dbPTM

TAXB1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TAXB1_HUMAN
UniProt AC	Q86VP1
Protein Name	Tax1-binding protein 1
Gene Name	TAX1BP1
Organism	Homo sapiens (Human).
Sequence Length	789
Subcellular Localization
Protein Description	Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade..
Protein Sequence	MTSFQEVPLQTSNFAHVIFQNVAKSYLPNAHLECHYTLTPYIHPHPKDWVGIFKVGWSTARDYYTFLWSPMPEHYVEGSTVNCVLAFQGYYLPNDDGEFYQFCYVTHKGEIRGASTPFQFRASSPVEELLTMEDEGNSDMLVVTTKAGLLELKIEKTMKEKEELLKLIAVLEKETAQLREQVGRMERELNHEKERCDQLQAEQKGLTEVTQSLKMENEEFKKRFSDATSKAHQLEEDIVSVTHKAIEKETELDSLKDKLKKAQHEREQLECQLKTEKDEKELYKVHLKNTEIENTKLMSEVQTLKNLDGNKESVITHFKEEIGRLQLCLAEKENLQRTFLLTTSSKEDTCFLKEQLRKAEEQVQATRQEVVFLAKELSDAVNVRDRTMADLHTARLENEKVKKQLADAVAELKLNAMKKDQDKTDTLEHELRREVEDLKLRLQMAADHYKEKFKECQRLQKQINKLSDQSANNNNVFTKKTGNQQKVNDASVNTDPATSASTVDVKPSPSAAEADFDIVTKGQVCEMTKEIADKTEKYNKCKQLLQDEKAKCNKYADELAKMELKWKEQVKIAENVKLELAEVQDNYKELKRSLENPAERKMEGQNSQSPQCFKTCSEQNGYVLTLSNAQPVLQYGNPYASQETRDGADGAFYPDEIQRPPVRVPSWGLEDNVVCSQPARNFSRPDGLEDSEDSKEDENVPTAPDPPSQHLRGHGTGFCFDSSFDVHKKCPLCELMFPPNYDQSKFEEHVESHWKVCPMCSEQFPPDYDQQVFERHVQTHFDQNVLNFD

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MTSFQEVPL ------CCCCCCCCC	37.94	25850435
3	Phosphorylation	-----MTSFQEVPLQ -----CCCCCCCCCC	24.51	26657352
11	Phosphorylation	FQEVPLQTSNFAHVI CCCCCCCCCCCHHHH	33.06	25850435
12	Phosphorylation	QEVPLQTSNFAHVIF CCCCCCCCCCHHHHH	19.59	25850435
25	Phosphorylation	IFQNVAKSYLPNAHL HHHHHHHHHCCCCEE	23.36	-
116	Phosphorylation	GEIRGASTPFQFRAS CEECCCCCCCEEECC	27.82	-
123	Phosphorylation	TPFQFRASSPVEELL CCCEEECCCCHHHHH	30.80	30278072
124	Phosphorylation	PFQFRASSPVEELLT CCEEECCCCHHHHHC	31.79	30278072
131	Phosphorylation	SPVEELLTMEDEGNS CCHHHHHCCCCCCCC	31.01	30278072
138	Phosphorylation	TMEDEGNSDMLVVTT CCCCCCCCCEEEEEE	34.94	30278072
144	Phosphorylation	NSDMLVVTTKAGLLE CCCEEEEEECHHHHH	18.33	27080861
145	Phosphorylation	SDMLVVTTKAGLLEL CCEEEEEECHHHHHH	13.79	27080861
153	Ubiquitination	KAGLLELKIEKTMKE CHHHHHHHHHHHHHH	39.17	-
157	O-linked_Glycosylation	LELKIEKTMKEKEEL HHHHHHHHHHHHHHH	22.23	55821353
161	Ubiquitination	IEKTMKEKEELLKLI HHHHHHHHHHHHHHH	51.47	-
166	Ubiquitination	KEKEELLKLIAVLEK HHHHHHHHHHHHHHH	50.93	-
204	Ubiquitination	DQLQAEQKGLTEVTQ HHHHHHHCCHHHHHH	47.60	-
207	Phosphorylation	QAEQKGLTEVTQSLK HHHHCCHHHHHHHHH	36.76	20068231
210	Phosphorylation	QKGLTEVTQSLKMEN HCCHHHHHHHHHHCC	13.25	29255136
212	Phosphorylation	GLTEVTQSLKMENEE CHHHHHHHHHHCCHH	22.16	29255136
225	Phosphorylation	EEFKKRFSDATSKAH HHHHHHHHHHHHHHH	30.30	20068231
228	Phosphorylation	KKRFSDATSKAHQLE HHHHHHHHHHHHHHH	35.43	29514088
229	Phosphorylation	KRFSDATSKAHQLEE HHHHHHHHHHHHHHH	29.57	28102081
230	Ubiquitination	RFSDATSKAHQLEED HHHHHHHHHHHHHHH	45.60	-
230 (in isoform 2)	Ubiquitination	-	45.60	-
240	Phosphorylation	QLEEDIVSVTHKAIE HHHHHHHHHHHHHHH	22.95	30108239
