dbPTM

CDCA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDCA2_HUMAN
UniProt AC	Q69YH5
Protein Name	Cell division cycle-associated protein 2
Gene Name	CDCA2
Organism	Homo sapiens (Human).
Sequence Length	1023
Subcellular Localization	Nucleus . Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase
Protein Description	Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates..
Protein Sequence	MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTVTVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKSPLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLTRKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSLISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGERKQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	"N6,N6-dimethyllysine"	--MDANSKDKPPETK --CCCCCCCCCCCCH	70.36	-
6	Methylation	--MDANSKDKPPETK --CCCCCCCCCCCCH	70.36	-
13	"N6,N6-dimethyllysine"	KDKPPETKESAMNNA CCCCCCCHHHHHHCC	48.27	-
13	Methylation	KDKPPETKESAMNNA CCCCCCCHHHHHHCC	48.27	-
24	Phosphorylation	MNNAGNASFILGTGK HHCCCCEEEEECCCC	19.47	25850435
34	Phosphorylation	LGTGKIVTPQKHAEL ECCCCCCCCCCCCCC	24.39	22199227
47	Phosphorylation	ELPPNPCTPDTFKSP CCCCCCCCCCCCCCC	26.00	28985074
50	Phosphorylation	PNPCTPDTFKSPLNF CCCCCCCCCCCCCCC	33.88	25627689
52	Methylation	PCTPDTFKSPLNFST CCCCCCCCCCCCCCE	53.94	-
53	Phosphorylation	CTPDTFKSPLNFSTV CCCCCCCCCCCCCEE	30.35	25159151
59	Phosphorylation	KSPLNFSTVTVEQLG CCCCCCCEEEHHHCC	18.96	22210691
68	Phosphorylation	TVEQLGITPESFVRN EHHHCCCCHHHHHHC	21.14	25159151
71	Phosphorylation	QLGITPESFVRNSAG HCCCCHHHHHHCCCC	30.19	22210691
76	Phosphorylation	PESFVRNSAGKSSSY HHHHHHCCCCCCHHH	28.03	26055452
79	Ubiquitination	FVRNSAGKSSSYLKK HHHCCCCCCHHHHHH	47.05	-
80	Phosphorylation	VRNSAGKSSSYLKKC HHCCCCCCHHHHHHH	24.49	28152594
81	Phosphorylation	RNSAGKSSSYLKKCR HCCCCCCHHHHHHHH	26.87	28152594
82	Phosphorylation	NSAGKSSSYLKKCRR CCCCCCHHHHHHHHH	41.39	28152594
83	Phosphorylation	SAGKSSSYLKKCRRR CCCCCHHHHHHHHHH	25.21	28152594
91	Phosphorylation	LKKCRRRSAVGARGS HHHHHHHCCCCCCCC	26.04	24732914
96	Methylation	RRSAVGARGSPETNH HHCCCCCCCCHHHHH	39.95	-
98	Phosphorylation	SAVGARGSPETNHLI CCCCCCCCHHHHHHH	17.63	30266825
99	Phosphorylation	AVGARGSPETNHLIR CCCCCCCHHHHHHHH	56.08	18220336
101	Phosphorylation	GARGSPETNHLIRFI CCCCCHHHHHHHHHH	31.18	30266825
106	Methylation	PETNHLIRFIARQQN HHHHHHHHHHHHHHC	24.23	-
115	Acetylation	IARQQNIKNARKSPL HHHHHCHHHHHHCCC	52.70	7674181
119	Acetylation	QNIKNARKSPLAQDS HCHHHHHHCCCCCCC	54.75	7674189
119	Methylation	QNIKNARKSPLAQDS HCHHHHHHCCCCCCC	54.75	-
119	Ubiquitination	QNIKNARKSPLAQDS HCHHHHHHCCCCCCC	54.75	-
120	Phosphorylation	NIKNARKSPLAQDSP CHHHHHHCCCCCCCC	21.42	25159151
121	Phosphorylation	IKNARKSPLAQDSPS HHHHHHCCCCCCCCC	34.45	18669648
126	Phosphorylation	KSPLAQDSPSQGSPA HCCCCCCCCCCCCHH	17.86	25159151
