EIFCL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EIFCL_HUMAN
• UniProt AC: B5ME19
• Protein Name: Eukaryotic translation initiation factor 3 subunit C-like protein
• Gene Name: EIF3CL
• Organism: Homo sapiens (Human).
• Sequence Length: 914
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression..
• Protein Sequence: MSRFFTTGSDSESESSLSGEELVTKPVGGNYGKQPLLLSEDEEDTKRVVRSAKDKRFEELTNLIRTIRNAMKIRDVTKCLEEFELLGKAYGKAKSIVDKEGVPRFYIRILADLEDYLNELWEDKEGKKKMNKNNAKALSTLRQKIRKYNRDFESHITSYKQNPEQSADEDAEKNEEDSEGSSDEDEDEDGVSAATFLKKKSEAPSGESRKFLKKMDDEDEDSEDSEDDEDWDTGSTSSDSDSEEEEGKQTALASRFLKKAPTTDEDKKAAEKKREDKAKKKHDRKSKRLDEEEEEDNEGGEWERVRGGVPLVKEKPKMFAKGTEITHAVVIKKLNEILQARGKKGTDRAAQIELLQLLVQIAAENNLGEGVIVKIKFNIIASLYDYNPNLATYMKPEMWGKCLDCINELMDILFANPNIFVGENILEESENLHNADQPLRVRGCILTLVERMDEEFTKIMQNTDPHSQEYVEHLKDEAQVCAIIERVQRYLEEKGTTEEVCRIYLLRILHTYYKFDYKAHQRQLTPPEGSSKSEQDQAENEGEDSAVLMERLCKYIYAKDRTDRIRTCAILCHIYHHALHSRWYQARDLMLMSHLQDNIQHADPPVQILYNRTMVQLGICAFRQGLTKDAHNALLDIQSSGRAKELLGQGLLLRSLQERNQEQEKVERRRQVPFHLHINLELLECVYLVSAMLLEIPYMAAHESDARRRMISKQFHHQLRVGERQPLLGPPESMREHVVAASKAMKMGDWKTCHSFIINEKMNGKVWDLFPEADKVRTMLVRKIQEESLRTYLFTYSSVYDSISMETLSDMFELDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVENNERVFDHKQGTYGGYFRDQKDGYRKNEGYMRRGGYRQQQSQTAY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSRFFTTGS ------CCCCCCCCC		29514088
6	Phosphorylation	--MSRFFTTGSDSES --CCCCCCCCCCCCC		23927012
7	Phosphorylation	-MSRFFTTGSDSESE -CCCCCCCCCCCCCC		30278072
9	Phosphorylation	SRFFTTGSDSESESS CCCCCCCCCCCCCCC		23927012
11	Phosphorylation	FFTTGSDSESESSLS CCCCCCCCCCCCCCC		23927012
13	Phosphorylation	TTGSDSESESSLSGE CCCCCCCCCCCCCCC		25159151
15	Phosphorylation	GSDSESESSLSGEEL CCCCCCCCCCCCCCE		25159151
16	Phosphorylation	SDSESESSLSGEELV CCCCCCCCCCCCCEE		23927012
18	Phosphorylation	SESESSLSGEELVTK CCCCCCCCCCCEEEC		28355574
24	Phosphorylation	LSGEELVTKPVGGNY CCCCCEEECCCCCCC		23927012
31	Phosphorylation	TKPVGGNYGKQPLLL ECCCCCCCCCCCCCC		23927012
39	Phosphorylation	GKQPLLLSEDEEDTK CCCCCCCCCCHHHHH		19664994
45	Phosphorylation	LSEDEEDTKRVVRSA CCCCHHHHHHHHHHH		22167270
61	Phosphorylation	DKRFEELTNLIRTIR HHHHHHHHHHHHHHH		-
66	Phosphorylation	ELTNLIRTIRNAMKI HHHHHHHHHHHHHHH		-
78	Ubiquitination	MKIRDVTKCLEEFEL HHHHHHHHHHHHHHH		-
88	Ubiquitination	EEFELLGKAYGKAKS HHHHHHHHHHCCHHH		-
92	Ubiquitination	LLGKAYGKAKSIVDK HHHHHHCCHHHCCCC		-
94	2-Hydroxyisobutyrylation	GKAYGKAKSIVDKEG HHHHCCHHHCCCCCC		-
94	Ubiquitination	GKAYGKAKSIVDKEG HHHHCCHHHCCCCCC		-
