NEBL_HUMAN - dbPTM
NEBL_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NEBL_HUMAN
UniProt AC O76041
Protein Name Nebulette
Gene Name NEBL
Organism Homo sapiens (Human).
Sequence Length 1014
Subcellular Localization Isoform 2: Cytoplasm .
Protein Description Binds to actin and plays an important role in the assembly of the Z-disk. May functionally link sarcomeric actin to the desmin intermediate filaments in the heart muscle sarcomeres. [PubMed: 27733623 Isoform 2 might play a role in the assembly of focal adhesion]
Protein Sequence MRVPVFEDIKDETEEEKIGEEENEEDQVFYKPVIEDLSMELARKCTELISDIRYKEEFKKSKDKCTFVTDSPMLNHVKNIGAFISEAKYKGTIKADLSNSLYKRMPATIDSVFAGEVTQLQSEVAYKQKHDAAKGFSDYAHMKEPPEVKHAMEVNKHQSNISYRKDVQDTHTYSAELDRPDIKMATQISKIISNAEYKKGQGIMNKEPAVIGRPDFEHAVEASKLSSQIKYKEKFDNEMKDKKHHYNPLESASFRQNQLAATLASNVKYKKDIQNMHDPVSDLPNLLFLDHVLKASKMLSGREYKKLFEENKGMYHFDADAVEHLHHKGNAVLQSQVKYKEEYEKNKGKPMLEFVETPSYQASKEAQKMQSEKVYKEDFEKEIKGRSSLDLDKTPEFLHVKYITNLLREKEYKKDLENEIKGKGMELNSEVLDIQRAKRASEMASEKEYKKDLESIIKGKGMQAGTDTLEMQHAKKAAEIASEKDYKRDLETEIKGKGMQVSTDTLDVQRAKKASEMASQKQYKKDLENEIKGKGMQVSMDIPDILRAKRTSEIYSQRKYKDEAEKMLSNYSTIADTPEIQRIKTTQQNISAVFYKKEVGAGTAVKDSPEIERVKKNQQNISSVKYKEEIKHATAISDPPELKRVKENQKNISNLQYKEQNYKATPVSMTPEIERVRRNQEQLSAVKYKGELQRGTAISDPPELKRAKENQKNISNVYYRGQLGRATTLSVTPEMERVKKNQENISSVKYTQDHKQMKGRPSLILDTPAMRHVKEAQNHISMVKYHEDFEKTKGRGFTPVVDDPVTERVRKNTQVVSDAAYKGVHPHIVEMDRRPGIIVDLKVWRTDPGSIFDLDPLEDNIQSRSLHMLSEKASHYRRHWSRSHSSSTFGTGLGDDRSEISEIYPSFSCCSEVTRPSDEGAPVLPGAYQQSHSQGYGYMHQTSVSSMRSMQHSPNLRTYRAMYDYSAQDEDEVSFRDGDYIVNVQPIDDGWMYGTVQRTGRTGMLPANYIEFVN
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
13PhosphorylationFEDIKDETEEEKIGE
CCCCCCCCHHHHCCC		59.8528102081
30PhosphorylationNEEDQVFYKPVIEDL
CHHHCCCHHHHHHHH		18.6126074081
38PhosphorylationKPVIEDLSMELARKC
HHHHHHHHHHHHHHH		23.6426074081
45 (in isoform 2)Ubiquitination-2.73-
46PhosphorylationMELARKCTELISDIR
HHHHHHHHHHHHHHH		36.5426074081
47 (in isoform 2)Phosphorylation-54.28-
50PhosphorylationRKCTELISDIRYKEE
HHHHHHHHHHHCHHH		39.3424719451
52 (in isoform 2)Phosphorylation-4.07-
54PhosphorylationELISDIRYKEEFKKS
HHHHHHHCHHHHHCC		24.0826074081
57 (in isoform 2)Phosphorylation-59.62-
68 (in isoform 2)Phosphorylation-2.9127050516
78 (in isoform 2)Phosphorylation-34.9824076635
89PhosphorylationAFISEAKYKGTIKAD
HHHCCCCCCCEEEEC		23.00-
96 (in isoform 2)Methylation-45.7024129315
98PhosphorylationGTIKADLSNSLYKRM
CEEEECCCCHHHHHC		25.5627642862
99 (in isoform 2)Phosphorylation-43.2427499020
102 (in isoform 2)Phosphorylation-9.0722617229
102PhosphorylationADLSNSLYKRMPATI
ECCCCHHHHHCCCCC		9.0727642862
103AcetylationDLSNSLYKRMPATID
CCCCHHHHHCCCCCH		47.7330590721
