dbPTM

CSK21_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CSK21_HUMAN
UniProt AC	P68400
Protein Name	Casein kinase II subunit alpha
Gene Name	CSNK2A1
Organism	Homo sapiens (Human).
Sequence Length	391
Subcellular Localization	Nucleus .
Protein Description	Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry. [PubMed: 11239457]
Protein Sequence	MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSGPVPSRA ------CCCCCCCCC	52.37	17192257
7	Phosphorylation	-MSGPVPSRARVYTD -CCCCCCCCCEEEEE	38.51	19369195
12	Phosphorylation	VPSRARVYTDVNTHR CCCCCEEEEECCCCC	7.53	28152594
13	Phosphorylation	PSRARVYTDVNTHRP CCCCEEEEECCCCCC	30.52	28152594
17	Phosphorylation	RVYTDVNTHRPREYW EEEEECCCCCCHHHC	21.07	28152594
22	Ubiquitination	VNTHRPREYWDYESH CCCCCCHHHCCCCCC	54.37	24816145
44	Ubiquitination	DDYQLVRKLGRGKYS HHHHHHHHHCCCCHH	48.06	22817900
49	Acetylation	VRKLGRGKYSEVFEA HHHHCCCCHHHHHHE	44.22	25953088
49	Ubiquitination	VRKLGRGKYSEVFEA HHHHCCCCHHHHHHE	44.22	21906983
50	Phosphorylation	RKLGRGKYSEVFEAI HHHCCCCHHHHHHEE	16.94	20090780
51	Phosphorylation	KLGRGKYSEVFEAIN HHCCCCHHHHHHEEE	30.67	28152594
60	Phosphorylation	VFEAINITNNEKVVV HHHEEECCCCCEEEE	27.74	20071362
64	Ubiquitination	INITNNEKVVVKILK EECCCCCEEEEEEEH	42.31	33845483
68	Ubiquitination	NNEKVVVKILKPVKK CCCEEEEEEEHHHCH	30.61	29967540
71	Ubiquitination	KVVVKILKPVKKKKI EEEEEEEHHHCHHHH	51.76	-
83	Ubiquitination	KKIKREIKILENLRG HHHHHHHHHHHHCCC	36.16	24816145
89	Methylation	IKILENLRGGPNIIT HHHHHHCCCCCCEEE	60.65	-
93	Ubiquitination	ENLRGGPNIITLADI HHCCCCCCEEEHHHH	41.38	22817900
102	2-Hydroxyisobutyrylation	ITLADIVKDPVSRTP EEHHHHHCCCCCCCC	57.56	-
102	Acetylation	ITLADIVKDPVSRTP EEHHHHHCCCCCCCC	57.56	23954790
102	Ubiquitination	ITLADIVKDPVSRTP EEHHHHHCCCCCCCC	57.56	23000965
111	Ubiquitination	PVSRTPALVFEHVNN CCCCCCEEEEEECCC	4.83	22817900
122	Ubiquitination	HVNNTDFKQLYQTLT ECCCCCHHHHHHHHC	42.05	21906983
122	Acetylation	HVNNTDFKQLYQTLT ECCCCCHHHHHHHHC	42.05	22362441
124	Ubiquitination	NNTDFKQLYQTLTDY CCCCHHHHHHHHCHH	3.36	33845483
125	Phosphorylation	NTDFKQLYQTLTDYD CCCHHHHHHHHCHHH	9.28	28152594
127	Phosphorylation	DFKQLYQTLTDYDIR CHHHHHHHHCHHHHH	20.33	28152594
129	Phosphorylation	KQLYQTLTDYDIRFY HHHHHHHCHHHHHHH	35.58	28152594
131	Phosphorylation	LYQTLTDYDIRFYMY HHHHHCHHHHHHHHH	14.18	24043423
158	Ubiquitination	GIMHRDVKPHNVMID CCCCCCCCCCCEEEE	44.86	24816145
163	Sulfoxidation	DVKPHNVMIDHEHRK CCCCCCEEEECCCCH	3.46	30846556
182	Phosphorylation	DWGLAEFYHPGQEYN HHHHHCCCCCCCCEE	9.90	11439109
188	Phosphorylation	FYHPGQEYNVRVASR CCCCCCCEEEEEECH	15.86	29496907
193	Ubiquitination	QEYNVRVASRYFKGP CCEEEEEECHHCCCC	4.26	22817900
193	Ubiquitination	QEYNVRVASRYFKGP CCEEEEEECHHCCCC	4.26	21890473
194	Phosphorylation	EYNVRVASRYFKGPE CEEEEEECHHCCCCE	25.34	28355574
196	Phosphorylation	NVRVASRYFKGPELL EEEEECHHCCCCEEE	13.72	23186163
209	Phosphorylation	LLVDYQMYDYSLDMW EEEEEECCCCCHHHH	9.01	-
217	Phosphorylation	DYSLDMWSLGCMLAS CCCHHHHHHHHHHHH	14.30	20068231
229	Malonylation	LASMIFRKEPFFHGH HHHHHHHCCCCCCCC	60.02	26320211
229	Ubiquitination	LASMIFRKEPFFHGH HHHHHHHCCCCCCCC	60.02	22817900
239	Phosphorylation	FFHGHDNYDQLVRIA CCCCCCCHHHHHHHH	15.89	28152594
247	2-Hydroxyisobutyrylation	DQLVRIAKVLGTEDL HHHHHHHHHHCCHHH	35.30	-
