| UniProt ID | DCTN1_HUMAN | |
|---|---|---|
| UniProt AC | Q14203 | |
| Protein Name | Dynactin subunit 1 | |
| Gene Name | DCTN1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1278 | |
| Subcellular Localization | Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, spindle . Nucleus envelope . Cytoplasm, cel | |
| Protein Description | Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. [PubMed: 25185702 Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon] | |
| Protein Sequence | MAQSKRHVYSRTPSGSRMSAEASARPLRVGSRVEVIGKGHRGTVAYVGATLFATGKWVGVILDEAKGKNDGTVQGRKYFTCDEGHGIFVRQSQIQVFEDGADTTSPETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRRPKPTRPASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAVPPLPSPSKEEEGLRAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEMELRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVLVLLLMPRLICKAELIRKQAQEKFELSENCSERPGLRGAAGEQLSFAAGLVYSLSLLQATLHRYEHALSQCSVDVYKKVGSLYPEMSAHERSLDFLIELLHKDQLDETVNVEPLTKAIKYYQHLYSIHLAEQPEDCTMQLADHIKFTQSALDCMSVEVGRLRAFLQGGQEATDIALLLRDLETSCSDIRQFCKKIRRRMPGTDAPGIPAALAFGPQVSDTLLDCRKHLTWVVAVLQEVAAAAAQLIAPLAENEGLLVAALEELAFKASEQIYGTPSSSPYECLRQSCNILISTMNKLATAMQEGEYDAERPPSKPPPVELRAAALRAEITDAEGLGLKLEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQALLRKKEKEFEETMDALQADIDQLEAEKAELKQRLNSQSKRTIEGLRGPPPSGIATLVSGIAGEEQQRGAIPGQAPGSVPGPGLVKDSPLLLQQISAMRLHISQLQHENSILKGAQMKASLASLPPLHVAKLSHEGPGSELPAGALYRKTSQLLETLNQLSTHTHVVDITRTSPAAKSPSAQLMEQVAQLKSLSDTVEKLKDEVLKETVSQRPGATVPTDFATFPSSAFLRAKEEQQDDTVYMGKVTFSCAAGFGQRHRLVLTQEQLHQLHSRLIS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | AQSKRHVYSRTPSGS CCCCCCCCCCCCCCC | 6.06 | 24719451 | |
| 10 | Phosphorylation | QSKRHVYSRTPSGSR CCCCCCCCCCCCCCC | 28.70 | 24719451 | |
| 11 (in isoform 2) | Phosphorylation | - | 32.73 | 22210691 | |
| 11 (in isoform 5) | Phosphorylation | - | 32.73 | 22210691 | |
| 12 (in isoform 2) | Phosphorylation | - | 18.83 | 22210691 | |
| 12 (in isoform 5) | Phosphorylation | - | 18.83 | 22210691 | |
| 13 (in isoform 2) | Phosphorylation | - | 35.27 | 22210691 | |
| 13 (in isoform 5) | Phosphorylation | - | 35.27 | 22210691 | |
| 16 | Phosphorylation | YSRTPSGSRMSAEAS CCCCCCCCCCCHHHC | 29.19 | 25690035 | |
| 17 | Methylation | SRTPSGSRMSAEASA CCCCCCCCCCHHHCC | 26.97 | - | |
| 19 | Phosphorylation | TPSGSRMSAEASARP CCCCCCCCHHHCCCC | 23.11 | 20363803 | |
| 23 | Phosphorylation | SRMSAEASARPLRVG CCCCHHHCCCCCCCC | 19.13 | 26270265 | |
