ASCC3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ASCC3_HUMAN
• UniProt AC: Q8N3C0
• Protein Name: Activating signal cointegrator 1 complex subunit 3
• Gene Name: ASCC3
• Organism: Homo sapiens (Human).
• Sequence Length: 2202
• Subcellular Localization: Nucleus .
• Protein Description: 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation..
• Protein Sequence: MALPRLTGALRSFSNVTKQDNYNEEVADLKIKRSKLHEQVLDLGLTWKKIIKFLNEKLEKSKMQSINEDLKDILHAAKQIVGTDNGREAIESGAAFLFMTFHLKDSVGHKETKAIKQMFGPFPSSSATAACNATNRIISHFSQDDLTALVQMTEKEHGDRVFFGKNLAFSFDMHDLDHFDELPINGETQKTISLDYKKFLNEHLQEACTPELKPVEKTNGSFLWCEVEKYLNSTLKEMTEVPRVEDLCCTLYDMLASIKSGDELQDELFELLGPEGLELIEKLLQNRITIVDRFLNSSNDHRFQALQDNCKKILGENAKPNYGCQVTIQSEQEKQLMKQYRREEKRIARREKKAGEDLEVSEGLMCFDPKELRIQREQALLNARSVPILSRQRDADVEKIHYPHVYDSQAEAMKTSAFIAGAKMILPEGIQRENNKLYEEVRIPYSEPMPLSFEEKPVYIQDLDEIGQLAFKGMKRLNRIQSIVFETAYNTNENMLICAPTGAGKTNIAMLTVLHEIRQHFQQGVIKKNEFKIVYVAPMKALAAEMTDYFSRRLEPLGIIVKELTGDMQLSKSEILRTQMLVTTPEKWDVVTRKSVGDVALSQIVRLLILDEVHLLHEDRGPVLESIVARTLRQVESTQSMIRILGLSATLPNYLDVATFLHVNPYIGLFFFDGRFRPVPLGQTFLGIKCANKMQQLNNMDEVCYENVLKQVKAGHQVMVFVHARNATVRTAMSLIERAKNCGHIPFFFPTQGHDYVLAEKQVQRSRNKQVRELFPDGFSIHHAGMLRQDRNLVENLFSNGHIKVLVCTATLAWGVNLPAHAVIIKGTQIYAAKRGSFVDLGILDVMQIFGRAGRPQFDKFGEGIIITTHDKLSHYLTLLTQRNPIESQFLESLADNLNAEIALGTVTNVEEAVKWISYTYLYVRMRANPLAYGISHKAYQIDPTLRKHREQLVIEVGRKLDKAQMIRFEERTGYFSSTDLGRTASHYYIKYNTIETFNELFDAHKTEGDIFAIVSKAEEFDQIKVREEEIEELDTLLSNFCELSTPGGVENSYGKINILLQTYISRGEMDSFSLISDSAYVAQNAARIVRALFEIALRKRWPTMTYRLLNLSKVIDKRLWGWASPLRQFSILPPHILTRLEEKKLTVDKLKDMRKDEIGHILHHVNIGLKVKQCVHQIPSVMMEASIQPITRTVLRVTLSIYADFTWNDQVHGTVGEPWWIWVEDPTNDHIYHSEYFLALKKQVISKEAQLLVFTIPIFEPLPSQYYIRAVSDRWLGAEAVCIINFQHLILPERHPPHTELLDLQPLPITALGCKAYEALYNFSHFNPVQTQIFHTLYHTDCNVLLGAPTGSGKTVAAELAIFRVFNKYPTSKAVYIAPLKALVRERMDDWKVRIEEKLGKKVIELTGDVTPDMKSIAKADLIVTTPEKWDGVSRSWQNRNYVQQVTILIIDEIHLLGEERGPVLEVIVSRTNFISSHTEKPVRIVGLSTALANARDLADWLNIKQMGLFNFRPSVRPVPLEVHIQGFPGQHYCPRMASMNKPAFQAIRSHSPAKPVLIFVSSRRQTRLTALELIAFLATEEDPKQWLNMDEREMENIIATVRDSNLKLTLAFGIGMHHAGLHERDRKTVEELFVNCKVQVLIATSTLAWGVNFPAHLVIIKGTEYYDGKTRRYVDFPITDVLQMMGRAGRPQFDDQGKAVILVHDIKKDFYKKFLYEPFPVESSLLGVLSDHLNAEIAGGTITSKQDALDYITWTYFFRRLIMNPSYYNLGDVSHDSVNKFLSHLIEKSLIELELSYCIEIGEDNRSIEPLTYGRIASYYYLKHQTVKMFKDRLKPECSTEELLSILSDAEEYTDLPVRHNEDHMNSELAKCLPIESNPHSFDSPHTKAHLLLQAHLSRAMLPCPDYDTDTKTVLDQALRVCQAMLDVAANQGWLVTVLNITNLIQMVIQGRWLKDSSLLTLPNIENHHLHLFKKWKPIMKGPHARGRTSIESLPELIHACGGKDHVFSSMVESELHAAKTKQAWNFLSHLPVINVGISVKGSWDDLVEGHNELSVSTLTADKRDDNKWIKLHADQEYVLQVSLQRVHFGFHKGKPESCAVTPRFPKSKDEGWFLILGEVDKRELIALKRVGYIRNHHVASLSFYTPEIPGRYIYTLYFMSDCYLGLDQQYDIYLNVTQASLSAQVNTKVSDSLTDLALK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	RLTGALRSFSNVTKQ HHHHHHHHHCCCCCC	33.60	29514088
14	Phosphorylation	TGALRSFSNVTKQDN HHHHHHHCCCCCCCC	31.47	29514088
17	Phosphorylation	LRSFSNVTKQDNYNE HHHHCCCCCCCCCCH	27.52	29514088
18	Ubiquitination	RSFSNVTKQDNYNEE HHHCCCCCCCCCCHH	51.91	21890473
30	Ubiquitination	NEEVADLKIKRSKLH CHHHHHHHHCHHHHH	46.88	21890473
30	Acetylation	NEEVADLKIKRSKLH CHHHHHHHHCHHHHH	46.88	25953088
52	Ubiquitination	LTWKKIIKFLNEKLE CCHHHHHHHHHHHHH	47.47	-
57	Ubiquitination	IIKFLNEKLEKSKMQ HHHHHHHHHHHHHHH	61.95	-
62	Ubiquitination	NEKLEKSKMQSINED HHHHHHHHHHHHCHH	52.61	-
65	Phosphorylation	LEKSKMQSINEDLKD HHHHHHHHHCHHHHH	24.71	20873877
78	Ubiquitination	KDILHAAKQIVGTDN HHHHHHHHHHHCCCC	41.14	21890473
116	Ubiquitination	HKETKAIKQMFGPFP CHHHHHHHHHHCCCC	40.34	-
134	Phosphorylation	ATAACNATNRIISHF HHHHHHHHHHHHHCC	15.84	23403867
139	Phosphorylation	NATNRIISHFSQDDL HHHHHHHHCCCHHHH	18.99	28348404
142	Phosphorylation	NRIISHFSQDDLTAL HHHHHCCCHHHHHHH	27.55	28348404
155	Ubiquitination	ALVQMTEKEHGDRVF HHHHHHHHHHCCEEE	45.93	-
160	Methylation	TEKEHGDRVFFGKNL HHHHHCCEEEEECCE	31.56	-
170	Phosphorylation	FGKNLAFSFDMHDLD EECCEEEEEECHHCC	18.09	28348404
190	Ubiquitination	PINGETQKTISLDYK CCCCCCCEEEECCHH	56.07	-
193	Phosphorylation	GETQKTISLDYKKFL CCCCEEEECCHHHHH	22.03	28555341
197	Ubiquitination	KTISLDYKKFLNEHL EEEECCHHHHHHHHH	36.39	21890473
198	Ubiquitination	TISLDYKKFLNEHLQ EEECCHHHHHHHHHH	49.18	-
209	Phosphorylation	EHLQEACTPELKPVE HHHHHHCCCCCCCCC	27.18	25159151
213	Ubiquitination	EACTPELKPVEKTNG HHCCCCCCCCCCCCC	45.41	-
218	Phosphorylation	ELKPVEKTNGSFLWC CCCCCCCCCCCEEEE	31.16	29396449
221	Phosphorylation	PVEKTNGSFLWCEVE CCCCCCCCEEEEEHH	21.16	21815630
234	Phosphorylation	VEKYLNSTLKEMTEV HHHHHHHHHHHHHCC	40.55	19413330
