RNF26_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RNF26_HUMAN
• UniProt AC: Q9BY78
• Protein Name: E3 ubiquitin-protein ligase RNF26 {ECO:0000305}
• Gene Name: RNF26 {ECO:0000312|HGNC:HGNC:14646}
• Organism: Homo sapiens (Human).
• Sequence Length: 433
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud. [PubMed: 27368102 Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1]
• Protein Sequence: MEAVYLVVNGLGLVLDVLTLVLDLNFLLVSSLLASLAWLLAFVYNLPHTVLTSLLHLGRGVLLSLLALIEAVVRFTCGGLQALCTLLYSCCSGLESLKLLGHLASHGALRSREILHRGVLNVVSSGHALLRQACDICAIAMSLVAYVINSLVNICLIGTQNLFSLVLALWDAVTGPLWRMTDVVAAFLAHISSSAVAMAILLWTPCQLALELLASAARLLASFVLVNLTGLVLLACVLAVTVTVLHPDFTLRLATQALSQLHARPSYHRLREDVMRLSRLALGSEAWRRVWSRSLQLASWPNRGGAPGAPQGDPMRVFSVRTRRQDTLPEAGRRSEAEEEEARTIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKKCVICQDQSKTVLLLPCRHLCLCQACTEILMRHPVYHRNCPLCRRGILQTLNVYL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
88	Phosphorylation	QALCTLLYSCCSGLE HHHHHHHHHHCCCHH	11.63	-
250	Phosphorylation	TVLHPDFTLRLATQA HHHCCCHHHHHHHHH	20.53	24719451
255	Phosphorylation	DFTLRLATQALSQLH CHHHHHHHHHHHHHH	20.97	23312004
259	Phosphorylation	RLATQALSQLHARPS HHHHHHHHHHHCCCC	33.44	23312004
266	Phosphorylation	SQLHARPSYHRLRED HHHHCCCCHHHHHHH	28.19	23312004
267	Phosphorylation	QLHARPSYHRLREDV HHHCCCCHHHHHHHH	8.14	23312004
299	Phosphorylation	SRSLQLASWPNRGGA HHHCHHHCCCCCCCC	52.22	29449344
327	Phosphorylation	VRTRRQDTLPEAGRR EEEECCCCCCCCCCC	35.55	28348404
348	Phosphorylation	EARTIRVTPVRGRER HHHCCEEECCCCCCC	13.25	23898821
369	Ubiquitination	PGGQDPWKLLKEQEE CCCCCHHHHHHHHHH	49.70	-
372	Ubiquitination	QDPWKLLKEQEERKK CCHHHHHHHHHHHCC	68.72	33845483
378	Acetylation	LKEQEERKKCVICQD HHHHHHHCCCEEECC	54.53	19813539
379	Acetylation	KEQEERKKCVICQDQ HHHHHHCCCEEECCC	39.70	19813547
432	Phosphorylation	ILQTLNVYL------ HHHHHCCCC------	12.96	16497976

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RNF26_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RNF26_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RNF26_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZN143_HUMAN	ZNF143	physical	26186194
RBM26_HUMAN	RBM26	physical	26186194
PSME1_HUMAN	PSME1	physical	26186194
CUED2_HUMAN	CUEDC2	physical	26186194
NB5R3_HUMAN	CYB5R3	physical	26186194
FACE1_HUMAN	ZMPSTE24	physical	26186194
STOM_HUMAN	STOM	physical	26186194
RAB1B_HUMAN	RAB1B	physical	26186194
RAB6A_HUMAN	RAB6A	physical	26186194
IF2B_HUMAN	EIF2S2	physical	26186194
EF1A2_HUMAN	EEF1A2	physical	26186194
ERF1_HUMAN	ETF1	physical	26186194
ARF5_HUMAN	ARF5	physical	26186194
RAB2A_HUMAN	RAB2A	physical	26186194
STING_HUMAN	TMEM173	physical	25254379
ZN143_HUMAN	ZNF143	physical	28514442
CUED2_HUMAN	CUEDC2	physical	28514442
FACE1_HUMAN	ZMPSTE24	physical	28514442
PSME2_HUMAN	PSME2	physical	28514442
PSME1_HUMAN	PSME1	physical	28514442
ERF1_HUMAN	ETF1	physical	28514442
NAA50_HUMAN	NAA50	physical	28514442
TAXB1_HUMAN	TAX1BP1	physical	27368102
SQSTM_HUMAN	SQSTM1	physical	27368102
EPS15_HUMAN	EPS15	physical	27368102
TOLIP_HUMAN	TOLLIP	physical	27368102
UBP15_HUMAN	USP15	physical	27368102

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.