NOM1_HUMAN - dbPTM
NOM1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID NOM1_HUMAN
UniProt AC Q5C9Z4
Protein Name Nucleolar MIF4G domain-containing protein 1
Gene Name NOM1
Organism Homo sapiens (Human).
Sequence Length 860
Subcellular Localization Nucleus, nucleolus .
Protein Description Plays a role in targeting PPP1CA to the nucleolus..
Protein Sequence MAASRSAGEAGPGGSQGRVVRMKRRGGRGPRRGPAGGGEKALKRLKLAVEEFVHATSEGEAPGGCEGRGAPVSFRPGGRKSRKELRKEKRHLRKARRLQRTAGPEQGPGLGGRSGAEEASGHRQDTEERARPAPSRDPSPPRKPRPSRVKAKATAATAKTRPSAAATAAARKRALLAANEEEDREIRKLERCLGLNKRKKKDGSSSVPLSFARDGLDYILGALESGKNSGLYDSSGEEEEDAGQTLPESDLESDSQDESEEEEEGDVEKEKKAQEAEAQSEDDDEDTEEEQGEEKEKGAQEKRRGKRVRFAEDEEKSENSSEDGDITDKSLCGSGEKYIPPHVRQAEETVDFKKKEELERLKKHVKGLLNRLSEPNMASISGQLEELYMAHSRKDMNDTLTSALMGACVTASAMPSRLMMEHVLLVSILHHTVGIEVGAHFLEAVVRKFDAIYKYGSEGKECDNLFTVIAHLYNFHVVQSLLIFDILKKLIGTFTEKDIELILLMLKNVGFSLRKDDALSLKELITEAQTKASGAGSEFQDQTRIRFMLETMLALKNNDMRKIPGYDPEPVEKLRKLQRALVRNAGSGSETQLRVSWDSVLSAEQTGRWWIVGSAWSGAPMIDNSHHTHLQKQLVGTVSSKILELARKQRMNTDIRRNIFCTIMTSEDFLDAFEKLLKLGLKDQQEREIIHVLMDCCLQEKTYNPFYAFLASKFCEYERRFQMTFQFSIWDKFRDLENLPATNFSNLVHLVAHLLKTKSLSLSILKVVEFSELDKPRVRFLRKVLSILLMETEVEDLSLIFTRVSDNPKLGVLREGLKLFISHFLLKNAQAHRSADEANVLREKADLATKCLQGKASLRM
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAASRSAGE
------CCCCCCCCC		17.72-
40AcetylationGPAGGGEKALKRLKL
CCCCCHHHHHHHHHH		63.3925953088
40UbiquitinationGPAGGGEKALKRLKL
CCCCCHHHHHHHHHH		63.3924816145
56PhosphorylationVEEFVHATSEGEAPG
HHHHHHHCCCCCCCC		16.6630576142
57PhosphorylationEEFVHATSEGEAPGG
HHHHHHCCCCCCCCC		44.3725159151
120PhosphorylationRSGAEEASGHRQDTE
CCCCCCCCCCCCCHH		38.1124425749
135PhosphorylationERARPAPSRDPSPPR
HHCCCCCCCCCCCCC		51.9629255136
139PhosphorylationPAPSRDPSPPRKPRP
CCCCCCCCCCCCCCC		52.4030266825
147PhosphorylationPPRKPRPSRVKAKAT
CCCCCCCCHHHHHHH		51.4926074081
167O-linked_GlycosylationTRPSAAATAAARKRA
CCCCHHHHHHHHHHH		16.4725367160
171MethylationAAATAAARKRALLAA
HHHHHHHHHHHHHHC		25.02115386861
204PhosphorylationKRKKKDGSSSVPLSF
CCCCCCCCCCCCCHH		29.58-
218PhosphorylationFARDGLDYILGALES
HHHCCHHHHHHHHHH		11.77-
280PhosphorylationAQEAEAQSEDDDEDT
HHHHHHHCCCCCCCC		50.4728176443
287PhosphorylationSEDDDEDTEEEQGEE
CCCCCCCCHHHHHHH		43.1628355574
302AcetylationKEKGAQEKRRGKRVR
HHHHHHHHHHCCCCC		35.0022368401
317PhosphorylationFAEDEEKSENSSEDG
CCCCHHHCCCCCCCC		45.3426503892
320PhosphorylationDEEKSENSSEDGDIT
CHHHCCCCCCCCCCC		30.9326503892
321PhosphorylationEEKSENSSEDGDITD
HHHCCCCCCCCCCCC		51.8226503892
327PhosphorylationSSEDGDITDKSLCGS
CCCCCCCCCHHHCCC		41.9630108239
330PhosphorylationDGDITDKSLCGSGEK
CCCCCCHHHCCCCCC		31.5328985074
334PhosphorylationTDKSLCGSGEKYIPP
CCHHHCCCCCCCCCH		42.6628634120
338PhosphorylationLCGSGEKYIPPHVRQ
HCCCCCCCCCHHHHC		17.8528634120
349PhosphorylationHVRQAEETVDFKKKE
HHHCHHHHCCCCHHH		19.5124043423
366UbiquitinationERLKKHVKGLLNRLS
HHHHHHHHHHHHHCC		43.4929967540
379PhosphorylationLSEPNMASISGQLEE