| 25 | Methylation | MSAEASARPLRVGSR CCHHHCCCCCCCCCE | 28.43 | - | |
| 31 | Phosphorylation | ARPLRVGSRVEVIGK CCCCCCCCEEEEECC | 30.23 | - | |
| 38 | Acetylation | SRVEVIGKGHRGTVA CEEEEECCCCCCCEE | 40.18 | 25953088 | |
| 77 | Malonylation | DGTVQGRKYFTCDEG CCCCCCEEEEEECCC | 52.09 | 26320211 | |
| 78 | Phosphorylation | GTVQGRKYFTCDEGH CCCCCEEEEEECCCC | 11.62 | 24248375 | |
| 92 | Phosphorylation | HGIFVRQSQIQVFED CEEEEEHHEEEEECC | 20.77 | 29396449 | |
| 96 | Acetylation | VRQSQIQVFEDGADT EEHHEEEEECCCCCC | 6.40 | 19608861 | |
| 103 | Phosphorylation | VFEDGADTTSPETPD EECCCCCCCCCCCCC | 28.74 | 25159151 | |
| 104 | Phosphorylation | FEDGADTTSPETPDS ECCCCCCCCCCCCCC | 42.71 | 25159151 | |
| 105 | Phosphorylation | EDGADTTSPETPDSS CCCCCCCCCCCCCCH | 23.88 | 30278072 | |
| 108 | Phosphorylation | ADTTSPETPDSSASK CCCCCCCCCCCHHHH | 35.46 | 25159151 | |
| 111 | Phosphorylation | TSPETPDSSASKVLK CCCCCCCCHHHHHHH | 29.07 | 21712546 | |
| 112 | Phosphorylation | SPETPDSSASKVLKR CCCCCCCHHHHHHHH | 43.89 | 19691289 | |
| 114 | Phosphorylation | ETPDSSASKVLKREG CCCCCHHHHHHHHCC | 25.83 | 19691289 | |
| 115 | Ubiquitination | TPDSSASKVLKREGT CCCCHHHHHHHHCCC | 51.83 | - | |
| 116 (in isoform 3) | Phosphorylation | - | 7.64 | 27251275 | |
| 122 | Phosphorylation | KVLKREGTDTTAKTS HHHHHCCCCCCHHHH | 25.97 | 30576142 | |
| 128 | Phosphorylation | GTDTTAKTSKLRGLK CCCCCHHHHHHCCCC | 28.73 | 20860994 | |
| 129 | Phosphorylation | TDTTAKTSKLRGLKP CCCCHHHHHHCCCCC | 29.05 | 29759185 | |
| 133 (in isoform 4) | Phosphorylation | - | 48.79 | 27251275 | |
| 134 (in isoform 6) | Phosphorylation | - | 7.49 | - | |
| 145 | Phosphorylation | KAPTARKTTTRRPKP CCCCCCCCCCCCCCC | 28.04 | 23985322 | |
| 146 | Phosphorylation | APTARKTTTRRPKPT CCCCCCCCCCCCCCC | 22.72 | 23985322 | |
| 147 | Phosphorylation | PTARKTTTRRPKPTR CCCCCCCCCCCCCCC | 29.88 | 23985322 | |
| 158 | Phosphorylation | KPTRPASTGVAGASS CCCCCCCCCCCCCCC | 37.47 | - | |
| 164 | Phosphorylation | STGVAGASSSLGPSG CCCCCCCCCCCCCCC | 21.39 | - | |
| 172 | Phosphorylation | SSLGPSGSASAGELS CCCCCCCCCCCCCCC | 24.32 | - | |
| 179 | Phosphorylation | SASAGELSSSEPSTP CCCCCCCCCCCCCCC | 27.76 | 20679239 | |
| 193 | Acetylation | PAQTPLAAPIIPTPV CCCCCCCCCCCCCCC | 11.96 | 19608861 | |
| 198 | Phosphorylation | LAAPIIPTPVLTSPG CCCCCCCCCCCCCCC | 18.67 | 26074081 | |
| 202 | Phosphorylation | IIPTPVLTSPGAVPP CCCCCCCCCCCCCCC | 32.86 | 26074081 | |
| 203 | Phosphorylation | IPTPVLTSPGAVPPL CCCCCCCCCCCCCCC | 19.71 | 26657352 | |
