| UniProt ID | JMJD6_HUMAN | |
|---|---|---|
| UniProt AC | Q6NYC1 | |
| Protein Name | Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 | |
| Gene Name | JMJD6 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 403 | |
| Subcellular Localization | Nucleus, nucleoplasm. Nucleus, nucleolus. Mainly found throughout the nucleoplasm outside of regions containing heterochromatic DNA, with some localization in nucleolus. During mitosis, excluded from the nucleus and reappears in the telophase of the | |
| Protein Description | Dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. Acts as a lysyl-hydroxylase that catalyzes 5-hydroxylation on specific lysine residues of target proteins such as U2AF2/U2AF65 and LUC7L2. Acts as a regulator of RNA splicing by mediating 5-hydroxylation of U2AF2/U2AF65, affecting the pre-mRNA splicing activity of U2AF2/U2AF65. In addition to peptidyl-lysine 5-dioxygenase activity, may act as an RNA hydroxylase, as suggested by its ability to bind single strand RNA. Also acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. However, histone arginine demethylation may not constitute the primary activity in vivo. Has no histone lysine demethylase activity. Required for differentiation of multiple organs during embryogenesis. Acts as a key regulator of hematopoietic differentiation: required for angiogenic sprouting by regulating the pre-mRNA splicing activity of U2AF2/U2AF65. Seems to be necessary for the regulation of macrophage cytokine responses.. | |
| Protein Sequence | MNHKSKKRIREAKRSARPELKDSLDWTRHNYYESFSLSPAAVADNVERADALQLSVEEFVERYERPYKPVVLLNAQEGWSAQEKWTLERLKRKYRNQKFKCGEDNDGYSVKMKMKYYIEYMESTRDDSPLYIFDSSYGEHPKRRKLLEDYKVPKFFTDDLFQYAGEKRRPPYRWFVMGPPRSGTGIHIDPLGTSAWNALVQGHKRWCLFPTSTPRELIKVTRDEGGNQQDEAITWFNVIYPRTQLPTWPPEFKPLEILQKPGETVFVPGGWWHVVLNLDTTIAITQNFASSTNFPVVWHKTVRGRPKLSRKWYRILKQEHPELAVLADSVDLQESTGIASDSSSDSSSSSSSSSSDSDSECESGSEGDGTVHRRKKRRTCSMVGNGDTTSQDDCVSKERSSSR | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 15 | Phosphorylation | RIREAKRSARPELKD HHHHHHHHHCHHHHH | 28.11 | 22210691 | |
| 23 (in isoform 3) | Phosphorylation | - | 27.00 | 27251275 | |
| 23 | Phosphorylation | ARPELKDSLDWTRHN HCHHHHHHCCCHHCC | 27.00 | 24275569 | |
| 31 | Phosphorylation | LDWTRHNYYESFSLS CCCHHCCCHHHHCCC | 11.50 | 27080861 | |
| 32 | Phosphorylation | DWTRHNYYESFSLSP CCHHCCCHHHHCCCH | 15.48 | 27080861 | |
| 34 | Phosphorylation | TRHNYYESFSLSPAA HHCCCHHHHCCCHHH | 12.19 | 27080861 | |
| 36 | Phosphorylation | HNYYESFSLSPAAVA CCCHHHHCCCHHHHC | 36.90 | 28450419 | |
| 38 | Phosphorylation | YYESFSLSPAAVADN CHHHHCCCHHHHCCC | 15.99 | 25159151 | |
| 68 (in isoform 3) | Ubiquitination | - | 33.74 | - | |
| 68 | Ubiquitination | ERYERPYKPVVLLNA HHCCCCCCCEEEEEC | 33.74 | - | |
| 100 (in isoform 3) | Ubiquitination | - | 48.65 | - | |
| 100 | Ubiquitination | KYRNQKFKCGEDNDG HHHCCCCCCCCCCCC | 48.65 | - | |
| 100 | Methylation | KYRNQKFKCGEDNDG HHHCCCCCCCCCCCC | 48.65 | 115971591 | |
| 108 | Phosphorylation | CGEDNDGYSVKMKMK CCCCCCCCEEEEEEE | 17.10 | - | |
| 120 | Phosphorylation | KMKYYIEYMESTRDD EEEEHHHHHHHCCCC | 9.16 | 29759185 | |
| 128 | Phosphorylation | MESTRDDSPLYIFDS HHHCCCCCCEEEECC | 22.54 | 23312004 | |
| 131 | Phosphorylation | TRDDSPLYIFDSSYG CCCCCCEEEECCCCC | 11.70 | 20873877 | |
| 135 | Phosphorylation | SPLYIFDSSYGEHPK CCEEEECCCCCCCHH | 18.08 | 20873877 | |
