PRP16_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PRP16_HUMAN
• UniProt AC: Q92620
• Protein Name: Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16
• Gene Name: DHX38
• Organism: Homo sapiens (Human).
• Sequence Length: 1227
• Subcellular Localization: Nucleus.
• Protein Description: Probable ATP-binding RNA helicase involved in pre-mRNA splicing..
• Protein Sequence: MGDTSEDASIHRLEGTDLDCQVGGLICKSKSAASEQHVFKAPAPRPSLLGLDLLASLKRREREEKDDGEDKKKSKVSSYKDWEESKDDQKDAEEEGGDQAGQNIRKDRHYRSARVETPSHPGGVSEEFWERSRQRERERREHGVYASSKEEKDWKKEKSRDRDYDRKRDRDERDRSRHSSRSERDGGSERSSRRNEPESPRHRPKDAATPSRSTWEEEDSGYGSSRRSQWESPSPTPSYRDSERSHRLSTRDRDRSVRGKYSDDTPLPTPSYKYNEWADDRRHLGSTPRLSRGRGRREEGEEGISFDTEEERQQWEDDQRQADRDWYMMDEGYDEFHNPLAYSSEDYVRRREQHLHKQKQKRISAQRRQINEDNERWETNRMLTSGVVHRLEVDEDFEEDNAAKVHLMVHNLVPPFLDGRIVFTKQPEPVIPVKDATSDLAIIARKGSQTVRKHREQKERKKAQHKHWELAGTKLGDIMGVKKEEEPDKAVTEDGKVDYRTEQKFADHMKRKSEASSEFAKKKSILEQRQYLPIFAVQQELLTIIRDNSIVIVVGETGSGKTTQLTQYLHEDGYTDYGMIGCTQPRRVAAMSVAKRVSEEMGGNLGEEVGYAIRFEDCTSENTLIKYMTDGILLRESLREADLDHYSAIIMDEAHERSLNTDVLFGLLREVVARRSDLKLIVTSATMDAEKFAAFFGNVPIFHIPGRTFPVDILFSKTPQEDYVEAAVKQSLQVHLSGAPGDILIFMPGQEDIEVTSDQIVEHLEELENAPALAVLPIYSQLPSDLQAKIFQKAPDGVRKCIVATNIAETSLTVDGIMFVIDSGYCKLKVFNPRIGMDALQIYPISQANANQRSGRAGRTGPGQCFRLYTQSAYKNELLTTTVPEIQRTNLANVVLLLKSLGVQDLLQFHFMDPPPEDNMLNSMYQLWILGALDNTGGLTSTGRLMVEFPLDPALSKMLIVSCDMGCSSEILLIVSMLSVPAIFYRPKGREEESDQIREKFAVPESDHLTYLNVYLQWKNNNYSTIWCNDHFIHAKAMRKVREVRAQLKDIMVQQRMSLASCGTDWDIVRKCICAAYFHQAAKLKGIGEYVNIRTGMPCHLHPTSSLFGMGYTPDYIVYHELVMTTKEYMQCVTAVDGEWLAELGPMFYSVKQAGKSRQENRRRAKEEASAMEEEMALAEEQLRARRQEQEKRSPLGSVRSTKIYTPGRKEQGEPMTPRRTPARFGL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGDTSEDAS ------CCCCCHHCC	59.20	19413330
30	Acetylation	GGLICKSKSAASEQH CCEEECCCCCCCCCC	29.61	27452117
31	Phosphorylation	GLICKSKSAASEQHV CEEECCCCCCCCCCC	35.84	22210691
34	Phosphorylation	CKSKSAASEQHVFKA ECCCCCCCCCCCCCC	37.19	24719451
47	Phosphorylation	KAPAPRPSLLGLDLL CCCCCCHHHHHHHHH	37.19	24719451
56	Phosphorylation	LGLDLLASLKRRERE HHHHHHHHHHHHHHH	34.10	28450419
58	Acetylation	LDLLASLKRREREEK HHHHHHHHHHHHHHC	47.08	30588135
74	Phosphorylation	DGEDKKKSKVSSYKD CCCCCCHHHCHHHHC	47.36	29449344