236	Ubiquitination	KYLNSTLKEMTEVPR HHHHHHHHHHHCCCC	45.59	21890473
236	Ubiquitination	KYLNSTLKEMTEVPR HHHHHHHHHHHCCCC	45.59	21890473
297	Phosphorylation	IVDRFLNSSNDHRFQ HHHHHHCCCCCHHHH	32.44	23663014
298	Phosphorylation	VDRFLNSSNDHRFQA HHHHHCCCCCHHHHH	45.24	23663014
311	Ubiquitination	QALQDNCKKILGENA HHHHHHHHHHHCCCC	49.45	-
312	Ubiquitination	ALQDNCKKILGENAK HHHHHHHHHHCCCCC	45.42	-
319	Ubiquitination	KILGENAKPNYGCQV HHHCCCCCCCCCEEE	45.43	-
334	Ubiquitination	TIQSEQEKQLMKQYR EECCHHHHHHHHHHH	48.72	-
338	Ubiquitination	EQEKQLMKQYRREEK HHHHHHHHHHHHHHH	53.41	-
353	Acetylation	RIARREKKAGEDLEV HHHHHHHHHCCCCCC	57.79	19811849
365	Sulfoxidation	LEVSEGLMCFDPKEL CCCCCCCCCCCHHHH	2.92	21406390
370	Ubiquitination	GLMCFDPKELRIQRE CCCCCCHHHHHHHHH	71.83	-
385	Phosphorylation	QALLNARSVPILSRQ HHHHHCCCCCCCCCC	29.81	27251275
399	Ubiquitination	QRDADVEKIHYPHVY CCCCCCHHCCCCCCC	34.33	-
414	Ubiquitination	DSQAEAMKTSAFIAG HHHHHHHHHHHHHHC	46.50	-
423	Ubiquitination	SAFIAGAKMILPEGI HHHHHCCCCCCCHHH	26.09	21890473
423	Ubiquitination	SAFIAGAKMILPEGI HHHHHCCCCCCCHHH	26.09	21890473
436	Ubiquitination	GIQRENNKLYEEVRI HHHHHCCCEEEECCC	65.12	21890473
438	Phosphorylation	QRENNKLYEEVRIPY HHHCCCEEEECCCCC	16.20	28442448
452	Phosphorylation	YSEPMPLSFEEKPVY CCCCCCCCCCCCCEE	25.41	24719451
456	Ubiquitination	MPLSFEEKPVYIQDL CCCCCCCCCEEEECH	32.36	-
472	Ubiquitination	EIGQLAFKGMKRLNR HHHHHHHHHHHHHHH	53.11	-
482	Phosphorylation	KRLNRIQSIVFETAY HHHHHHHHHEEECCC	20.53	29083192
487	Phosphorylation	IQSIVFETAYNTNEN HHHHEEECCCCCCCC	23.99	29083192
489	Phosphorylation	SIVFETAYNTNENML HHEEECCCCCCCCEE	29.91	29083192
491	Phosphorylation	VFETAYNTNENMLIC EEECCCCCCCCEEEE	31.10	29083192
501	Phosphorylation	NMLICAPTGAGKTNI CEEEEECCCCCHHHH	22.57	29083192
506	Phosphorylation	APTGAGKTNIAMLTV ECCCCCHHHHHHHHH	30.82	23403867
512	Phosphorylation	KTNIAMLTVLHEIRQ HHHHHHHHHHHHHHH	14.13	23403867
527	Ubiquitination	HFQQGVIKKNEFKIV HHHHCCCCCCCEEEE	47.33	-
540	Ubiquitination	IVYVAPMKALAAEMT EEEEECHHHHHHHHH	38.91	-
565	Phosphorylation	GIIVKELTGDMQLSK CEEEEECCCCCCCCH	32.02	19651622
568	Sulfoxidation	VKELTGDMQLSKSEI EEECCCCCCCCHHHH	4.58	21406390
572	Acetylation	TGDMQLSKSEILRTQ CCCCCCCHHHHHHHC	61.78	19608861