247	Acetylation	DQLVRIAKVLGTEDL HHHHHHHHHHCCHHH	35.30	23236377
247	Ubiquitination	DQLVRIAKVLGTEDL HHHHHHHHHHCCHHH	35.30	21906983
255	Phosphorylation	VLGTEDLYDYIDKYN HHCCHHHHHHHHHCC	21.01	12628006
257	Phosphorylation	GTEDLYDYIDKYNIE CCHHHHHHHHHCCCE	9.47	28102081
260	Ubiquitination	DLYDYIDKYNIELDP HHHHHHHHCCCEECH	30.55	21906983
277	Phosphorylation	NDILGRHSRKRWERF HHHCCHHHHHHHHHH	37.83	19369195
287	Phosphorylation	RWERFVHSENQHLVS HHHHHCCCCCCCCCC	32.70	30266825
303	Ubiquitination	EALDFLDKLLRYDHQ HHHHHHHHHHCCCHH	52.12	-
319	Sulfoxidation	RLTAREAMEHPYFYT CCCHHHHHHCCCEEE	4.10	30846556
323	Phosphorylation	REAMEHPYFYTVVKD HHHHHCCCEEEEEEC	15.89	29496907
326	Phosphorylation	MEHPYFYTVVKDQAR HHCCCEEEEEECCCC	14.66	26074081
329	Ubiquitination	PYFYTVVKDQARMGS CCEEEEEECCCCCCC	39.52	22817900
329	Acetylation	PYFYTVVKDQARMGS CCEEEEEECCCCCCC	39.52	23236377
329	2-Hydroxyisobutyrylation	PYFYTVVKDQARMGS CCEEEEEECCCCCCC	39.52	-
336	Phosphorylation	KDQARMGSSSMPGGS ECCCCCCCCCCCCCC	15.19	20068231
337	Phosphorylation	DQARMGSSSMPGGST CCCCCCCCCCCCCCC	25.56	20068231
338	Phosphorylation	QARMGSSSMPGGSTP CCCCCCCCCCCCCCC	30.60	26074081
343	Phosphorylation	SSSMPGGSTPVSSAN CCCCCCCCCCCCCCC	35.14	20068231
344	Phosphorylation	SSMPGGSTPVSSANM CCCCCCCCCCCCCCC	30.86	7592773
344	O-linked_Glycosylation	SSMPGGSTPVSSANM CCCCCCCCCCCCCCC	30.86	32830957
347	Phosphorylation	PGGSTPVSSANMMSG CCCCCCCCCCCCCCC	25.57	26074081
347	O-linked_Glycosylation	PGGSTPVSSANMMSG CCCCCCCCCCCCCCC	25.57	32830957
348	Phosphorylation	GGSTPVSSANMMSGI CCCCCCCCCCCCCCC	24.72	26074081
348	O-linked_Glycosylation	GGSTPVSSANMMSGI CCCCCCCCCCCCCCC	24.72	32830957
353	Phosphorylation	VSSANMMSGISSVPT CCCCCCCCCCCCCCC	23.39	20068231
356	Phosphorylation	ANMMSGISSVPTPSP CCCCCCCCCCCCCCC	28.89	20068231
357	Phosphorylation	NMMSGISSVPTPSPL CCCCCCCCCCCCCCC	30.14	28348404
360	Phosphorylation	SGISSVPTPSPLGPL CCCCCCCCCCCCCCC	33.95	7592773
362	Phosphorylation	ISSVPTPSPLGPLAG CCCCCCCCCCCCCCC	34.92	7592773
370	Phosphorylation	PLGPLAGSPVIAAAN CCCCCCCCCEEEEEC	15.47	7592773

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
13	T	Phosphorylation	Kinase	AKT1	P31749	PSP
182	Y	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
255	Y	Phosphorylation	Kinase	FGR	P09769	PhosphoELM
255	Y	Phosphorylation	Kinase	FGR	Q6P6U0	PSP
255	Y	Phosphorylation	Kinase	LYN	P07948	PhosphoELM
255	Y	Phosphorylation	Kinase	LYN	Q07014	PSP
344	T	Phosphorylation	Kinase	CDK1	P06493	Uniprot
344	T	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
344	T	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
360	T	Phosphorylation	Kinase	CDK1	P06493	Uniprot
360	T	Phosphorylation	Kinase	MAPK1	P28482	GPS
360	T	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
360	T	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
362	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
362	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM
362	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
362	S	Phosphorylation	Kinase	CDK1	P06493	Uniprot
370	S	Phosphorylation	Kinase	CDK-FAMILY	-	GPS
370	S	Phosphorylation	Kinase	CDK1	P06493	Uniprot
370	S	Phosphorylation	Kinase	CDK_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
344	T	Phosphorylation	7592773
Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase.
