| UniProt ID | LMNA_HUMAN | |
|---|---|---|
| UniProt AC | P02545 | |
| Protein Name | Prelamin-A/C | |
| Gene Name | LMNA | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 664 | |
| Subcellular Localization | Nucleus . Nucleus envelope. Nucleus lamina. Nucleus, nucleoplasm. Farnesylation of prelamin-A/C facilitates nuclear envelope targeting and subsequent cleaveage by ZMPSTE24/FACE1 to remove the farnesyl group produces mature lamin-A/C, which can then b | |
| Protein Description | Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. [PubMed: 10080180] | |
| Protein Sequence | METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTRSYRSVGGSGGGSFGDNLVTRSYLLGNSSPRTQSPQNCSIM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------METPSQRR -------CCCHHHHH | 13.44 | 20068231 | |
| 3 | Phosphorylation | -----METPSQRRAT -----CCCHHHHHHC | 27.26 | 29255136 | |
| 5 | Phosphorylation | ---METPSQRRATRS ---CCCHHHHHHCCC | 43.68 | 29255136 | |
| 10 | Phosphorylation | TPSQRRATRSGAQAS CHHHHHHCCCCCCCC | 24.45 | 27273156 | |
| 12 | Phosphorylation | SQRRATRSGAQASST HHHHHCCCCCCCCCC | 33.84 | 29255136 | |
| 12 (in isoform 2) | Phosphorylation | - | 33.84 | 18669648 | |
| 17 | Phosphorylation | TRSGAQASSTPLSPT CCCCCCCCCCCCCCC | 23.75 | 29255136 | |
| 18 | Phosphorylation | RSGAQASSTPLSPTR CCCCCCCCCCCCCCH | 36.74 | 29255136 | |
| 18 (in isoform 2) | Phosphorylation | - | 36.74 | 18669648 | |
| 19 | Phosphorylation | SGAQASSTPLSPTRI CCCCCCCCCCCCCHH | 26.25 | 29255136 | |
| 19 (in isoform 2) | Phosphorylation | - | 26.25 | 18669648 | |
| 22 | Phosphorylation | QASSTPLSPTRITRL CCCCCCCCCCHHHHC | 25.98 | 19664994 | |
| 22 (in isoform 2) | Phosphorylation | - | 25.98 | 18669648 | |
| 23 | Ubiquitination | ASSTPLSPTRITRLQ CCCCCCCCCHHHHCH | 33.12 | 21890473 | |
| 24 | Phosphorylation | SSTPLSPTRITRLQE CCCCCCCCHHHHCHH | 31.18 | 29255136 | |
| 27 | Phosphorylation | PLSPTRITRLQEKED CCCCCHHHHCHHHHH | 23.26 | 22617229 | |
| 32 | Ubiquitination | RITRLQEKEDLQELN HHHHCHHHHHHHHHH | 43.50 | 21890473 | |
| 32 | 2-Hydroxyisobutyrylation | RITRLQEKEDLQELN HHHHCHHHHHHHHHH | 43.50 | - | |
| 32 | Acetylation | RITRLQEKEDLQELN HHHHCHHHHHHHHHH | 43.50 | 23236377 | |
| 32 | Succinylation | RITRLQEKEDLQELN HHHHCHHHHHHHHHH | 43.50 | - | |
| 32 | Succinylation | RITRLQEKEDLQELN HHHHCHHHHHHHHHH | 43.50 | 23954790 | |
| 32 | Sumoylation | RITRLQEKEDLQELN HHHHCHHHHHHHHHH | 43.50 | 28112733 | |
| 32 | Ubiquitination | RITRLQEKEDLQELN HHHHCHHHHHHHHHH | 43.50 | - | |
| 32 (in isoform 1) | Ubiquitination | - | 43.50 | 21890473 | |
| 32 (in isoform 2) | Ubiquitination | - | 43.50 | 21890473 | |
| 32 (in isoform 3) | Ubiquitination | - | 43.50 | 21890473 | |
| 32 | Ubiquitination | RITRLQEKEDLQELN HHHHCHHHHHHHHHH | 43.50 | 21890473 | |
| 36 | Ubiquitination | LQEKEDLQELNDRLA CHHHHHHHHHHHHHH | 66.51 | 21906983 | |
| 41 | Methylation | DLQELNDRLAVYIDR HHHHHHHHHHHHHHH | 24.39 | 115481563 | |
| 45 | Ubiquitination | LNDRLAVYIDRVRSL HHHHHHHHHHHHHHH | 7.47 | 21906983 | |
| 45 | Phosphorylation | LNDRLAVYIDRVRSL HHHHHHHHHHHHHHH | 7.47 | 28152594 | |
| 48 | Methylation | RLAVYIDRVRSLETE HHHHHHHHHHHHCCC | 19.05 | 115481571 | |
| 51 | Phosphorylation | VYIDRVRSLETENAG HHHHHHHHHCCCCCC | 27.92 | 29255136 | |
| 54 | Phosphorylation | DRVRSLETENAGLRL HHHHHHCCCCCCEEE | 39.57 | 19691289 | |
| 56 | Ubiquitination | VRSLETENAGLRLRI HHHHCCCCCCEEEEE | 46.88 | 21906983 | |
| 59 | Ubiquitination | LETENAGLRLRITES HCCCCCCEEEEEECC | 4.30 | 21890473 | |
| 64 | Phosphorylation | AGLRLRITESEEVVS CCEEEEEECCHHHHH | 27.33 | 29255136 | |
| 66 | Phosphorylation | LRLRITESEEVVSRE EEEEEECCHHHHHHH | 30.33 | 29255136 | |
| 69 | Ubiquitination | RITESEEVVSREVSG EEECCHHHHHHHHHC | 4.09 | 21890473 | |
| 71 | Phosphorylation | TESEEVVSREVSGIK ECCHHHHHHHHHCHH | 28.09 | 29255136 | |
| 72 | Ubiquitination | ESEEVVSREVSGIKA CCHHHHHHHHHCHHH | 36.40 | 21906983 | |
| 75 | Phosphorylation | EVVSREVSGIKAAYE HHHHHHHHCHHHHHH | 30.01 | 22199227 | |
| 78 | 2-Hydroxyisobutyrylation | SREVSGIKAAYEAEL HHHHHCHHHHHHHHH | 30.41 | - | |
| 78 | Acetylation | SREVSGIKAAYEAEL HHHHHCHHHHHHHHH | 30.41 | 26051181 | |
| 78 | Malonylation | SREVSGIKAAYEAEL HHHHHCHHHHHHHHH | 30.41 | 26320211 | |
| 78 | Ubiquitination | SREVSGIKAAYEAEL HHHHHCHHHHHHHHH | 30.41 | 21890473 | |
| 78 (in isoform 1) | Ubiquitination | - | 30.41 | 21890473 | |
| 78 (in isoform 2) | Ubiquitination | - | 30.41 | 21890473 | |
| 78 (in isoform 3) | Ubiquitination | - | 30.41 | 21890473 | |
| 78 | Ubiquitination | SREVSGIKAAYEAEL HHHHHCHHHHHHHHH | 30.41 | 21890473 | |
| 78 | Ubiquitination | SREVSGIKAAYEAEL HHHHHCHHHHHHHHH | 30.41 | 21890473 | |
| 78 | Ubiquitination | SREVSGIKAAYEAEL HHHHHCHHHHHHHHH | 30.41 | 21890473 | |
| 81 | Ubiquitination | VSGIKAAYEAELGDA HHCHHHHHHHHHCCH | 22.11 | 21906983 | |
| 81 | Phosphorylation | VSGIKAAYEAELGDA HHCHHHHHHHHHCCH | 22.11 | 28152594 | |
| 82 | Ubiquitination | SGIKAAYEAELGDAR HCHHHHHHHHHCCHH | 30.82 | 21906983 | |
| 89 | Ubiquitination | EAELGDARKTLDSVA HHHHCCHHHHHHHHH | 36.91 | 21890473 | |
| 90 | 2-Hydroxyisobutyrylation | AELGDARKTLDSVAK HHHCCHHHHHHHHHH | 55.98 | - | |
| 90 | Ubiquitination | AELGDARKTLDSVAK HHHCCHHHHHHHHHH | 55.98 | 906983 | |
| 90 (in isoform 1) | Ubiquitination | - | 55.98 | 21890473 | |
| 90 (in isoform 2) | Ubiquitination | - | 55.98 | 21890473 | |
| 90 (in isoform 3) | Ubiquitination | - | 55.98 | 21890473 | |
| 90 | Ubiquitination | AELGDARKTLDSVAK HHHCCHHHHHHHHHH | 55.98 | 21890473 | |
| 91 | O-linked_Glycosylation | ELGDARKTLDSVAKE HHCCHHHHHHHHHHH | 30.19 | 32574038 | |
| 91 | Phosphorylation | ELGDARKTLDSVAKE HHCCHHHHHHHHHHH | 30.19 | 30266825 | |
| 94 | Phosphorylation | DARKTLDSVAKERAR CHHHHHHHHHHHHHH | 27.38 | 30266825 | |
| 96 | Ubiquitination | RKTLDSVAKERARLQ HHHHHHHHHHHHHHH | 16.37 | 21890473 | |
