GBRR1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GBRR1_HUMAN
• UniProt AC: P24046
• Protein Name: Gamma-aminobutyric acid receptor subunit rho-1
• Gene Name: GABRR1
• Organism: Homo sapiens (Human).
• Sequence Length: 479
• Subcellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
• Protein Description: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission..
• Protein Sequence: MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
134	Phosphorylation	YWKDERLSFPSTNNL HHCCCCCCCCCCCCE	41.13	-
140	N-linked_Glycosylation	LSFPSTNNLSMTFDG CCCCCCCCEEEEECC	33.31	UniProtKB CARBOHYD
166	Phosphorylation	FFVHSKRSFIHDTTT EEEEECCCCEEECCC	32.08	-
171	Phosphorylation	KRSFIHDTTTDNVML CCCCEEECCCCCEEE	19.89	-
172	Phosphorylation	RSFIHDTTTDNVMLR CCCEEECCCCCEEEE	37.90	-
189	Phosphorylation	PDGKVLYSLRVTVTA CCCCEEEEEEEEEEE	12.92	24719451
219	Phosphorylation	CSLEIESYAYTEDDL CEEEEEEEEECCCCE	7.28	20736484
221	Phosphorylation	LEIESYAYTEDDLML EEEEEEEECCCCEEE	11.48	20736484
229	Phosphorylation	TEDDLMLYWKKGNDS CCCCEEEEEECCCCC	10.96	20736484
234	N-linked_Glycosylation	MLYWKKGNDSLKTDE EEEEECCCCCCCHHH	44.57	UniProtKB CARBOHYD
239	Phosphorylation	KGNDSLKTDERISLS CCCCCCCHHHCCCHH	48.67	26074081
274	N-linked_Glycosylation	WYNRLYINFTLRRHI CCCCEEEEEHHHHHH	15.42	UniProtKB CARBOHYD
276	Phosphorylation	NRLYINFTLRRHIFF CCEEEEEHHHHHHHH	18.18	24719451
288	Phosphorylation	IFFFLLQTYFPATLM HHHHHHHHHCHHHHH	27.40	26552605
289	Phosphorylation	FFFLLQTYFPATLMV HHHHHHHHCHHHHHH	8.46	26552605
293	Phosphorylation	LQTYFPATLMVMLSW HHHHCHHHHHHHHHH	18.67	26552605
299	Phosphorylation	ATLMVMLSWVSFWID HHHHHHHHHHHHHHH	13.82	26552605
302	Phosphorylation	MVMLSWVSFWIDRRA HHHHHHHHHHHHCCC	14.49	26552605
319	Phosphorylation	ARVPLGITTVLTMST CCCCCCHHEEEEHHH	14.73	22210691
320	Phosphorylation	RVPLGITTVLTMSTI CCCCCHHEEEEHHHH	16.17	22210691
323	Phosphorylation	LGITTVLTMSTIITG CCHHEEEEHHHHHHC	12.53	26552605
325	Phosphorylation	ITTVLTMSTIITGVN HHEEEEHHHHHHCCC	15.95	26552605
326	Phosphorylation	TTVLTMSTIITGVNA HEEEEHHHHHHCCCC	12.94	26552605
329	Phosphorylation	LTMSTIITGVNASMP EEHHHHHHCCCCCCC	31.09	26552605
334	Phosphorylation	IITGVNASMPRVSYI HHHCCCCCCCCHHHH	24.90	26552605
352	Ubiquitination	DIYLWVSFVFVFLSV HHHHHHHHHHHHHHH	3.42	21963094
362	Phosphorylation	VFLSVLEYAAVNYLT HHHHHHHHHHHHHHH	8.83	29759185
394	Phosphorylation	SGLPPPRTAMLDGNY CCCCCCCEEEECCCC	23.38	12175859
402	Phosphorylation	AMLDGNYSDGEVNDL EEECCCCCCCCCCCH	43.04	12175859
422	Ubiquitination	ENGEKPDRMMVQLTL CCCCCCCCEEEHHHH	24.51	21963094
431	Phosphorylation	MVQLTLASERSSPQR EEHHHHHCCCCCCCH	36.33	24719451
434	Phosphorylation	LTLASERSSPQRKSQ HHHHCCCCCCCHHHH	42.17	24144214
435	Phosphorylation	TLASERSSPQRKSQR HHHCCCCCCCHHHHH	31.13	24144214
439	Ubiquitination	ERSSPQRKSQRSSYV CCCCCCHHHHHHHHH	45.77	21963094
440	Phosphorylation	RSSPQRKSQRSSYVS CCCCCHHHHHHHHHH	32.77	24144214
443	Phosphorylation	PQRKSQRSSYVSMRI CCHHHHHHHHHHEEE	20.55	12175859
444	Phosphorylation	QRKSQRSSYVSMRID CHHHHHHHHHHEEEC	31.57	12175859
447	Phosphorylation	SQRSSYVSMRIDTHA HHHHHHHHEEECHHH	8.29	10779366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
394	T	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
402	S	Phosphorylation	Kinase	CAMK2-FAMILY	-	GPS
434	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
435	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
440	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
443	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
443	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
443	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS
444	S	Phosphorylation	Kinase	PKA-FAMILY	-	GPS
444	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
444	S	Phosphorylation	Kinase	PKG-FAMILY	-	GPS
447	S	Phosphorylation	Kinase	PKC-FAMILY	-	GPS

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GBRR1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GBRR1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TAXB1_HUMAN	TAX1BP1	physical	16999686
GBRR1_HUMAN	GABRR1	physical	16999686
BCR_HUMAN	BCR	physical	16999686
DNM1L_HUMAN	DNM1L	physical	16999686
IP6K2_HUMAN	IP6K2	physical	16999686
FEZF1_HUMAN	FEZF1	physical	16999686

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.