360	T	Phosphorylation	7592773
Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase.
362	S	Phosphorylation	7592773
Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase.
370	S	Phosphorylation	7592773
Phosphorylated at Thr-344, Thr-360, Ser-362 and Ser-370 by CDK1 in prophase and metaphase and dephosphorylated during anaphase.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CSK21_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CHK1_HUMAN	CHEK1	physical	12902976
BRCA1_HUMAN	BRCA1	physical	10403822
VAMP4_HUMAN	VAMP4	physical	14608369
DDIT3_HUMAN	DDIT3	physical	12876286
LIS1_HUMAN	PAFAH1B1	physical	10491172
KLF1_HUMAN	KLF1	physical	9722526
UBF1_HUMAN	UBTF	physical	7651819
PTEN_HUMAN	PTEN	physical	12297295
TF3B_HUMAN	BRF1	physical	11997511
TOP1_HUMAN	TOP1	physical	2998765
TF65_HUMAN	RELA	physical	10938077
CSK2B_HUMAN	CSNK2B	physical	9571630
MGMT_HUMAN	MGMT	physical	10667577
CSK2B_HUMAN	CSNK2B	physical	10799509
PKHO1_HUMAN	PLEKHO1	physical	10799509
ROA2_HUMAN	HNRNPA2B1	physical	10381337
IRF2_HUMAN	IRF2	physical	9213219
PSA4_HUMAN	PSMA4	physical	8619999
SPI1_HUMAN	SPI1	physical	8632909
SPIB_HUMAN	SPIB	physical	8632909
HDAC2_HUMAN	HDAC2	physical	12176973
EF1D_HUMAN	EEF1D	physical	10094407
XK_HUMAN	XK	physical	9647734
XKRY2_HUMAN	XKRY	physical	9647734
XKRY_HUMAN	XKRY	physical	9647734
RL5_HUMAN	RPL5	physical	10491318
FGF1_HUMAN	FGF1	physical	12145206
FGF2_HUMAN	FGF2	physical	12145206
ATF1_HUMAN	ATF1	physical	9685505
ZHX1_HUMAN	ZHX1	physical	16169070
HCLS1_HUMAN	HCLS1	physical	11988074
MAZ_HUMAN	MAZ	physical	10448092
NEP_HUMAN	MME	physical	8943850
KS6B1_HUMAN	RPS6KB1	physical	16895915
MPIP2_HUMAN	CDC25B	physical	12527891
UBC3_YEAST	CDC34	physical	18418079
CSK2B_HUMAN	CSNK2B	physical	10094392
TAF1_HUMAN	TAF1	physical	18548200
TSPY1_HUMAN	TSPY1	physical	16426576
ESC_DROME	esc	physical	15896722
HDAC3_HUMAN	HDAC3	physical	15805470
HDAC1_HUMAN	HDAC1	physical	11602581
HDAC1_HUMAN	HDAC1	physical	11327722
MAF1_HUMAN	MAF1	physical	21383183
MAF1_YEAST	MAF1	physical	21383183
HIRP3_HUMAN	HIRIP3	physical	17391060
HDAC1_HUMAN	HDAC1	physical	17827154
HDAC2_HUMAN	HDAC2	physical	17827154
SIN3A_HUMAN	SIN3A	physical	17827154
GEMI_HUMAN	GMNN	physical	17261582
Y3377_ARATH	AT3G03773	physical	21735091
STP1_HUMAN	TNP1	physical	20524034
CDK1_HUMAN	CDK1	physical	1400350
MYCN_HUMAN	MYCN	physical	1425701
SRF_HUMAN	SRF	physical	1740119
PPR1B_HUMAN	PPP1R1B	physical	2557337
KIF5C_HUMAN	KIF5C	physical	19011756
GBRR1_HUMAN	GABRR1	physical	12175859
T2FA_HUMAN	GTF2F1	physical	12591939
HDAC2_HUMAN	HDAC2	physical	12082111
WASP_HUMAN	WAS	physical	12769847
HSP82_YEAST	HSP82	physical	21419342
