RAB6A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RAB6A_HUMAN
• UniProt AC: P20340
• Protein Name: Ras-related protein Rab-6A
• Gene Name: RAB6A
• Organism: Homo sapiens (Human).
• Sequence Length: 208
• Subcellular Localization: Golgi apparatus membrane ; Lipid-anchor . BICD2 facilitates its targeting to Golgi apparatus membrane.; Isoform 1: Golgi apparatus membrane ; Lipid-anchor .; Isoform 2: Golgi apparatus membrane ; Lipid-anchor .
• Protein Description: Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER). Has a low GTPase activity. Involved in COPI-independent retrograde transport from the Golgi to the ER. [PubMed: 25962623]
• Protein Sequence: MSTGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNVNSFQQTTKWIDDVRTERGSDVIIMLVGNKTDLADKRQVSIEEGERKAKELNVMFIETSAKAGYNVKQLFRRVAAALPGMESTQDRSREDMIDIKLEKPQEQPVSEGGCSC

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSTGGDFGN ------CCCCCCCCC	35.44	23401153
2	Acetylation	------MSTGGDFGN ------CCCCCCCCC	35.44	20068231
3	Phosphorylation	-----MSTGGDFGNP -----CCCCCCCCCC	43.83	22167270
23	Phosphorylation	LVFLGEQSVGKTSLI EEEEECCCCCCCHHH	28.65	29255136
26	Ubiquitination	LGEQSVGKTSLITRF EECCCCCCCHHHHHH	32.55	-
28	Phosphorylation	EQSVGKTSLITRFMY CCCCCCCHHHHHHHH	22.66	24719451
35	Phosphorylation	SLITRFMYDSFDNTY HHHHHHHHHCCCCCE	13.01	-
37	Phosphorylation	ITRFMYDSFDNTYQA HHHHHHHCCCCCEEE	19.60	29978859
41	Phosphorylation	MYDSFDNTYQATIGI HHHCCCCCEEEEEEE	20.89	29978859
42	Phosphorylation	YDSFDNTYQATIGID HHCCCCCEEEEEEEE	11.47	27642862
45	Phosphorylation	FDNTYQATIGIDFLS CCCCEEEEEEEEECC	12.29	29978859
52	Phosphorylation	TIGIDFLSKTMYLED EEEEEECCCCCEECC	26.52	24719451
54	Phosphorylation	GIDFLSKTMYLEDRT EEEECCCCCEECCCE	13.99	21712546
56	Phosphorylation	DFLSKTMYLEDRTVR EECCCCCEECCCEEE	16.51	25884760
60 (in isoform 2)	Methylation	-	26.24	-
60	Methylation	KTMYLEDRTVRLQLW CCCEECCCEEEEEEE	26.24	-
61	Phosphorylation	TMYLEDRTVRLQLWD CCEECCCEEEEEEEC	23.46	29978859
69	Phosphorylation	VRLQLWDTAGQERFR EEEEEECCCCHHHHH	22.55	28857561
77	Phosphorylation	AGQERFRSLIPSYIR CCHHHHHHHCHHHHC	28.12	21406692
81	Phosphorylation	RFRSLIPSYIRDSTV HHHHHCHHHHCCCEE	26.63	20860994
82	AMPylation	FRSLIPSYIRDSTVA HHHHCHHHHCCCEEE	8.46	21822290
82	O-AMP-tyrosine	FRSLIPSYIRDSTVA HHHHCHHHHCCCEEE	8.46	-
82	Phosphorylation	FRSLIPSYIRDSTVA HHHHCHHHHCCCEEE	8.46	21406692
112	Methylation	TKWIDDVRTERGSDV CHHHHHHHHHCCCCE	37.55	-
113	Phosphorylation	KWIDDVRTERGSDVI HHHHHHHHHCCCCEE	29.86	23898821
117	Phosphorylation	DVRTERGSDVIIMLV HHHHHCCCCEEEEEE	34.62	28348404
127	Ubiquitination	IIMLVGNKTDLADKR EEEEECCCCCCCCHH	37.17	-
133	Acetylation	NKTDLADKRQVSIEE CCCCCCCHHCCCHHH	38.84	25953088
137	Phosphorylation	LADKRQVSIEEGERK CCCHHCCCHHHHHHH	18.88	25159151
151	Sulfoxidation	KAKELNVMFIETSAK HHHHCCEEEEECHHH	2.45	21406390
164	Acetylation	AKAGYNVKQLFRRVA HHCCCCHHHHHHHHH	37.33	25953088
164	Ubiquitination	AKAGYNVKQLFRRVA HHCCCCHHHHHHHHH	37.33	21890473
164 (in isoform 1)	Ubiquitination	-	37.33	21890473
164	Malonylation	AKAGYNVKQLFRRVA HHCCCCHHHHHHHHH	37.33	26320211
164 (in isoform 2)	Ubiquitination	-	37.33	21890473
164	Ubiquitination	AKAGYNVKQLFRRVA HHCCCCHHHHHHHHH	37.33	21890473
177	Sulfoxidation	VAAALPGMESTQDRS HHHHCCCCCCCCCCC	3.29	21406390
179	Phosphorylation	AALPGMESTQDRSRE HHCCCCCCCCCCCHH	23.60	28857561
180	Phosphorylation	ALPGMESTQDRSRED HCCCCCCCCCCCHHH	22.60	28857561
184	Phosphorylation	MESTQDRSREDMIDI CCCCCCCCHHHCEEE	48.59	30266825
188	Sulfoxidation	QDRSREDMIDIKLEK CCCCHHHCEEEECCC	2.25	21406390
192	Acetylation	REDMIDIKLEKPQEQ HHHCEEEECCCCCCC	47.01	19813175
206	Geranylgeranylation	QPVSEGGCSC----- CCCCCCCCCC-----	5.73	-
208	Geranylgeranylation	VSEGGCSC------- CCCCCCCC-------	8.22	-
208	Methylation	VSEGGCSC------- CCCCCCCC-------	8.22	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RAB6A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RAB6A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RAB6A_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
BICD1_HUMAN	BICD1	physical	12401177
DCTN1_HUMAN	DCTN1	physical	12401177
RB6I2_HUMAN	ERC1	physical	11929610
GOGA2_HUMAN	GOLGA2	physical	11718716
KI20A_HUMAN	KIF20A	physical	9438855
BICD1_HUMAN	BICD1	physical	12447383
BICD2_HUMAN	BICD2	physical	12447383
RBGP1_HUMAN	RABGAP1	physical	11071909
KI20A_HUMAN	KIF20A	physical	11071909
BICL1_MOUSE	Ccdc64	physical	20360680
BICD1_HUMAN	BICD1	physical	16473624
BICD2_HUMAN	BICD2	physical	16473624
DCTN1_HUMAN	DCTN1	physical	16473624
KI20A_HUMAN	KIF20A	physical	16473624
RB11B_HUMAN	RAB11B	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.