RSRC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RSRC1_HUMAN
• UniProt AC: Q96IZ7
• Protein Name: Serine/Arginine-related protein 53
• Gene Name: RSRC1
• Organism: Homo sapiens (Human).
• Sequence Length: 334
• Subcellular Localization: Nucleus. Nucleus speckle. Cytoplasm. Shuttles between the nucleus and cytoplasm..
• Protein Description: Plays a role in pre-mRNA splicing. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing..
• Protein Sequence: MGRRSSDTEEESRSKRKKKHRRRSSSSSSSDSRTYSRKKGGRKSRSKSRSWSRDLQPRSHSYDRRRRHRSSSSSSYGSRRKRSRSRSRGRGKSYRVQRSRSKSRTRRSRSRPRLRSHSRSSERSSHRRTRSRSRDRERRKGRDKEKREKEKDKGKDKELHNIKRGESGNIKAGLEHLPPAEQAKARLQLVLEAAAKADEALKAKERNEEEAKRRKEEDQATLVEQVKRVKEIEAIESDSFVQQTFRSSKEVKKSVEPSEVKQATSTSGPASAVADPPSTEKEIDPTSIPTAIKYQDDNSLAHPNLFIEKADAEEKWFKRLIALRQERLMGSPVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MGRRSSDTEEES ---CCCCCCCCHHHH	31.07	28176443
6	Phosphorylation	--MGRRSSDTEEESR --CCCCCCCCHHHHH	46.90	28176443
8	Phosphorylation	MGRRSSDTEEESRSK CCCCCCCCHHHHHHH	47.44	25850435
12	Phosphorylation	SSDTEEESRSKRKKK CCCCHHHHHHHHHHH	45.17	20068231
24	Phosphorylation	KKKHRRRSSSSSSSD HHHHHHHCCCCCCCC	32.53	21406692
25	Phosphorylation	KKHRRRSSSSSSSDS HHHHHHCCCCCCCCH	32.21	21406692
26	Phosphorylation	KHRRRSSSSSSSDSR HHHHHCCCCCCCCHH	35.17	21406692
27	Phosphorylation	HRRRSSSSSSSDSRT HHHHCCCCCCCCHHH	35.87	21406692
28	Phosphorylation	RRRSSSSSSSDSRTY HHHCCCCCCCCHHHC	35.49	21406692
29	Phosphorylation	RRSSSSSSSDSRTYS HHCCCCCCCCHHHCC	39.86	30576142
30	Phosphorylation	RSSSSSSSDSRTYSR HCCCCCCCCHHHCCC	41.37	21406692
32	Phosphorylation	SSSSSSDSRTYSRKK CCCCCCCHHHCCCCC	28.59	21406692
36	Phosphorylation	SSDSRTYSRKKGGRK CCCHHHCCCCCCCCC	36.69	21406692
46	Phosphorylation	KGGRKSRSKSRSWSR CCCCCCCCCCCCCHH	41.91	24144214
48	Phosphorylation	GRKSRSKSRSWSRDL CCCCCCCCCCCHHHC	32.56	22617229
50	Phosphorylation	KSRSKSRSWSRDLQP CCCCCCCCCHHHCCC	36.17	22617229
52	Phosphorylation	RSKSRSWSRDLQPRS CCCCCCCHHHCCCCC	19.70	22617229
59	Phosphorylation	SRDLQPRSHSYDRRR HHHCCCCCCCCHHHH	24.38	26425664
61	Phosphorylation	DLQPRSHSYDRRRRH HCCCCCCCCHHHHHH	29.94	30576142
62	Phosphorylation	LQPRSHSYDRRRRHR CCCCCCCCHHHHHHH	14.19	21406692
70	Phosphorylation	DRRRRHRSSSSSSYG HHHHHHHCCCCCCCC	28.57	23663014
71	Phosphorylation	RRRRHRSSSSSSYGS HHHHHHCCCCCCCCH	33.91	23663014
72	Phosphorylation	RRRHRSSSSSSYGSR HHHHHCCCCCCCCHH	35.17	23663014
73	Phosphorylation	RRHRSSSSSSYGSRR HHHHCCCCCCCCHHH	25.83	23663014
74	Phosphorylation	RHRSSSSSSYGSRRK HHHCCCCCCCCHHHH	29.53	23663014
75	Phosphorylation	HRSSSSSSYGSRRKR HHCCCCCCCCHHHHH	35.15	23663014
76	Phosphorylation	RSSSSSSYGSRRKRS HCCCCCCCCHHHHHC	22.52	23663014
78	Phosphorylation	SSSSSYGSRRKRSRS CCCCCCCHHHHHCCC	22.22	23663014
83	Phosphorylation	YGSRRKRSRSRSRGR CCHHHHHCCCCCCCC	37.33	26074081
85	Phosphorylation	SRRKRSRSRSRGRGK HHHHHCCCCCCCCCC	35.54	26074081
87	Phosphorylation	RKRSRSRSRGRGKSY HHHCCCCCCCCCCCH	40.09	26074081
116	Phosphorylation	RSRPRLRSHSRSSER CCCHHHHHCCCCCCH	30.33	23663014
118	Phosphorylation	RPRLRSHSRSSERSS CHHHHHCCCCCCHHH	34.79	23663014
120	Phosphorylation	RLRSHSRSSERSSHR HHHHCCCCCCHHHHH	39.30	23663014
121	Phosphorylation	LRSHSRSSERSSHRR HHHCCCCCCHHHHHH	35.60	23663014
