UniProt ID | RS2_HUMAN | |
---|---|---|
UniProt AC | P15880 | |
Protein Name | 40S ribosomal protein S2 | |
Gene Name | RPS2 | |
Organism | Homo sapiens (Human). | |
Sequence Length | 293 | |
Subcellular Localization | ||
Protein Description | ||
Protein Sequence | MADDAGAAGGPGGPGGPGMGNRGGFRGGFGSGIRGRGRGRGRGRGRGRGARGGKAEDKEWMPVTKLGRLVKDMKIKSLEEIYLFSLPIKESEIIDFFLGASLKDEVLKIMPVQKQTRAGQRTRFKAFVAIGDYNGHVGLGVKCSKEVATAIRGAIILAKLSIVPVRRGYWGNKIGKPHTVPCKVTGRCGSVLVRLIPAPRGTGIVSAPVPKKLLMMAGIDDCYTSARGCTATLGNFAKATFDAISKTYSYLTPDLWKETVFTKSPYQEFTDHLVKTHTRVSVQRTQAPAVATT | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
2 | Acetylation | ------MADDAGAAG ------CCCCCCCCC | 24.32 | 22814378 | |
22 | Dimethylation | GGPGMGNRGGFRGGF CCCCCCCCCCCCCCC | 40.66 | - | |
22 | Methylation | GGPGMGNRGGFRGGF CCCCCCCCCCCCCCC | 40.66 | 30989261 | |
26 | Methylation | MGNRGGFRGGFGSGI CCCCCCCCCCCCCCC | 47.83 | 24383453 | |
34 | Methylation | GGFGSGIRGRGRGRG CCCCCCCCCCCCCCC | 32.08 | 5149723 | |
36 | Methylation | FGSGIRGRGRGRGRG CCCCCCCCCCCCCCC | 23.06 | 5149731 | |
38 | Methylation | SGIRGRGRGRGRGRG CCCCCCCCCCCCCCC | 30.21 | - | |
40 | Methylation | IRGRGRGRGRGRGRG CCCCCCCCCCCCCCC | 30.21 | - | |
42 | Methylation | GRGRGRGRGRGRGRG CCCCCCCCCCCCCCC | 30.21 | - | |
44 | Methylation | GRGRGRGRGRGRGAR CCCCCCCCCCCCCCC | 30.21 | - | |
46 | Methylation | GRGRGRGRGRGARGG CCCCCCCCCCCCCCC | 30.21 | - | |
48 | Methylation | GRGRGRGRGARGGKA CCCCCCCCCCCCCCC | 33.95 | - | |
54 | Ubiquitination | GRGARGGKAEDKEWM CCCCCCCCCCCCCCC | 51.96 | 23000965 | |
58 | 2-Hydroxyisobutyrylation | RGGKAEDKEWMPVTK CCCCCCCCCCCCHHH | 44.79 | - | |
58 | Acetylation | RGGKAEDKEWMPVTK CCCCCCCCCCCCHHH | 44.79 | 23236377 | |
58 | Ubiquitination | RGGKAEDKEWMPVTK CCCCCCCCCCCCHHH | 44.79 | 21906983 | |
61 | Sulfoxidation | KAEDKEWMPVTKLGR CCCCCCCCCHHHHHH | 1.69 | 30846556 | |
65 | 2-Hydroxyisobutyrylation | KEWMPVTKLGRLVKD CCCCCHHHHHHHHHH | 49.53 | - | |
65 | Acetylation | KEWMPVTKLGRLVKD CCCCCHHHHHHHHHH | 49.53 | 25953088 | |
65 | Ubiquitination | KEWMPVTKLGRLVKD CCCCCHHHHHHHHHH | 49.53 | 23000965 | |
71 | Ubiquitination | TKLGRLVKDMKIKSL HHHHHHHHHCCCCCH | 57.61 | 23000965 | |
74 | Ubiquitination | GRLVKDMKIKSLEEI HHHHHHCCCCCHHEE | 58.05 | 23000965 | |
76 | Sumoylation | LVKDMKIKSLEEIYL HHHHCCCCCHHEEEE | 43.39 | - | |
76 | Ubiquitination | LVKDMKIKSLEEIYL HHHHCCCCCHHEEEE | 43.39 | 23000965 | |
77 | Phosphorylation | VKDMKIKSLEEIYLF HHHCCCCCHHEEEEE | 44.48 | 22617229 | |
82 | Phosphorylation | IKSLEEIYLFSLPIK CCCHHEEEEEECCCC | 12.65 | 23403867 | |
85 | Phosphorylation | LEEIYLFSLPIKESE HHEEEEEECCCCHHH | 30.55 | 23403867 | |
89 | Ubiquitination | YLFSLPIKESEIIDF EEEECCCCHHHHHHH | 53.93 | 16196087 | |
103 | Sumoylation | FFLGASLKDEVLKIM HHHCCCCCHHHHHHC | 49.72 | - | |
103 | Ubiquitination | FFLGASLKDEVLKIM HHHCCCCCHHHHHHC | 49.72 | 23000965 | |
