	17676934
SMUF1_HUMAN	SMURF1	physical	22496338
PKHO1_HUMAN	PLEKHO1	physical	23032291
PRS8_HUMAN	PSMC5	physical	23032291
MYD88_HUMAN	MYD88	physical	21897371
SMAD6_HUMAN	SMAD6	physical	21897371
SMUF2_HUMAN	SMURF2	physical	21897371
UB2D3_HUMAN	UBE2D3	physical	20621832
UB2D3_HUMAN	UBE2D3	physical	20484049
MAVS_HUMAN	MAVS	physical	23087404
FZR1_HUMAN	FZR1	physical	22949615
A4_HUMAN	APP	physical	21832049
RHG32_HUMAN	ARHGAP32	physical	23226367
RS15_HUMAN	RPS15	physical	23184937
NUDT5_HUMAN	NUDT5	physical	23184937
PUR1_HUMAN	PPAT	physical	23184937
USP9X_HUMAN	USP9X	physical	23184937
RS3A_HUMAN	RPS3A	physical	23184937
RS11_HUMAN	RPS11	physical	23184937
SRSF1_HUMAN	SRSF1	physical	23184937
NUMA1_HUMAN	NUMA1	physical	23184937
RHG05_HUMAN	ARHGAP5	physical	23184937
DDX21_HUMAN	DDX21	physical	23184937
RS13_HUMAN	RPS13	physical	23184937
CPSF5_HUMAN	NUDT21	physical	23184937
DDX5_HUMAN	DDX5	physical	23184937
RS12_HUMAN	RPS12	physical	23184937
UBC_HUMAN	UBC	physical	23184937
HNRPU_HUMAN	HNRNPU	physical	23184937
ROA1_HUMAN	HNRNPA1	physical	23184937
RS17_HUMAN	RPS17	physical	23184937
LA_HUMAN	SSB	physical	23184937
RS19_HUMAN	RPS19	physical	23184937
XRCC5_HUMAN	XRCC5	physical	23184937
RT22_HUMAN	MRPS22	physical	23184937
HNRPQ_HUMAN	SYNCRIP	physical	23184937
2AAA_HUMAN	PPP2R1A	physical	23184937
PP2AA_HUMAN	PPP2CA	physical	23184937
ROA0_HUMAN	HNRNPA0	physical	23184937
ROAA_HUMAN	HNRNPAB	physical	23184937
U2AF1_HUMAN	U2AF1	physical	23184937
H2B2E_HUMAN	HIST2H2BE	physical	23184937
RS15A_HUMAN	RPS15A	physical	23184937
XRCC6_HUMAN	XRCC6	physical	23184937
HNRPD_HUMAN	HNRNPD	physical	23184937
2ABA_HUMAN	PPP2R2A	physical	23184937
RS10_HUMAN	RPS10	physical	23184937
CPSF6_HUMAN	CPSF6	physical	23184937
H12_HUMAN	HIST1H1C	physical	23184937
RS3_HUMAN	RPS3	physical	23184937
RT23_HUMAN	MRPS23	physical	23184937
RS8_HUMAN	RPS8	physical	23184937
RL17_HUMAN	RPL17	physical	23184937
RS14_HUMAN	RPS14	physical	23184937
RL22_HUMAN	RPL22	physical	23184937
RS6_HUMAN	RPS6	physical	23184937
RS4X_HUMAN	RPS4X	physical	23184937
RS25_HUMAN	RPS25	physical	23184937
DHX9_HUMAN	DHX9	physical	23184937
RS20_HUMAN	RPS20	physical	23184937
NUCL_HUMAN	NCL	physical	23184937
RT27_HUMAN	MRPS27	physical	23184937
RL23_HUMAN	RPL23	physical	23184937
FAS_HUMAN	FASN	physical	23184937
RS18_HUMAN	RPS18	physical	23184937
BYST_HUMAN	BYSL	physical	23184937
SPF45_HUMAN	RBM17	physical	23184937
MPCP_HUMAN	SLC25A3	physical	23184937
OGT1_HUMAN	OGT	physical	23184937
SF3B2_HUMAN	SF3B2	physical	23184937