131	Phosphorylation	SSHRRTRSRSRDRER HHHHHHHHHHHHHHH	33.71	20068231
133	Phosphorylation	HRRTRSRSRDRERRK HHHHHHHHHHHHHHH	39.52	20068231
153	Acetylation	KREKEKDKGKDKELH HHHHHHHCCCCHHHH	78.06	18529179
155	Acetylation	EKEKDKGKDKELHNI HHHHHCCCCHHHHHH	71.95	164887
155	Ubiquitination	EKEKDKGKDKELHNI HHHHHCCCCHHHHHH	71.95	24816145
157	Acetylation	EKDKGKDKELHNIKR HHHCCCCHHHHHHCC	66.71	164891
169	Ubiquitination	IKRGESGNIKAGLEH HCCCCCCCCCCCCCC	41.70	24816145
227	Ubiquitination	ATLVEQVKRVKEIEA HHHHHHHHHHHHHHH	51.69	24816145
235	Ubiquitination	RVKEIEAIESDSFVQ HHHHHHHHHCCHHHH	3.19	29967540
237	Phosphorylation	KEIEAIESDSFVQQT HHHHHHHCCHHHHHH	32.23	30266825
239	Phosphorylation	IEAIESDSFVQQTFR HHHHHCCHHHHHHHH	36.27	30266825
244	Phosphorylation	SDSFVQQTFRSSKEV CCHHHHHHHHCCHHH	12.15	30266825
251	Ubiquitination	TFRSSKEVKKSVEPS HHHCCHHHHHCCCHH	12.44	29967540
254	Phosphorylation	SSKEVKKSVEPSEVK CCHHHHHCCCHHHHH	26.45	21815630
257	Ubiquitination	EVKKSVEPSEVKQAT HHHHCCCHHHHHHCC	33.36	29967540
258	Phosphorylation	VKKSVEPSEVKQATS HHHCCCHHHHHHCCC	41.33	28102081
264	Phosphorylation	PSEVKQATSTSGPAS HHHHHHCCCCCCCCH	30.00	20068231
265	Phosphorylation	SEVKQATSTSGPASA HHHHHCCCCCCCCHH	24.48	26074081
266	Phosphorylation	EVKQATSTSGPASAV HHHHCCCCCCCCHHC	33.09	28985074
267	Phosphorylation	VKQATSTSGPASAVA HHHCCCCCCCCHHCC	42.41	26074081
271	Phosphorylation	TSTSGPASAVADPPS CCCCCCCHHCCCCCC	26.81	26074081
278	Phosphorylation	SAVADPPSTEKEIDP HHCCCCCCCCCCCCC	55.37	21815630
279	Phosphorylation	AVADPPSTEKEIDPT HCCCCCCCCCCCCCC	57.77	21815630
286	Phosphorylation	TEKEIDPTSIPTAIK CCCCCCCCCCCCEEE	35.22	26074081
287	Phosphorylation	EKEIDPTSIPTAIKY CCCCCCCCCCCEEEE	31.77	26074081
290	Phosphorylation	IDPTSIPTAIKYQDD CCCCCCCCEEEECCC	39.07	26074081
293	Ubiquitination	TSIPTAIKYQDDNSL CCCCCEEEECCCCCC	34.10	29967540
299	Phosphorylation	IKYQDDNSLAHPNLF EEECCCCCCCCCCEE	33.65	25159151
309	Ubiquitination	HPNLFIEKADAEEKW CCCEEEECCCHHHHH	46.91	29967540
315	Ubiquitination	EKADAEEKWFKRLIA ECCCHHHHHHHHHHH	49.81	29967540
318	Ubiquitination	DAEEKWFKRLIALRQ CHHHHHHHHHHHHHH	45.22	-
331	Phosphorylation	RQERLMGSPVA---- HHHHHCCCCCC----	11.39	28985074

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RSRC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RSRC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RSRC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EF1A1_HUMAN	EEF1A1	physical	16169070
GDF9_HUMAN	GDF9	physical	16169070
LSM2_HUMAN	LSM2	physical	16169070
UT14A_HUMAN	UTP14A	physical	16169070
JMJD6_HUMAN	JMJD6	physical	23455924
TFP11_HUMAN	TFIP11	physical	26186194
NCBP3_HUMAN	C17orf85	physical	26186194
PAXB1_HUMAN	PAXBP1	physical	26186194
JMJD6_HUMAN	JMJD6	physical	26186194
SNR40_HUMAN	SNRNP40	physical	26186194
CSK21_HUMAN	CSNK2A1	physical	26186194
CSK22_HUMAN	CSNK2A2	physical	26186194
JMJD6_HUMAN	JMJD6	physical	28514442
TFP11_HUMAN	TFIP11	physical	28514442
PAXB1_HUMAN	PAXBP1	physical	28514442
SNR40_HUMAN	SNRNP40	physical	28514442
CSK22_HUMAN	CSNK2A2	physical	28514442
NCBP3_HUMAN	C17orf85	physical	28514442
CSK21_HUMAN	CSNK2A1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.