127	Phosphorylation	SPLAQDSPSQGSPAL CCCCCCCCCCCCHHH	38.67	18669648
128	Phosphorylation	PLAQDSPSQGSPALY CCCCCCCCCCCHHHH	51.64	21712546
129	Phosphorylation	LAQDSPSQGSPALYR CCCCCCCCCCHHHHH	60.82	18669648
131	Phosphorylation	QDSPSQGSPALYRNV CCCCCCCCHHHHHCH	10.20	25159151
132	Phosphorylation	DSPSQGSPALYRNVN CCCCCCCHHHHHCHH	32.86	18669648
135	Phosphorylation	SQGSPALYRNVNTLR CCCCHHHHHCHHHHH	11.40	22199227
146	Phosphorylation	NTLRERISAFQSAFH HHHHHHHHHHHHHHH	29.29	28555341
154	Phosphorylation	AFQSAFHSIKENEKM HHHHHHHHHHHCCCC	28.97	28555341
162	Phosphorylation	IKENEKMTGCLEFSE HHHCCCCCCEEEHHH	35.49	23403867
168	Phosphorylation	MTGCLEFSEAGKESE CCCEEEHHHCCCHHH	19.70	23403867
182	Ubiquitination	EMTDLTRKEGLSACQ HCCHHHHHHHHHHHH	51.39	-
186	Phosphorylation	LTRKEGLSACQQSGF HHHHHHHHHHHHHCC	37.54	28555341
191	Phosphorylation	GLSACQQSGFPAVLS HHHHHHHHCCCHHHC	19.27	28555341
198	Phosphorylation	SGFPAVLSSKRRRIS HCCCHHHCCCCCCCE	27.49	22199227
199	Phosphorylation	GFPAVLSSKRRRISY CCCHHHCCCCCCCEE	26.48	22199227
200	Acetylation	FPAVLSSKRRRISYQ CCHHHCCCCCCCEEE	46.69	25953088
200	Ubiquitination	FPAVLSSKRRRISYQ CCHHHCCCCCCCEEE	46.69	-
205	Phosphorylation	SSKRRRISYQRDSDE CCCCCCCEEECCCCC	17.25	28450419
206	Phosphorylation	SKRRRISYQRDSDEN CCCCCCEEECCCCCC	12.75	28450419
210	Phosphorylation	RISYQRDSDENLTDA CCEEECCCCCCCCCC	49.35	25159151
215	Phosphorylation	RDSDENLTDAEGKVI CCCCCCCCCCCCCEE	44.75	20068231
239	Phosphorylation	DRACAVETSVDLSEI CCCEEEEEEEEHHHH	27.70	30266825
240	Phosphorylation	RACAVETSVDLSEIS CCEEEEEEEEHHHHH	10.50	30266825
244	Phosphorylation	VETSVDLSEISSKLG EEEEEEHHHHHHHHC	28.55	30266825
247	Phosphorylation	SVDLSEISSKLGSTQ EEEHHHHHHHHCCCC	19.85	30266825
276	Ubiquitination	TETSNALKVADCVVG CCCCCHHHHHCEEEC	32.73	-
284	Ubiquitination	VADCVVGKGSSDAVS HHCEEECCCCCCCCC	43.97	-
286	Phosphorylation	DCVVGKGSSDAVSPD CEEECCCCCCCCCCC	28.65	30278072
287	Phosphorylation	CVVGKGSSDAVSPDT EEECCCCCCCCCCCC	37.95	30266825
291	Phosphorylation	KGSSDAVSPDTFTAE CCCCCCCCCCCEEEE	20.83	30266825
292	Phosphorylation	GSSDAVSPDTFTAEV CCCCCCCCCCEEEEE	37.75	18669648
294	Phosphorylation	SDAVSPDTFTAEVSS CCCCCCCCEEEEECC	26.69	30266825
296	Phosphorylation	AVSPDTFTAEVSSDA CCCCCCEEEEECCCC	24.81	30266825
300	Phosphorylation	DTFTAEVSSDAVPDV CCEEEEECCCCCCCC	17.63	22199227
301	Phosphorylation	TFTAEVSSDAVPDVR CEEEEECCCCCCCCC	34.46	22199227
309	Phosphorylation	DAVPDVRSPATPACR CCCCCCCCCCCHHHC	20.80	25159151
310	Phosphorylation	AVPDVRSPATPACRR CCCCCCCCCCHHHCC	29.59	18669648
312	Phosphorylation	PDVRSPATPACRRDL CCCCCCCCHHHCCCC	18.14	25159151
313	Phosphorylation	DVRSPATPACRRDLP CCCCCCCHHHCCCCC	31.31	18669648
321	Phosphorylation	ACRRDLPTPKTFVLR HHCCCCCCCCCHHHH	44.72	24719451
323	Ubiquitination	RRDLPTPKTFVLRSV CCCCCCCCCHHHHHH	58.01	21890473