572	Ubiquitination	TGDMQLSKSEILRTQ CCCCCCCHHHHHHHC	61.78	21906983
572	Malonylation	TGDMQLSKSEILRTQ CCCCCCCHHHHHHHC	61.78	26320211
578	Phosphorylation	SKSEILRTQMLVTTP CHHHHHHHCCEEECH	18.19	22210691
583	Phosphorylation	LRTQMLVTTPEKWDV HHHCCEEECHHHCCC	32.45	22210691
584	Phosphorylation	RTQMLVTTPEKWDVV HHCCEEECHHHCCCC	23.21	22210691
587	Ubiquitination	MLVTTPEKWDVVTRK CEEECHHHCCCCCCC	50.31	-
592	Phosphorylation	PEKWDVVTRKSVGDV HHHCCCCCCCCHHHH	32.03	-
594	Ubiquitination	KWDVVTRKSVGDVAL HCCCCCCCCHHHHHH	39.88	-
595	Phosphorylation	WDVVTRKSVGDVALS CCCCCCCCHHHHHHH	28.21	20068231
602	Phosphorylation	SVGDVALSQIVRLLI CHHHHHHHHHHHHHH	14.23	20068231
637	Phosphorylation	RTLRQVESTQSMIRI HHHHHHHHHHHHHHH	32.65	-
640	Phosphorylation	RQVESTQSMIRILGL HHHHHHHHHHHHHHH	19.10	-
693	Ubiquitination	LGIKCANKMQQLNNM HHHHHCHHHHHHCCC	21.40	-
710	Ubiquitination	VCYENVLKQVKAGHQ HHHHHHHHHHHCCCE	49.08	-
733	Sulfoxidation	NATVRTAMSLIERAK CHHHHHHHHHHHHHH	3.11	21406390
740	Ubiquitination	MSLIERAKNCGHIPF HHHHHHHHHCCCCCE	60.02	-
761	Ubiquitination	HDYVLAEKQVQRSRN CCHHHHHHHHHHHHC	50.60	-
834	Ubiquitination	GTQIYAAKRGSFVDL CCEEEEECCCCCCCC	49.47	-
860	Ubiquitination	AGRPQFDKFGEGIII CCCCCCCCCCCCEEE	57.46	21890473
860	Ubiquitination	AGRPQFDKFGEGIII CCCCCCCCCCCCEEE	57.46	21890473
860	Acetylation	AGRPQFDKFGEGIII CCCCCCCCCCCCEEE	57.46	26051181
938	Ubiquitination	LAYGISHKAYQIDPT CCCCCCCCCEECCHH	41.83	21890473
938	Ubiquitination	LAYGISHKAYQIDPT CCCCCCCCCEECCHH	41.83	21890473
960	Ubiquitination	LVIEVGRKLDKAQMI HHHHHCCCCCHHHEE	55.92	-
973	Phosphorylation	MIRFEERTGYFSSTD EEEEEHHCCCCCCCC	39.24	-
975	Phosphorylation	RFEERTGYFSSTDLG EEEHHCCCCCCCCCC	10.32	-
1006	Ubiquitination	NELFDAHKTEGDIFA HHHHHHHCCCCCEEE	50.41	-
1017	Ubiquitination	DIFAIVSKAEEFDQI CEEEEEECHHHHHCC	49.26	21890473
1025	Ubiquitination	AEEFDQIKVREEEIE HHHHHCCCCCHHHHH	29.61	21890473
1070	Sulfoxidation	TYISRGEMDSFSLIS EECCCCCCCCCCCCC	6.11	30846556
1104	Phosphorylation	ALRKRWPTMTYRLLN HHHHCCCHHHHHHHH	18.38	22461510
1106	Phosphorylation	RKRWPTMTYRLLNLS HHCCCHHHHHHHHHH	14.15	22461510
1107	Phosphorylation	KRWPTMTYRLLNLSK HCCCHHHHHHHHHHH	6.61	22461510
1131	Phosphorylation	ASPLRQFSILPPHIL CCCHHHHCCCCHHHH	18.19	24043423