| 97 | Sumoylation | KTLDSVAKERARLQL HHHHHHHHHHHHHHH | 45.65 | - | |
| 97 | Acetylation | KTLDSVAKERARLQL HHHHHHHHHHHHHHH | 45.65 | 23236377 | |
| 97 | Malonylation | KTLDSVAKERARLQL HHHHHHHHHHHHHHH | 45.65 | 26320211 | |
| 97 | Sumoylation | KTLDSVAKERARLQL HHHHHHHHHHHHHHH | 45.65 | 28112733 | |
| 97 | Ubiquitination | KTLDSVAKERARLQL HHHHHHHHHHHHHHH | 45.65 | - | |
| 97 (in isoform 1) | Ubiquitination | - | 45.65 | 21890473 | |
| 97 (in isoform 2) | Ubiquitination | - | 45.65 | 21890473 | |
| 97 (in isoform 3) | Ubiquitination | - | 45.65 | 21890473 | |
| 97 | Ubiquitination | KTLDSVAKERARLQL HHHHHHHHHHHHHHH | 45.65 | 21890473 | |
| 102 | Acetylation | VAKERARLQLELSKV HHHHHHHHHHHHHHH | 7.13 | - | |
| 102 | Ubiquitination | VAKERARLQLELSKV HHHHHHHHHHHHHHH | 7.13 | 21906983 | |
| 107 | Phosphorylation | ARLQLELSKVREEFK HHHHHHHHHHHHHHH | 21.52 | 30266825 | |
| 108 | 2-Hydroxyisobutyrylation | RLQLELSKVREEFKE HHHHHHHHHHHHHHH | 58.92 | - | |
| 108 | Acetylation | RLQLELSKVREEFKE HHHHHHHHHHHHHHH | 58.92 | 19608861 | |
| 108 | Malonylation | RLQLELSKVREEFKE HHHHHHHHHHHHHHH | 58.92 | 26320211 | |
| 108 | Ubiquitination | RLQLELSKVREEFKE HHHHHHHHHHHHHHH | 58.92 | 21890473 | |
| 108 (in isoform 1) | Ubiquitination | - | 58.92 | 21890473 | |
| 108 (in isoform 2) | Ubiquitination | - | 58.92 | 21890473 | |
| 108 (in isoform 3) | Ubiquitination | - | 58.92 | 21890473 | |
| 108 | Ubiquitination | RLQLELSKVREEFKE HHHHHHHHHHHHHHH | 58.92 | 21890473 | |
| 108 | Ubiquitination | RLQLELSKVREEFKE HHHHHHHHHHHHHHH | 58.92 | 21890473 | |
| 108 | Ubiquitination | RLQLELSKVREEFKE HHHHHHHHHHHHHHH | 58.92 | 21890473 | |
| 109 | Ubiquitination | LQLELSKVREEFKEL HHHHHHHHHHHHHHH | 9.28 | 21906983 | |
| 114 | 2-Hydroxyisobutyrylation | SKVREEFKELKARNT HHHHHHHHHHHHHCC | 66.47 | - | |
| 114 | Acetylation | SKVREEFKELKARNT HHHHHHHHHHHHHCC | 66.47 | 23236377 | |
| 114 | Malonylation | SKVREEFKELKARNT HHHHHHHHHHHHHCC | 66.47 | 26320211 | |
| 114 | Succinylation | SKVREEFKELKARNT HHHHHHHHHHHHHCC | 66.47 | 23954790 | |
| 114 | Ubiquitination | SKVREEFKELKARNT HHHHHHHHHHHHHCC | 66.47 | - | |
| 114 (in isoform 2) | Ubiquitination | - | 66.47 | - | |
| 117 | Acetylation | REEFKELKARNTKKE HHHHHHHHHHCCCCH | 46.52 | 26051181 | |
| 117 | Malonylation | REEFKELKARNTKKE HHHHHHHHHHCCCCH | 46.52 | 26320211 | |
| 117 | Ubiquitination | REEFKELKARNTKKE HHHHHHHHHHCCCCH | 46.52 | - | |
| 120 | Ubiquitination | FKELKARNTKKEGDL HHHHHHHCCCCHHHH | 62.20 | - | |
| 122 | Malonylation | ELKARNTKKEGDLIA HHHHHCCCCHHHHHH | 52.99 | 26320211 | |
| 123 | Acetylation | LKARNTKKEGDLIAA HHHHCCCCHHHHHHH | 65.96 | 26051181 | |
| 123 | Malonylation | LKARNTKKEGDLIAA HHHHCCCCHHHHHHH | 65.96 | 26320211 | |
| 123 | Ubiquitination | LKARNTKKEGDLIAA HHHHCCCCHHHHHHH | 65.96 | - | |
| 134 | Ubiquitination | LIAAQARLKDLEALL HHHHHHHHHHHHHHH | 5.92 | 21906983 | |
| 135 | 2-Hydroxyisobutyrylation | IAAQARLKDLEALLN HHHHHHHHHHHHHHC | 55.50 | - | |
| 135 | Acetylation | IAAQARLKDLEALLN HHHHHHHHHHHHHHC | 55.50 | 23954790 | |
| 135 | Malonylation | IAAQARLKDLEALLN HHHHHHHHHHHHHHC | 55.50 | 26320211 | |
| 135 | Ubiquitination | IAAQARLKDLEALLN HHHHHHHHHHHHHHC | 55.50 | 21890473 | |
| 135 (in isoform 1) | Ubiquitination | - | 55.50 | 21890473 | |
| 135 (in isoform 2) | Ubiquitination | - | 55.50 | 21890473 | |
| 135 (in isoform 3) | Ubiquitination | - | 55.50 | 21890473 | |
| 135 | Ubiquitination | IAAQARLKDLEALLN HHHHHHHHHHHHHHC | 55.50 | 21890473 | |
| 135 | Ubiquitination | IAAQARLKDLEALLN HHHHHHHHHHHHHHC | 55.50 | 21890473 | |
| 135 | Ubiquitination | IAAQARLKDLEALLN HHHHHHHHHHHHHHC | 55.50 | 21890473 | |
| 143 | Phosphorylation | DLEALLNSKEAALST HHHHHHCCHHHHHHH | 31.66 | 22199227 | |
| 144 | 2-Hydroxyisobutyrylation | LEALLNSKEAALSTA HHHHHCCHHHHHHHH | 50.75 | - | |
| 144 | Acetylation | LEALLNSKEAALSTA HHHHHCCHHHHHHHH | 50.75 | 23954790 | |
| 144 | Ubiquitination | LEALLNSKEAALSTA HHHHHCCHHHHHHHH | 50.75 | 21890473 | |
| 144 (in isoform 1) | Ubiquitination | - | 50.75 | 21890473 | |
| 144 (in isoform 2) | Ubiquitination | - | 50.75 | 21890473 | |
| 144 (in isoform 3) | Ubiquitination | - | 50.75 | 21890473 | |
| 144 | Ubiquitination | LEALLNSKEAALSTA HHHHHCCHHHHHHHH | 50.75 | 21890473 | |
| 144 | Ubiquitination | LEALLNSKEAALSTA HHHHHCCHHHHHHHH | 50.75 | 21890473 | |
| 144 | Ubiquitination | LEALLNSKEAALSTA HHHHHCCHHHHHHHH | 50.75 | 21890473 | |
| 149 | Phosphorylation | NSKEAALSTALSEKR CCHHHHHHHHHHHCC | 13.60 | 29255136 | |
| 150 | Phosphorylation | SKEAALSTALSEKRT CHHHHHHHHHHHCCH | 32.25 | 29255136 | |
| 153 | Ubiquitination | AALSTALSEKRTLEG HHHHHHHHHCCHHHH | 38.31 | 21890473 | |
| 153 | Phosphorylation | AALSTALSEKRTLEG HHHHHHHHHCCHHHH | 38.31 | 29255136 | |
| 155 | 2-Hydroxyisobutyrylation | LSTALSEKRTLEGEL HHHHHHHCCHHHHHH | 47.51 | - | |
| 155 | Acetylation | LSTALSEKRTLEGEL HHHHHHHCCHHHHHH | 47.51 | 23954790 | |
| 155 | Malonylation | LSTALSEKRTLEGEL HHHHHHHCCHHHHHH | 47.51 | 26320211 | |
| 155 | Ubiquitination | LSTALSEKRTLEGEL HHHHHHHCCHHHHHH | 47.51 | - | |
| 155 (in isoform 1) | Ubiquitination | - | 47.51 | 21890473 | |
| 155 (in isoform 2) | Ubiquitination | - | 47.51 | 21890473 | |
| 155 (in isoform 3) | Ubiquitination | - | 47.51 | 21890473 | |
| 155 | Ubiquitination | LSTALSEKRTLEGEL HHHHHHHCCHHHHHH | 47.51 | 21890473 | |
| 155 | Ubiquitination | LSTALSEKRTLEGEL HHHHHHHCCHHHHHH | 47.51 | 21890473 | |
| 157 | Phosphorylation | TALSEKRTLEGELHD HHHHHCCHHHHHHHH | 39.98 | 23312004 | |
| 158 | Ubiquitination | ALSEKRTLEGELHDL HHHHCCHHHHHHHHH | 10.39 | 21890473 | |
| 158 | Acetylation | ALSEKRTLEGELHDL HHHHCCHHHHHHHHH | 10.39 | 19608861 | |
| 158 | Ubiquitination | ALSEKRTLEGELHDL HHHHCCHHHHHHHHH | 10.39 | 19608861 | |
| 161 | Ubiquitination | EKRTLEGELHDLRGQ HCCHHHHHHHHHHHH | 33.29 | 21906983 | |
| 162 | Ubiquitination | KRTLEGELHDLRGQV CCHHHHHHHHHHHHH | 5.83 | 21906983 | |