EF1D_HUMAN	EEF1D	physical	23184937
FHL1_HUMAN	FHL1	physical	23184937
ROA3_HUMAN	HNRNPA3	physical	23184937
RS9_HUMAN	RPS9	physical	23184937
RS16_HUMAN	RPS16	physical	23184937
GRP75_HUMAN	HSPA9	physical	23184937
TBB5_HUMAN	TUBB	physical	23184937
TBB4B_HUMAN	TUBB4B	physical	23184937
SNRPA_HUMAN	SNRPA	physical	23184937
HNRPF_HUMAN	HNRNPF	physical	23184937
SF3B1_HUMAN	SF3B1	physical	23184937
PRPS1_HUMAN	PRPS1	physical	23184937
GDIB_HUMAN	GDI2	physical	23184937
ROA2_HUMAN	HNRNPA2B1	physical	23184937
TIM50_HUMAN	TIMM50	physical	23184937
RS5_HUMAN	RPS5	physical	23184937
LPPRC_HUMAN	LRPPRC	physical	23184937
TCPA_HUMAN	TCP1	physical	23184937
TIF1B_HUMAN	TRIM28	physical	23184937
LDHB_HUMAN	LDHB	physical	23184937
TBA1A_HUMAN	TUBA1A	physical	23184937
TCPB_HUMAN	CCT2	physical	23184937
ADT2_HUMAN	SLC25A5	physical	23184937
RL24_HUMAN	RPL24	physical	23184937
TCPD_HUMAN	CCT4	physical	23184937
TF2B_HUMAN	GTF2B	physical	23184937
PTPS_HUMAN	PTS	physical	23184937
MAP1B_HUMAN	MAP1B	physical	23184937
CCAR1_HUMAN	CCAR1	physical	23184937
RU2A_HUMAN	SNRPA1	physical	23184937
GRP78_HUMAN	HSPA5	physical	23184937
HSP7C_HUMAN	HSPA8	physical	23184937
UBP15_HUMAN	USP15	physical	23184937
VIME_HUMAN	VIM	physical	23184937
PRS6B_HUMAN	PSMC4	physical	23184937
TCPQ_HUMAN	CCT8	physical	23184937
EF1A1_HUMAN	EEF1A1	physical	23184937
FLNA_HUMAN	FLNA	physical	23184937
CLH1_HUMAN	CLTC	physical	23184937
EF1G_HUMAN	EEF1G	physical	23184937
RBM10_HUMAN	RBM10	physical	23184937
TCP4_HUMAN	SUB1	physical	23184937
EIF3A_HUMAN	EIF3A	physical	23184937
SPTN1_HUMAN	SPTAN1	physical	23184937
PPM1A_HUMAN	PPM1A	physical	23184937
SMD2_HUMAN	SNRPD2	physical	23184937
HNRPK_HUMAN	HNRNPK	physical	23184937
CAZA1_HUMAN	CAPZA1	physical	23184937
TCPH_HUMAN	CCT7	physical	23184937
CH60_HUMAN	HSPD1	physical	23184937
YBOX1_HUMAN	YBX1	physical	23184937
CIRBP_HUMAN	CIRBP	physical	23184937
EFTU_HUMAN	TUFM	physical	23184937
EF1B_HUMAN	EEF1B2	physical	23184937
ACTB_HUMAN	ACTB	physical	23184937
SPTB2_HUMAN	SPTBN1	physical	23184937
LAP2A_HUMAN	TMPO	physical	23184937
LAP2B_HUMAN	TMPO	physical	23184937
KAP0_HUMAN	PRKAR1A	physical	23184937
STK38_HUMAN	STK38	physical	23184937
NS1BP_HUMAN	IVNS1ABP	physical	23184937
CLAP2_HUMAN	CLASP2	physical	23184937
LTBP1_HUMAN	LTBP1	physical	23184937
ANFY1_HUMAN	ANKFY1	physical	23184937
SPIN1_HUMAN	SPIN1	physical	23184937
EIF3H_HUMAN	EIF3H	physical	23184937
PDIA6_HUMAN	PDIA6	physical	23184937
KIF11_HUMAN	KIF11	physical	23184937
ZRAB2_HUMAN	ZRANB2	physical	23184937