108 | 2-Hydroxyisobutyrylation | SLKDEVLKIMPVQKQ CCCHHHHHHCCCCCC | 41.98 | - | |
108 | Acetylation | SLKDEVLKIMPVQKQ CCCHHHHHHCCCCCC | 41.98 | 23236377 | |
108 | Sumoylation | SLKDEVLKIMPVQKQ CCCHHHHHHCCCCCC | 41.98 | - | |
108 | Ubiquitination | SLKDEVLKIMPVQKQ CCCHHHHHHCCCCCC | 41.98 | 23000965 | |
114 | 2-Hydroxyisobutyrylation | LKIMPVQKQTRAGQR HHHCCCCCCCCCCCC | 54.60 | - | |
114 | Acetylation | LKIMPVQKQTRAGQR HHHCCCCCCCCCCCC | 54.60 | 25953088 | |
114 | Malonylation | LKIMPVQKQTRAGQR HHHCCCCCCCCCCCC | 54.60 | 26320211 | |
114 | Ubiquitination | LKIMPVQKQTRAGQR HHHCCCCCCCCCCCC | 54.60 | 23000965 | |
116 | Phosphorylation | IMPVQKQTRAGQRTR HCCCCCCCCCCCCCE | 29.53 | 21964256 | |
125 | Acetylation | AGQRTRFKAFVAIGD CCCCCEEEEEEEEEC | 37.31 | 26051181 | |
133 | Phosphorylation | AFVAIGDYNGHVGLG EEEEEECCCCCEEEC | 20.17 | 25159151 | |
142 | 2-Hydroxyisobutyrylation | GHVGLGVKCSKEVAT CCEEECCCCCHHHHH | 30.87 | - | |
142 | Ubiquitination | GHVGLGVKCSKEVAT CCEEECCCCCHHHHH | 30.87 | 16196087 | |
145 | Acetylation | GLGVKCSKEVATAIR EECCCCCHHHHHHHH | 66.72 | 26051181 | |
145 | Ubiquitination | GLGVKCSKEVATAIR EECCCCCHHHHHHHH | 66.72 | 33845483 | |
159 | Acetylation | RGAIILAKLSIVPVR HHHHHHHCCCCEEEC | 39.04 | 26051181 | |
173 | Acetylation | RRGYWGNKIGKPHTV CCCCCCCCCCCCCEE | 49.23 | 26051181 | |
173 | Ubiquitination | RRGYWGNKIGKPHTV CCCCCCCCCCCCCEE | 49.23 | 32015554 | |
176 | Acetylation | YWGNKIGKPHTVPCK CCCCCCCCCCEECCE | 36.78 | 25825284 | |
176 | Ubiquitination | YWGNKIGKPHTVPCK CCCCCCCCCCEECCE | 36.78 | 32015554 | |
183 | Acetylation | KPHTVPCKVTGRCGS CCCEECCEEECCCCC | 36.44 | 25953088 | |
183 | Ubiquitination | KPHTVPCKVTGRCGS CCCEECCEEECCCCC | 36.44 | 21963094 | |
190 | Phosphorylation | KVTGRCGSVLVRLIP EEECCCCCEEEEEEE | 18.86 | 24719451 | |
202 | Phosphorylation | LIPAPRGTGIVSAPV EEECCCCCCCCCCCC | 25.64 | 21712546 | |
206 | Phosphorylation | PRGTGIVSAPVPKKL CCCCCCCCCCCCHHH | 25.57 | 22817900 | |
211 | 2-Hydroxyisobutyrylation | IVSAPVPKKLLMMAG CCCCCCCHHHHHHCC | 57.18 | - | |
211 | Acetylation | IVSAPVPKKLLMMAG CCCCCCCHHHHHHCC | 57.18 | 26051181 | |
211 | Ubiquitination | IVSAPVPKKLLMMAG CCCCCCCHHHHHHCC | 57.18 | 33845483 | |
212 | 2-Hydroxyisobutyrylation | VSAPVPKKLLMMAGI CCCCCCHHHHHHCCC | 40.56 | - | |
212 | Ubiquitination | VSAPVPKKLLMMAGI CCCCCCHHHHHHCCC | 40.56 | - | |
215 | Sulfoxidation | PVPKKLLMMAGIDDC CCCHHHHHHCCCCHH | 2.22 | 28465586 | |
216 | Sulfoxidation | VPKKLLMMAGIDDCY CCHHHHHHCCCCHHH | 2.89 | 28465586 | |
222 | Glutathionylation | MMAGIDDCYTSARGC HHCCCCHHHHHHCCC | 3.37 | 22555962 | |
223 | Phosphorylation | MAGIDDCYTSARGCT HCCCCHHHHHHCCCC | 15.66 | 29496907 | |
224 | Phosphorylation | AGIDDCYTSARGCTA CCCCHHHHHHCCCCC | 23.42 | - | |
225 | Phosphorylation | GIDDCYTSARGCTAT CCCHHHHHHCCCCCC | 6.90 | - | |
227 | Methylation | DDCYTSARGCTATLG CHHHHHHCCCCCCHH | 40.25 | 115492565 | |