324	Phosphorylation	RDLPTPKTFVLRSVL CCCCCCCCHHHHHHH	21.85	-
324 (in isoform 1)	Ubiquitination	-	21.85	21890473
329	Phosphorylation	PKTFVLRSVLKKPSV CCCHHHHHHHCCCCH	27.86	22617229
335	Phosphorylation	RSVLKKPSVKMCLES HHHHCCCCHHHHHHH	43.16	17081983
336	Phosphorylation	SVLKKPSVKMCLESL HHHCCCCHHHHHHHH	6.58	17081983
394	Phosphorylation	MRKRKRVTFGEDLSP CCCCCCCCCCCCCCH	29.92	28176443
400	Phosphorylation	VTFGEDLSPEVFDES CCCCCCCCHHHHCCC	31.19	25159151
401	Phosphorylation	TFGEDLSPEVFDESL CCCCCCCHHHHCCCC	49.41	18669648
407	Phosphorylation	SPEVFDESLPANTPL CHHHHCCCCCCCCCC	41.31	25159151
408	Phosphorylation	PEVFDESLPANTPLR HHHHCCCCCCCCCCC	4.34	18669648
412	Phosphorylation	DESLPANTPLRKGGT CCCCCCCCCCCCCCC	26.30	25159151
413	Phosphorylation	ESLPANTPLRKGGTP CCCCCCCCCCCCCCC	29.94	18669648
424	Ubiquitination	GGTPVCKKDFSGLSS CCCCCCCCCCCCHHH	59.90	-
427	Phosphorylation	PVCKKDFSGLSSLLL CCCCCCCCCHHHHHH	49.29	27732954
430	Phosphorylation	KKDFSGLSSLLLEQS CCCCCCHHHHHHHCC	23.59	27732954
431	Phosphorylation	KDFSGLSSLLLEQSP CCCCCHHHHHHHCCC	28.25	27732954
437	Phosphorylation	SSLLLEQSPVPEPLP HHHHHHCCCCCCCCC	20.63	20068231
464	Phosphorylation	NIEPLQVSFAVLSSP CCCCEEEEEEEECCC	8.43	25850435
469	Phosphorylation	QVSFAVLSSPNKSSI EEEEEEECCCCCCCC	36.83	25850435
470	Phosphorylation	VSFAVLSSPNKSSIS EEEEEECCCCCCCCC	28.47	25159151
474	Phosphorylation	VLSSPNKSSISETLS EECCCCCCCCCEECC	39.27	26074081
475	Phosphorylation	LSSPNKSSISETLSG ECCCCCCCCCEECCC	31.57	26074081
477	Phosphorylation	SPNKSSISETLSGTD CCCCCCCCEECCCCC	26.86	26074081
483	Phosphorylation	ISETLSGTDTFSSSN CCEECCCCCCCCCCC	28.61	22468782
488	Phosphorylation	SGTDTFSSSNNHEKI CCCCCCCCCCCCCCC	32.66	22468782
494	Ubiquitination	SSSNNHEKISSPKVG CCCCCCCCCCCCCCC	40.10	-
496	Phosphorylation	SNNHEKISSPKVGRI CCCCCCCCCCCCCEE	52.21	24719451
497	Phosphorylation	NNHEKISSPKVGRIT CCCCCCCCCCCCEEE	32.01	20860994
507	Phosphorylation	VGRITRTSNRRNQLV CCEEEECCCCCCHHH	25.67	-
556	Phosphorylation	KRALPKKSQVLKSCR HHHCCHHHHHHHHHH	31.48	20068231
561	Phosphorylation	KKSQVLKSCRKKKGK HHHHHHHHHHHHCCC	18.26	20068231
575	Acetylation	KGKKSVQKSLYGERD CCCHHHHHHHHCCCC	40.03	25953088
575	Ubiquitination	KGKKSVQKSLYGERD CCCHHHHHHHHCCCC	40.03	-
576	Phosphorylation	GKKSVQKSLYGERDI CCHHHHHHHHCCCCC	15.10	28348404
578	Phosphorylation	KSVQKSLYGERDIAS HHHHHHHHCCCCCCC	24.83	28348404
591	Phosphorylation	ASKKPLLSPIPELPE CCCCCCCCCCCCCCC	28.59	29255136
592	Phosphorylation	SKKPLLSPIPELPEV CCCCCCCCCCCCCCC	46.23	18669648
603	Phosphorylation	LPEVPEMTPSIPSIR CCCCCCCCCCCHHHH	16.54	25159151
604	Phosphorylation	PEVPEMTPSIPSIRR CCCCCCCCCCHHHHC	29.02	18669648
608	Phosphorylation	EMTPSIPSIRRLGSG CCCCCCHHHHCCCCC	27.36	25159151
614	Phosphorylation	PSIRRLGSGYFSSNG HHHHCCCCCCCCCCC	34.61	25159151
616	Phosphorylation	IRRLGSGYFSSNGKL HHCCCCCCCCCCCCE	11.28	29214152