CA109_HUMAN	C1orf109	physical	22548824
H2AX_HUMAN	H2AFX	physical	22404984
PRKDC_HUMAN	PRKDC	physical	22404984
SQSTM_HUMAN	SQSTM1	physical	22017874
CSK2B_HUMAN	CSNK2B	physical	11827172
CASA1_HUMAN	CSN1S1	physical	11827172
UBAC1_HUMAN	UBAC1	physical	10857748
MPRI_HUMAN	IGF2R	physical	12060753
GGA1_HUMAN	GGA1	physical	12060753
IKKA_HUMAN	CHUK	physical	9914500
ITCH_HUMAN	ITCH	physical	17437719
SCNNA_HUMAN	SCNN1A	physical	18981174
VHL_HUMAN	VHL	physical	15824109
RB_MOUSE	Rb1	physical	21652635
CSN2_HUMAN	COPS2	physical	12628923
CSN7A_HUMAN	COPS7A	physical	12628923
P53_HUMAN	TP53	physical	12628923
JUN_HUMAN	JUN	physical	12628923
CSK2B_HUMAN	CSNK2B	physical	12628923
CSK21_HUMAN	CSNK2A1	physical	12628923
HSP74_HUMAN	HSPA4	physical	22824801
HS90A_HUMAN	HSP90AA1	physical	22824801
PIAS1_HUMAN	PIAS1	physical	19217413
PML_HUMAN	PML	physical	19217413
RAGP1_HUMAN	RANGAP1	physical	16428860
CASB_HUMAN	CSN2	physical	7790358
CASA1_HUMAN	CSN1S1	physical	7790358
RBX2_HUMAN	RNF7	physical	10512750
CSK21_HUMAN	CSNK2A1	physical	10512750
CSK2B_HUMAN	CSNK2B	physical	10512750
SNCAP_HUMAN	SNCAIP	physical	14645218
RPB1_HUMAN	POLR2A	physical	15282296
PML_HUMAN	PML	physical	20625391
VHL_HUMAN	VHL	physical	17936701
CARD9_HUMAN	CARD9	physical	17936701
IFRD1_HUMAN	IFRD1	physical	7809103
SYUA_HUMAN	SNCA	physical	15033366
SYUA_HUMAN	SNCA	physical	10617630
APOE_HUMAN	APOE	physical	15882073
CSK21_HUMAN	CSNK2A1	physical	15882073
TAU_HUMAN	MAPT	physical	15882073
KANK2_HUMAN	KANK2	physical	17476305
A4_HUMAN	APP	physical	21832049
CSK2B_HUMAN	CSNK2B	physical	22939629
SSRP1_HUMAN	SSRP1	physical	22939629
SP16H_HUMAN	SUPT16H	physical	22939629
HDAC2_HUMAN	HDAC2	physical	22939629
NP1L4_HUMAN	NAP1L4	physical	22939629
SIN3A_HUMAN	SIN3A	physical	22939629
CTR9_HUMAN	CTR9	physical	22939629
RTF1_HUMAN	RTF1	physical	22939629
RBBP4_HUMAN	RBBP4	physical	22939629
PAF1_HUMAN	PAF1	physical	22939629
NP1L1_HUMAN	NAP1L1	physical	22939629
LEO1_HUMAN	LEO1	physical	22939629
MDFIC_HUMAN	MDFIC	physical	22939629
HMGA2_MOUSE	Hmga2	physical	10636877
CD5_HUMAN	CD5	physical	11123317
IL16_HUMAN	IL16	physical	12450396
MYC_HUMAN	MYC	physical	12149649
XRCC1_HUMAN	XRCC1	physical	15367657
XRCC6_HUMAN	XRCC6	physical	20711232
XRCC5_HUMAN	XRCC5	physical	20711232
MDC1_HUMAN	MDC1	physical	18583988
CSK2B_HUMAN	CSNK2B	physical	12901717
IF2B_HUMAN	EIF2S2	physical	12901717
CASB_HUMAN	CSN2	physical	12901717
IKBB_HUMAN	NFKBIB	physical	8887627
XRCC4_HUMAN	XRCC4	physical	15385968
PML_HUMAN	PML	physical	16873060
ZC3HF_HUMAN	ZC3H15	physical	22113938
RL5_HUMAN	RPL5	physical	22113938
CCDC6_HUMAN	CCDC6	physical	22113938
UTP18_HUMAN	UTP18	physical	22113938
CHD4_HUMAN	CHD4	physical	22113938