| 136 | Phosphorylation | PLYIFDSSYGEHPKR CEEEECCCCCCCHHH | 38.71 | 20873877 | |
| 137 | Phosphorylation | LYIFDSSYGEHPKRR EEEECCCCCCCHHHH | 30.41 | 22817900 | |
| 142 | Ubiquitination | SSYGEHPKRRKLLED CCCCCCHHHHHHHHH | 67.74 | 29967540 | |
| 145 (in isoform 3) | Ubiquitination | - | 62.55 | - | |
| 145 | Ubiquitination | GEHPKRRKLLEDYKV CCCHHHHHHHHHCCC | 62.55 | 29967540 | |
| 151 (in isoform 2) | Ubiquitination | - | 65.47 | 21890473 | |
| 151 (in isoform 3) | Ubiquitination | - | 65.47 | 21890473 | |
| 151 (in isoform 1) | Ubiquitination | - | 65.47 | 21890473 | |
| 151 | Ubiquitination | RKLLEDYKVPKFFTD HHHHHHCCCCCHHCC | 65.47 | 22817900 | |
| 151 | Sumoylation | RKLLEDYKVPKFFTD HHHHHHCCCCCHHCC | 65.47 | - | |
| 154 | Ubiquitination | LEDYKVPKFFTDDLF HHHCCCCCHHCCHHH | 56.98 | 22817900 | |
| 154 | Sumoylation | LEDYKVPKFFTDDLF HHHCCCCCHHCCHHH | 56.98 | - | |
| 154 | Sumoylation | LEDYKVPKFFTDDLF HHHCCCCCHHCCHHH | 56.98 | - | |
| 167 (in isoform 2) | Ubiquitination | - | 53.44 | 21890473 | |
| 167 | Ubiquitination | LFQYAGEKRRPPYRW HHHHCCCCCCCCCEE | 53.44 | 21963094 | |
| 167 (in isoform 3) | Ubiquitination | - | 53.44 | 21890473 | |
| 167 (in isoform 1) | Ubiquitination | - | 53.44 | 21890473 | |
| 204 | Acetylation | NALVQGHKRWCLFPT HHHHHCCCCEEECCC | 55.19 | 26051181 | |
| 204 | Ubiquitination | NALVQGHKRWCLFPT HHHHHCCCCEEECCC | 55.19 | - | |
| 219 | Ubiquitination | STPRELIKVTRDEGG CCHHHHEEEEECCCC | 50.61 | 24816145 | |
| 219 (in isoform 3) | Ubiquitination | - | 50.61 | - | |
| 329 | Phosphorylation | ELAVLADSVDLQEST HHHEEECCCCCHHHC | 16.36 | 30576142 | |
| 348 | Phosphorylation | DSSSDSSSSSSSSSS CCCCCCCCCCCCCCC | 37.89 | - | |
| 349 | Phosphorylation | SSSDSSSSSSSSSSD CCCCCCCCCCCCCCC | 35.87 | - | |
| 350 | Phosphorylation | SSDSSSSSSSSSSDS CCCCCCCCCCCCCCC | 35.87 | - | |
| 351 | Phosphorylation | SDSSSSSSSSSSDSD CCCCCCCCCCCCCCC | 35.87 | - | |
| 370 | Phosphorylation | SGSEGDGTVHRRKKR CCCCCCCCCCCCCCC | 20.20 | 30576142 | |
| 379 | Phosphorylation | HRRKKRRTCSMVGNG CCCCCCCCEECCCCC | 16.99 | 25159151 | |
| 381 | Phosphorylation | RKKRRTCSMVGNGDT CCCCCCEECCCCCCC | 18.85 | 25159151 | |
| 381 (in isoform 3) | Phosphorylation | - | 18.85 | 24719451 | |
| 388 | Phosphorylation | SMVGNGDTTSQDDCV ECCCCCCCCCHHHHH | 29.73 | 28450419 | |
| 388 (in isoform 3) | Phosphorylation | - | 29.73 | 24719451 | |
| 389 | Phosphorylation | MVGNGDTTSQDDCVS CCCCCCCCCHHHHHC | 29.18 | 28450419 | |
| 390 | Phosphorylation | VGNGDTTSQDDCVSK CCCCCCCCHHHHHCH | 33.43 | 21815630 | |
| 390 (in isoform 3) | Phosphorylation | - | 33.43 | 24719451 | |
| 396 | Phosphorylation | TSQDDCVSKERSSSR CCHHHHHCHHHHCCC | 34.82 | 28450419 | |
| 397 | Acetylation | SQDDCVSKERSSSR- CHHHHHCHHHHCCC- | 36.43 | 26051181 | |
| 400 | Phosphorylation | DCVSKERSSSR---- HHHCHHHHCCC---- | 33.48 | 28450419 | |
| 401 (in isoform 3) | Phosphorylation | - | 36.03 | 30631047 | |
| 401 | Phosphorylation | CVSKERSSSR----- HHCHHHHCCC----- | 36.03 | 28450419 | |
| 402 (in isoform 3) | Phosphorylation | - | 43.16 | 30631047 | |
| 402 | Phosphorylation | VSKERSSSR------ HCHHHHCCC------ | 43.16 | 28450419 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of JMJD6_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of JMJD6_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of JMJD6_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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