| 166 | Ubiquitination | EGELHDLRGQVAKLE HHHHHHHHHHHHHHH | 39.28 | 21906983 | |
| 166 | Methylation | EGELHDLRGQVAKLE HHHHHHHHHHHHHHH | 39.28 | 115481595 | |
| 171 | Acetylation | DLRGQVAKLEAALGE HHHHHHHHHHHHHHH | 48.26 | - | |
| 171 | Ubiquitination | DLRGQVAKLEAALGE HHHHHHHHHHHHHHH | 48.26 | 21906983 | |
| 171 | 2-Hydroxyisobutyrylation | DLRGQVAKLEAALGE HHHHHHHHHHHHHHH | 48.26 | - | |
| 171 | Acetylation | DLRGQVAKLEAALGE HHHHHHHHHHHHHHH | 48.26 | 23954790 | |
| 171 | Malonylation | DLRGQVAKLEAALGE HHHHHHHHHHHHHHH | 48.26 | 26320211 | |
| 171 | Succinylation | DLRGQVAKLEAALGE HHHHHHHHHHHHHHH | 48.26 | - | |
| 171 | Succinylation | DLRGQVAKLEAALGE HHHHHHHHHHHHHHH | 48.26 | - | |
| 171 | Sumoylation | DLRGQVAKLEAALGE HHHHHHHHHHHHHHH | 48.26 | 28112733 | |
| 171 | Ubiquitination | DLRGQVAKLEAALGE HHHHHHHHHHHHHHH | 48.26 | 21890473 | |
| 171 (in isoform 1) | Ubiquitination | - | 48.26 | 21890473 | |
| 171 (in isoform 2) | Ubiquitination | - | 48.26 | 21890473 | |
| 171 (in isoform 3) | Ubiquitination | - | 48.26 | 21890473 | |
| 171 | Ubiquitination | DLRGQVAKLEAALGE HHHHHHHHHHHHHHH | 48.26 | 21890473 | |
| 171 | Ubiquitination | DLRGQVAKLEAALGE HHHHHHHHHHHHHHH | 48.26 | 21890473 | |
| 171 | Ubiquitination | DLRGQVAKLEAALGE HHHHHHHHHHHHHHH | 48.26 | 21890473 | |
| 180 | 2-Hydroxyisobutyrylation | EAALGEAKKQLQDEM HHHHHHHHHHHHHHH | 36.43 | - | |
| 180 | Acetylation | EAALGEAKKQLQDEM HHHHHHHHHHHHHHH | 36.43 | 26051181 | |
| 180 | Malonylation | EAALGEAKKQLQDEM HHHHHHHHHHHHHHH | 36.43 | 26320211 | |
| 180 | Ubiquitination | EAALGEAKKQLQDEM HHHHHHHHHHHHHHH | 36.43 | 21906983 | |
| 180 (in isoform 1) | Ubiquitination | - | 36.43 | 21890473 | |
| 180 (in isoform 2) | Ubiquitination | - | 36.43 | 21890473 | |
| 180 (in isoform 3) | Ubiquitination | - | 36.43 | 21890473 | |
| 180 | Ubiquitination | EAALGEAKKQLQDEM HHHHHHHHHHHHHHH | 36.43 | 21890473 | |
| 180 | Ubiquitination | EAALGEAKKQLQDEM HHHHHHHHHHHHHHH | 36.43 | 21890473 | |
| 181 | 2-Hydroxyisobutyrylation | AALGEAKKQLQDEML HHHHHHHHHHHHHHH | 64.39 | - | |
| 181 | Acetylation | AALGEAKKQLQDEML HHHHHHHHHHHHHHH | 64.39 | 21339330 | |
| 181 | Malonylation | AALGEAKKQLQDEML HHHHHHHHHHHHHHH | 64.39 | 26320211 | |
| 181 | Ubiquitination | AALGEAKKQLQDEML HHHHHHHHHHHHHHH | 64.39 | 21890473 | |
| 181 (in isoform 1) | Ubiquitination | - | 64.39 | 21890473 | |
| 181 (in isoform 2) | Ubiquitination | - | 64.39 | 21890473 | |
| 181 (in isoform 3) | Ubiquitination | - | 64.39 | 21890473 | |
| 181 | Ubiquitination | AALGEAKKQLQDEML HHHHHHHHHHHHHHH | 64.39 | 21890473 | |
| 181 | Ubiquitination | AALGEAKKQLQDEML HHHHHHHHHHHHHHH | 64.39 | 21890473 | |
| 181 | Ubiquitination | AALGEAKKQLQDEML HHHHHHHHHHHHHHH | 64.39 | 21890473 | |
| 187 | Sulfoxidation | KKQLQDEMLRRVDAE HHHHHHHHHHHHCHH | 4.79 | 30846556 | |
| 189 | Methylation | QLQDEMLRRVDAENR HHHHHHHHHHCHHHH | 34.95 | 115481587 | |
| 199 | Ubiquitination | DAENRLQTMKEELDF CHHHHHHHHHHHHHH | 34.50 | 21890473 | |
| 199 | Acetylation | DAENRLQTMKEELDF CHHHHHHHHHHHHHH | 34.50 | 19608861 | |
| 199 | Phosphorylation | DAENRLQTMKEELDF CHHHHHHHHHHHHHH | 34.50 | 8477740 | |
| 199 | Ubiquitination | DAENRLQTMKEELDF CHHHHHHHHHHHHHH | 34.50 | 19608861 | |
| 200 | Sulfoxidation | AENRLQTMKEELDFQ HHHHHHHHHHHHHHH | 3.12 | 28465586 | |
| 201 | Sumoylation | ENRLQTMKEELDFQK HHHHHHHHHHHHHHH | 51.96 | - | |
| 201 | Acetylation | ENRLQTMKEELDFQK HHHHHHHHHHHHHHH | 51.96 | 23954790 | |
| 201 | Malonylation | ENRLQTMKEELDFQK HHHHHHHHHHHHHHH | 51.96 | 26320211 | |
| 201 | Sumoylation | ENRLQTMKEELDFQK HHHHHHHHHHHHHHH | 51.96 | 28112733 | |
| 201 | Ubiquitination | ENRLQTMKEELDFQK HHHHHHHHHHHHHHH | 51.96 | 21890473 | |
| 201 (in isoform 1) | Ubiquitination | - | 51.96 | 21890473 | |
| 201 (in isoform 2) | Ubiquitination | - | 51.96 | 21890473 | |
| 201 (in isoform 3) | Ubiquitination | - | 51.96 | 21890473 | |
| 201 | Ubiquitination | ENRLQTMKEELDFQK HHHHHHHHHHHHHHH | 51.96 | 21890473 | |
| 201 | Ubiquitination | ENRLQTMKEELDFQK HHHHHHHHHHHHHHH | 51.96 | 21890473 | |
| 201 | Ubiquitination | ENRLQTMKEELDFQK HHHHHHHHHHHHHHH | 51.96 | 21890473 | |
| 208 | Sumoylation | KEELDFQKNIYSEEL HHHHHHHHHHCCHHH | 45.35 | - | |
| 208 | 2-Hydroxyisobutyrylation | KEELDFQKNIYSEEL HHHHHHHHHHCCHHH | 45.35 | - | |
| 208 | Acetylation | KEELDFQKNIYSEEL HHHHHHHHHHCCHHH | 45.35 | 25825284 | |
| 208 | Malonylation | KEELDFQKNIYSEEL HHHHHHHHHHCCHHH | 45.35 | 26320211 | |
| 208 | Sumoylation | KEELDFQKNIYSEEL HHHHHHHHHHCCHHH | 45.35 | 28112733 | |
| 208 | Ubiquitination | KEELDFQKNIYSEEL HHHHHHHHHHCCHHH | 45.35 | 21890473 | |
| 208 (in isoform 1) | Ubiquitination | - | 45.35 | 21890473 | |
| 208 (in isoform 2) | Ubiquitination | - | 45.35 | 21890473 | |
| 208 (in isoform 3) | Ubiquitination | - | 45.35 | 21890473 | |
| 208 | Ubiquitination | KEELDFQKNIYSEEL HHHHHHHHHHCCHHH | 45.35 | 21890473 | |
| 208 | Ubiquitination | KEELDFQKNIYSEEL HHHHHHHHHHCCHHH | 45.35 | 21890473 | |
| 208 | Ubiquitination | KEELDFQKNIYSEEL HHHHHHHHHHCCHHH | 45.35 | 21890473 | |
| 211 | Phosphorylation | LDFQKNIYSEELRET HHHHHHHCCHHHHHH | 21.30 | 25159151 | |
| 212 | Acetylation | DFQKNIYSEELRETK HHHHHHCCHHHHHHH | 22.31 | - | |
| 212 | Ubiquitination | DFQKNIYSEELRETK HHHHHHCCHHHHHHH | 22.31 | 21906983 | |
| 212 | Phosphorylation | DFQKNIYSEELRETK HHHHHHCCHHHHHHH | 22.31 | 29255136 | |
| 218 | Phosphorylation | YSEELRETKRRHETR CCHHHHHHHHHHCCE | 24.34 | 23403867 | |
| 219 | Sumoylation | SEELRETKRRHETRL CHHHHHHHHHHCCEE | 42.56 | - | |
| 219 | Sumoylation | SEELRETKRRHETRL CHHHHHHHHHHCCEE | 42.56 | 28112733 | |
| 219 | Ubiquitination | SEELRETKRRHETRL CHHHHHHHHHHCCEE | 42.56 | - | |
| 219 (in isoform 2) | Ubiquitination | - | 42.56 | - | |
| 220 | Ubiquitination | EELRETKRRHETRLV HHHHHHHHHHCCEEE | 53.24 | - | |