| 210 | Acetylation | SPGAVPPLPSPSKEE CCCCCCCCCCCCHHH | 5.55 | 19608861 | |
| 212 | Phosphorylation | GAVPPLPSPSKEEEG CCCCCCCCCCHHHHC | 49.87 | 26972003 | |
| 214 | Phosphorylation | VPPLPSPSKEEEGLR CCCCCCCCHHHHCHH | 57.97 | 26074081 | |
| 230 | Acetylation | QVRDLEEKLETLRLK HHHCHHHHHHHHHHH | 42.10 | 23749302 | |
| 230 | Ubiquitination | QVRDLEEKLETLRLK HHHCHHHHHHHHHHH | 42.10 | 19608861 | |
| 233 | Phosphorylation | DLEEKLETLRLKRAE CHHHHHHHHHHHHHH | 27.84 | - | |
| 262 | Acetylation | LEQVQEWKSKMQEQQ HHHHHHHHHHHHHHH | 39.17 | 25953088 | |
| 290 | Acetylation | AKEALEAKERYMEEM HHHHHHHHHHHHHHH | 33.09 | 7290025 | |
| 320 | Phosphorylation | MAEERAESLQQEVEA HHHHHHHHHHHHHHH | 30.41 | 29255136 | |
| 329 | Ubiquitination | QQEVEALKERVDELT HHHHHHHHHHHHHHH | 50.99 | - | |
| 336 | Phosphorylation | KERVDELTTDLEILK HHHHHHHHHHHHHHH | 19.06 | - | |
| 337 | Phosphorylation | ERVDELTTDLEILKA HHHHHHHHHHHHHHH | 51.73 | - | |
| 351 | Phosphorylation | AEIEEKGSDGAASSY HHHHHHCCCCCHHHH | 43.89 | 25159151 | |
| 356 | Phosphorylation | KGSDGAASSYQLKQL HCCCCCHHHHHHHHH | 29.10 | 21406692 | |
| 357 | Phosphorylation | GSDGAASSYQLKQLE CCCCCHHHHHHHHHH | 16.51 | 28152594 | |
| 358 | Phosphorylation | SDGAASSYQLKQLEE CCCCHHHHHHHHHHH | 18.50 | 21406692 | |
| 367 (in isoform 2) | Ubiquitination | - | 30.24 | 21906983 | |
| 371 | 2-Hydroxyisobutyrylation | EEQNARLKDALVRMR HHHHHHHHHHHHHHH | 35.09 | - | |
| 371 | Ubiquitination | EEQNARLKDALVRMR HHHHHHHHHHHHHHH | 35.09 | - | |
| 383 | Phosphorylation | RMRDLSSSEKQEHVK HHHCCCCHHHHHHHH | 45.49 | 28842319 | |
| 390 | Acetylation | SEKQEHVKLQKLMEK HHHHHHHHHHHHHHH | 47.29 | 25953088 | |
| 393 | Acetylation | QEHVKLQKLMEKKNQ HHHHHHHHHHHHHHH | 61.30 | 25953088 | |
| 398 | Malonylation | LQKLMEKKNQELEVV HHHHHHHHHHHHHHH | 51.02 | 26320211 | |
| 417 | Phosphorylation | ERLQEELSQAESTID HHHHHHHHHHHHHHH | 30.53 | 28348404 | |
| 439 | Sulfoxidation | AALGAEEMVEMLTDR HHCCHHHHHHHHHHC | 2.02 | 30846556 | |
| 442 | Sulfoxidation | GAEEMVEMLTDRNLN CHHHHHHHHHHCCCC | 3.12 | 30846556 | |
| 453 | 2-Hydroxyisobutyrylation | RNLNLEEKVRELRET CCCCHHHHHHHHHHH | 36.90 | - | |
| 453 | Malonylation | RNLNLEEKVRELRET CCCCHHHHHHHHHHH | 36.90 | 26320211 | |
| 453 | Ubiquitination | RNLNLEEKVRELRET CCCCHHHHHHHHHHH | 36.90 | - | |
| 491 | Sulfoxidation | ELREQLDMAGARVRE HHHHHHHHHHHHHHH | 5.15 | 30846556 | |
| 501 | Ubiquitination | ARVREAQKRVEAAQE HHHHHHHHHHHHHHH | 66.51 | 21906983 | |