242	Phosphorylation	EEDIVSVTHKAIEKE HHHHHHHHHHHHHHH	15.34	29514088
244	Ubiquitination	DIVSVTHKAIEKETE HHHHHHHHHHHHHHH	41.51	-
244 (in isoform 2)	Ubiquitination	-	41.51	-
254	Phosphorylation	EKETELDSLKDKLKK HHHHHHHHHHHHHHH	50.36	30108239
281 (in isoform 3)	Ubiquitination	-	56.11	21890473
288	Ubiquitination	ELYKVHLKNTEIENT HHHHHHHCCCHHCCC	47.12	-
296	Ubiquitination	NTEIENTKLMSEVQT CCHHCCCHHHHHHHH	54.49	-
299	Phosphorylation	IENTKLMSEVQTLKN HCCCHHHHHHHHHHC	45.08	29083192
303	Phosphorylation	KLMSEVQTLKNLDGN HHHHHHHHHHCCCCC	44.89	29083192
313	Phosphorylation	NLDGNKESVITHFKE CCCCCHHHHHHHHHH	22.04	20873877
316	Phosphorylation	GNKESVITHFKEEIG CCHHHHHHHHHHHHH	21.07	29514088
319	Ubiquitination	ESVITHFKEEIGRLQ HHHHHHHHHHHHHHH	47.00	-
332	Ubiquitination	LQLCLAEKENLQRTF HHHHHHCHHCCCCEE	46.42	-
338	Phosphorylation	EKENLQRTFLLTTSS CHHCCCCEEEEECCC	12.98	20860994
342	Phosphorylation	LQRTFLLTTSSKEDT CCCEEEEECCCHHHC	27.12	28348404
343	Phosphorylation	QRTFLLTTSSKEDTC CCEEEEECCCHHHCC	30.85	28348404
344	Phosphorylation	RTFLLTTSSKEDTCF CEEEEECCCHHHCCH	33.89	24961811
345	Phosphorylation	TFLLTTSSKEDTCFL EEEEECCCHHHCCHH	37.66	28348404
346	Ubiquitination	FLLTTSSKEDTCFLK EEEECCCHHHCCHHH	60.42	-
349	Phosphorylation	TTSSKEDTCFLKEQL ECCCHHHCCHHHHHH	13.27	28348404
350 (in isoform 3)	Ubiquitination	-	6.10	21890473
353	Acetylation	KEDTCFLKEQLRKAE HHHCCHHHHHHHHHH	24.14	26822725
353	Ubiquitination	KEDTCFLKEQLRKAE HHHCCHHHHHHHHHH	24.14	-
353 (in isoform 3)	Ubiquitination	-	24.14	21890473
356 (in isoform 3)	Ubiquitination	-	6.77	21890473
375	Ubiquitination	QEVVFLAKELSDAVN HHHHHHHHHHHHHCC	62.43	-
377 (in isoform 3)	Ubiquitination	-	5.75	21890473
378	Phosphorylation	VFLAKELSDAVNVRD HHHHHHHHHHCCCCC	25.31	20068231
387 (in isoform 3)	Ubiquitination	-	22.47	21890473
393	Phosphorylation	RTMADLHTARLENEK CCHHHHHHHHHCCHH	22.29	-
404 (in isoform 3)	Ubiquitination	-	35.84	21890473
413	Ubiquitination	ADAVAELKLNAMKKD HHHHHHHHHHHHHCC	31.06	-
423	Ubiquitination	AMKKDQDKTDTLEHE HHHCCCCHHHHHHHH	42.54	-
424	Phosphorylation	MKKDQDKTDTLEHEL HHCCCCHHHHHHHHH	42.37	25056879
426	Phosphorylation	KDQDKTDTLEHELRR CCCCHHHHHHHHHHH	39.00	24961811
440 (in isoform 3)	Phosphorylation	-	9.56	28348404
449	Phosphorylation	LQMAADHYKEKFKEC HHHHHHHHHHHHHHH	22.76	-
461	Ubiquitination	KECQRLQKQINKLSD HHHHHHHHHHHHHCC	58.71	-
465	Ubiquitination	RLQKQINKLSDQSAN HHHHHHHHHCCCCCC	51.50	21890473
465	Ubiquitination	RLQKQINKLSDQSAN HHHHHHHHHCCCCCC	51.50	21890473
465	Ubiquitination	RLQKQINKLSDQSAN HHHHHHHHHCCCCCC	51.50	21890473
465 (in isoform 1)	Ubiquitination	-	51.50	21890473
465 (in isoform 2)	Ubiquitination	-	51.50	21890473
467 (in isoform 4)	Phosphorylation	-	34.90	28348404
470	Phosphorylation	INKLSDQSANNNNVF HHHHCCCCCCCCCCC	37.64	28555341
479	Ubiquitination	NNNNVFTKKTGNQQK CCCCCCEECCCCCEE	36.55	-
491	Phosphorylation	QQKVNDASVNTDPAT CEECCCCCCCCCCCC	20.82	20068231