| 224 | Phosphorylation | ETKRRHETRLVEIDN HHHHHHCCEEEEECC | 24.15 | 28555341 | |
| 233 | Sumoylation | LVEIDNGKQREFESR EEEECCCCHHHHHHH | 53.06 | - | |
| 233 | Acetylation | LVEIDNGKQREFESR EEEECCCCHHHHHHH | 53.06 | 26051181 | |
| 233 | Malonylation | LVEIDNGKQREFESR EEEECCCCHHHHHHH | 53.06 | 26320211 | |
| 233 | Sumoylation | LVEIDNGKQREFESR EEEECCCCHHHHHHH | 53.06 | 28112733 | |
| 233 | Ubiquitination | LVEIDNGKQREFESR EEEECCCCHHHHHHH | 53.06 | 21906983 | |
| 233 (in isoform 1) | Ubiquitination | - | 53.06 | 21890473 | |
| 233 (in isoform 2) | Ubiquitination | - | 53.06 | 21890473 | |
| 233 (in isoform 3) | Ubiquitination | - | 53.06 | 21890473 | |
| 233 | Ubiquitination | LVEIDNGKQREFESR EEEECCCCHHHHHHH | 53.06 | 21890473 | |
| 233 | Ubiquitination | LVEIDNGKQREFESR EEEECCCCHHHHHHH | 53.06 | 21890473 | |
| 259 | Phosphorylation | HEDQVEQYKKELEKT CHHHHHHHHHHHHHH | 15.55 | 28152594 | |
| 260 | Sumoylation | EDQVEQYKKELEKTY HHHHHHHHHHHHHHH | 39.19 | - | |
| 260 | 2-Hydroxyisobutyrylation | EDQVEQYKKELEKTY HHHHHHHHHHHHHHH | 39.19 | - | |
| 260 | Acetylation | EDQVEQYKKELEKTY HHHHHHHHHHHHHHH | 39.19 | 25825284 | |
| 260 | Sumoylation | EDQVEQYKKELEKTY HHHHHHHHHHHHHHH | 39.19 | 28112733 | |
| 260 | Ubiquitination | EDQVEQYKKELEKTY HHHHHHHHHHHHHHH | 39.19 | 21906983 | |
| 260 (in isoform 1) | Ubiquitination | - | 39.19 | 21890473 | |
| 260 (in isoform 2) | Ubiquitination | - | 39.19 | 21890473 | |
| 260 (in isoform 3) | Ubiquitination | - | 39.19 | 21890473 | |
| 260 | Ubiquitination | EDQVEQYKKELEKTY HHHHHHHHHHHHHHH | 39.19 | 21890473 | |
| 260 | Ubiquitination | EDQVEQYKKELEKTY HHHHHHHHHHHHHHH | 39.19 | 21890473 | |
| 261 | Acetylation | DQVEQYKKELEKTYS HHHHHHHHHHHHHHH | 63.70 | 129603 | |
| 261 | Malonylation | DQVEQYKKELEKTYS HHHHHHHHHHHHHHH | 63.70 | 26320211 | |
| 261 | Ubiquitination | DQVEQYKKELEKTYS HHHHHHHHHHHHHHH | 63.70 | 21906983 | |
| 261 (in isoform 1) | Ubiquitination | - | 63.70 | 21890473 | |
| 261 (in isoform 2) | Ubiquitination | - | 63.70 | 21890473 | |
| 261 (in isoform 3) | Ubiquitination | - | 63.70 | 21890473 | |
| 261 | Ubiquitination | DQVEQYKKELEKTYS HHHHHHHHHHHHHHH | 63.70 | 21890473 | |
| 261 | Ubiquitination | DQVEQYKKELEKTYS HHHHHHHHHHHHHHH | 63.70 | 21890473 | |
| 265 | Sumoylation | QYKKELEKTYSAKLD HHHHHHHHHHHHHHH | 66.44 | - | |
| 265 | 2-Hydroxyisobutyrylation | QYKKELEKTYSAKLD HHHHHHHHHHHHHHH | 66.44 | - | |
| 265 | Acetylation | QYKKELEKTYSAKLD HHHHHHHHHHHHHHH | 66.44 | 25825284 | |
| 265 | Malonylation | QYKKELEKTYSAKLD HHHHHHHHHHHHHHH | 66.44 | 26320211 | |
| 265 | Sumoylation | QYKKELEKTYSAKLD HHHHHHHHHHHHHHH | 66.44 | - | |
| 265 | Ubiquitination | QYKKELEKTYSAKLD HHHHHHHHHHHHHHH | 66.44 | 21890473 | |
| 265 (in isoform 1) | Ubiquitination | - | 66.44 | 21890473 | |
| 265 (in isoform 2) | Ubiquitination | - | 66.44 | 21890473 | |
| 265 (in isoform 3) | Ubiquitination | - | 66.44 | 21890473 | |
| 265 | Ubiquitination | QYKKELEKTYSAKLD HHHHHHHHHHHHHHH | 66.44 | 21890473 | |
| 265 | Ubiquitination | QYKKELEKTYSAKLD HHHHHHHHHHHHHHH | 66.44 | 21890473 | |
| 265 | Ubiquitination | QYKKELEKTYSAKLD HHHHHHHHHHHHHHH | 66.44 | 21890473 | |
| 266 | Acetylation | YKKELEKTYSAKLDN HHHHHHHHHHHHHHH | 17.21 | 19608861 | |
| 266 | Phosphorylation | YKKELEKTYSAKLDN HHHHHHHHHHHHHHH | 17.21 | 24719451 | |
| 266 | Ubiquitination | YKKELEKTYSAKLDN HHHHHHHHHHHHHHH | 17.21 | 19608861 | |
| 268 | Phosphorylation | KELEKTYSAKLDNAR HHHHHHHHHHHHHHH | 24.94 | 27134283 | |
| 270 | Sumoylation | LEKTYSAKLDNARQS HHHHHHHHHHHHHHH | 50.89 | - | |
| 270 | 2-Hydroxyisobutyrylation | LEKTYSAKLDNARQS HHHHHHHHHHHHHHH | 50.89 | - | |
| 270 | Acetylation | LEKTYSAKLDNARQS HHHHHHHHHHHHHHH | 50.89 | 19608861 | |
| 270 | Malonylation | LEKTYSAKLDNARQS HHHHHHHHHHHHHHH | 50.89 | 26320211 | |
| 270 | Sumoylation | LEKTYSAKLDNARQS HHHHHHHHHHHHHHH | 50.89 | 28112733 | |
| 270 | Ubiquitination | LEKTYSAKLDNARQS HHHHHHHHHHHHHHH | 50.89 | 21890473 | |
| 270 (in isoform 1) | Ubiquitination | - | 50.89 | 21890473 | |
| 270 (in isoform 2) | Ubiquitination | - | 50.89 | 21890473 | |
| 270 (in isoform 3) | Ubiquitination | - | 50.89 | 21890473 | |
| 270 | Ubiquitination | LEKTYSAKLDNARQS HHHHHHHHHHHHHHH | 50.89 | 21890473 | |
| 270 | Ubiquitination | LEKTYSAKLDNARQS HHHHHHHHHHHHHHH | 50.89 | 21890473 | |
| 270 | Ubiquitination | LEKTYSAKLDNARQS HHHHHHHHHHHHHHH | 50.89 | 21890473 | |
| 277 | Phosphorylation | KLDNARQSAERNSNL HHHHHHHHHHHHHCH | 26.92 | 22167270 | |
| 279 | Acetylation | DNARQSAERNSNLVG HHHHHHHHHHHCHHH | 58.61 | - | |
| 279 | Ubiquitination | DNARQSAERNSNLVG HHHHHHHHHHHCHHH | 58.61 | 21906983 | |
| 282 | Phosphorylation | RQSAERNSNLVGAAH HHHHHHHHCHHHHHH | 37.45 | 23927012 | |
| 295 | Phosphorylation | AHEELQQSRIRIDSL HHHHHHHHCHHHHHH | 19.40 | 24732914 | |
| 301 | Phosphorylation | QSRIRIDSLSAQLSQ HHCHHHHHHHHHHHH | 23.11 | 29255136 | |
| 301 (in isoform 2) | Phosphorylation | - | 23.11 | 18669648 | |
| 303 | Phosphorylation | RIRIDSLSAQLSQLQ CHHHHHHHHHHHHHH | 20.23 | 30266825 | |
| 307 | Phosphorylation | DSLSAQLSQLQKQLA HHHHHHHHHHHHHHH | 19.43 | 23927012 | |
| 311 | Sumoylation | AQLSQLQKQLAAKEA HHHHHHHHHHHHHHH | 56.74 | - | |
| 311 | 2-Hydroxyisobutyrylation | AQLSQLQKQLAAKEA HHHHHHHHHHHHHHH | 56.74 | - | |
| 311 | Acetylation | AQLSQLQKQLAAKEA HHHHHHHHHHHHHHH | 56.74 | 19608861 | |
| 311 | Sumoylation | AQLSQLQKQLAAKEA HHHHHHHHHHHHHHH | 56.74 | 28112733 | |
| 311 | Ubiquitination | AQLSQLQKQLAAKEA HHHHHHHHHHHHHHH | 56.74 | 21890473 | |
| 311 (in isoform 1) | Ubiquitination | - | 56.74 | 21890473 | |
| 311 (in isoform 2) | Ubiquitination | - | 56.74 | 21890473 | |
| 311 (in isoform 3) | Ubiquitination | - | 56.74 | 21890473 | |
| 311 | Ubiquitination | AQLSQLQKQLAAKEA HHHHHHHHHHHHHHH | 56.74 | 21890473 | |
| 311 | Ubiquitination | AQLSQLQKQLAAKEA HHHHHHHHHHHHHHH | 56.74 | 21890473 | |