77	Phosphorylation	DKKKSKVSSYKDWEE CCCHHHCHHHHCHHH	31.52	29449344
78	Phosphorylation	KKKSKVSSYKDWEES CCHHHCHHHHCHHHC	38.91	29449344
79	Phosphorylation	KKSKVSSYKDWEESK CHHHCHHHHCHHHCH	12.88	29449344
85	Phosphorylation	SYKDWEESKDDQKDA HHHCHHHCHHHHHHH	29.84	22468782
105	Ubiquitination	DQAGQNIRKDRHYRS CHHHHHHHCCCCCCC	42.23	-
112	Phosphorylation	RKDRHYRSARVETPS HCCCCCCCCCEECCC	17.17	23312004
117	Phosphorylation	YRSARVETPSHPGGV CCCCCEECCCCCCCC	27.51	23927012
119	Phosphorylation	SARVETPSHPGGVSE CCCEECCCCCCCCCH	50.13	23403867
125	Phosphorylation	PSHPGGVSEEFWERS CCCCCCCCHHHHHHH	34.38	23403867
141	Ubiquitination	QRERERREHGVYASS HHHHHHHHHCCCCCC	51.74	-
145	Phosphorylation	ERREHGVYASSKEEK HHHHHCCCCCCHHHH	12.83	-
149	Sumoylation	HGVYASSKEEKDWKK HCCCCCCHHHHHHHH	68.35	-
149	Sumoylation	HGVYASSKEEKDWKK HCCCCCCHHHHHHHH	68.35	-
176	Phosphorylation	DRDERDRSRHSSRSE CHHHHHHHHHHCHHC	38.34	17081983
179	Phosphorylation	ERDRSRHSSRSERDG HHHHHHHHCHHCCCC	26.74	20068231
180	Phosphorylation	RDRSRHSSRSERDGG HHHHHHHCHHCCCCC	33.43	20068231
182	O-linked_Glycosylation	RSRHSSRSERDGGSE HHHHHCHHCCCCCCC	38.64	30379171
187	Ubiquitination	SRSERDGGSERSSRR CHHCCCCCCCCCCCC	30.53	-
188	O-linked_Glycosylation	RSERDGGSERSSRRN HHCCCCCCCCCCCCC	35.05	30379171
199	Phosphorylation	SRRNEPESPRHRPKD CCCCCCCCCCCCCCC	37.64	27794612
209	Phosphorylation	HRPKDAATPSRSTWE CCCCCCCCCCCCCCC	24.42	27422710
211	Phosphorylation	PKDAATPSRSTWEEE CCCCCCCCCCCCCCC	34.21	28450419
213	Phosphorylation	DAATPSRSTWEEEDS CCCCCCCCCCCCCCC	42.06	28450419
214	Phosphorylation	AATPSRSTWEEEDSG CCCCCCCCCCCCCCC	35.47	30576142
220	Phosphorylation	STWEEEDSGYGSSRR CCCCCCCCCCCCCCC	36.88	30576142
222	Phosphorylation	WEEEDSGYGSSRRSQ CCCCCCCCCCCCCCC	20.13	27642862
224	Phosphorylation	EEDSGYGSSRRSQWE CCCCCCCCCCCCCCC	16.52	30576142
225	Phosphorylation	EDSGYGSSRRSQWES CCCCCCCCCCCCCCC	27.61	30576142
228	Phosphorylation	GYGSSRRSQWESPSP CCCCCCCCCCCCCCC	38.24	28450419
232	Phosphorylation	SRRSQWESPSPTPSY CCCCCCCCCCCCCCC	27.93	25159151
234	Phosphorylation	RSQWESPSPTPSYRD CCCCCCCCCCCCCCC	51.16	25159151
236	Phosphorylation	QWESPSPTPSYRDSE CCCCCCCCCCCCCCH	29.24	28450419
238	Phosphorylation	ESPSPTPSYRDSERS CCCCCCCCCCCCHHH	34.97	30576142
239	Phosphorylation	SPSPTPSYRDSERSH CCCCCCCCCCCHHHH	21.46	28450419