1139	Phosphorylation	ILPPHILTRLEEKKL CCCHHHHHHHHHCCC	32.38	20068231
1150	Ubiquitination	EKKLTVDKLKDMRKD HCCCCHHHHHHHCHH	53.77	-
1156	Ubiquitination	DKLKDMRKDEIGHIL HHHHHHCHHHHHHHH	53.74	-
1369	Ubiquitination	AIFRVFNKYPTSKAV HHHHHHHCCCCCCCE	40.94	-
1370	Phosphorylation	IFRVFNKYPTSKAVY HHHHHHCCCCCCCEE	16.91	29083192
1372	Phosphorylation	RVFNKYPTSKAVYIA HHHHCCCCCCCEEEH	39.51	29083192
1373	Phosphorylation	VFNKYPTSKAVYIAP HHHCCCCCCCEEEHH	17.70	29083192
1374	Ubiquitination	FNKYPTSKAVYIAPL HHCCCCCCCEEEHHH	44.33	-
1377	Phosphorylation	YPTSKAVYIAPLKAL CCCCCCEEEHHHHHH	9.02	29083192
1382	Methylation	AVYIAPLKALVRERM CEEEHHHHHHHHHHC	38.32	-
1382	Ubiquitination	AVYIAPLKALVRERM CEEEHHHHHHHHHHC	38.32	21890473
1382	Ubiquitination	AVYIAPLKALVRERM CEEEHHHHHHHHHHC	38.32	21890473
1399	Acetylation	WKVRIEEKLGKKVIE CCHHHHHHHCCCEEE	50.15	23749302
1399	Ubiquitination	WKVRIEEKLGKKVIE CCHHHHHHHCCCEEE	50.15	-
1403	Acetylation	IEEKLGKKVIELTGD HHHHHCCCEEEECCC	46.80	18530623
1403	Ubiquitination	IEEKLGKKVIELTGD HHHHHCCCEEEECCC	46.80	-
1412	Phosphorylation	IELTGDVTPDMKSIA EEECCCCCCCHHHHH	20.50	21815630
1415	Sulfoxidation	TGDVTPDMKSIAKAD CCCCCCCHHHHHCCC	3.74	21406390
1416	Ubiquitination	GDVTPDMKSIAKADL CCCCCCHHHHHCCCE	46.20	21890473
1420	Ubiquitination	PDMKSIAKADLIVTT CCHHHHHCCCEEEEC	40.54	21890473
1426	Phosphorylation	AKADLIVTTPEKWDG HCCCEEEECHHHCCC	29.64	23186163
1427	Phosphorylation	KADLIVTTPEKWDGV CCCEEEECHHHCCCC	20.68	27050516
1430	Ubiquitination	LIVTTPEKWDGVSRS EEEECHHHCCCCCHH	52.36	21890473
1473	Phosphorylation	LEVIVSRTNFISSHT EEEEEECCCCCCCCC	27.29	21406692
1477	Phosphorylation	VSRTNFISSHTEKPV EECCCCCCCCCCCCE	16.36	21406692
1478	Phosphorylation	SRTNFISSHTEKPVR ECCCCCCCCCCCCEE	29.61	21406692
1480	Phosphorylation	TNFISSHTEKPVRIV CCCCCCCCCCCEEEE	47.88	21406692
1482	Ubiquitination	FISSHTEKPVRIVGL CCCCCCCCCEEEEEH	50.39	21890473
1490	Phosphorylation	PVRIVGLSTALANAR CEEEEEHHHHHHHHH	13.00	-
1491	Phosphorylation	VRIVGLSTALANARD EEEEEHHHHHHHHHH	30.63	-
1540	Phosphorylation	HYCPRMASMNKPAFQ CCCCCHHHCCCHHHH	17.34	27080861
1543	Ubiquitination	PRMASMNKPAFQAIR CCHHHCCCHHHHHHH	29.13	-
1551	Phosphorylation	PAFQAIRSHSPAKPV HHHHHHHCCCCCCCE	23.39	20068231