| 311 | Ubiquitination | AQLSQLQKQLAAKEA HHHHHHHHHHHHHHH | 56.74 | 21890473 | |
| 316 | 2-Hydroxyisobutyrylation | LQKQLAAKEAKLRDL HHHHHHHHHHHHHHH | 53.23 | - | |
| 316 | Malonylation | LQKQLAAKEAKLRDL HHHHHHHHHHHHHHH | 53.23 | 26320211 | |
| 316 | Ubiquitination | LQKQLAAKEAKLRDL HHHHHHHHHHHHHHH | 53.23 | - | |
| 318 | Ubiquitination | KQLAAKEAKLRDLED HHHHHHHHHHHHHHH | 18.57 | 21906983 | |
| 319 | Ubiquitination | QLAAKEAKLRDLEDS HHHHHHHHHHHHHHH | 45.18 | - | |
| 319 (in isoform 2) | Ubiquitination | - | 45.18 | - | |
| 321 | Ubiquitination | AAKEAKLRDLEDSLA HHHHHHHHHHHHHHH | 45.84 | 21906983 | |
| 326 | Phosphorylation | KLRDLEDSLARERDT HHHHHHHHHHHHHHH | 17.98 | 21815630 | |
| 338 | Acetylation | RDTSRRLLAEKEREM HHHHHHHHHHHHHHH | 5.69 | 19608861 | |
| 338 | Ubiquitination | RDTSRRLLAEKEREM HHHHHHHHHHHHHHH | 5.69 | 19608861 | |
| 341 | 2-Hydroxyisobutyrylation | SRRLLAEKEREMAEM HHHHHHHHHHHHHHH | 57.36 | - | |
| 341 | Acetylation | SRRLLAEKEREMAEM HHHHHHHHHHHHHHH | 57.36 | 26051181 | |
| 341 | Malonylation | SRRLLAEKEREMAEM HHHHHHHHHHHHHHH | 57.36 | 26320211 | |
| 351 | Acetylation | EMAEMRARMQQQLDE HHHHHHHHHHHHHHH | 17.05 | - | |
| 351 | Ubiquitination | EMAEMRARMQQQLDE HHHHHHHHHHHHHHH | 17.05 | 21906983 | |
| 352 | Sulfoxidation | MAEMRARMQQQLDEY HHHHHHHHHHHHHHH | 4.04 | 28183972 | |
| 358 | Ubiquitination | RMQQQLDEYQELLDI HHHHHHHHHHHHHHH | 58.68 | 21890473 | |
| 358 | Ubiquitination | RMQQQLDEYQELLDI HHHHHHHHHHHHHHH | 58.68 | 21906983 | |
| 359 | Phosphorylation | MQQQLDEYQELLDIK HHHHHHHHHHHHHHH | 13.62 | - | |
| 366 | Sumoylation | YQELLDIKLALDMEI HHHHHHHHHHHHHHH | 27.63 | 28112733 | |
| 371 | Acetylation | DIKLALDMEIHAYRK HHHHHHHHHHHHHHH | 5.61 | - | |
| 371 | Ubiquitination | DIKLALDMEIHAYRK HHHHHHHHHHHHHHH | 5.61 | 21906983 | |
| 371 | Sulfoxidation | DIKLALDMEIHAYRK HHHHHHHHHHHHHHH | 5.61 | 30846556 | |
| 374 | Ubiquitination | LALDMEIHAYRKLLE HHHHHHHHHHHHHHC | 11.91 | 21890473 | |
| 376 | Phosphorylation | LDMEIHAYRKLLEGE HHHHHHHHHHHHCCH | 8.30 | - | |
| 378 | Sumoylation | MEIHAYRKLLEGEEE HHHHHHHHHHCCHHH | 44.76 | - | |
| 378 | Acetylation | MEIHAYRKLLEGEEE HHHHHHHHHHCCHHH | 44.76 | 19608861 | |
| 378 | Malonylation | MEIHAYRKLLEGEEE HHHHHHHHHHCCHHH | 44.76 | 26320211 | |
| 378 | Sumoylation | MEIHAYRKLLEGEEE HHHHHHHHHHCCHHH | 44.76 | 28112733 | |
| 378 | Ubiquitination | MEIHAYRKLLEGEEE HHHHHHHHHHCCHHH | 44.76 | 21906983 | |
| 378 (in isoform 1) | Ubiquitination | - | 44.76 | 21890473 | |
| 378 (in isoform 2) | Ubiquitination | - | 44.76 | 21890473 | |
| 378 (in isoform 3) | Ubiquitination | - | 44.76 | 21890473 | |
| 378 | Ubiquitination | MEIHAYRKLLEGEEE HHHHHHHHHHCCHHH | 44.76 | 21890473 | |
| 378 | Ubiquitination | MEIHAYRKLLEGEEE HHHHHHHHHHCCHHH | 44.76 | 21890473 | |
| 386 | Methylation | LLEGEEERLRLSPSP HHCCHHHHHCCCCCC | 28.52 | 115481579 | |
| 387 | Ubiquitination | LEGEEERLRLSPSPT HCCHHHHHCCCCCCC | 7.95 | - | |
| 390 | Phosphorylation | EEERLRLSPSPTSQR HHHHHCCCCCCCCCC | 19.52 | 19664994 | |
| 390 (in isoform 2) | Phosphorylation | - | 19.52 | 18669648 | |
| 392 | Phosphorylation | ERLRLSPSPTSQRSR HHHCCCCCCCCCCCC | 37.12 | 19664994 | |
| 392 (in isoform 2) | Phosphorylation | - | 37.12 | 18669648 | |
| 394 | Phosphorylation | LRLSPSPTSQRSRGR HCCCCCCCCCCCCCC | 41.66 | 29255136 | |
| 394 (in isoform 2) | Phosphorylation | - | 41.66 | 18669648 | |
| 395 | Phosphorylation | RLSPSPTSQRSRGRA CCCCCCCCCCCCCCC | 27.29 | 29255136 | |
| 395 (in isoform 2) | Phosphorylation | - | 27.29 | 18669648 | |
| 398 | Phosphorylation | PSPTSQRSRGRASSH CCCCCCCCCCCCCCC | 31.30 | 25159151 | |
| 398 (in isoform 2) | Phosphorylation | - | 31.30 | 18669648 | |
| 403 | Phosphorylation | QRSRGRASSHSSQTQ CCCCCCCCCCCCCCC | 27.50 | 29255136 | |
| 404 | Phosphorylation | RSRGRASSHSSQTQG CCCCCCCCCCCCCCC | 26.80 | 22322096 | |
| 406 | Phosphorylation | RGRASSHSSQTQGGG CCCCCCCCCCCCCCC | 26.53 | 22322096 | |
| 407 | Phosphorylation | GRASSHSSQTQGGGS CCCCCCCCCCCCCCC | 31.65 | 29255136 | |
| 409 | Phosphorylation | ASSHSSQTQGGGSVT CCCCCCCCCCCCCCC | 31.00 | 29255136 | |
| 414 | Phosphorylation | SQTQGGGSVTKKRKL CCCCCCCCCCCCCCC | 29.86 | 22167270 | |
| 416 | Phosphorylation | TQGGGSVTKKRKLES CCCCCCCCCCCCCCC | 32.33 | 22167270 | |
| 417 | Sumoylation | QGGGSVTKKRKLEST CCCCCCCCCCCCCCC | 48.72 | - | |
| 417 | 2-Hydroxyisobutyrylation | QGGGSVTKKRKLEST CCCCCCCCCCCCCCC | 48.72 | - | |
| 417 | Acetylation | QGGGSVTKKRKLEST CCCCCCCCCCCCCCC | 48.72 | 26051181 | |
| 417 | Sumoylation | QGGGSVTKKRKLEST CCCCCCCCCCCCCCC | 48.72 | 28112733 | |
| 417 | Ubiquitination | QGGGSVTKKRKLEST CCCCCCCCCCCCCCC | 48.72 | 21906983 | |
| 417 (in isoform 1) | Ubiquitination | - | 48.72 | 21890473 | |
| 417 (in isoform 2) | Ubiquitination | - | 48.72 | 21890473 | |
| 417 (in isoform 3) | Ubiquitination | - | 48.72 | 21890473 | |
| 417 | Ubiquitination | QGGGSVTKKRKLEST CCCCCCCCCCCCCCC | 48.72 | 21890473 | |
| 417 | Ubiquitination | QGGGSVTKKRKLEST CCCCCCCCCCCCCCC | 48.72 | 21890473 | |
| 418 | Acetylation | GGGSVTKKRKLESTE CCCCCCCCCCCCCCC | 45.45 | 19666589 | |
| 418 | Ubiquitination | GGGSVTKKRKLESTE CCCCCCCCCCCCCCC | 45.45 | - | |
| 420 | Sumoylation | GSVTKKRKLESTESR CCCCCCCCCCCCCCC | 66.54 | - | |
| 420 | 2-Hydroxyisobutyrylation | GSVTKKRKLESTESR CCCCCCCCCCCCCCC | 66.54 | - | |
| 420 | Sumoylation | GSVTKKRKLESTESR CCCCCCCCCCCCCCC | 66.54 | 28112733 | |
| 420 | Ubiquitination | GSVTKKRKLESTESR CCCCCCCCCCCCCCC | 66.54 | 21906983 | |
| 420 (in isoform 1) | Ubiquitination | - | 66.54 | 21890473 | |
| 420 (in isoform 2) | Ubiquitination | - | 66.54 | 21890473 | |
| 420 (in isoform 3) | Ubiquitination | - | 66.54 | 21890473 | |
| 420 | Ubiquitination | GSVTKKRKLESTESR CCCCCCCCCCCCCCC | 66.54 | 21890473 | |
| 420 | Ubiquitination | GSVTKKRKLESTESR CCCCCCCCCCCCCCC | 66.54 | 21890473 | |