229 | S-nitrosocysteine | CYTSARGCTATLGNF HHHHHCCCCCCHHHH | 1.63 | - | |
229 | Glutathionylation | CYTSARGCTATLGNF HHHHHCCCCCCHHHH | 1.63 | 22555962 | |
229 | S-nitrosylation | CYTSARGCTATLGNF HHHHHCCCCCCHHHH | 1.63 | 19483679 | |
229 | S-palmitoylation | CYTSARGCTATLGNF HHHHHCCCCCCHHHH | 1.63 | 26865113 | |
230 | Phosphorylation | YTSARGCTATLGNFA HHHHCCCCCCHHHHH | 26.04 | 21406692 | |
232 | Phosphorylation | SARGCTATLGNFAKA HHCCCCCCHHHHHHH | 19.62 | 21406692 | |
238 | 2-Hydroxyisobutyrylation | ATLGNFAKATFDAIS CCHHHHHHHHHHHHH | 43.77 | - | |
238 | Acetylation | ATLGNFAKATFDAIS CCHHHHHHHHHHHHH | 43.77 | 25953088 | |
238 | Methylation | ATLGNFAKATFDAIS CCHHHHHHHHHHHHH | 43.77 | 82989107 | |
238 | Ubiquitination | ATLGNFAKATFDAIS CCHHHHHHHHHHHHH | 43.77 | 21963094 | |
240 | Phosphorylation | LGNFAKATFDAISKT HHHHHHHHHHHHHHH | 22.72 | 28102081 | |
245 | Phosphorylation | KATFDAISKTYSYLT HHHHHHHHHHHHHCC | 22.21 | 21712546 | |
246 | Acetylation | ATFDAISKTYSYLTP HHHHHHHHHHHHCCH | 45.42 | 26051181 | |
246 | Ubiquitination | ATFDAISKTYSYLTP HHHHHHHHHHHHCCH | 45.42 | 21906983 | |
247 | Phosphorylation | TFDAISKTYSYLTPD HHHHHHHHHHHCCHH | 15.77 | 28152594 | |
248 | Phosphorylation | FDAISKTYSYLTPDL HHHHHHHHHHCCHHH | 10.08 | 28152594 | |
249 | Phosphorylation | DAISKTYSYLTPDLW HHHHHHHHHCCHHHH | 20.92 | 28152594 | |
250 | Phosphorylation | AISKTYSYLTPDLWK HHHHHHHHCCHHHHH | 12.27 | 28152594 | |
252 | Phosphorylation | SKTYSYLTPDLWKET HHHHHHCCHHHHHHC | 13.41 | 22617229 | |
257 | 2-Hydroxyisobutyrylation | YLTPDLWKETVFTKS HCCHHHHHHCCCCCC | 51.29 | - | |
257 | Acetylation | YLTPDLWKETVFTKS HCCHHHHHHCCCCCC | 51.29 | 25953088 | |
257 | Methylation | YLTPDLWKETVFTKS HCCHHHHHHCCCCCC | 51.29 | 7632019 | |
257 | Neddylation | YLTPDLWKETVFTKS HCCHHHHHHCCCCCC | 51.29 | 32015554 | |
257 | Ubiquitination | YLTPDLWKETVFTKS HCCHHHHHHCCCCCC | 51.29 | 23000965 | |
259 | Phosphorylation | TPDLWKETVFTKSPY CHHHHHHCCCCCCHH | 19.72 | 23927012 | |
262 | Phosphorylation | LWKETVFTKSPYQEF HHHHCCCCCCHHHHH | 26.69 | 23927012 | |
263 | 2-Hydroxyisobutyrylation | WKETVFTKSPYQEFT HHHCCCCCCHHHHHH | 37.66 | - | |
263 | Acetylation | WKETVFTKSPYQEFT HHHCCCCCCHHHHHH | 37.66 | 19608861 | |
263 | Sumoylation | WKETVFTKSPYQEFT HHHCCCCCCHHHHHH | 37.66 | 19608861 | |
263 | Ubiquitination | WKETVFTKSPYQEFT HHHCCCCCCHHHHHH | 37.66 | 23000965 | |
264 | Phosphorylation | KETVFTKSPYQEFTD HHCCCCCCHHHHHHH | 26.28 | 22167270 | |
266 | Nitration | TVFTKSPYQEFTDHL CCCCCCHHHHHHHHH | 27.97 | - | |
266 | Phosphorylation | TVFTKSPYQEFTDHL CCCCCCHHHHHHHHH | 27.97 | 23927012 | |
270 | Phosphorylation | KSPYQEFTDHLVKTH CCHHHHHHHHHHHHC | 23.04 | 23927012 | |
275 | 2-Hydroxyisobutyrylation | EFTDHLVKTHTRVSV HHHHHHHHHCCCCEE | 40.73 | - | |
275 | Acetylation | EFTDHLVKTHTRVSV HHHHHHHHHCCCCEE | 40.73 | 19608861 | |