104 (in isoform 2)Phosphorylation-23.8225849741
139PhosphorylationAAKGFSDYAHMKEPP
HHCCCCCCCCCCCCH		9.37-
163PhosphorylationKHQSNISYRKDVQDT
CCCCCCCCCCCCCCC		20.2017929957
174PhosphorylationVQDTHTYSAELDRPD
CCCCCEEEEECCCCC		19.2017929957
184 (in isoform 2)Phosphorylation-5.0827251275
186PhosphorylationRPDIKMATQISKIIS
CCCHHHHHHHHHHHH		23.9622617229
187 (in isoform 2)Phosphorylation-28.5528348404
189PhosphorylationIKMATQISKIISNAE
HHHHHHHHHHHHCCC		14.1622617229
189 (in isoform 2)Phosphorylation-14.1628348404
192 (in isoform 2)Phosphorylation-2.7427642862
193PhosphorylationTQISKIISNAEYKKG
HHHHHHHHCCCHHCC		33.2022617229
194 (in isoform 2)Phosphorylation-26.7827251275
197PhosphorylationKIISNAEYKKGQGIM
HHHHCCCHHCCCCCC		18.6522617229
198 (in isoform 2)Phosphorylation-41.7728348404
199 (in isoform 2)Phosphorylation-56.4128348404
201 (in isoform 2)Phosphorylation-47.3127251275
202 (in isoform 2)Phosphorylation-29.7627251275
226PhosphorylationAVEASKLSSQIKYKE
HHHHHHHHHHHCHHH		24.7524719451
230AcetylationSKLSSQIKYKEKFDN
HHHHHHHCHHHHHCC		42.507683269
232AcetylationLSSQIKYKEKFDNEM
HHHHHCHHHHHCCHH		49.807683281
234AcetylationSQIKYKEKFDNEMKD
HHHCHHHHHCCHHCC		54.597683293
269PhosphorylationTLASNVKYKKDIQNM
HHHHCCCCHHHHHCC		20.9818083107
271MethylationASNVKYKKDIQNMHD
HHCCCCHHHHHCCCC		57.90-
357PhosphorylationPMLEFVETPSYQASK
CCEEEECCCCHHHHH		16.5428302921
359PhosphorylationLEFVETPSYQASKEA
EEEECCCCHHHHHHH		36.9828302921
360PhosphorylationEFVETPSYQASKEAQ
EEECCCCHHHHHHHH		14.8628302921
363PhosphorylationETPSYQASKEAQKMQ
CCCCHHHHHHHHHHH		18.5928302921
394PhosphorylationSSLDLDKTPEFLHVK
CCCCCCCCCCHHHHH		27.93-
455PhosphorylationEYKKDLESIIKGKGM
HHHHHHHHHHHCCCC		36.5924719451
486PhosphorylationEIASEKDYKRDLETE
HHHCHHHHHHHHHHH		20.9918083107
487AcetylationIASEKDYKRDLETEI
HHCHHHHHHHHHHHH		49.9630590717
513"N6,N6-dimethyllysine"LDVQRAKKASEMASQ
HHHHHHHHHHHHHHH		57.04-
513MethylationLDVQRAKKASEMASQ
HHHHHHHHHHHHHHH		57.04-
515PhosphorylationVQRAKKASEMASQKQ
HHHHHHHHHHHHHHH		36.4629083192
519PhosphorylationKKASEMASQKQYKKD
HHHHHHHHHHHHHHH		36.2829083192
524"N6,N6-dimethyllysine"MASQKQYKKDLENEI
HHHHHHHHHHHHHHH		37.00-
524MethylationMASQKQYKKDLENEI
HHHHHHHHHHHHHHH		37.00-
525AcetylationASQKQYKKDLENEIK
HHHHHHHHHHHHHHC		63.7120167786
525"N6,N6-dimethyllysine"ASQKQYKKDLENEIK
HHHHHHHHHHHHHHC		63.71-
525MethylationASQKQYKKDLENEIK
HHHHHHHHHHHHHHC		63.71-
532AcetylationKDLENEIKGKGMQVS
HHHHHHHCCCCCEEE		48.687683061
585PhosphorylationPEIQRIKTTQQNISA
HHHHHCCCCCCCEEE		27.71-
603PhosphorylationKKEVGAGTAVKDSPE
ECCCCCCCCCCCCHH		27.9523532336
608O-linked_GlycosylationAGTAVKDSPEIERVK
CCCCCCCCHHHHHHH		20.7930379171
616AcetylationPEIERVKKNQQNISS
HHHHHHHHHCCCCCC		58.0724886705