| 423 | Phosphorylation | TKKRKLESTESRSSF CCCCCCCCCCCCCHH | 48.16 | 28355574 | |
| 424 | Phosphorylation | KKRKLESTESRSSFS CCCCCCCCCCCCHHH | 28.71 | 20044836 | |
| 426 | Phosphorylation | RKLESTESRSSFSQH CCCCCCCCCCHHHHH | 37.24 | 20044836 | |
| 428 | Phosphorylation | LESTESRSSFSQHAR CCCCCCCCHHHHHHH | 45.04 | 23927012 | |
| 429 | Phosphorylation | ESTESRSSFSQHART CCCCCCCHHHHHHHH | 28.01 | 23927012 | |
| 431 | Phosphorylation | TESRSSFSQHARTSG CCCCCHHHHHHHHCC | 24.01 | 30266825 | |
| 436 | Phosphorylation | SFSQHARTSGRVAVE HHHHHHHHCCCEEEE | 35.99 | 22199227 | |
| 437 | Phosphorylation | FSQHARTSGRVAVEE HHHHHHHCCCEEEEE | 21.03 | 22199227 | |
| 450 | Sumoylation | EEVDEEGKFVRLRNK EEECCCCCEEEEECC | 43.92 | - | |
| 450 | 2-Hydroxyisobutyrylation | EEVDEEGKFVRLRNK EEECCCCCEEEEECC | 43.92 | - | |
| 450 | Acetylation | EEVDEEGKFVRLRNK EEECCCCCEEEEECC | 43.92 | 19608861 | |
| 450 | Malonylation | EEVDEEGKFVRLRNK EEECCCCCEEEEECC | 43.92 | 26320211 | |
| 450 | Sumoylation | EEVDEEGKFVRLRNK EEECCCCCEEEEECC | 43.92 | 28112733 | |
| 450 | Ubiquitination | EEVDEEGKFVRLRNK EEECCCCCEEEEECC | 43.92 | - | |
| 450 (in isoform 1) | Ubiquitination | - | 43.92 | 21890473 | |
| 450 (in isoform 2) | Ubiquitination | - | 43.92 | 21890473 | |
| 450 (in isoform 3) | Ubiquitination | - | 43.92 | 21890473 | |
| 450 | Ubiquitination | EEVDEEGKFVRLRNK EEECCCCCEEEEECC | 43.92 | 21890473 | |
| 450 | Ubiquitination | EEVDEEGKFVRLRNK EEECCCCCEEEEECC | 43.92 | 21890473 | |
| 457 | Acetylation | KFVRLRNKSNEDQSM CEEEEECCCCCCCCC | 48.50 | 25825284 | |
| 457 | Malonylation | KFVRLRNKSNEDQSM CEEEEECCCCCCCCC | 48.50 | 26320211 | |
| 457 | Ubiquitination | KFVRLRNKSNEDQSM CEEEEECCCCCCCCC | 48.50 | - | |
| 457 (in isoform 1) | Ubiquitination | - | 48.50 | 21890473 | |
| 457 (in isoform 2) | Ubiquitination | - | 48.50 | 21890473 | |
| 457 (in isoform 3) | Ubiquitination | - | 48.50 | 21890473 | |
| 457 | Ubiquitination | KFVRLRNKSNEDQSM CEEEEECCCCCCCCC | 48.50 | 21890473 | |
| 457 | Ubiquitination | KFVRLRNKSNEDQSM CEEEEECCCCCCCCC | 48.50 | 21890473 | |
| 458 | Phosphorylation | FVRLRNKSNEDQSMG EEEEECCCCCCCCCC | 49.34 | 22167270 | |
| 458 (in isoform 2) | Phosphorylation | - | 49.34 | 18669648 | |
| 463 | Phosphorylation | NKSNEDQSMGNWQIK CCCCCCCCCCCCEEE | 40.76 | 23927012 | |
| 470 | 2-Hydroxyisobutyrylation | SMGNWQIKRQNGDDP CCCCCEEECCCCCCC | 32.60 | - | |
| 470 | Acetylation | SMGNWQIKRQNGDDP CCCCCEEECCCCCCC | 32.60 | 23954790 | |
| 470 | Malonylation | SMGNWQIKRQNGDDP CCCCCEEECCCCCCC | 32.60 | 26320211 | |
| 470 | Methylation | SMGNWQIKRQNGDDP CCCCCEEECCCCCCC | 32.60 | 129611 | |
| 470 | Sumoylation | SMGNWQIKRQNGDDP CCCCCEEECCCCCCC | 32.60 | 28112733 | |
| 470 | Ubiquitination | SMGNWQIKRQNGDDP CCCCCEEECCCCCCC | 32.60 | 21890473 | |
| 470 (in isoform 1) | Ubiquitination | - | 32.60 | 21890473 | |
| 470 (in isoform 2) | Ubiquitination | - | 32.60 | 21890473 | |
| 470 (in isoform 3) | Ubiquitination | - | 32.60 | 21890473 | |
| 470 | Ubiquitination | SMGNWQIKRQNGDDP CCCCCEEECCCCCCC | 32.60 | 21890473 | |
| 470 | Ubiquitination | SMGNWQIKRQNGDDP CCCCCEEECCCCCCC | 32.60 | 21890473 | |
| 470 | Ubiquitination | SMGNWQIKRQNGDDP CCCCCEEECCCCCCC | 32.60 | 21890473 | |
| 480 | Phosphorylation | NGDDPLLTYRFPPKF CCCCCCEEEECCCCE | 21.97 | 8477740 | |
| 481 | Phosphorylation | GDDPLLTYRFPPKFT CCCCCEEEECCCCEE | 15.38 | - | |
| 486 | Sumoylation | LTYRFPPKFTLKAGQ EEEECCCCEEECCCC | 51.74 | - | |
| 486 | Acetylation | LTYRFPPKFTLKAGQ EEEECCCCEEECCCC | 51.74 | 26051181 | |
| 486 | Malonylation | LTYRFPPKFTLKAGQ EEEECCCCEEECCCC | 51.74 | 26320211 | |
| 486 | Sumoylation | LTYRFPPKFTLKAGQ EEEECCCCEEECCCC | 51.74 | 28112733 | |
| 486 | Ubiquitination | LTYRFPPKFTLKAGQ EEEECCCCEEECCCC | 51.74 | 21890473 | |
| 486 (in isoform 1) | Ubiquitination | - | 51.74 | 21890473 | |
| 486 (in isoform 2) | Ubiquitination | - | 51.74 | 21890473 | |
| 486 (in isoform 3) | Ubiquitination | - | 51.74 | 21890473 | |
| 486 | Ubiquitination | LTYRFPPKFTLKAGQ EEEECCCCEEECCCC | 51.74 | 21890473 | |
| 486 | Ubiquitination | LTYRFPPKFTLKAGQ EEEECCCCEEECCCC | 51.74 | 21890473 | |
| 486 | Ubiquitination | LTYRFPPKFTLKAGQ EEEECCCCEEECCCC | 51.74 | 21890473 | |
| 488 | Phosphorylation | YRFPPKFTLKAGQVV EECCCCEEECCCCEE | 33.21 | 23312004 | |
| 496 | Phosphorylation | LKAGQVVTIWAAGAG ECCCCEEEEEECCCC | 16.37 | 21082442 | |
| 498 | Ubiquitination | AGQVVTIWAAGAGAT CCCEEEEEECCCCCC | 3.18 | - | |
| 505 | Phosphorylation | WAAGAGATHSPPTDL EECCCCCCCCCCCCC | 23.20 | 25159151 | |
| 507 | Phosphorylation | AGAGATHSPPTDLVW CCCCCCCCCCCCCEE | 28.37 | 22199227 | |
| 510 | Phosphorylation | GATHSPPTDLVWKAQ CCCCCCCCCCEEECC | 45.40 | 22199227 | |
| 515 | Acetylation | PPTDLVWKAQNTWGC CCCCCEEECCCCCCC | 32.39 | 26051181 | |
| 519 | Phosphorylation | LVWKAQNTWGCGNSL CEEECCCCCCCCHHH | 15.91 | 30108239 | |
| 522 | S-nitrosylation | KAQNTWGCGNSLRTA ECCCCCCCCHHHHHH | 3.34 | 22178444 | |
| 522 | S-palmitoylation | KAQNTWGCGNSLRTA ECCCCCCCCHHHHHH | 3.34 | 29575903 | |
| 525 | Phosphorylation | NTWGCGNSLRTALIN CCCCCCHHHHHHHHC | 12.43 | 25159151 | |
| 528 | Phosphorylation | GCGNSLRTALINSTG CCCHHHHHHHHCCCC | 30.98 | 23403867 | |
| 533 | Phosphorylation | LRTALINSTGEEVAM HHHHHHCCCCHHHHH | 30.69 | 29255136 | |
| 533 (in isoform 3) | Phosphorylation | - | 30.69 | 28348404 | |
| 534 | Phosphorylation | RTALINSTGEEVAMR HHHHHCCCCHHHHHH | 44.09 | 29255136 | |
| 534 (in isoform 3) | Phosphorylation | - | 44.09 | 28348404 | |
| 538 (in isoform 3) | Phosphorylation | - | 4.39 | 28348404 | |
| 541 (in isoform 3) | Phosphorylation | - | 21.30 | 28348404 | |
| 542 (in isoform 3) | Phosphorylation | - | 37.94 | 28348404 | |
| 546 | Phosphorylation | AMRKLVRSVTVVEDD HHHHHHCEEEEEECC | 18.05 | 29116813 | |
| 546 (in isoform 2) | Phosphorylation | - | 18.05 | 30108239 | |
| 548 | Phosphorylation | RKLVRSVTVVEDDED HHHHCEEEEEECCCC | 21.78 | 25849741 | |