275 | Malonylation | EFTDHLVKTHTRVSV HHHHHHHHHCCCCEE | 40.73 | 26320211 | |
275 | Neddylation | EFTDHLVKTHTRVSV HHHHHHHHHCCCCEE | 40.73 | 32015554 | |
275 | Sumoylation | EFTDHLVKTHTRVSV HHHHHHHHHCCCCEE | 40.73 | 19608861 | |
275 | Ubiquitination | EFTDHLVKTHTRVSV HHHHHHHHHCCCCEE | 40.73 | 23000965 | |
276 | Phosphorylation | FTDHLVKTHTRVSVQ HHHHHHHHCCCCEEE | 22.47 | 30266825 | |
278 | Phosphorylation | DHLVKTHTRVSVQRT HHHHHHCCCCEEECC | 37.69 | 30266825 | |
279 | Methylation | HLVKTHTRVSVQRTQ HHHHHCCCCEEECCC | 15.88 | 115492573 | |
281 | Phosphorylation | VKTHTRVSVQRTQAP HHHCCCCEEECCCCC | 14.83 | 23401153 | |
285 | O-linked_Glycosylation | TRVSVQRTQAPAVAT CCCEEECCCCCCCCC | 16.40 | 30059200 | |
285 | Phosphorylation | TRVSVQRTQAPAVAT CCCEEECCCCCCCCC | 16.40 | 23403867 | |
292 | O-linked_Glycosylation | TQAPAVATT------ CCCCCCCCC------ | 26.83 | 30059200 | |
292 | Phosphorylation | TQAPAVATT------ CCCCCCCCC------ | 26.83 | 25159151 | |
293 | O-linked_Glycosylation | QAPAVATT------- CCCCCCCC------- | 27.20 | 30059200 | |
293 | Phosphorylation | QAPAVATT------- CCCCCCCC------- | 27.20 | 16964243 |
Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RS2_HUMAN !! |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RS2_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RS2_HUMAN !! |
Kegg Disease | ||||||
---|---|---|---|---|---|---|
There are no disease associations of PTM sites. | ||||||
OMIM Disease | ||||||
There are no disease associations of PTM sites. | ||||||
Kegg Drug | ||||||
There are no disease associations of PTM sites. | ||||||
DrugBank | ||||||
There are no disease associations of PTM sites. |
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Acetylation | |
Reference | PubMed |
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-281, AND MASS SPECTROMETRY. | |
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-263 AND LYS-275, AND MASSSPECTROMETRY. | |
Phosphorylation | |
Reference | PubMed |
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT SER-281, AND MASS SPECTROMETRY. | |
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264, AND MASSSPECTROMETRY. | |
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264, AND MASSSPECTROMETRY. | |
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-264 AND SER-281, ANDMASS SPECTROMETRY. | |
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-293, AND MASSSPECTROMETRY. | |
"Global proteomic profiling of phosphopeptides using electron transferdissociation tandem mass spectrometry."; Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A.; Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-278, AND MASSSPECTROMETRY. | |
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-293, AND MASSSPECTROMETRY. | |
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-133, AND MASSSPECTROMETRY. |