| 501 (in isoform 1) | Ubiquitination | - | 66.51 | 21906983 | |
| 509 | Phosphorylation | RVEAAQETVADYQQT HHHHHHHHHHHHHHH | 14.65 | 28509920 | |
| 513 | Phosphorylation | AQETVADYQQTIKKY HHHHHHHHHHHHHHH | 7.87 | 28509920 | |
| 516 | Phosphorylation | TVADYQQTIKKYRQL HHHHHHHHHHHHHHH | 21.17 | 28509920 | |
| 518 | Malonylation | ADYQQTIKKYRQLTA HHHHHHHHHHHHHHH | 47.33 | 26320211 | |
| 518 | Ubiquitination | ADYQQTIKKYRQLTA HHHHHHHHHHHHHHH | 47.33 | - | |
| 541 | Phosphorylation | LTNQQEASVERQQQP HHHHHHHHHHHHCCC | 24.61 | 21815630 | |
| 556 | Ubiquitination | PPETFDFKIKFAETK CCCCCCEEEEEHHHH | 46.99 | - | |
| 558 | Ubiquitination | ETFDFKIKFAETKAH CCCCEEEEEHHHHHH | 38.83 | - | |
| 563 | Ubiquitination | KIKFAETKAHAKAIE EEEEHHHHHHHHHHH | 29.67 | - | |
| 567 | Malonylation | AETKAHAKAIEMELR HHHHHHHHHHHHHHH | 39.78 | 26320211 | |
| 567 | Ubiquitination | AETKAHAKAIEMELR HHHHHHHHHHHHHHH | 39.78 | - | |
| 571 | Sulfoxidation | AHAKAIEMELRQMEV HHHHHHHHHHHHHHH | 4.86 | 30846556 | |
| 576 | Sulfoxidation | IEMELRQMEVAQANR HHHHHHHHHHHHHHH | 3.46 | 30846556 | |
| 586 | Phosphorylation | AQANRHMSLLTAFMP HHHHHCHHHHHHHCC | 17.69 | 27251275 | |
| 589 | Phosphorylation | NRHMSLLTAFMPDSF HHCHHHHHHHCCHHH | 24.12 | 27251275 | |
| 595 | Phosphorylation | LTAFMPDSFLRPGGD HHHHCCHHHCCCCCC | 21.95 | 27251275 | |
| 618 | Ubiquitination | LMPRLICKAELIRKQ HHHHHHHHHHHHHHH | 37.59 | - | |
| 629 | Ubiquitination | IRKQAQEKFELSENC HHHHHHHHCCCCCCC | 31.87 | - | |
| 637 | Phosphorylation | FELSENCSERPGLRG CCCCCCCCCCCCCCC | 48.50 | 18452278 | |
| 687 | Phosphorylation | DVYKKVGSLYPEMSA HHHHHHHHHCHHCCH | 27.93 | - | |
| 693 | Phosphorylation | GSLYPEMSAHERSLD HHHCHHCCHHHHHHH | 25.47 | - | |
| 722 | Ubiquitination | VNVEPLTKAIKYYQH CCHHHHHHHHHHHHH | 56.66 | - | |
| 725 | Acetylation | EPLTKAIKYYQHLYS HHHHHHHHHHHHHHH | 42.64 | 25038526 | |
| 919 | Phosphorylation | YDAERPPSKPPPVEL CCCCCCCCCCCCHHH | 61.55 | 28348404 | |
| 920 | Ubiquitination | DAERPPSKPPPVELR CCCCCCCCCCCHHHH | 68.28 | - | |
| 924 (in isoform 5) | Phosphorylation | - | 15.51 | 28258704 | |
| 927 (in isoform 5) | Phosphorylation | - | 14.52 | 28258704 | |
| 936 | Phosphorylation | AALRAEITDAEGLGL HHHHHHCCCCCCCCC | 22.21 | - | |
| 941 (in isoform 5) | Phosphorylation | - | 5.67 | 28258704 | |
| 960 | Malonylation | KELKKSLKIKGEELS HHHHHHCCCCCHHHH | 49.84 | 26320211 | |
| 962 | 2-Hydroxyisobutyrylation | LKKSLKIKGEELSEA HHHHCCCCCHHHHHH | 59.70 | - | |
| 962 | Ubiquitination | LKKSLKIKGEELSEA HHHHCCCCCHHHHHH | 59.70 | - | |