494	Phosphorylation	VNDASVNTDPATSAS CCCCCCCCCCCCCCC	41.00	20068231
498	Phosphorylation	SVNTDPATSASTVDV CCCCCCCCCCCCEEC	30.16	20068231
499	Phosphorylation	VNTDPATSASTVDVK CCCCCCCCCCCEECC	23.48	20068231
501	Phosphorylation	TDPATSASTVDVKPS CCCCCCCCCEECCCC	28.82	20068231
502	Phosphorylation	DPATSASTVDVKPSP CCCCCCCCEECCCCC	22.05	20068231
508	Phosphorylation	STVDVKPSPSAAEAD CCEECCCCCCHHHCC	26.26	25159151
511 (in isoform 3)	Ubiquitination	-	16.83	21890473
534	Ubiquitination	MTKEIADKTEKYNKC HHHHHHHHHHHHHHH	49.95	21890473
534	Ubiquitination	MTKEIADKTEKYNKC HHHHHHHHHHHHHHH	49.95	21906983
534 (in isoform 1)	Ubiquitination	-	49.95	21890473
534 (in isoform 2)	Ubiquitination	-	49.95	21890473
537	Ubiquitination	EIADKTEKYNKCKQL HHHHHHHHHHHHHHH	60.39	21890473
537	Acetylation	EIADKTEKYNKCKQL HHHHHHHHHHHHHHH	60.39	7823231
537	Ubiquitination	EIADKTEKYNKCKQL HHHHHHHHHHHHHHH	60.39	21906983
537 (in isoform 1)	Ubiquitination	-	60.39	21890473
537 (in isoform 2)	Ubiquitination	-	60.39	21890473
540	Ubiquitination	DKTEKYNKCKQLLQD HHHHHHHHHHHHHHH	39.45	21890473
540	Ubiquitination	DKTEKYNKCKQLLQD HHHHHHHHHHHHHHH	39.45	21906983
540 (in isoform 1)	Ubiquitination	-	39.45	21890473
540 (in isoform 2)	Ubiquitination	-	39.45	21890473
549 (in isoform 2)	Ubiquitination	-	62.53	-
554	Ubiquitination	DEKAKCNKYADELAK HHHHHHHHHHHHHHH	51.81	-
561	Ubiquitination	KYADELAKMELKWKE HHHHHHHHHHCHHHH	45.60	21890473
561	Ubiquitination	KYADELAKMELKWKE HHHHHHHHHHCHHHH	45.60	21890473
561	Ubiquitination	KYADELAKMELKWKE HHHHHHHHHHCHHHH	45.60	21890473
561 (in isoform 1)	Ubiquitination	-	45.60	21890473
561 (in isoform 2)	Ubiquitination	-	45.60	21890473
567	Ubiquitination	AKMELKWKEQVKIAE HHHHCHHHHHHHHHH	36.36	-
571	Ubiquitination	LKWKEQVKIAENVKL CHHHHHHHHHHHHHE	35.57	21890473
571	Ubiquitination	LKWKEQVKIAENVKL CHHHHHHHHHHHHHE	35.57	21906983
571 (in isoform 1)	Ubiquitination	-	35.57	21890473
571 (in isoform 2)	Ubiquitination	-	35.57	21890473
577	Ubiquitination	VKIAENVKLELAEVQ HHHHHHHHEEHHHHH	48.07	-
577 (in isoform 2)	Ubiquitination	-	48.07	-
587	Phosphorylation	LAEVQDNYKELKRSL HHHHHHHHHHHHHHH	17.71	25159151
588	Ubiquitination	AEVQDNYKELKRSLE HHHHHHHHHHHHHHC	63.93	21906983
588 (in isoform 1)	Ubiquitination	-	63.93	21890473
588 (in isoform 2)	Ubiquitination	-	63.93	21890473
591	Ubiquitination	QDNYKELKRSLENPA HHHHHHHHHHHCCHH	40.82	-
593	Phosphorylation	NYKELKRSLENPAER HHHHHHHHHCCHHHH	38.15	30108239
601	Ubiquitination	LENPAERKMEGQNSQ HCCHHHHHCCCCCCC	32.58	-
601 (in isoform 2)	Ubiquitination	-	32.58	21890473
609	Phosphorylation	MEGQNSQSPQCFKTC CCCCCCCCCHHHCHH	19.43	25159151
624 (in isoform 2)	Phosphorylation	-	2.76	28348404
653 (in isoform 2)	Ubiquitination	-	14.83	21890473
666	Phosphorylation	RPPVRVPSWGLEDNV CCCEECCCCCCCCCE	30.80	30266825
676	Phosphorylation	LEDNVVCSQPARNFS CCCCEEECCCCCCCC	27.82	26552605
683	Phosphorylation	SQPARNFSRPDGLED CCCCCCCCCCCCCCC	46.59	29496963