ICLN_HUMAN	CLNS1A	physical	22113938
TMOD3_HUMAN	TMOD3	physical	22113938
SSRP1_HUMAN	SSRP1	physical	22113938
SRSF2_HUMAN	SRSF2	physical	22113938
BCLF1_HUMAN	BCLAF1	physical	22113938
BMS1_HUMAN	BMS1	physical	22113938
CD2B2_HUMAN	CD2BP2	physical	22113938
NOP58_HUMAN	NOP58	physical	22113938
DDX24_HUMAN	DDX24	physical	22113938
AN32B_HUMAN	ANP32B	physical	22113938
RLA1_HUMAN	RPLP1	physical	22113938
RLA0_HUMAN	RPLP0	physical	22113938
RL1D1_HUMAN	RSL1D1	physical	22113938
LA_HUMAN	SSB	physical	22113938
ARMX3_HUMAN	ARMCX3	physical	22113938
SLIRP_HUMAN	SLIRP	physical	22113938
SFPQ_HUMAN	SFPQ	physical	22113938
RS3_HUMAN	RPS3	physical	22113938
HNRDL_HUMAN	HNRNPDL	physical	22113938
IF4B_HUMAN	EIF4B	physical	22113938
MPP10_HUMAN	MPHOSPH10	physical	22113938
IMA3_HUMAN	KPNA4	physical	22113938
CPSF6_HUMAN	CPSF6	physical	22113938
RS18_HUMAN	RPS18	physical	22113938
HAP28_HUMAN	PDAP1	physical	22113938
HDAC1_HUMAN	HDAC1	physical	22113938
HTSF1_HUMAN	HTATSF1	physical	22113938
SEPT2_HUMAN	SEPT2	physical	22113938
AKAP8_HUMAN	AKAP8	physical	22113938
DDX21_HUMAN	DDX21	physical	22113938
ZC3HD_HUMAN	ZC3H13	physical	22113938
SF3A1_HUMAN	SF3A1	physical	22113938
DEK_HUMAN	DEK	physical	22113938
IF2B_HUMAN	EIF2S2	physical	22113938
VIGLN_HUMAN	HDLBP	physical	22113938
MFAP1_HUMAN	MFAP1	physical	22113938
RM04_HUMAN	MRPL4	physical	22113938
OSBP1_HUMAN	OSBP	physical	22113938
SF3B1_HUMAN	SF3B1	physical	22113938
SURF6_HUMAN	SURF6	physical	22113938
HNRPL_HUMAN	HNRNPL	physical	22113938
PSIP1_HUMAN	PSIP1	physical	22113938
EXOS9_HUMAN	EXOSC9	physical	22113938
YBOX1_HUMAN	YBX1	physical	22113938
NXF1_HUMAN	NXF1	physical	22113938
PURB_HUMAN	PURB	physical	22113938
CALU_HUMAN	CALU	physical	22113938
NAF1_HUMAN	NAF1	physical	22113938
SRS10_HUMAN	SRSF10	physical	22113938
XRN2_HUMAN	XRN2	physical	22113938
RRP12_HUMAN	RRP12	physical	22113938
LEO1_HUMAN	LEO1	physical	22113938
TR150_HUMAN	THRAP3	physical	22113938
UT14A_HUMAN	UTP14A	physical	22113938
SND1_HUMAN	SND1	physical	22113938
LTV1_HUMAN	LTV1	physical	22113938
FNBP4_HUMAN	FNBP4	physical	22113938
PSA3_HUMAN	PSMA3	physical	22113938
PR38A_HUMAN	PRPF38A	physical	22113938
SPF45_HUMAN	RBM17	physical	22113938
HMGA1_HUMAN	HMGA1	physical	22113938
EF1B_HUMAN	EEF1B2	physical	22113938
CIRBP_HUMAN	CIRBP	physical	22113938
LAP2A_HUMAN	TMPO	physical	22113938
LAP2B_HUMAN	TMPO	physical	22113938
MCM2_HUMAN	MCM2	physical	22113938
DDX3X_HUMAN	DDX3X	physical	22113938
ACINU_HUMAN	ACIN1	physical	22113938
SMRC2_HUMAN	SMARCC2	physical	22113938
AT2B1_HUMAN	ATP2B1	physical	22113938
HNRPC_HUMAN	HNRNPC	physical	22113938
SPB1_HUMAN	FTSJ3	physical	22113938
U3IP2_HUMAN	RRP9	physical	22113938