CCCCCHHHHHHHHHH		13.4027362937
399PhosphorylationSRKDMNDTLTSALMG
CCCCCCHHHHHHHHH		27.2525219547
401PhosphorylationKDMNDTLTSALMGAC
CCCCHHHHHHHHHHH		17.6625219547
402PhosphorylationDMNDTLTSALMGACV
CCCHHHHHHHHHHHH		23.6325219547
410PhosphorylationALMGACVTASAMPSR
HHHHHHHHHHCCCHH		18.1225219547
493PhosphorylationILKKLIGTFTEKDIE
HHHHHHCCCCHHHHH		22.01-
495PhosphorylationKKLIGTFTEKDIELI
HHHHCCCCHHHHHHH		41.80-
512PhosphorylationMLKNVGFSLRKDDAL
HHHHCCCCCCCCCCC		22.7224719451
520PhosphorylationLRKDDALSLKELITE
CCCCCCCCHHHHHHH		38.8324719451
522UbiquitinationKDDALSLKELITEAQ
CCCCCCHHHHHHHHH		47.2829967540
530PhosphorylationELITEAQTKASGAGS
HHHHHHHHHHCCCCC		35.31-
531UbiquitinationLITEAQTKASGAGSE
HHHHHHHHHCCCCCC		28.6022817900
562UbiquitinationLKNNDMRKIPGYDPE
HHCCCCCCCCCCCCH		46.7629967540
566PhosphorylationDMRKIPGYDPEPVEK
CCCCCCCCCCHHHHH		23.9922817900
573UbiquitinationYDPEPVEKLRKLQRA
CCCHHHHHHHHHHHH		54.5524816145
587PhosphorylationALVRNAGSGSETQLR
HHHHCCCCCCCEEEE		36.4124905233
589PhosphorylationVRNAGSGSETQLRVS
HHCCCCCCCEEEEEE		38.8924905233
591PhosphorylationNAGSGSETQLRVSWD
CCCCCCCEEEEEEHH		34.3024905233
596PhosphorylationSETQLRVSWDSVLSA
CCEEEEEEHHHCCCH		20.8024905233
599PhosphorylationQLRVSWDSVLSAEQT
EEEEEHHHCCCHHHH		20.7824905233
602PhosphorylationVSWDSVLSAEQTGRW
EEHHHCCCHHHHCCE		27.8324905233
606PhosphorylationSVLSAEQTGRWWIVG
HCCCHHHHCCEEEEE		21.8824905233
637PhosphorylationLQKQLVGTVSSKILE
HHHHHHHHHHHHHHH		15.10-
639PhosphorylationKQLVGTVSSKILELA
HHHHHHHHHHHHHHH		26.2528509920
640PhosphorylationQLVGTVSSKILELAR
HHHHHHHHHHHHHHH		21.2728509920
641UbiquitinationLVGTVSSKILELARK
HHHHHHHHHHHHHHH		43.75-
650MethylationLELARKQRMNTDIRR
HHHHHHHCCCHHHHH		24.2924384479
657MethylationRMNTDIRRNIFCTIM
CCCHHHHHHCHHEEC		40.7124384487
682UbiquitinationKLLKLGLKDQQEREI
HHHHCCCCHHHHHHH		52.2529967540
6822-HydroxyisobutyrylationKLLKLGLKDQQEREI
HHHHCCCCHHHHHHH		52.25-
763PhosphorylationKTKSLSLSILKVVEF
HHCCCCCHHEEEHHC		23.6224719451
775UbiquitinationVEFSELDKPRVRFLR
HHCHHCCCHHHHHHH		47.5529967540
809UbiquitinationTRVSDNPKLGVLREG
EECCCCCCCCHHHHH		65.2224816145
8092-HydroxyisobutyrylationTRVSDNPKLGVLREG
EECCCCCCCCHHHHH		65.22-
849PhosphorylationREKADLATKCLQGKA
HHHHHHHHHHHCCCH		29.5926074081
850UbiquitinationEKADLATKCLQGKAS
HHHHHHHHHHCCCHH		27.6029967540
857PhosphorylationKCLQGKASLRM----
HHHCCCHHHCC----		21.7226074081
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of NOM1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of NOM1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of NOM1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of NOM1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of NOM1_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.
Phosphorylation
ReferencePubMed
"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-317; SER-320 ANDSER-321, AND MASS SPECTROMETRY.

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