BICL1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: BICL1_MOUSE
• UniProt AC: A0JNT9
• Protein Name: BICD family-like cargo adapter 1
• Gene Name: Bicdl1
• Organism: Mus musculus (Mouse).
• Sequence Length: 577
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Localizes around the centrosome.
• Protein Description: Component of secretory vesicle machinery in developing neurons that acts as a regulator of neurite outgrowth. Regulates the secretory vesicle transport by controlling the accumulation of Rab6-containing secretory vesicles in the pericentrosomal region restricting anterograde secretory transport during the early phase of neuronal differentiation, thereby inhibiting neuritogenesis..
• Protein Sequence: MSAFCLGLAGRASAPAEPDSACCMELPAGAGDAVRSPATAAALVSFPGGPGELELALEEELALLAAGERSSEPGEHPQAEPESPVEGHGPPLPPPPTQDPELLSVIRQKEKDLVLAARLGKALLERNQDMSRQYEQMHKELTDKLEHLEQEKHELRRRFENREGEWEGRVSELETDVKQLQDELERQQLHLREADREKTRAVQELSEQNQRLLDQLSRASEVERQLSMQVHALKEDFREKNSSTNQHIIRLESLQAEIKMLSDRKRELEHRLSATLEENDLLQGTVEELQDRVLILERQGHDKDLQLHQSQLELQEVRLSYRQLQGKVEELTEERSLQSSAATSTSLLSEIEQSMEAEELEQEREQLRLQLWEAYCQVRYLCSHLRGNDSADSAVSTDSSMDESSETSSAKDVPAGSLRTALNDLKRLIQSIVDGVEPTVTLLSVEMTALKEERDRLRVTSEDKEPKEQLQKAIRDRDEAIAKKNAVELELAKCKMDMMSLNSQLLDAIQQKLNLSQQLEAWQDDMHRVIDRQLMDTHLKEQSRPAAAAFPRGHGVGRGQEPSTADGKRLFSFFRKI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	Phosphorylation	HPQAEPESPVEGHGP CCCCCCCCCCCCCCC		25266776
156	Dimethylation	EQEKHELRRRFENRE HHHHHHHHHHHHCCC		-
157	Dimethylation	QEKHELRRRFENREG HHHHHHHHHHHCCCC		-
206	Phosphorylation	TRAVQELSEQNQRLL HHHHHHHHHHHHHHH		28285833
253	Phosphorylation	QHIIRLESLQAEIKM HHEEHHHHHHHHHHH		-
558	Methylation	PRGHGVGRGQEPSTA CCCCCCCCCCCCCCC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of BICL1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of BICL1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of BICL1_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KIF1C_HUMAN	KIF1C	physical	20360680
DC1I1_HUMAN	DYNC1I1	physical	20360680
DCTN1_HUMAN	DCTN1	physical	20360680
DYHC1_HUMAN	DYNC1H1	physical	20360680

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.