618	Phosphorylation	RLGSGYFSSNGKLEE CCCCCCCCCCCCEEE	17.89	25159151
619	Phosphorylation	LGSGYFSSNGKLEEV CCCCCCCCCCCEEEC	39.44	25627689
622	Sumoylation	GYFSSNGKLEEVKTP CCCCCCCCEEECCCC	57.91	-
622	Acetylation	GYFSSNGKLEEVKTP CCCCCCCCEEECCCC	57.91	20167786
622	Sumoylation	GYFSSNGKLEEVKTP CCCCCCCCEEECCCC	57.91	-
627	Acetylation	NGKLEEVKTPKNPVK CCCEEECCCCCCCCC	63.49	20167786
628	Phosphorylation	GKLEEVKTPKNPVKR CCEEECCCCCCCCCH	44.67	29214152
661	Phosphorylation	YDVSEFCSYIKSSSS CCHHHHHHHHHCCCC	34.90	28555341
668	Phosphorylation	SYIKSSSSLGNATSD HHHHCCCCCCCCCCC	42.09	28555341
673	Phosphorylation	SSSLGNATSDEDPNT CCCCCCCCCCCCCCC	40.48	25627689
674	Phosphorylation	SSLGNATSDEDPNTN CCCCCCCCCCCCCCC	36.27	25627689
708	Phosphorylation	ENEPKAGTDSPVSCA CCCCCCCCCCCCCCC	37.86	29255136
710	Phosphorylation	EPKAGTDSPVSCASV CCCCCCCCCCCCCCC	27.34	29255136
713	Phosphorylation	AGTDSPVSCASVTEE CCCCCCCCCCCCCCH	13.83	21815630
716	Phosphorylation	DSPVSCASVTEERVA CCCCCCCCCCCHHCC	33.62	24732914
718	Phosphorylation	PVSCASVTEERVASD CCCCCCCCCHHCCCC	29.63	24732914
724	Phosphorylation	VTEERVASDSPKPAL CCCHHCCCCCCCCCE	35.45	30266825
726	Phosphorylation	EERVASDSPKPALTL CHHCCCCCCCCCEEE	32.12	30266825
727	Phosphorylation	ERVASDSPKPALTLQ HHCCCCCCCCCEEEC	52.20	18669648
732	Phosphorylation	DSPKPALTLQQGQEF CCCCCCEEECCCCEE	25.32	30266825
740	Phosphorylation	LQQGQEFSAGGQNAE ECCCCEECCCCCCHH	25.83	30266825
756	Phosphorylation	LCQFFKISPDLNIKC HHHHHHCCCCCCCEE	16.98	23401153
757	Phosphorylation	CQFFKISPDLNIKCE HHHHHCCCCCCCEEE	54.29	18669648
762	Sumoylation	ISPDLNIKCERKDDF CCCCCCCEEEECCCH	29.04	-
762	Sumoylation	ISPDLNIKCERKDDF CCCCCCCEEEECCCH	29.04	28112733
766	Ubiquitination	LNIKCERKDDFLGAA CCCEEEECCCHHHHH	39.08	-
776	Ubiquitination	FLGAAEGKLQCNRLM HHHHHCCCEECCCCC	27.22	-
806	Phosphorylation	ENTKESKSQSEDLGR HCCCCCHHCCHHHCC	48.49	24719451
808	Phosphorylation	TKESKSQSEDLGRKP CCCCHHCCHHHCCCC	39.92	22210691
813	Methylation	SQSEDLGRKPMESSS HCCHHHCCCCCCCCC	47.40	-
814	Acetylation	QSEDLGRKPMESSSV CCHHHCCCCCCCCCC	47.09	26051181
818	Phosphorylation	LGRKPMESSSVVSCR HCCCCCCCCCCEECC	22.97	28555341
820	Phosphorylation	RKPMESSSVVSCRDR CCCCCCCCCEECCCC	35.50	28555341
833	Phosphorylation	DRKDRRRSMCYSDGR CCCCCCCCEECCCCC	16.05	25262027
837	Phosphorylation	RRRSMCYSDGRSLHL CCCCEECCCCCEEEE	28.76	23882029
841	Phosphorylation	MCYSDGRSLHLEKNG EECCCCCEEEEEECC	26.18	23882029
851	Phosphorylation	LEKNGNHTPSSSVGS EEECCCCCCCCCCCC	28.94	25627689
853	Phosphorylation	KNGNHTPSSSVGSSV ECCCCCCCCCCCCEE	36.08	25627689
854	Phosphorylation	NGNHTPSSSVGSSVE CCCCCCCCCCCCEEE	30.19	25627689
855	Phosphorylation	GNHTPSSSVGSSVEI CCCCCCCCCCCEEEE	34.53	25627689
874	Phosphorylation	SELFKDLSDAIEQTF CHHHHHHHHHHHHHH	34.82	21406692
880	Phosphorylation	LSDAIEQTFQRRNSE HHHHHHHHHHHHCCH	14.67	23882029