| 548 (in isoform 2) | Phosphorylation | - | 21.78 | 30108239 | |
| 567 (in isoform 3) | Ubiquitination | - | 18.09 | 21890473 | |
| 568 | Phosphorylation | LLHHHHGSHCSSSGD CCCCCCCCCCCCCCC | 19.57 | 25849741 | |
| 568 (in isoform 2) | Phosphorylation | - | 19.57 | 30266825 | |
| 570 (in isoform 2) | Phosphorylation | - | 4.52 | 30266825 | |
| 571 | Phosphorylation | HHHGSHCSSSGDPAE CCCCCCCCCCCCHHH | 23.32 | 25849741 | |
| 572 | Phosphorylation | HHGSHCSSSGDPAEY CCCCCCCCCCCHHHH | 43.67 | 26657352 | |
| 573 | Phosphorylation | HGSHCSSSGDPAEYN CCCCCCCCCCHHHHC | 30.81 | 26657352 | |
| 579 | Phosphorylation | SSGDPAEYNLRSRTV CCCCHHHHCCCCCEE | 22.92 | 30108239 | |
| 583 | Phosphorylation | PAEYNLRSRTVLCGT HHHHCCCCCEEEECC | 35.15 | 20068231 | |
| 585 | Phosphorylation | EYNLRSRTVLCGTCG HHCCCCCEEEECCCC | 21.05 | 21712546 | |
| 590 | Phosphorylation | SRTVLCGTCGQPADK CCEEEECCCCCCCCH | 16.68 | 25159151 | |
| 597 | Acetylation | TCGQPADKASASGSG CCCCCCCHHHCCCCC | 46.47 | 26051181 | |
| 597 | Malonylation | TCGQPADKASASGSG CCCCCCCHHHCCCCC | 46.47 | 26320211 | |
| 597 | Sumoylation | TCGQPADKASASGSG CCCCCCCHHHCCCCC | 46.47 | 25114211 | |
| 597 | Ubiquitination | TCGQPADKASASGSG CCCCCCCHHHCCCCC | 46.47 | 2190698 | |
| 597 (in isoform 1) | Ubiquitination | - | 46.47 | 21890473 | |
| 597 | Ubiquitination | TCGQPADKASASGSG CCCCCCCHHHCCCCC | 46.47 | 21890473 | |
| 599 | O-linked_Glycosylation | GQPADKASASGSGAQ CCCCCHHHCCCCCCC | 28.80 | 32574038 | |
| 599 | Phosphorylation | GQPADKASASGSGAQ CCCCCHHHCCCCCCC | 28.80 | 30278072 | |
| 601 | Phosphorylation | PADKASASGSGAQVG CCCHHHCCCCCCCCC | 30.88 | 30278072 | |
| 601 (in isoform 6) | Phosphorylation | - | 30.88 | 22468782 | |
| 603 | O-linked_Glycosylation | DKASASGSGAQVGGP CHHHCCCCCCCCCCC | 28.58 | 32574038 | |
| 603 | Phosphorylation | DKASASGSGAQVGGP CHHHCCCCCCCCCCC | 28.58 | 30278072 | |
| 612 | O-linked_Glycosylation | AQVGGPISSGSSASS CCCCCCCCCCCCCCE | 31.60 | 32574038 | |
| 612 | Phosphorylation | AQVGGPISSGSSASS CCCCCCCCCCCCCCE | 31.60 | 30266825 | |
| 613 | O-linked_Glycosylation | QVGGPISSGSSASSV CCCCCCCCCCCCCEE | 43.33 | 32574038 | |
| 613 | Phosphorylation | QVGGPISSGSSASSV CCCCCCCCCCCCCEE | 43.33 | 29255136 | |
| 615 | O-linked_Glycosylation | GGPISSGSSASSVTV CCCCCCCCCCCEEEE | 25.36 | 32574038 | |
| 615 | Phosphorylation | GGPISSGSSASSVTV CCCCCCCCCCCEEEE | 25.36 | 29255136 | |
| 616 | O-linked_Glycosylation | GPISSGSSASSVTVT CCCCCCCCCCEEEEE | 35.38 | 32574038 | |
| 616 | Phosphorylation | GPISSGSSASSVTVT CCCCCCCCCCEEEEE | 35.38 | 29255136 | |
| 618 | O-linked_Glycosylation | ISSGSSASSVTVTRS CCCCCCCCEEEEEEE | 27.56 | 32574038 | |
| 618 | Phosphorylation | ISSGSSASSVTVTRS CCCCCCCCEEEEEEE | 27.56 | 30266825 | |
| 619 | O-linked_Glycosylation | SSGSSASSVTVTRSY CCCCCCCEEEEEEEE | 22.86 | 32574038 | |
| 619 | Phosphorylation | SSGSSASSVTVTRSY CCCCCCCEEEEEEEE | 22.86 | 30266825 | |
| 621 | O-linked_Glycosylation | GSSASSVTVTRSYRS CCCCCEEEEEEEECC | 20.36 | 32574038 | |
| 621 | Phosphorylation | GSSASSVTVTRSYRS CCCCCEEEEEEEECC | 20.36 | 30266825 | |
| 623 | O-linked_Glycosylation | SASSVTVTRSYRSVG CCCEEEEEEEECCCC | 12.44 | 32574038 | |
| 623 | Phosphorylation | SASSVTVTRSYRSVG CCCEEEEEEEECCCC | 12.44 | 30266825 | |
| 625 | Phosphorylation | SSVTVTRSYRSVGGS CEEEEEEEECCCCCC | 18.61 | 20201521 | |
| 626 | Phosphorylation | SVTVTRSYRSVGGSG EEEEEEEECCCCCCC | 12.01 | 23403867 | |
| 628 | O-linked_Glycosylation | TVTRSYRSVGGSGGG EEEEEECCCCCCCCC | 19.51 | 32574038 | |
| 628 | Phosphorylation | TVTRSYRSVGGSGGG EEEEEECCCCCCCCC | 19.51 | 29255136 | |
| 632 | Phosphorylation | SYRSVGGSGGGSFGD EECCCCCCCCCCCCC | 28.47 | 22167270 | |
| 636 | Phosphorylation | VGGSGGGSFGDNLVT CCCCCCCCCCCCHHC | 29.36 | 29255136 | |
| 643 | O-linked_Glycosylation | SFGDNLVTRSYLLGN CCCCCHHCHHHHCCC | 19.64 | 32574038 | |
| 643 | Phosphorylation | SFGDNLVTRSYLLGN CCCCCHHCHHHHCCC | 19.64 | 23927012 | |
| 644 | Methylation | FGDNLVTRSYLLGNS CCCCHHCHHHHCCCC | 18.80 | 54557053 | |
| 645 | Phosphorylation | GDNLVTRSYLLGNSS CCCHHCHHHHCCCCC | 15.69 | 23403867 | |
| 646 | Phosphorylation | DNLVTRSYLLGNSSP CCHHCHHHHCCCCCC | 11.58 | 23403867 | |
| 651 | Phosphorylation | RSYLLGNSSPRTQSP HHHHCCCCCCCCCCC | 39.66 | 25159151 | |
| 652 | Phosphorylation | SYLLGNSSPRTQSPQ HHHCCCCCCCCCCCC | 23.54 | 25159151 | |
| 655 | Phosphorylation | LGNSSPRTQSPQNCS CCCCCCCCCCCCCCC | 36.46 | 23911959 | |
| 657 | Phosphorylation | NSSPRTQSPQNCSIM CCCCCCCCCCCCCCC | 28.04 | 18815303 | |
| 661 | Farnesylation | RTQSPQNCSIM---- CCCCCCCCCCC---- | 2.16 | 9030603 | |
| 661 | Farnesylation | RTQSPQNCSIM---- CCCCCCCCCCC---- | 2.16 | 9030603 | |
| 661 | Methylation | RTQSPQNCSIM---- CCCCCCCCCCC---- | 2.16 | 9030603 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 5 | S | Phosphorylation | Kinase | PKC_GROUP | - | PhosphoELM |
| 5 | S | Phosphorylation | Kinase | PKC-FAMILY | - | GPS |
| 19 | T | Phosphorylation | Kinase | CDK1 | P06493 | PSP |
| 19 | T | Phosphorylation | Kinase | CDK-FAMILY | - | GPS |
| 19 | T | Phosphorylation | Kinase | CDK_GROUP | - | PhosphoELM |
| 22 | S | Phosphorylation | Kinase | CDK1 | P06493 | PSP |
| 22 | S | Phosphorylation | Kinase | CDK-FAMILY | - | GPS |
| 22 | S | Phosphorylation | Kinase | CDK_GROUP | - | PhosphoELM |
| 199 | T | Phosphorylation | Kinase | PKC-FAMILY | - | GPS |
| 199 | T | Phosphorylation | Kinase | PKC_GROUP | - | PhosphoELM |
| 301 | S | Phosphorylation | Kinase | AKT1 | P31749 | PSP |
| 307 | S | Phosphorylation | Kinase | CHEK1 | O14757 | GPS |
| 390 | S | Phosphorylation | Kinase | CDK1 | P06493 | PSP |
| 392 | S | Phosphorylation | Kinase | CDK1 | P06493 | PSP |
| 392 | S | Phosphorylation | Kinase | CDK5 | Q00535 | PSP |
| 403 | S | Phosphorylation | Kinase | PKC_GROUP | - | PhosphoELM |
