NHP2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NHP2_HUMAN
• UniProt AC: Q9NX24
• Protein Name: H/ACA ribonucleoprotein complex subunit 2
• Gene Name: NHP2
• Organism: Homo sapiens (Human).
• Sequence Length: 153
• Subcellular Localization: Nucleus, nucleolus. Nucleus, Cajal body. Also localized to Cajal bodies (coiled bodies).
• Protein Description: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme..
• Protein Sequence: MTKIKADPDGPEAQAEACSGERTYQELLVNQNPIAQPLASRRLTRKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVMCEDRNLPYVYIPSKTDLGAAAGSKRPTCVIMVKPHEEYQEAYDECLEEVQSLPLPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Sumoylation	-----MTKIKADPDG -----CCCCCCCCCC	40.69	28112733
5	Sumoylation	---MTKIKADPDGPE ---CCCCCCCCCCHH	48.57	-
5	Ubiquitination	---MTKIKADPDGPE ---CCCCCCCCCCHH	48.57	-
5	Acetylation	---MTKIKADPDGPE ---CCCCCCCCCCHH	48.57	23749302
5	Sumoylation	---MTKIKADPDGPE ---CCCCCCCCCCHH	48.57	25114211
18	Glutathionylation	PEAQAEACSGERTYQ HHHHHHHHCCCCCHH	3.95	22555962
19	Phosphorylation	EAQAEACSGERTYQE HHHHHHHCCCCCHHH	51.22	18523010
23	Phosphorylation	EACSGERTYQELLVN HHHCCCCCHHHHHHC	25.84	29978859
24	Phosphorylation	ACSGERTYQELLVNQ HHCCCCCHHHHHHCC	13.25	24043423
48	Phosphorylation	RRLTRKLYKCIKKAV HHHHHHHHHHHHHHH	13.57	-
49	Acetylation	RLTRKLYKCIKKAVK HHHHHHHHHHHHHHH	39.66	25953088
56	Methylation	KCIKKAVKQKQIRRG HHHHHHHHHHHHHHH	57.55	23748837
69	Ubiquitination	RGVKEVQKFVNKGEK HHHHHHHHHHHCCCC	57.36	-
73	Ubiquitination	EVQKFVNKGEKGIMV HHHHHHHCCCCCEEE	64.24	-
91	Phosphorylation	DTLPIEVYCHLPVMC CCCCEEEEECCCEEE	2.14	27642862
105	Phosphorylation	CEDRNLPYVYIPSKT ECCCCCCEEEECCCC	14.73	28796482
107	Phosphorylation	DRNLPYVYIPSKTDL CCCCCEEEECCCCCC	10.98	28796482
110	Phosphorylation	LPYVYIPSKTDLGAA CCEEEECCCCCCCCC	38.33	24719451
111	Acetylation	PYVYIPSKTDLGAAA CEEEECCCCCCCCCC	40.48	25953088
111	Ubiquitination	PYVYIPSKTDLGAAA CEEEECCCCCCCCCC	40.48	-
112	Phosphorylation	YVYIPSKTDLGAAAG EEEECCCCCCCCCCC	40.57	21406692
120	Phosphorylation	DLGAAAGSKRPTCVI CCCCCCCCCCCEEEE	22.29	21406692
121	2-Hydroxyisobutyrylation	LGAAAGSKRPTCVIM CCCCCCCCCCEEEEE	62.57	-
121	Ubiquitination	LGAAAGSKRPTCVIM CCCCCCCCCCEEEEE	62.57	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of NHP2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NHP2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NHP2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOP58_HUMAN	NOP58	physical	22939629
JMJD6_HUMAN	JMJD6	physical	23455924

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 613987: Dyskeratosis congenita, autosomal recessive, 2 (DKCB2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Sumoylation

"A proteomic screen for nucleolar SUMO targets shows SUMOylationmodulates the function of Nop5/Nop58.";
Westman B.J., Verheggen C., Hutten S., Lam Y.W., Bertrand E.,Lamond A.I.;
Mol. Cell 39:618-631(2010).
Cited for: SUMOYLATION AT LYS-5.
PubMed: 20797632