95	Phosphorylation	KAYGKAKSIVDKEGV HHHCCHHHCCCCCCC		22817900
99	Acetylation	KAKSIVDKEGVPRFY CHHHCCCCCCCCHHH		-
99	Ubiquitination	KAKSIVDKEGVPRFY CHHHCCCCCCCCHHH		-
104	Methylation	VDKEGVPRFYIRILA CCCCCCCHHHHHHHH		-
127	Acetylation	LWEDKEGKKKMNKNN HHCCHHHHHHCCHHH		24430999
128	Acetylation	WEDKEGKKKMNKNNA HCCHHHHHHCCHHHH		24471041
136	Malonylation	KMNKNNAKALSTLRQ HCCHHHHHHHHHHHH		26320211
136	Ubiquitination	KMNKNNAKALSTLRQ HCCHHHHHHHHHHHH		-
140	Phosphorylation	NNAKALSTLRQKIRK HHHHHHHHHHHHHHH		-
148	Phosphorylation	LRQKIRKYNRDFESH HHHHHHHHHHHHHHH		21406692
154	Phosphorylation	KYNRDFESHITSYKQ HHHHHHHHHHHHCCC		21406692
157	Phosphorylation	RDFESHITSYKQNPE HHHHHHHHHCCCCCC		21406692
158	Phosphorylation	DFESHITSYKQNPEQ HHHHHHHHCCCCCCC		21406692
159	Phosphorylation	FESHITSYKQNPEQS HHHHHHHCCCCCCCC		21406692
160	Ubiquitination	ESHITSYKQNPEQSA HHHHHHCCCCCCCCC		-
166	Phosphorylation	YKQNPEQSADEDAEK CCCCCCCCCCHHHHH		29255136
178	Phosphorylation	AEKNEEDSEGSSDED HHHCHHCCCCCCCCC		26503892
181	Phosphorylation	NEEDSEGSSDEDEDE CHHCCCCCCCCCCCC		26503892
182	Phosphorylation	EEDSEGSSDEDEDED HHCCCCCCCCCCCCC		26503892
192	Phosphorylation	DEDEDGVSAATFLKK CCCCCCCCHHHHHHH		25850435
195	Phosphorylation	EDGVSAATFLKKKSE CCCCCHHHHHHHHCC		25850435
201	Phosphorylation	ATFLKKKSEAPSGES HHHHHHHCCCCCHHH		28674151
205	Phosphorylation	KKKSEAPSGESRKFL HHHCCCCCHHHHHHH		30576142
208	Phosphorylation	SEAPSGESRKFLKKM CCCCCHHHHHHHHHC		28102081
222	Phosphorylation	MDDEDEDSEDSEDDE CCCCCCCCCCCCCCC		22210691
225	Phosphorylation	EDEDSEDSEDDEDWD CCCCCCCCCCCCCCC		25137130
233	Phosphorylation	EDDEDWDTGSTSSDS CCCCCCCCCCCCCCC		25137130
235	Phosphorylation	DEDWDTGSTSSDSDS CCCCCCCCCCCCCCC		25137130
236	Phosphorylation	EDWDTGSTSSDSDSE CCCCCCCCCCCCCCH		22210691
237	Phosphorylation	DWDTGSTSSDSDSEE CCCCCCCCCCCCCHH		25137130
238	Phosphorylation	WDTGSTSSDSDSEEE CCCCCCCCCCCCHHH		25137130
240	Phosphorylation	TGSTSSDSDSEEEEG CCCCCCCCCCHHHHH		22210691
242	Phosphorylation	STSSDSDSEEEEGKQ CCCCCCCCHHHHHHH		26657352
250	Phosphorylation	EEEEGKQTALASRFL HHHHHHHHHHHHHHH		24719451
262	Phosphorylation	RFLKKAPTTDEDKKA HHHHHCCCCHHHHHH		30576142
263	Phosphorylation	FLKKAPTTDEDKKAA HHHHCCCCHHHHHHH		26657352
306	Methylation	GGEWERVRGGVPLVK CCCCEECCCCCCCCC		-
313	Ubiquitination	RGGVPLVKEKPKMFA CCCCCCCCCCCCCCC		-
315	Ubiquitination	GVPLVKEKPKMFAKG CCCCCCCCCCCCCCC		-
321	Malonylation	EKPKMFAKGTEITHA CCCCCCCCCCCCCHH		32601280
321	Ubiquitination	EKPKMFAKGTEITHA CCCCCCCCCCCCCHH		-
332	Ubiquitination	ITHAVVIKKLNEILQ CCHHHHHHHHHHHHH		21906983
333	2-Hydroxyisobutyrylation	THAVVIKKLNEILQA CHHHHHHHHHHHHHH		-
333	Ubiquitination	THAVVIKKLNEILQA CHHHHHHHHHHHHHH		-
447	Phosphorylation	RVRGCILTLVERMDE HHHHHHHHHHHHCHH		20068231
463	Phosphorylation	FTKIMQNTDPHSQEY HHHHHHCCCCCCHHH		28851738
467	Phosphorylation	MQNTDPHSQEYVEHL HHCCCCCCHHHHHHH		28851738
470	Phosphorylation	TDPHSQEYVEHLKDE CCCCCHHHHHHHHHH		-
475	Ubiquitination	QEYVEHLKDEAQVCA HHHHHHHHHHHHHHH		-
494	2-Hydroxyisobutyrylation	VQRYLEEKGTTEEVC HHHHHHHCCCHHHHH		-
494	Ubiquitination	VQRYLEEKGTTEEVC HHHHHHHCCCHHHHH		-
514	Ubiquitination	RILHTYYKFDYKAHQ HHHHHHHHCCHHHHH		-
518	Ubiquitination	TYYKFDYKAHQRQLT HHHHCCHHHHHCCCC		-
525	Phosphorylation	KAHQRQLTPPEGSSK HHHHCCCCCCCCCCH		25159151
530	Phosphorylation	QLTPPEGSSKSEQDQ CCCCCCCCCHHHHHH		30266825
531	Phosphorylation	LTPPEGSSKSEQDQA CCCCCCCCHHHHHHH		30266825
532	Ubiquitination	TPPEGSSKSEQDQAE CCCCCCCHHHHHHHH		21890473
533	Phosphorylation	PPEGSSKSEQDQAEN CCCCCCHHHHHHHHH		25159151
545	Phosphorylation	AENEGEDSAVLMERL HHHCCCHHHHHHHHH		23322592
549	Sulfoxidation	GEDSAVLMERLCKYI CCHHHHHHHHHHHHH		28183972
551	Methylation	DSAVLMERLCKYIYA HHHHHHHHHHHHHHH		-
554	Ubiquitination	VLMERLCKYIYAKDR HHHHHHHHHHHHCCC		-
559	2-Hydroxyisobutyrylation	LCKYIYAKDRTDRIR HHHHHHHCCCCHHHH		-
559	Acetylation	LCKYIYAKDRTDRIR HHHHHHHCCCCHHHH		-
559	Ubiquitination	LCKYIYAKDRTDRIR HHHHHHHCCCCHHHH		-
613	Phosphorylation	VQILYNRTMVQLGIC HHHEECCHHHHHHHH		-
628	Malonylation	AFRQGLTKDAHNALL HHHCCCCCHHHHHHH		26320211
628	Ubiquitination	AFRQGLTKDAHNALL HHHCCCCCHHHHHHH		21890473
639	Phosphorylation	NALLDIQSSGRAKEL HHHHHHHCCCHHHHH		20873877
640	Phosphorylation	ALLDIQSSGRAKELL HHHHHHCCCHHHHHH		20873877
644	2-Hydroxyisobutyrylation	IQSSGRAKELLGQGL HHCCCHHHHHHHHHH		-
644	Acetylation	IQSSGRAKELLGQGL HHCCCHHHHHHHHHH		-
644	Malonylation	IQSSGRAKELLGQGL HHCCCHHHHHHHHHH		26320211
644	Ubiquitination	IQSSGRAKELLGQGL HHCCCHHHHHHHHHH		21906983
654	Methylation	LGQGLLLRSLQERNQ HHHHHHHHHHHHHHH		-
665	Acetylation	ERNQEQEKVERRRQV HHHHHHHHHHHHHHC		178226225
665	Ubiquitination	ERNQEQEKVERRRQV HHHHHHHHHHHHHHC		21906983
713	Acetylation	ARRRMISKQFHHQLR HHHHHHHHHHHHHCC		24695921
713	Ubiquitination	ARRRMISKQFHHQLR HHHHHHHHHHHHHCC		21890473
720	Methylation	KQFHHQLRVGERQPL HHHHHHCCCCCCCCC		-
733	Phosphorylation	PLLGPPESMREHVVA CCCCCCHHHHHHHHH		22985185
743	Ubiquitination	EHVVAASKAMKMGDW HHHHHHHHHHHCCCC		-
746	Ubiquitination	VAASKAMKMGDWKTC HHHHHHHHCCCCCCC		-
751	Ubiquitination	AMKMGDWKTCHSFII HHHCCCCCCCEEEEE		-
752	Phosphorylation	MKMGDWKTCHSFIIN HHCCCCCCCEEEEEE		21406692
755	Phosphorylation	GDWKTCHSFIINEKM CCCCCCEEEEEEHHH		21406692
761	Ubiquitination	HSFIINEKMNGKVWD EEEEEEHHHCCCHHH		-
765	Ubiquitination	INEKMNGKVWDLFPE EEHHHCCCHHHCCCC		-
775	2-Hydroxyisobutyrylation	DLFPEADKVRTMLVR HCCCCHHHHHHHHHH		-
775	Ubiquitination	DLFPEADKVRTMLVR HCCCCHHHHHHHHHH		-
783	2-Hydroxyisobutyrylation	VRTMLVRKIQEESLR HHHHHHHHHCHHHHH		-
783	Ubiquitination	VRTMLVRKIQEESLR HHHHHHHHHCHHHHH		-
788	Phosphorylation	VRKIQEESLRTYLFT HHHHCHHHHHHHHHC		21406692
821	Phosphorylation	LDLPTVHSIISKMII CCHHHHHHHHHHHHC		24719451
840	Phosphorylation	MASLDQPTQTVVMHR HHCCCCCCCEEEEEC		20860994
842	Phosphorylation	SLDQPTQTVVMHRTE CCCCCCCEEEEECCC		21601212
848	Phosphorylation	QTVVMHRTEPTAQQN CEEEEECCCCHHHHH		20860994
863	Ubiquitination	LALQLAEKLGSLVEN HHHHHHHHHHHHHHC		21890473
866	Phosphorylation	QLAEKLGSLVENNER HHHHHHHHHHHCCCC		21815630
878	Ubiquitination	NERVFDHKQGTYGGY CCCEECCCCCCCCCC		21890473
881	Phosphorylation	VFDHKQGTYGGYFRD EECCCCCCCCCCCCC		28152594
882	Phosphorylation	FDHKQGTYGGYFRDQ ECCCCCCCCCCCCCC		28152594
885	Phosphorylation	KQGTYGGYFRDQKDG CCCCCCCCCCCCCCC		28152594
890	Ubiquitination	GGYFRDQKDGYRKNE CCCCCCCCCCCCCCC		890473
893	Phosphorylation	FRDQKDGYRKNEGYM CCCCCCCCCCCCCCC		29759185
895	Ubiquitination	DQKDGYRKNEGYMRR CCCCCCCCCCCCCCC		21890473
899	Phosphorylation	GYRKNEGYMRRGGYR CCCCCCCCCCCCCCC		-
902	Methylation	KNEGYMRRGGYRQQQ CCCCCCCCCCCCCCC		-
905	Phosphorylation	GYMRRGGYRQQQSQT CCCCCCCCCCCCCCC		26074081
910	Phosphorylation	GGYRQQQSQTAY--- CCCCCCCCCCCC---		25159151
912	Phosphorylation	YRQQQSQTAY----- CCCCCCCCCC-----		22617229
914	Phosphorylation	QQQSQTAY------- CCCCCCCC-------		22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EIFCL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EIFCL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EIFCL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
EIF3A_HUMAN	EIF3A	physical	22863883
EIF3E_HUMAN	EIF3E	physical	22863883
CPSF5_HUMAN	NUDT21	physical	22863883
RS12_HUMAN	RPS12	physical	22863883
RS18_HUMAN	RPS18	physical	22863883
RS24_HUMAN	RPS24	physical	22863883
RS2_HUMAN	RPS2	physical	22863883
RS3_HUMAN	RPS3	physical	22863883
EIF3B_HUMAN	EIF3B	physical	26344197
EIF3D_HUMAN	EIF3D	physical	26344197
EIF3G_HUMAN	EIF3G	physical	26344197
CLCB_HUMAN	CLTB	physical	27173435
DP13A_HUMAN	APPL1	physical	27173435
CLCA_HUMAN	CLTA	physical	27173435

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.