ST38L_HUMAN	STK38L	physical	23184937
IMB1_HUMAN	KPNB1	physical	23184937
ACTZ_HUMAN	ACTR1A	physical	23184937
TCPZ_HUMAN	CCT6A	physical	23184937
PRP31_HUMAN	PRPF31	physical	23184937
MEP50_HUMAN	WDR77	physical	23184937
ICLN_HUMAN	CLNS1A	physical	23184937
RL31_HUMAN	RPL31	physical	23184937
IF4B_HUMAN	EIF4B	physical	23184937
CMBL_HUMAN	CMBL	physical	23184937
KCTD5_HUMAN	KCTD5	physical	23184937
SF3A1_HUMAN	SF3A1	physical	23184937
E2F7_HUMAN	E2F7	physical	23184937
METK2_HUMAN	MAT2A	physical	23184937
PSMD2_HUMAN	PSMD2	physical	23184937
COF1_HUMAN	CFL1	physical	23184937
RSMB_HUMAN	SNRPB	physical	23184937
EF2_HUMAN	EEF2	physical	23184937
ROCK1_HUMAN	ROCK1	physical	23184937
YYAP1_HUMAN	YY1AP1	physical	23184937
HNRH2_HUMAN	HNRNPH2	physical	23184937
COPRS_HUMAN	COPRS	physical	23184937
EIF3E_HUMAN	EIF3E	physical	23184937
BCLF1_HUMAN	BCLAF1	physical	23184937
PSA4_HUMAN	PSMA4	physical	23184937
SMD3_HUMAN	SNRPD3	physical	23184937
HNRH1_HUMAN	HNRNPH1	physical	23184937
TERA_HUMAN	VCP	physical	23184937
GOGA3_HUMAN	GOLGA3	physical	23184937
ANM5_HUMAN	PRMT5	physical	23184937
RIOK1_HUMAN	RIOK1	physical	23184937
GRDN_HUMAN	CCDC88A	physical	23184937
ANM1_HUMAN	PRMT1	physical	23184937
DCTN2_HUMAN	DCTN2	physical	23184937
DAPLE_HUMAN	CCDC88C	physical	23184937
JAK1_HUMAN	JAK1	physical	23184937
ACAP2_HUMAN	ACAP2	physical	23184937
SMD1_HUMAN	SNRPD1	physical	23184937
TR150_HUMAN	THRAP3	physical	23184937
DCTN1_HUMAN	DCTN1	physical	23184937
RS24_HUMAN	RPS24	physical	23184937
E41L3_HUMAN	EPB41L3	physical	23184937
EIF3B_HUMAN	EIF3B	physical	23184937
EFNB1_HUMAN	EFNB1	physical	23475958
FXL15_HUMAN	FBXL15	physical	21572392
FBW1A_HUMAN	BTRC	physical	21572392
FBX42_HUMAN	FBXO42	physical	21572392
FBX21_HUMAN	FBXO21	physical	21572392
FBXL5_HUMAN	FBXL5	physical	21572392
AXIN1_HUMAN	AXIN1	physical	23959799
UB2D3_HUMAN	UBE2D3	physical	23959799
TRIB2_HUMAN	TRIB2	physical	24089522
UB2D3_HUMAN	UBE2D3	physical	24089522
AXIN1_HUMAN	AXIN1	physical	24700460
SMAD7_HUMAN	SMAD7	physical	24700460
SMAD4_HUMAN	SMAD4	physical	23973329
TRAF4_HUMAN	TRAF4	physical	23973329
SMAD1_HUMAN	SMAD1	physical	24828823
UB2D3_HUMAN	UBE2D3	physical	24828823
UB2L3_HUMAN	UBE2L3	physical	24828823
UBC12_HUMAN	UBE2M	physical	24821572
SMUF1_HUMAN	SMURF1	physical	24821572
UB2D3_HUMAN	UBE2D3	physical	24821572
UB2L3_HUMAN	UBE2L3	physical	24821572
SMUF1_HUMAN	SMURF1	physical	17996703
UB2L3_HUMAN	UBE2L3	physical	17996703
RPB1_HUMAN	POLR2A	physical	17996703
SMAD1_HUMAN	SMAD1	physical	17510966
SMUF1_HUMAN	SMURF1	physical	18641638