622PhosphorylationKKNQQNISSVKYKEE
HHHCCCCCCCCHHHH		36.3129978859
623PhosphorylationKNQQNISSVKYKEEI
HHCCCCCCCCHHHHH		20.8729978859
626PhosphorylationQNISSVKYKEEIKHA
CCCCCCCHHHHHCHH		22.8329978859
699O-linked_GlycosylationLQRGTAISDPPELKR
CCCCCCCCCCHHHHH		41.4230379171
708MethylationPPELKRAKENQKNIS
CHHHHHHHHHCCCCC		62.32-
708TrimethylationPPELKRAKENQKNIS
CHHHHHHHHHCCCCC		62.32-
712MethylationKRAKENQKNISNVYY
HHHHHHCCCCCCEEC		68.76-
712TrimethylationKRAKENQKNISNVYY
HHHHHHCCCCCCEEC		68.76-
718PhosphorylationQKNISNVYYRGQLGR
CCCCCCEECCCCCCC		7.5329116813
719PhosphorylationKNISNVYYRGQLGRA
CCCCCEECCCCCCCC		12.1829116813
727PhosphorylationRGQLGRATTLSVTPE
CCCCCCCEECCCCHH		27.2323403867
728PhosphorylationGQLGRATTLSVTPEM
CCCCCCEECCCCHHH		18.9523403867
730PhosphorylationLGRATTLSVTPEMER
CCCCEECCCCHHHHH		23.1223403867
732PhosphorylationRATTLSVTPEMERVK
CCEECCCCHHHHHHH		15.3423403867
767PhosphorylationRPSLILDTPAMRHVK
CCEEEECCHHHHHHH		14.9728787133
795MethylationDFEKTKGRGFTPVVD
HHHHCCCCCCCCCCC		38.3124129315
806PhosphorylationPVVDDPVTERVRKNT
CCCCCCCCHHHHHHC		24.38-
808MethylationVDDPVTERVRKNTQV
CCCCCCHHHHHHCCC		24.95115484777
813PhosphorylationTERVRKNTQVVSDAA
CHHHHHHCCCCCHHH		26.2728857561
817PhosphorylationRKNTQVVSDAAYKGV
HHHCCCCCHHHHCCC		23.7527499020
821PhosphorylationQVVSDAAYKGVHPHI
CCCCHHHHCCCCCCC		15.2527259358
928PhosphorylationAPVLPGAYQQSHSQG
CCCCCCCCCCCCCCC		17.01-
949PhosphorylationTSVSSMRSMQHSPNL
CCHHHHHHCCCCCCH		17.7230242111
953PhosphorylationSMRSMQHSPNLRTYR
HHHHCCCCCCHHHEE		9.8922617229
958PhosphorylationQHSPNLRTYRAMYDY
CCCCCHHHEEECCCC		22.1126434776
959PhosphorylationHSPNLRTYRAMYDYS
CCCCHHHEEECCCCC		7.0226434776
963PhosphorylationLRTYRAMYDYSAQDE
HHHEEECCCCCCCCC		15.6726434776
965PhosphorylationTYRAMYDYSAQDEDE
HEEECCCCCCCCCCC		6.6026434776
966PhosphorylationYRAMYDYSAQDEDEV
EEECCCCCCCCCCCC		19.2926434776
974PhosphorylationAQDEDEVSFRDGDYI
CCCCCCCCCCCCCEE		16.7128674419
980PhosphorylationVSFRDGDYIVNVQPI
CCCCCCCEEEEEEEC		16.58-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NEBL_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NEBL_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NEBL_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
XIRP2_HUMANXIRP2physical
23985323
XIRP1_HUMANXIRP1physical
23985323
GMCL1_HUMANGMCL1physical
25416956
CC136_HUMANCCDC136physical
25416956
LZTS2_HUMANLZTS2physical
25416956
MIPO1_HUMANMIPOL1physical
25416956
FAM9B_HUMANFAM9Bphysical
25416956
NUTM1_HUMANNUTM1physical
25416956
PRP16_HUMANDHX38physical
28514442
NNRD_HUMANCARKDphysical
28514442
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NEBL_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory