dbPTM

RS20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RS20_HUMAN
UniProt AC	P60866
Protein Name	40S ribosomal protein S20
Gene Name	RPS20
Organism	Homo sapiens (Human).
Sequence Length	119
Subcellular Localization	Cytoplasm.
Protein Description
Protein Sequence	MAFKDTGKTPVEPEVAIHRIRITLTSRNVKSLEKVCADLIRGAKEKNLKVKGPVRMPTKTLRITTRKTPCGEGSKTWDRFQMRIHKRLIDLHSPSEIVKQITSISIEPGVEVEVTIADA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAFKDTGKT ------CCCCCCCCC	21.87	-
4	Acetylation	----MAFKDTGKTPV ----CCCCCCCCCCC	44.86	21466224
4	Ubiquitination	----MAFKDTGKTPV ----CCCCCCCCCCC	44.86	23000965
4	Malonylation	----MAFKDTGKTPV ----CCCCCCCCCCC	44.86	26320211
4	Ubiquitination	----MAFKDTGKTPV ----CCCCCCCCCCC	44.86	21890473
4	Ubiquitination	----MAFKDTGKTPV ----CCCCCCCCCCC	44.86	21890473
4 (in isoform 2)	Ubiquitination	-	44.86	-
6	Phosphorylation	--MAFKDTGKTPVEP --CCCCCCCCCCCCH	40.96	30266825
8	Sumoylation	MAFKDTGKTPVEPEV CCCCCCCCCCCCHHH	52.31	-
8	Malonylation	MAFKDTGKTPVEPEV CCCCCCCCCCCCHHH	52.31	26320211
8	Ubiquitination	MAFKDTGKTPVEPEV CCCCCCCCCCCCHHH	52.31	21890473
8	Ubiquitination	MAFKDTGKTPVEPEV CCCCCCCCCCCCHHH	52.31	21890473
8	Succinylation	MAFKDTGKTPVEPEV CCCCCCCCCCCCHHH	52.31	-
8 (in isoform 2)	Ubiquitination	-	52.31	-
8	Neddylation	MAFKDTGKTPVEPEV CCCCCCCCCCCCHHH	52.31	32015554
8	Methylation	MAFKDTGKTPVEPEV CCCCCCCCCCCCHHH	52.31	23644510
8	Ubiquitination	MAFKDTGKTPVEPEV CCCCCCCCCCCCHHH	52.31	27667366
8	Acetylation	MAFKDTGKTPVEPEV CCCCCCCCCCCCHHH	52.31	23749302
8	Succinylation	MAFKDTGKTPVEPEV CCCCCCCCCCCCHHH	52.31	-
9	Phosphorylation	AFKDTGKTPVEPEVA CCCCCCCCCCCHHHE	33.63	29255136
9 (in isoform 2)	Phosphorylation	-	33.63	24719451
19	Methylation	EPEVAIHRIRITLTS CHHHEEEEEEEEEEC	17.48	115492581
23	Phosphorylation	AIHRIRITLTSRNVK EEEEEEEEEECCCHH	17.71	20068231
25	Phosphorylation	HRIRITLTSRNVKSL EEEEEEEECCCHHHH	19.59	20068231
26	Phosphorylation	RIRITLTSRNVKSLE EEEEEEECCCHHHHH	25.60	20068231
30 (in isoform 2)	Ubiquitination	-	53.52	-
30	Ubiquitination	TLTSRNVKSLEKVCA EEECCCHHHHHHHHH	53.52	21890473
30	Acetylation	TLTSRNVKSLEKVCA EEECCCHHHHHHHHH	53.52	25953088
30	Ubiquitination	TLTSRNVKSLEKVCA EEECCCHHHHHHHHH	53.52	21890473
30	Ubiquitination	TLTSRNVKSLEKVCA EEECCCHHHHHHHHH	53.52	21906983
31 (in isoform 2)	Phosphorylation	-	37.16	24719451
31	Phosphorylation	LTSRNVKSLEKVCAD EECCCHHHHHHHHHH	37.16	24719451
34	Acetylation	RNVKSLEKVCADLIR CCHHHHHHHHHHHHH	48.16	23954790
34	Ubiquitination	RNVKSLEKVCADLIR CCHHHHHHHHHHHHH	48.16	23000965
34	Malonylation	RNVKSLEKVCADLIR CCHHHHHHHHHHHHH	48.16	26320211
34 (in isoform 2)	Ubiquitination	-	48.16	-
36	Glutathionylation	VKSLEKVCADLIRGA HHHHHHHHHHHHHHH	3.45	22555962
36	S-palmitoylation	VKSLEKVCADLIRGA HHHHHHHHHHHHHHH	3.45	29575903
41	Methylation	KVCADLIRGAKEKNL HHHHHHHHHHHHHCC	46.44	115492597
44	Ubiquitination	ADLIRGAKEKNLKVK HHHHHHHHHHCCCCC	72.54	22817900
44	Acetylation	ADLIRGAKEKNLKVK HHHHHHHHHHCCCCC	72.54	11921159
46	Ubiquitination	LIRGAKEKNLKVKGP HHHHHHHHCCCCCCC	67.86	22817900
49	Ubiquitination	GAKEKNLKVKGPVRM HHHHHCCCCCCCEEC	51.82	21906983
51 (in isoform 2)	Ubiquitination	-	56.78	-
51	Ubiquitination	KEKNLKVKGPVRMPT HHHCCCCCCCEECCC	56.78	21906983
58	Phosphorylation	KGPVRMPTKTLRITT CCCEECCCCEEEEEE	27.58	21406692
59	Ubiquitination	GPVRMPTKTLRITTR CCEECCCCEEEEEEC	39.43	21906983
59	Ubiquitination	GPVRMPTKTLRITTR CCEECCCCEEEEEEC	39.43	21890473
59	Acetylation	GPVRMPTKTLRITTR CCEECCCCEEEEEEC	39.43	26051181
59 (in isoform 2)	Ubiquitination	-	39.43	-
67 (in isoform 2)	Ubiquitination	-	55.52	-
67	Ubiquitination	TLRITTRKTPCGEGS EEEEEECCCCCCCCC	55.52	23000965
68	Phosphorylation	LRITTRKTPCGEGSK EEEEECCCCCCCCCC	22.11	24719451
68 (in isoform 2)	Phosphorylation	-	22.11	24719451
70	S-palmitoylation	ITTRKTPCGEGSKTW EEECCCCCCCCCCHH	10.56	21044946
74	Phosphorylation	KTPCGEGSKTWDRFQ CCCCCCCCCHHHHHH	23.70	27732954
75 (in isoform 2)	Ubiquitination	-	65.57	-
75	Acetylation	TPCGEGSKTWDRFQM CCCCCCCCHHHHHHH	65.57	25953088
75	Ubiquitination	TPCGEGSKTWDRFQM CCCCCCCCHHHHHHH	65.57	23000965
76	Phosphorylation	PCGEGSKTWDRFQMR CCCCCCCHHHHHHHH	34.00	27732954
76 (in isoform 2)	Phosphorylation	-	34.00	27251275
79	Methylation	EGSKTWDRFQMRIHK CCCCHHHHHHHHHHH	18.43	115492589
93	Phosphorylation	KRLIDLHSPSEIVKQ HHHHHCCCHHHHHHH	37.10	30266825
93 (in isoform 2)	Phosphorylation	-	37.10	24719451
95	Phosphorylation	LIDLHSPSEIVKQIT HHHCCCHHHHHHHHH	42.86	21712546
99	Ubiquitination	HSPSEIVKQITSISI CCHHHHHHHHHCCEE	41.46	33845483

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RS20_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RS20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RS20_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
RS23_HUMAN	RPS23	physical	22939629
RS25_HUMAN	RPS25	physical	22939629
RS4X_HUMAN	RPS4X	physical	22939629
RS6_HUMAN	RPS6	physical	22939629
RS8_HUMAN	RPS8	physical	22939629
RS2_HUMAN	RPS2	physical	22939629
RS3_HUMAN	RPS3	physical	22939629
RS26_HUMAN	RPS26	physical	22939629
RS3A_HUMAN	RPS3A	physical	22939629
RS28_HUMAN	RPS28	physical	22939629
RSSA_HUMAN	RPSA	physical	22939629
RS21_HUMAN	RPS21	physical	22939629
RS27L_HUMAN	RPS27L	physical	22939629
SND1_HUMAN	SND1	physical	22939629
TCPA_HUMAN	TCP1	physical	22939629
IL7RA_HUMAN	IL7R	physical	23151878
MDM2_HUMAN	MDM2	physical	23874713
MDM4_HUMAN	MDM4	physical	23874713
SUN2_HUMAN	SUN2	physical	21988832
EIF3A_HUMAN	EIF3A	physical	22863883
EIFCL_HUMAN	EIF3CL	physical	22863883
EIF3E_HUMAN	EIF3E	physical	22863883
RSSA_HUMAN	RPSA	physical	22863883
PNO1_HUMAN	PNO1	physical	22863883
RS10_HUMAN	RPS10	physical	22863883
RS11_HUMAN	RPS11	physical	22863883
RS12_HUMAN	RPS12	physical	22863883
RS13_HUMAN	RPS13	physical	22863883
RS14_HUMAN	RPS14	physical	22863883
RS15A_HUMAN	RPS15A	physical	22863883
RS16_HUMAN	RPS16	physical	22863883
RS17_HUMAN	RPS17	physical	22863883
RS18_HUMAN	RPS18	physical	22863883
RS19_HUMAN	RPS19	physical	22863883
RS23_HUMAN	RPS23	physical	22863883
RS27_HUMAN	RPS27	physical	22863883
RS2_HUMAN	RPS2	physical	22863883
RS3A_HUMAN	RPS3A	physical	22863883
RS3_HUMAN	RPS3	physical	22863883
RS6_HUMAN	RPS6	physical	22863883
RS8_HUMAN	RPS8	physical	22863883
PAIRB_HUMAN	SERBP1	physical	22863883
TSR1_HUMAN	TSR1	physical	22863883
PYM1_HUMAN	WIBG	physical	22863883
SELB_HUMAN	EEFSEC	physical	26344197
HBS1L_HUMAN	HBS1L	physical	26344197
MAP4_HUMAN	MAP4	physical	26344197
RM01_HUMAN	MRPL1	physical	26344197
RL10_HUMAN	RPL10	physical	26344197
RL10A_HUMAN	RPL10A	physical	26344197
RL11_HUMAN	RPL11	physical	26344197
RL13_HUMAN	RPL13	physical	26344197
RL13A_HUMAN	RPL13A	physical	26344197
RL14_HUMAN	RPL14	physical	26344197
RL15_HUMAN	RPL15	physical	26344197
RL17_HUMAN	RPL17	physical	26344197
RL18_HUMAN	RPL18	physical	26344197
RL18A_HUMAN	RPL18A	physical	26344197
RL19_HUMAN	RPL19	physical	26344197
RL21_HUMAN	RPL21	physical	26344197
RL22_HUMAN	RPL22	physical	26344197
RL23_HUMAN	RPL23	physical	26344197
RL23A_HUMAN	RPL23A	physical	26344197
RL24_HUMAN	RPL24	physical	26344197
RL27_HUMAN	RPL27	physical	26344197
RL27A_HUMAN	RPL27A	physical	26344197
RL30_HUMAN	RPL30	physical	26344197
RL31_HUMAN	RPL31	physical	26344197
RL34_HUMAN	RPL34	physical	26344197
RL35_HUMAN	RPL35	physical	26344197
RL35A_HUMAN	RPL35A	physical	26344197
RL37A_HUMAN	RPL37A	physical	26344197
RL38_HUMAN	RPL38	physical	26344197
RL4_HUMAN	RPL4	physical	26344197
RL5_HUMAN	RPL5	physical	26344197
RL6_HUMAN	RPL6	physical	26344197
RL7A_HUMAN	RPL7A	physical	26344197
RL9_HUMAN	RPL9	physical	26344197
RLA1_HUMAN	RPLP1	physical	26344197
RLA2_HUMAN	RPLP2	physical	26344197
RS11_HUMAN	RPS11	physical	26344197
RS12_HUMAN	RPS12	physical	26344197
RS13_HUMAN	RPS13	physical	26344197
RS15A_HUMAN	RPS15A	physical	26344197
RS16_HUMAN	RPS16	physical	26344197
RS18_HUMAN	RPS18	physical	26344197
RS19_HUMAN	RPS19	physical	26344197
RS2_HUMAN	RPS2	physical	26344197
RS23_HUMAN	RPS23	physical	26344197
RS26_HUMAN	RPS26	physical	26344197
RS3A_HUMAN	RPS3A	physical	26344197
RS4X_HUMAN	RPS4X	physical	26344197
RS5_HUMAN	RPS5	physical	26344197
RS6_HUMAN	RPS6	physical	26344197
RS7_HUMAN	RPS7	physical	26344197
RS8_HUMAN	RPS8	physical	26344197
RSSA_HUMAN	RPSA	physical	26344197
RRP7A_HUMAN	RRP7A	physical	26344197
EFTU_HUMAN	TUFM	physical	26344197
RL40_HUMAN	UBA52	physical	26344197

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RS20_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-9, AND MASSSPECTROMETRY.	17287340 [Abstract]
Ubiquitylation
Reference	PubMed
"Quantitative analysis of global ubiquitination in HeLa cells by massspectrometry."; Meierhofer D., Wang X., Huang L., Kaiser P.; J. Proteome Res. 7:4566-4576(2008). Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-8, AND MASS SPECTROMETRY.	18781797 [Abstract]