SMAD5_HUMAN	SMAD5	physical	18641638
UB2D3_HUMAN	UBE2D3	physical	18641638
SMUF1_HUMAN	SMURF1	physical	22152476
SMAD1_HUMAN	SMAD1	physical	22152476
PKHO1_HUMAN	PLEKHO1	physical	22152476
SMAD7_HUMAN	SMAD7	physical	22152476
FZR1_HUMAN	FZR1	physical	22152476
CTNB1_HUMAN	CTNNB1	physical	26015066
FBX3_HUMAN	FBXO3	physical	25721664
ECSIT_HUMAN	ECSIT	physical	25241761
GBG11_HUMAN	GNG11	physical	25241761
UBC_HUMAN	UBC	physical	25723849
UB2D1_HUMAN	UBE2D1	physical	25723849
UB2D2_HUMAN	UBE2D2	physical	25723849
UB2D3_HUMAN	UBE2D3	physical	25723849
UB2L3_HUMAN	UBE2L3	physical	25723849
RASF1_HUMAN	RASSF1	physical	26825171
RHOA_HUMAN	RHOA	physical	26825171
NR2E1_HUMAN	NR2E1	physical	27048878
TGFR2_HUMAN	TGFBR2	physical	27048878
UBP5_HUMAN	USP5	physical	27133717
SMUF1_HUMAN	SMURF1	physical	26949039
UB2L3_HUMAN	UBE2L3	physical	26949039
AN13D_HUMAN	ANKRD13D	physical	20804422
PSMD4_HUMAN	PSMD4	physical	20804422
UB2V1_HUMAN	UBE2V1	physical	20804422
TOM1_HUMAN	TOM1	physical	20804422
HOIL1_HUMAN	RBCK1	physical	20804422
CUED1_HUMAN	CUEDC1	physical	20804422
UBAC1_HUMAN	UBAC1	physical	20804422
UBP5_HUMAN	USP5	physical	20804422
MINY3_HUMAN	FAM188A	physical	20804422
UB2G1_HUMAN	UBE2G1	physical	20804422
UB2D3_HUMAN	UBE2D3	physical	20804422
UBQL2_HUMAN	UBQLN2	physical	20804422
TNIP2_HUMAN	TNIP2	physical	20804422
TM1L2_HUMAN	TOM1L2	physical	20804422
RABE1_HUMAN	RABEP1	physical	20804422
RD23A_HUMAN	RAD23A	physical	20804422
ATX3_HUMAN	ATXN3	physical	20804422
TAOK3_HUMAN	TAOK3	physical	20804422
EPHA1_HUMAN	EPHA1	physical	20804422
EPN1_HUMAN	EPN1	physical	20804422
CF106_HUMAN	C6orf106	physical	20804422
KPCA_HUMAN	PRKCA	physical	20804422
ODFP2_HUMAN	ODF2	physical	20804422
ANS4B_HUMAN	ANKS4B	physical	20804422
UBXN6_HUMAN	UBXN6	physical	20804422
NEK2_HUMAN	NEK2	physical	20804422
UBE2K_HUMAN	UBE2K	physical	20804422
UBQL1_HUMAN	UBQLN1	physical	20804422
HIP1_HUMAN	HIP1	physical	20804422
UBXN7_HUMAN	UBXN7	physical	20804422
SDCG3_HUMAN	SDCCAG3	physical	20804422
ANR50_HUMAN	ANKRD50	physical	20804422
HOME2_HUMAN	HOMER2	physical	20804422
KPCI_HUMAN	PRKCI	physical	20804422
ZFAN5_HUMAN	ZFAND5	physical	20804422
TPM4_HUMAN	TPM4	physical	20804422
KRT36_HUMAN	KRT36	physical	20804422
FKBP3_HUMAN	FKBP3	physical	20804422
FAF2_HUMAN	FAF2	physical	20804422
FES_HUMAN	FES	physical	20804422
SRC8_HUMAN	CTTN	physical	20804422
MATK_HUMAN	MATK	physical	20804422
ELOF1_HUMAN	ELOF1	physical	20804422
RIOK3_HUMAN	RIOK3	physical	20804422
CIP4_HUMAN	TRIP10	physical	20804422