IF2A_HUMAN	EIF2S1	physical	22113938
ZRAB2_HUMAN	ZRANB2	physical	22113938
SRRT_HUMAN	SRRT	physical	22113938
SF3B2_HUMAN	SF3B2	physical	22113938
TCP4_HUMAN	SUB1	physical	22113938
HDAC2_HUMAN	HDAC2	physical	22113938
PDCD4_HUMAN	PDCD4	physical	22113938
RU17_HUMAN	SNRNP70	physical	22113938
EIF3J_HUMAN	EIF3J	physical	22113938
RSF1_HUMAN	RSF1	physical	22113938
RRP1B_HUMAN	RRP1B	physical	22113938
PRP16_HUMAN	DHX38	physical	22113938
PRCC_HUMAN	PRCC	physical	22113938
LARP7_HUMAN	LARP7	physical	22113938
IWS1_HUMAN	IWS1	physical	22113938
SPT5H_HUMAN	SUPT5H	physical	22113938
IF2P_HUMAN	EIF5B	physical	22113938
THOC5_HUMAN	THOC5	physical	22113938
CND1_HUMAN	NCAPD2	physical	22113938
SAFB1_HUMAN	SAFB	physical	22113938
WDR55_HUMAN	WDR55	physical	22113938
TB182_HUMAN	TNKS1BP1	physical	22113938
RBMX_HUMAN	RBMX	physical	22113938
HIRP3_HUMAN	HIRIP3	physical	22113938
RIOK2_HUMAN	RIOK2	physical	22113938
NADAP_HUMAN	SLC4A1AP	physical	22113938
ZC3H8_HUMAN	ZC3H8	physical	22113938
LYRIC_HUMAN	MTDH	physical	22113938
RL6_HUMAN	RPL6	physical	22113938
SSF1_HUMAN	PPAN	physical	22113938
NMT1_HUMAN	NMT1	physical	22113938
MAK16_HUMAN	MAK16	physical	22113938
CD11A_HUMAN	CDK11A	physical	22113938
PR40A_HUMAN	PRPF40A	physical	22113938
NUP98_HUMAN	NUP98	physical	22113938
RBM10_HUMAN	RBM10	physical	22113938
MSH6_HUMAN	MSH6	physical	22113938
RPRD2_HUMAN	RPRD2	physical	22113938
FIP1_HUMAN	FIP1L1	physical	22113938
KAPCB_HUMAN	PRKACB	physical	22113938
LRC59_HUMAN	LRRC59	physical	22113938
ROA2_HUMAN	HNRNPA2B1	physical	22113938
LARP1_HUMAN	LARP1	physical	22113938
NOP56_HUMAN	NOP56	physical	22113938
PAIRB_HUMAN	SERBP1	physical	22113938
ALKB5_HUMAN	ALKBH5	physical	22113938
HS90B_HUMAN	HSP90AB1	physical	22113938
AR6P4_HUMAN	ARL6IP4	physical	22113938
ATPA_HUMAN	ATP5A1	physical	22113938
WDR44_HUMAN	WDR44	physical	22113938
SRS11_HUMAN	SRSF11	physical	22113938
RL13_HUMAN	RPL13	physical	22113938
TOP2A_HUMAN	TOP2A	physical	22113938
LS14A_HUMAN	LSM14A	physical	22113938
NPM_HUMAN	NPM1	physical	22113938
S30BP_HUMAN	SAP30BP	physical	22113938
DHX16_HUMAN	DHX16	physical	22113938
NUCL_HUMAN	NCL	physical	22113938
SDS3_HUMAN	SUDS3	physical	22113938
EF1D_HUMAN	EEF1D	physical	22113938
PDIA6_HUMAN	PDIA6	physical	22113938
SRRM1_HUMAN	SRRM1	physical	22113938
CPSF7_HUMAN	CPSF7	physical	22113938
ZC3H1_HUMAN	ZFC3H1	physical	22113938
SRRM2_HUMAN	SRRM2	physical	22113938
RM38_HUMAN	MRPL38	physical	22113938
SPT6H_HUMAN	SUPT6H	physical	22113938
HS90A_HUMAN	HSP90AA1	physical	22113938
PININ_HUMAN	PNN	physical	22113938
NMD3_HUMAN	NMD3	physical	22113938
FXR1_HUMAN	FXR1	physical	22113938
RBM33_HUMAN	RBM33	physical	22113938
INF2_HUMAN	INF2	physical	22113938