| 967 | Phosphorylation | KIKGEELSEANVRLS CCCCHHHHHHHHHHH | 37.63 | 25921289 | |
| 974 | Phosphorylation | SEANVRLSLLEKKLD HHHHHHHHHHHHHHH | 21.97 | 24719451 | |
| 978 | 2-Hydroxyisobutyrylation | VRLSLLEKKLDSAAK HHHHHHHHHHHHHCH | 59.62 | - | |
| 978 | Ubiquitination | VRLSLLEKKLDSAAK HHHHHHHHHHHHHCH | 59.62 | - | |
| 982 | Phosphorylation | LLEKKLDSAAKDADE HHHHHHHHHCHHHHH | 40.33 | - | |
| 986 (in isoform 2) | Ubiquitination | - | 55.30 | 21906983 | |
| 993 | Ubiquitination | DADERIEKVQTRLEE HHHHHHHHHHHHHHH | 36.95 | - | |
| 996 | Phosphorylation | ERIEKVQTRLEETQA HHHHHHHHHHHHHHH | 39.96 | 21955146 | |
| 999 (in isoform 2) | Ubiquitination | - | 56.56 | - | |
| 1001 | Phosphorylation | VQTRLEETQALLRKK HHHHHHHHHHHHHHH | 15.12 | 21406692 | |
| 1016 | Sulfoxidation | EKEFEETMDALQADI HHHHHHHHHHHHHCH | 2.99 | 30846556 | |
| 1017 (in isoform 2) | Ubiquitination | - | 52.09 | - | |
| 1021 (in isoform 3) | Phosphorylation | - | 19.31 | 28258704 | |
| 1024 (in isoform 3) | Phosphorylation | - | 47.78 | 28258704 | |
| 1034 | Ubiquitination | EAEKAELKQRLNSQS HHHHHHHHHHHHHHC | 25.52 | - | |
| 1038 (in isoform 3) | Phosphorylation | - | 39.94 | 28258704 | |
| 1038 (in isoform 4) | Phosphorylation | - | 39.94 | 28258704 | |
| 1041 | Phosphorylation | KQRLNSQSKRTIEGL HHHHHHHCCHHHHCC | 24.75 | - | |
| 1041 (in isoform 4) | Phosphorylation | - | 24.75 | 28258704 | |
| 1045 (in isoform 2) | Ubiquitination | - | 4.61 | 21906983 | |
| 1055 (in isoform 4) | Phosphorylation | - | 21.23 | 28258704 | |
| 1059 (in isoform 2) | Ubiquitination | - | 1.82 | 21906983 | |
| 1090 | Phosphorylation | GPGLVKDSPLLLQQI CCCCCCCCHHHHHHH | 16.24 | 28555341 | |
| 1100 | Sulfoxidation | LLQQISAMRLHISQL HHHHHHHHHHHHHHH | 3.60 | 30846556 | |
| 1101 (in isoform 2) | Ubiquitination | - | 23.88 | 21906983 | |
| 1112 | Phosphorylation | SQLQHENSILKGAQM HHHHHHCCCCHHHHH | 26.72 | 24719451 | |
| 1115 | Ubiquitination | QHENSILKGAQMKAS HHHCCCCHHHHHHHH | 51.00 | - | |
| 1120 | Ubiquitination | ILKGAQMKASLASLP CCHHHHHHHHHHHCC | 23.81 | 21906983 | |
| 1120 (in isoform 1) | Ubiquitination | - | 23.81 | 21906983 | |
| 1133 | Ubiquitination | LPPLHVAKLSHEGPG CCCEEEEECCCCCCC | 49.81 | - | |
| 1149 | Phosphorylation | ELPAGALYRKTSQLL CCCHHHHHHHHHHHH | 14.99 | - | |
| 1151 | Ubiquitination | PAGALYRKTSQLLET CHHHHHHHHHHHHHH | 38.68 | - | |
| 1152 | Phosphorylation | AGALYRKTSQLLETL HHHHHHHHHHHHHHH | 16.83 | 28450419 | |