CACO1_HUMAN	CALCOCO1	physical	20804422
SCYL1_HUMAN	SCYL1	physical	20804422
ADRM1_HUMAN	ADRM1	physical	20804422
RN114_HUMAN	RNF114	physical	20804422
M3K2_HUMAN	MAP3K2	physical	20804422
M3K9_HUMAN	MAP3K9	physical	20804422
IMPCT_HUMAN	IMPACT	physical	20804422
PICAL_HUMAN	PICALM	physical	20804422
PGFRA_HUMAN	PDGFRA	physical	20804422
ANXA6_HUMAN	ANXA6	physical	20804422
LMNA_HUMAN	LMNA	physical	20804422
PADI4_HUMAN	PADI4	physical	20804422
TNIK_HUMAN	TNIK	physical	20804422
SLAI2_HUMAN	SLAIN2	physical	20804422
OTU6B_HUMAN	OTUD6B	physical	20804422
CSK22_HUMAN	CSNK2A2	physical	20804422
LARGN_HUMAN	PRR16	physical	20804422
KC1D_HUMAN	CSNK1D	physical	20804422
BTK_HUMAN	BTK	physical	20804422
ASCC2_HUMAN	ASCC2	physical	20804422
FGF12_HUMAN	FGF12	physical	20804422
MARK2_HUMAN	MARK2	physical	20804422
FGR_HUMAN	FGR	physical	20804422
M3K10_HUMAN	MAP3K10	physical	20804422
KPCG_HUMAN	PRKCG	physical	20804422
TLS1_HUMAN	C9orf78	physical	20804422
CCD69_HUMAN	CCDC69	physical	20804422
MOES_HUMAN	MSN	physical	20804422
TAB1_HUMAN	TAB1	physical	20804422
LCK_HUMAN	LCK	physical	20804422
ARBK2_HUMAN	ADRBK2	physical	20804422
M4K5_HUMAN	MAP4K5	physical	20804422
STK31_HUMAN	STK31	physical	20804422
AN13A_HUMAN	ANKRD13A	physical	20804422
SPART_HUMAN	SPG20	physical	20804422
ITK_HUMAN	ITK	physical	20804422
UB2D1_HUMAN	UBE2D1	physical	20804422
UB2D2_HUMAN	UBE2D2	physical	20804422
UB2L3_HUMAN	UBE2L3	physical	20804422
DDX54_HUMAN	DDX54	physical	20804422
TBK1_HUMAN	TBK1	physical	20804422
VHL_HUMAN	VHL	physical	27517496
NEDD8_HUMAN	NEDD8	physical	28169289
SMUF1_HUMAN	SMURF1	physical	28169289
RHOA_HUMAN	RHOA	physical	28169289
UB2D3_HUMAN	UBE2D3	physical	28169289
UB2L3_HUMAN	UBE2L3	physical	28169289
UBC12_HUMAN	UBE2M	physical	28169289
FSCN1_HUMAN	FSCN1	physical	27879315
FBW1A_HUMAN	BTRC	physical	28063214
SMUF1_HUMAN	SMURF1	physical	28063214
SMAD3_HUMAN	SMAD3	physical	28839186
UBC_HUMAN	UBC	physical	28881580
UB2L3_HUMAN	UBE2L3	physical	28881580
SMAD1_HUMAN	SMAD1	physical	28881580
UB2D3_HUMAN	UBE2D3	physical	28881580

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Ubiquitylation

"SCF(FBXL15) regulates BMP signalling by directing the degradation ofHECT-type ubiquitin ligase Smurf1.";
Cui Y., He S., Xing C., Lu K., Wang J., Xing G., Meng A., Jia S.,He F., Zhang L.;
EMBO J. 30:2675-2689(2011).
Cited for: SUBCELLULAR LOCATION, UBIQUITINATION AT LYS-381 AND LYS-383,INTERACTION WITH FBXL15, AND MUTAGENESIS OF LYS-350; LYS-381; LYS-383AND CYS-725.
PubMed: 21572392