DDX54_HUMAN	DDX54	physical	22113938
HDGR2_HUMAN	HDGFRP2	physical	22113938
DDX17_HUMAN	DDX17	physical	22113938
UBP24_HUMAN	USP24	physical	22113938
DKC1_HUMAN	DKC1	physical	22113938
SPS2L_HUMAN	SPATS2L	physical	22113938
BIRC6_HUMAN	BIRC6	physical	22113938
GPN1_HUMAN	GPN1	physical	22113938
MCM3_HUMAN	MCM3	physical	22113938
CALX_HUMAN	CANX	physical	22113938
CLAP2_HUMAN	CLASP2	physical	22113938
AIP_HUMAN	AIP	physical	22113938
DNM1L_MOUSE	Dnm1l	physical	20368287
HAND1_MOUSE	Hand1	physical	20368287
HTRA2_MOUSE	Htra2	physical	20368287
RN111_MOUSE	Rnf111	physical	20368287
ZN574_MOUSE	Zfp574	physical	20368287
CSK2B_MOUSE	Csnk2b	physical	20368287
SGT1_HUMAN	SUGT1	physical	22869522
PTN1_HUMAN	PTPN1	physical	9600099
PTN1_CHICK	PTPN1	physical	9600099
RAD_HUMAN	RRAD	physical	9677319
LA_HUMAN	SSB	physical	19039329
NCOR1_HUMAN	NCOR1	physical	22675025
DTD1_HUMAN	DTD1	physical	20065034
GCH1_HUMAN	GCH1	physical	19294699
MYH9_HUMAN	MYH9	physical	16186248
HMGA1_HUMAN	HMGA1	physical	11034995
NRF1_HUMAN	NRF1	physical	23816881
CSK2B_HUMAN	CSNK2B	physical	19592636
CAV2_HUMAN	CAV2	physical	12743374
CSK2B_HUMAN	CSNK2B	physical	21988832
NAP1_YEAST	NAP1	physical	18086883
POP1_HUMAN	POP1	physical	24778252
RS3_HUMAN	RPS3	physical	23188828
AKT1_HUMAN	AKT1	physical	15818404
SGT1_YEAST	SGT1	physical	19398558
SGT1_HUMAN	SUGT1	physical	19398558
MAGAB_HUMAN	MAGEA11	physical	25416956
NFYA_HUMAN	NFYA	physical	25416956
RN111_HUMAN	RNF111	physical	25416956
THAP1_HUMAN	THAP1	physical	25416956
STAC3_HUMAN	STAC3	physical	25416956
DAXX_HUMAN	DAXX	physical	21474068
NOP58_HUMAN	NOP58	physical	20797634
RBX2_HUMAN	RNF7	physical	12470599
CD11A_HUMAN	CDK11A	physical	25852190
CSK22_HUMAN	CSNK2A2	physical	25852190
EIF3J_HUMAN	EIF3J	physical	25852190
EIF3C_HUMAN	EIF3C	physical	25852190
FBRS_HUMAN	FBRS	physical	25852190
HIRP3_HUMAN	HIRIP3	physical	25852190
EFC14_HUMAN	EFCAB14	physical	25852190
CSK2B_HUMAN	CSNK2B	physical	25852190
MYO1B_HUMAN	MYO1B	physical	25852190
NOLC1_HUMAN	NOLC1	physical	25852190
PCGF5_HUMAN	PCGF5	physical	25852190
RING1_HUMAN	RING1	physical	25852190
SRRM2_HUMAN	SRRM2	physical	25852190
SSRP1_HUMAN	SSRP1	physical	25852190
SP16H_HUMAN	SUPT16H	physical	25852190
DCAF7_HUMAN	DCAF7	physical	25852190
PCS1_ARATH	CAD1	physical	19653625
CSK21_HUMAN	CSNK2A1	physical	18082144
TOM20_YEAST	TOM20	physical	24093680
UBP48_HUMAN	USP48	physical	25486460
KDM1A_HUMAN	KDM1A	physical	25999347
CSK2B_HUMAN	CSNK2B	physical	23555304
DEC1_HUMAN	DEC1	physical	23555304
BHE41_HUMAN	BHLHE41	physical	23555304
OTUB1_HUMAN	OTUB1	physical	25872870
CSN5_HUMAN	COPS5	physical	24725084
CSN4_HUMAN	COPS4	physical	24725084
GCYA3_HUMAN	GUCY1A3	physical	24725084