| 403 | S | Phosphorylation | Kinase | PKC-FAMILY | - | GPS |
| 404 | S | Phosphorylation | Kinase | PKC-FAMILY | - | GPS |
| 404 | S | Phosphorylation | Kinase | PKC_GROUP | - | PhosphoELM |
| 404 | S | Phosphorylation | Kinase | AKT1 | P31749 | PSP |
| 416 | T | Phosphorylation | Kinase | PKC-FAMILY | - | GPS |
| 416 | T | Phosphorylation | Kinase | PKC_GROUP | - | PhosphoELM |
| 480 | T | Phosphorylation | Kinase | PKC-FAMILY | - | GPS |
| 480 | T | Phosphorylation | Kinase | PKC_GROUP | - | PhosphoELM |
| 625 | S | Phosphorylation | Kinase | PKC-FAMILY | - | GPS |
| 625 | S | Phosphorylation | Kinase | PKC_GROUP | - | PhosphoELM |
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of LMNA_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of LMNA_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 181350 | Emery-Dreifuss muscular dystrophy 2, autosomal dominant (EDMD2) | |||||
| 181350 | Emery-Dreifuss muscular dystrophy 3, autosomal recessive (EDMD3) | |||||
| 115200 | Cardiomyopathy, dilated 1A (CMD1A) | |||||
| 151660 | Lipodystrophy, familial partial, 2 (FPLD2) | |||||
| 159001 | Limb-girdle muscular dystrophy 1B (LGMD1B) | |||||
| 605588 | Charcot-Marie-Tooth disease 2B1 (CMT2B1) | |||||
| 176670 | Hutchinson-Gilford progeria syndrome (HGPS) | |||||
| 212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism (CMDHH) | |||||
| 248370 | Mandibuloacral dysplasia with type A lipodystrophy (MADA) | |||||
| 275210 | Lethal tight skin contracture syndrome (LTSCS) | |||||
| 610140 | Heart-hand syndrome Slovenian type (HHS-Slovenian) | |||||
| 613205 | Muscular dystrophy congenital LMNA-related (MDCL) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Acetylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-19; SER-22; THR-24; SER-404 AND SER-406, ANDMASS SPECTROMETRY. | |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-97; LYS-108; LYS-114;LYS-270; LYS-311 AND LYS-450, AND MASS SPECTROMETRY. | |
| "Substrate and functional diversity of lysine acetylation revealed bya proteomics survey."; Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T.,Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.; Mol. Cell 23:607-618(2006). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-417, AND MASS SPECTROMETRY. | |
| Methylation | |
| Reference | PubMed |
| "In vitro assay and characterization of the farnesylation-dependentprelamin A endoprotease."; Kilic F., Dalton M.B., Burrell S.K., Mayer J.P., Patterson S.D.,Sinensky M.; J. Biol. Chem. 272:5298-5304(1997). Cited for: PROTEOLYTIC CLEAVAGE, ISOPRENYLATION AT CYS-661, AND METHYLATION ATCYS-661. | |
| "The processing pathway of prelamin A."; Sinensky M., Fantle K., Trujillo M., McLain T., Kupfer A., Dalton M.; J. Cell Sci. 107:61-67(1994). Cited for: PROTEOLYTIC CLEAVAGE, ISOPRENYLATION AT CYS-661, AND METHYLATION ATCYS-661. | |
| Phosphorylation | |
| Reference | PubMed |
| "Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-19; SER-22; THR-24; SER-404 AND SER-406, ANDMASS SPECTROMETRY. | |
| "A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12; SER-18; THR-19;SER-22; SER-301; SER-390; SER-392; THR-394; SER-395; SER-398; SER-458;SER-628; SER-632; SER-636 AND SER-652, AND MASS SPECTROMETRY. | |
| "Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-390; SER-392;SER-632 AND SER-652, AND MASS SPECTROMETRY. | |
| "Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-390; SER-392 ANDSER-628, AND MASS SPECTROMETRY. | |
| "Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."; Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.; Anal. Sci. 24:161-166(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-390; SER-392 ANDSER-395, AND MASS SPECTROMETRY. | |
| "Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-390; SER-392 ANDSER-395, AND MASS SPECTROMETRY. | |
| "Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22, AND MASSSPECTROMETRY. | |
| "Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-19; SER-22; SER-390;SER-392; SER-395; SER-403; SER-404; SER-414; THR-416; SER-628 ANDSER-632, AND MASS SPECTROMETRY. | |
| "Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-22; SER-390 AND SER-392,AND MASS SPECTROMETRY. | |
| "A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-19; SER-22; SER-390;SER-392; SER-395; SER-628; SER-632 AND SER-636, AND MASS SPECTROMETRY. | |
| "Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-10; THR-19; SER-22;SER-277; SER-390; SER-392 AND THR-424, AND MASS SPECTROMETRY. | |
| "Global phosphoproteome of HT-29 human colon adenocarcinoma cells."; Kim J.-E., Tannenbaum S.R., White F.M.; J. Proteome Res. 4:1339-1346(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-390; SER-392; SER-406;SER-407; THR-409 AND SER-423, AND MASS SPECTROMETRY. | |
| "Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-390; SER-392 ANDSER-652, AND MASS SPECTROMETRY. | |
| Prenylation | |
| Reference | PubMed |
| "In vitro assay and characterization of the farnesylation-dependentprelamin A endoprotease."; Kilic F., Dalton M.B., Burrell S.K., Mayer J.P., Patterson S.D.,Sinensky M.; J. Biol. Chem. 272:5298-5304(1997). Cited for: PROTEOLYTIC CLEAVAGE, ISOPRENYLATION AT CYS-661, AND METHYLATION ATCYS-661. | |
| "The processing pathway of prelamin A."; Sinensky M., Fantle K., Trujillo M., McLain T., Kupfer A., Dalton M.; J. Cell Sci. 107:61-67(1994). Cited for: PROTEOLYTIC CLEAVAGE, ISOPRENYLATION AT CYS-661, AND METHYLATION ATCYS-661. | |
| Sumoylation | |
| Reference | PubMed |
| "Sumoylation regulates lamin A function and is lost in lamin A mutantsassociated with familial cardiomyopathies."; Zhang Y.Q., Sarge K.D.; J. Cell Biol. 182:35-39(2008). Cited for: SUBCELLULAR LOCATION, SUMOYLATION AT LYS-201, MUTAGENESIS OF LYS-201,AND CHARACTERIZATION OF VARIANTS CMD1A GLY-203 AND LYS-203. | |