242	Phosphorylation	PTPSYRDSERSHRLS CCCCCCCCHHHHCCC	26.38	28450419
260	Acetylation	RDRSVRGKYSDDTPL CCCCCCCCCCCCCCC	30.89	19608861
260	Methylation	RDRSVRGKYSDDTPL CCCCCCCCCCCCCCC	30.89	19608861
261	Phosphorylation	DRSVRGKYSDDTPLP CCCCCCCCCCCCCCC	21.84	23312004
262	Phosphorylation	RSVRGKYSDDTPLPT CCCCCCCCCCCCCCC	32.28	27732954
265	Phosphorylation	RGKYSDDTPLPTPSY CCCCCCCCCCCCCCC	31.54	21815630
269	Phosphorylation	SDDTPLPTPSYKYNE CCCCCCCCCCCCCCC	32.33	28387310
271	Phosphorylation	DTPLPTPSYKYNEWA CCCCCCCCCCCCCCC	36.41	23312004
272	Phosphorylation	TPLPTPSYKYNEWAD CCCCCCCCCCCCCCC	20.78	-
286	Phosphorylation	DDRRHLGSTPRLSRG CCCCCCCCCCCCCCC	41.41	23312004
287	Phosphorylation	DRRHLGSTPRLSRGR CCCCCCCCCCCCCCC	15.61	20068231
289	Methylation	RHLGSTPRLSRGRGR CCCCCCCCCCCCCCC	45.44	-
291	Phosphorylation	LGSTPRLSRGRGRRE CCCCCCCCCCCCCCC	33.69	25159151
305	Phosphorylation	EEGEEGISFDTEEER CCCCCCCCCCCHHHH	28.11	29457462
327	Phosphorylation	RQADRDWYMMDEGYD HHHHHCHHHCCCCCC	6.20	24043423
333	Phosphorylation	WYMMDEGYDEFHNPL HHHCCCCCCCCCCCC	15.39	24043423
342	Phosphorylation	EFHNPLAYSSEDYVR CCCCCCCCCCHHHHH	22.03	24043423
343	Phosphorylation	FHNPLAYSSEDYVRR CCCCCCCCCHHHHHH	22.96	24043423
344	Phosphorylation	HNPLAYSSEDYVRRR CCCCCCCCHHHHHHH	23.08	24043423
347	Phosphorylation	LAYSSEDYVRRREQH CCCCCHHHHHHHHHH	7.57	24043423
361	Ubiquitination	HLHKQKQKRISAQRR HHHHHHHHHHHHHHH	59.75	-
384	Phosphorylation	WETNRMLTSGVVHRL HHHHHHHHHCCEEEE	17.68	-
385	Phosphorylation	ETNRMLTSGVVHRLE HHHHHHHHCCEEEEE	26.15	28555341
425	Sumoylation	DGRIVFTKQPEPVIP CCEEEEECCCCCCEE	53.01	-
425	Sumoylation	DGRIVFTKQPEPVIP CCEEEEECCCCCCEE	53.01	-
425	Ubiquitination	DGRIVFTKQPEPVIP CCEEEEECCCCCCEE	53.01	33845483
434	Ubiquitination	PEPVIPVKDATSDLA CCCCEECCCCCCCEE	35.97	29967540
437	Phosphorylation	VIPVKDATSDLAIIA CEECCCCCCCEEHHH	32.67	20873877
438	Phosphorylation	IPVKDATSDLAIIAR EECCCCCCCEEHHHH	32.14	20873877
448	Phosphorylation	AIIARKGSQTVRKHR EHHHHCCCHHHHHHH	26.22	23882029
450	Phosphorylation	IARKGSQTVRKHREQ HHHCCCHHHHHHHHH	24.79	23882029
466	Ubiquitination	ERKKAQHKHWELAGT HHHHHHHHHHHHHCC	38.03	29967540
478	Ubiquitination	AGTKLGDIMGVKKEE HCCHHHHHCCCCCCC	2.16	-
482	Sumoylation	LGDIMGVKKEEEPDK HHHHCCCCCCCCCCC	49.06	-
482	Sumoylation	LGDIMGVKKEEEPDK HHHHCCCCCCCCCCC	49.06	28112733
483	Sumoylation	GDIMGVKKEEEPDKA HHHCCCCCCCCCCCC	68.87	28112733
488	Ubiquitination	VKKEEEPDKAVTEDG CCCCCCCCCCCCCCC	55.62	24816145
504	Sumoylation	VDYRTEQKFADHMKR CCHHHHHHHHHHHHH	35.97	-
504	Sumoylation	VDYRTEQKFADHMKR CCHHHHHHHHHHHHH	35.97	28112733
504	Ubiquitination	VDYRTEQKFADHMKR CCHHHHHHHHHHHHH	35.97	29967540
510	Ubiquitination	QKFADHMKRKSEASS HHHHHHHHHHHHHHH	53.94	-
513	Phosphorylation	ADHMKRKSEASSEFA HHHHHHHHHHHHHHH	42.29	26462736
516	Phosphorylation	MKRKSEASSEFAKKK HHHHHHHHHHHHHHH	26.75	26270265
517	Phosphorylation	KRKSEASSEFAKKKS HHHHHHHHHHHHHHH	43.72	26270265
521	Acetylation	EASSEFAKKKSILEQ HHHHHHHHHHHHHHH	67.08	19608861
523	2-Hydroxyisobutyrylation	SSEFAKKKSILEQRQ HHHHHHHHHHHHHHC	41.86	-
523	Ubiquitination	SSEFAKKKSILEQRQ HHHHHHHHHHHHHHC	41.86	24816145
560	Ubiquitination	VVGETGSGKTTQLTQ EEECCCCCCHHHHHH	32.45	24816145
562	Phosphorylation	GETGSGKTTQLTQYL ECCCCCCHHHHHHHH	24.25	26552605
563	Phosphorylation	ETGSGKTTQLTQYLH CCCCCCHHHHHHHHC	25.68	26552605
566	Phosphorylation	SGKTTQLTQYLHEDG CCCHHHHHHHHCCCC	12.83	26552605
568	Phosphorylation	KTTQLTQYLHEDGYT CHHHHHHHHCCCCCC	12.56	26552605
574	Phosphorylation	QYLHEDGYTDYGMIG HHHCCCCCCCCCEEC	14.57	26552605
575	Phosphorylation	YLHEDGYTDYGMIGC HHCCCCCCCCCEECC	28.42	26552605
577	Phosphorylation	HEDGYTDYGMIGCTQ CCCCCCCCCEECCCC	10.78	26552605
583	Phosphorylation	DYGMIGCTQPRRVAA CCCEECCCCHHHHHH	36.07	26552605
595	Acetylation	VAAMSVAKRVSEEMG HHHHHHHHHHHHHHC	51.69	26051181
595	Ubiquitination	VAAMSVAKRVSEEMG HHHHHHHHHHHHHHC	51.69	24816145
637	Phosphorylation	DGILLRESLREADLD HCHHHCHHHHHCCCC	26.71	28188228
679	Acetylation	VARRSDLKLIVTSAT HHHHCCCEEEEEECC	40.95	19820289
687	Sulfoxidation	LIVTSATMDAEKFAA EEEEECCCCHHHHHH	4.61	21406390
708	Phosphorylation	IFHIPGRTFPVDILF EEECCCCCCCCEEEE	37.90	-
716	Phosphorylation	FPVDILFSKTPQEDY CCCEEEEECCCCHHH	31.97	24719451
717	Ubiquitination	PVDILFSKTPQEDYV CCEEEEECCCCHHHH	57.82	-
758	Ubiquitination	EDIEVTSDQIVEHLE CCCEECHHHHHHHHH	32.62	22505724
793	Ubiquitination	LQAKIFQKAPDGVRK HHHHHHHHCCCCHHE	51.65	22505724
794	Ubiquitination	QAKIFQKAPDGVRKC HHHHHHHCCCCHHEE	9.16	27667366
805	Phosphorylation	VRKCIVATNIAETSL HHEEEEEECCCCCEE	19.10	-