| 1153 | Phosphorylation | GALYRKTSQLLETLN HHHHHHHHHHHHHHH | 23.13 | 28450419 | |
| 1158 | Phosphorylation | KTSQLLETLNQLSTH HHHHHHHHHHHHCCC | 30.86 | 27080861 | |
| 1174 | Phosphorylation | HVVDITRTSPAAKSP EEEECCCCCCCCCCH | 30.34 | 28555341 | |
| 1179 | Ubiquitination | TRTSPAAKSPSAQLM CCCCCCCCCHHHHHH | 66.07 | 21906983 | |
| 1179 (in isoform 1) | Ubiquitination | - | 66.07 | 21906983 | |
| 1180 | Phosphorylation | RTSPAAKSPSAQLME CCCCCCCCHHHHHHH | 21.25 | 25850435 | |
| 1182 | Phosphorylation | SPAAKSPSAQLMEQV CCCCCCHHHHHHHHH | 35.42 | 25850435 | |
| 1186 | Sulfoxidation | KSPSAQLMEQVAQLK CCHHHHHHHHHHHHH | 1.94 | 21406390 | |
| 1193 | Ubiquitination | MEQVAQLKSLSDTVE HHHHHHHHHHHHHHH | 36.95 | 21906983 | |
| 1193 (in isoform 1) | Ubiquitination | - | 36.95 | 21906983 | |
| 1201 | Ubiquitination | SLSDTVEKLKDEVLK HHHHHHHHHHHHHHH | 57.40 | - | |
| 1203 | Ubiquitination | SDTVEKLKDEVLKET HHHHHHHHHHHHHHH | 64.01 | - | |
| 1208 | Ubiquitination | KLKDEVLKETVSQRP HHHHHHHHHHHHCCC | 57.42 | - | |
| 1235 | Ubiquitination | SSAFLRAKEEQQDDT CHHHHHCCHHHCCCC | 56.18 | 2190698 | |
| 1235 (in isoform 1) | Ubiquitination | - | 56.18 | 21906983 | |
| 1244 | Phosphorylation | EQQDDTVYMGKVTFS HHCCCCEEEEEEEEE | 11.40 | 25839225 | |
| 1245 | Sulfoxidation | QQDDTVYMGKVTFSC HCCCCEEEEEEEEEE | 3.49 | 30846556 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
| 19 | S | Phosphorylation | Kinase | AURKA | O14965 | GPS |
| 145 | T | Phosphorylation | Kinase | SLK | Q9H2G2 | Uniprot |
| 146 | T | Phosphorylation | Kinase | SLK | Q9H2G2 | Uniprot |
| 147 | T | Phosphorylation | Kinase | SLK | Q9H2G2 | Uniprot |
| 179 | S | Phosphorylation | Kinase | PLK1 | P53350 | Uniprot |
| 212 | S | Phosphorylation | Kinase | CDK1 | P06493 | Uniprot |
| - | K | Ubiquitination | E3 ubiquitin ligase | FBXL5 | Q9UKA1 | PMID:17532294 |
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DCTN1_HUMAN !! | ||||||
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 607641 | Neuronopathy, distal hereditary motor, 7B (HMN7B) | |||||
| 105400 | Amyotrophic lateral sclerosis (ALS) | |||||
| 168605 | Perry syndrome (PERRYS) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
| Acetylation | |
| Reference | PubMed |
| "Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-230, AND MASS SPECTROMETRY. | |
| Phosphorylation | |
| Reference | PubMed |
| "Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105 AND THR-108, ANDMASS SPECTROMETRY. | |