P53_HUMAN	TP53	physical	24725084
BRWD3_HUMAN	BRWD3	physical	26344197
CSK2B_HUMAN	CSNK2B	physical	26344197
EIF3H_HUMAN	EIF3H	physical	26344197
HDAC2_HUMAN	HDAC2	physical	26344197
WASC4_HUMAN	KIAA1033	physical	26344197
NUCL_HUMAN	NCL	physical	26344197
PI42A_HUMAN	PIP4K2A	physical	26344197
PI42C_HUMAN	PIP4K2C	physical	26344197
PR38A_HUMAN	PRPF38A	physical	26344197
RBM34_HUMAN	RBM34	physical	26344197
SIN3A_HUMAN	SIN3A	physical	26344197
SSRP1_HUMAN	SSRP1	physical	26344197
SP16H_HUMAN	SUPT16H	physical	26344197
SPT4H_HUMAN	SUPT4H1	physical	26344197
SPT5H_HUMAN	SUPT5H	physical	26344197
TOP2A_HUMAN	TOP2A	physical	26344197
CSK22_HUMAN	CSNK2A2	physical	25519132
CSK2B_HUMAN	CSNK2B	physical	25519132
AUTS2_HUMAN	AUTS2	physical	25519132
UB2D3_HUMAN	UBE2D3	physical	25519132
RING2_HUMAN	RNF2	physical	25519132
TFC5_YEAST	BDP1	physical	25970584
ARRB2_HUMAN	ARRB2	physical	11877451
NP1L1_HUMAN	NAP1L1	physical	10764593
NP1L4_HUMAN	NAP1L4	physical	10764593
RN111_HUMAN	RNF111	physical	21516116
CR3L3_HUMAN	CREB3L3	physical	26108621
AP2A_HUMAN	TFAP2A	physical	21777522
ATG32_YEAST	ATG32	physical	23897086
ECD_HUMAN	ECD	physical	26711270
MRP1_HUMAN	ABCC1	physical	22695718
PAX7_HUMAN	PAX7	physical	27144531
DGK1_YEAST	DGK1	physical	27834677
H2AX_HUMAN	H2AFX	physical	25252977
RPB1_HUMAN	POLR2A	physical	25252977
CTNA1_HUMAN	CTNNA1	physical	19941816
MK01_HUMAN	MAPK1	physical	19941816
P53_HUMAN	TP53	physical	15358769
SQSTM_HUMAN	SQSTM1	physical	27846364
PTEN_HUMAN	PTEN	physical	25047839
DPF3_HUMAN	DPF3	physical	26582913
DNJB2_HUMAN	DNAJB2	physical	28031292
P73_HUMAN	TP73	physical	25379016
SIC1_YEAST	SIC1	physical	27571477
APC_HUMAN	APC	genetic	27453043
ATAD5_HUMAN	ATAD5	genetic	27453043
STK11_HUMAN	STK11	genetic	27453043
OCLN_HUMAN	OCLN	physical	23758859
MDM2_HUMAN	MDM2	physical	10561590
CSK2B_HUMAN	CSNK2B	physical	10561590
MDM2_HUMAN	MDM2	physical	11284721
BRMS1_HUMAN	BRMS1	physical	26980766

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CSK21_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-102, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-7; TYR-50;TYR-125; THR-127; TYR-255; SER-277 AND SER-287, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2; SER-194; SER-362 ANDSER-370, AND MASS SPECTROMETRY.	18691976 [Abstract]
"Phosphorylation of casein kinase II by p34cdc2. Identification ofphosphorylation sites using phosphorylation site mutants in vitro."; Bosc D.G., Slominski E., Sichler C., Litchfield D.W.; J. Biol. Chem. 270:25872-25878(1995). Cited for: PHOSPHORYLATION AT THR-344; THR-360; SER-362 AND SER-370.	7592773 [Abstract]

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