886	Phosphorylation	QTFQRRNSETKVRRS HHHHHHCCHHHHHHH	44.85	23882029
888	Phosphorylation	FQRRNSETKVRRSTR HHHHCCHHHHHHHHH	34.36	23882029
893	Phosphorylation	SETKVRRSTRLQKDL CHHHHHHHHHCHHHH	13.81	-
923	Phosphorylation	SQKAKRRTICTFDSS CHHHCCCEEEEECCC	25.16	24732914
926	Phosphorylation	AKRRTICTFDSSGFE HCCCEEEEECCCCCC	26.99	24732914
929	Phosphorylation	RTICTFDSSGFESMS CEEEEECCCCCCCCC	28.33	30266825
930	Phosphorylation	TICTFDSSGFESMSP EEEEECCCCCCCCCC	49.71	23401153
934	Phosphorylation	FDSSGFESMSPIKET ECCCCCCCCCCCHHH	23.46	30266825
936	Phosphorylation	SSGFESMSPIKETVS CCCCCCCCCCHHHHC	32.52	29255136
941	Phosphorylation	SMSPIKETVSSRQKP CCCCCHHHHCCCCCC	22.23	30266825
943	Phosphorylation	SPIKETVSSRQKPQM CCCHHHHCCCCCCCC	27.50	30266825
944	Phosphorylation	PIKETVSSRQKPQMA CCHHHHCCCCCCCCC	34.10	30266825
955	Phosphorylation	PQMAPPVSDPENSQG CCCCCCCCCCCCCCC	53.90	25159151
960	Phosphorylation	PVSDPENSQGPAAGS CCCCCCCCCCCCCCC	34.55	25159151
967	Phosphorylation	SQGPAAGSSDEPGKR CCCCCCCCCCCCCCC	29.86	27690223
968	Phosphorylation	QGPAAGSSDEPGKRR CCCCCCCCCCCCCCC	45.11	27690223
973	Acetylation	GSSDEPGKRRKSFCI CCCCCCCCCCCCEEE	60.80	26051181
977	Phosphorylation	EPGKRRKSFCISTLA CCCCCCCCEEEHHHC	24.44	23401153
981	Phosphorylation	RRKSFCISTLANTKA CCCCEEEHHHCCCCC	20.67	26552605
982	Phosphorylation	RKSFCISTLANTKAT CCCEEEHHHCCCCCC	15.24	26552605
986	Phosphorylation	CISTLANTKATSQFK EEHHHCCCCCCHHCC	19.22	26552605
999	Phosphorylation	FKGYRRRSSLNGKGE CCCCCCCHHCCCCCH	37.05	20873877
1000	Phosphorylation	KGYRRRSSLNGKGES CCCCCCHHCCCCCHH	24.84	23401153
1004	Acetylation	RRSSLNGKGESSLTA CCHHCCCCCHHHHHH	59.43	26051181
1007	Phosphorylation	SLNGKGESSLTALER HCCCCCHHHHHHHHH	39.04	28111955
1008	Phosphorylation	LNGKGESSLTALERI CCCCCHHHHHHHHHH	25.99	28111955
1010	Phosphorylation	GKGESSLTALERIEH CCCHHHHHHHHHHHH	31.01	20873877

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
412	T	Phosphorylation	Kinase	CDK1	P06493	PSP
893	S	Phosphorylation	Kinase	AURKB	Q96GD4	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CDCA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDCA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of CDCA2_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDCA2_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-400 AND THR-412, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120; SER-126; SER-128;SER-131; SER-291; SER-309; THR-312; SER-400; SER-407; THR-412;SER-591; THR-603; SER-726 AND SER-756, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98 AND SER-210, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-98, AND MASSSPECTROMETRY.	17924679 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-291, AND MASSSPECTROMETRY.	16565220 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-400, ANDMASS SPECTROMETRY.	17081983 [Abstract]