829	Ubiquitination	DSGYCKLKVFNPRIG ECCCEEEEECCCCCC	30.21	27667366
860	Phosphorylation	RSGRAGRTGPGQCFR CCCCCCCCCCCHHHH	46.97	24719451
875	Ubiquitination	LYTQSAYKNELLTTT EEECCHHCCCCCCCC	43.60	-
1014	Ubiquitination	DHLTYLNVYLQWKNN CCCEEEEEEEEECCC	4.69	24816145
1049	Ubiquitination	REVRAQLKDIMVQQR HHHHHHHHHHHHHHH	32.88	24816145
1058	Phosphorylation	IMVQQRMSLASCGTD HHHHHHHHHHHCCCC	23.99	18491316
1064	Phosphorylation	MSLASCGTDWDIVRK HHHHHCCCCHHHHHH	37.94	-
1083	Acetylation	AYFHQAAKLKGIGEY HHHHHHHHCCCCCCC	54.47	19820299
1166	Sumoylation	QENRRRAKEEASAME HHHHHHHHHHHHHHH	55.03	-
1166	Sumoylation	QENRRRAKEEASAME HHHHHHHHHHHHHHH	55.03	28112733
1166	Ubiquitination	QENRRRAKEEASAME HHHHHHHHHHHHHHH	55.03	-
1172	Sulfoxidation	AKEEASAMEEEMALA HHHHHHHHHHHHHHH	6.53	21406390
1194	Phosphorylation	RQEQEKRSPLGSVRS HHHHHHCCCCCCCCC	35.23	25159151
1198	Phosphorylation	EKRSPLGSVRSTKIY HHCCCCCCCCCCEEE	23.26	20873877
1201	Phosphorylation	SPLGSVRSTKIYTPG CCCCCCCCCEEECCC	31.71	25137130
1202	Phosphorylation	PLGSVRSTKIYTPGR CCCCCCCCEEECCCC	15.76	25137130
1206	Phosphorylation	VRSTKIYTPGRKEQG CCCCEEECCCCCCCC	23.80	21815630
1217	Phosphorylation	KEQGEPMTPRRTPAR CCCCCCCCCCCCCCC	25.10	21815630
1221	Phosphorylation	EPMTPRRTPARFGL- CCCCCCCCCCCCCC-	23.68	28555341

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PRP16_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PRP16_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PRP16_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBM8A_HUMAN	RBM8A	physical	22939629
SLU7_HUMAN	SLU7	physical	22939629
DX39B_HUMAN	DDX39B	physical	22939629
SNW1_HUMAN	SNW1	physical	22939629
CWC27_HUMAN	CWC27	physical	22939629
RS20_HUMAN	RPS20	physical	22939629
RBBP5_HUMAN	RBBP5	physical	22939629
U2AF1_HUMAN	U2AF1	physical	22365833
RBM10_HUMAN	RBM10	physical	22365833
MFAP1_HUMAN	MFAP1	physical	22365833
DHX16_HUMAN	DHX16	physical	22365833
GPKOW_HUMAN	GPKOW	physical	22365833
COPA_HUMAN	COPA	physical	22863883
PSB8_HUMAN	PSMB8	physical	22863883
CLH1_HUMAN	CLTC	physical	26344197
PITH1_HUMAN	PITHD1	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-260, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1194, AND MASSSPECTROMETRY.
PubMed: 18669648