691	Phosphorylation	RPDGLEDSEDSKEDE CCCCCCCCCCCCCCC	33.65	29496963
694	Phosphorylation	GLEDSEDSKEDENVP CCCCCCCCCCCCCCC	33.61	29496963
695	Ubiquitination	LEDSEDSKEDENVPT CCCCCCCCCCCCCCC	79.92	21890473
695	Ubiquitination	LEDSEDSKEDENVPT CCCCCCCCCCCCCCC	79.92	2190698
695 (in isoform 1)	Ubiquitination	-	79.92	21890473
702	Phosphorylation	KEDENVPTAPDPPSQ CCCCCCCCCCCCCCC	46.68	27251275
708	Phosphorylation	PTAPDPPSQHLRGHG CCCCCCCCCCCCCCC	35.30	23312004
722	Phosphorylation	GTGFCFDSSFDVHKK CCCCCCCCCCCCCCC	16.80	28348404
723	Phosphorylation	TGFCFDSSFDVHKKC CCCCCCCCCCCCCCC	27.58	28348404
761	Phosphorylation	WKVCPMCSEQFPPDY CEECCCCCCCCCCCH	28.34	30387612

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
593	S	Phosphorylation	Kinase	IKKA	O15111	Uniprot
593	S	Phosphorylation	Kinase	CHUK	O15111	GPS
593	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS
624	S	Phosphorylation	Kinase	CHUK	O15111	GPS
666	S	Phosphorylation	Kinase	IKKA	O15111	Uniprot
666	S	Phosphorylation	Kinase	IKK-FAMILY	-	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TAXB1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TAXB1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TNAP3_HUMAN	TNFAIP3	physical	10435631
TRAF6_HUMAN	TRAF6	physical	10920205
OPTN_HUMAN	OPTN	physical	19609363
TNIP1_HUMAN	TNIP1	physical	21885437
IKKE_HUMAN	IKBKE	physical	21885437
TBK1_HUMAN	TBK1	physical	21885437
ITCH_HUMAN	ITCH	physical	18246070
TRAF6_HUMAN	TRAF6	physical	21988832
F1892_HUMAN	FAM189A2	physical	25416956
DAZP2_HUMAN	DAZAP2	physical	25416956
TNIP1_HUMAN	TNIP1	physical	25416956
DEST_HUMAN	DSTN	physical	25416956
EMIL1_HUMAN	EMILIN1	physical	25416956
RAB18_HUMAN	RAB18	physical	25416956
F168A_HUMAN	FAM168A	physical	25416956
CXXC1_HUMAN	CXXC1	physical	25416956
NRK1_HUMAN	NMRK1	physical	25416956
LMO3_HUMAN	LMO3	physical	25416956
RAD18_HUMAN	RAD18	physical	25416956
TSH3_HUMAN	TSHZ3	physical	25416956
RM11_HUMAN	MRPL11	physical	25416956
TNIP3_HUMAN	TNIP3	physical	25416956
PKHN1_HUMAN	PLEKHN1	physical	25416956
COG7_HUMAN	COG7	physical	25416956
RM53_HUMAN	MRPL53	physical	25416956
C19L2_HUMAN	CWF19L2	physical	25416956
UBC_HUMAN	UBC	physical	26451915
MYO6_HUMAN	MYO6	physical	26451915
MLP3B_HUMAN	MAP1LC3B	physical	26451915
MLP3C_HUMAN	MAP1LC3C	physical	26451915
GBRL1_HUMAN	GABARAPL1	physical	26451915
GBRL2_HUMAN	GABARAPL2	physical	26451915
RNF26_HUMAN	RNF26	physical	27368102
TBK1_HUMAN	TBK1	physical	28877469

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TAXB1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"The kinase IKKalpha inhibits activation of the transcription factorNF-kappaB by phosphorylating the regulatory molecule TAX1BP1."; Shembade N., Pujari R., Harhaj N.S., Abbott D.W., Harhaj E.W.; Nat. Immunol. 12:834-843(2011). Cited for: PHOSPHORYLATION AT SER-593 AND SER-666 BY CHUK/IKKA.	21765415 [Abstract]