1553	Phosphorylation	FQAIRSHSPAKPVLI HHHHHCCCCCCCEEE	28.00	20068231
1563	Phosphorylation	KPVLIFVSSRRQTRL CCEEEEECCCCHHHH	13.84	20068231
1564	Phosphorylation	PVLIFVSSRRQTRLT CEEEEECCCCHHHHH	26.61	20068231
1568	Phosphorylation	FVSSRRQTRLTALEL EECCCCHHHHHHHHH	26.32	24905233
1606	Phosphorylation	IIATVRDSNLKLTLA HHHHHCCCCCEEEEE	33.23	28348404
1609	"N6,N6-dimethyllysine"	TVRDSNLKLTLAFGI HHCCCCCEEEEEEEC	43.61	-
1609	Methylation	TVRDSNLKLTLAFGI HHCCCCCEEEEEEEC	43.61	23644510
1611	Phosphorylation	RDSNLKLTLAFGIGM CCCCCEEEEEEECCC	17.91	24719451
1671	Ubiquitination	GTEYYDGKTRRYVDF CCCEECCCCEEEECC	35.64	21890473
1700	Ubiquitination	PQFDDQGKAVILVHD CCCCCCCCEEEEEEE	33.57	-
1709	Acetylation	VILVHDIKKDFYKKF EEEEEECCHHHHHHH	52.96	25825284
1709	Sumoylation	VILVHDIKKDFYKKF EEEEEECCHHHHHHH	52.96	-
1709	Ubiquitination	VILVHDIKKDFYKKF EEEEEECCHHHHHHH	52.96	-
1709	Sumoylation	VILVHDIKKDFYKKF EEEEEECCHHHHHHH	52.96	17000644
1715	Sumoylation	IKKDFYKKFLYEPFP CCHHHHHHHCCCCCC	29.26	-
1745	Phosphorylation	EIAGGTITSKQDALD EECCCCCCCHHHHHH	29.70	-
1746	Phosphorylation	IAGGTITSKQDALDY ECCCCCCCHHHHHHH	25.19	-
1820	Phosphorylation	LTYGRIASYYYLKHQ CCHHHHHHHHHHHHH	15.99	29978859
1821	Phosphorylation	TYGRIASYYYLKHQT CHHHHHHHHHHHHHH	6.26	29978859
1822	Phosphorylation	YGRIASYYYLKHQTV HHHHHHHHHHHHHHH	10.38	29978859
1823	Phosphorylation	GRIASYYYLKHQTVK HHHHHHHHHHHHHHH	10.88	29978859
1825	Methylation	IASYYYLKHQTVKMF HHHHHHHHHHHHHHH	19.97	-
1828	Phosphorylation	YYYLKHQTVKMFKDR HHHHHHHHHHHHHHH	23.08	29978859
1830	Ubiquitination	YLKHQTVKMFKDRLK HHHHHHHHHHHHHCC	41.84	-
1837	Sumoylation	KMFKDRLKPECSTEE HHHHHHCCCCCCHHH	39.40	-
1837	Ubiquitination	KMFKDRLKPECSTEE HHHHHHCCCCCCHHH	39.40	-
1837	Sumoylation	KMFKDRLKPECSTEE HHHHHHCCCCCCHHH	39.40	17000644
1873	Ubiquitination	HMNSELAKCLPIESN CCCCHHHHCCCCCCC	49.26	-
1909	Phosphorylation	AMLPCPDYDTDTKTV HCCCCCCCCCCHHHH	13.09	-
1915	Phosphorylation	DYDTDTKTVLDQALR CCCCCHHHHHHHHHH	28.52	20068231
1976	Ubiquitination	NHHLHLFKKWKPIMK CCCHHHHHCCCCCCC	65.17	-
1983	Ubiquitination	KKWKPIMKGPHARGR HCCCCCCCCCCCCCC	70.75	-
1991	Phosphorylation	GPHARGRTSIESLPE CCCCCCCCCHHHHHH	36.56	23898821
1992	Phosphorylation	PHARGRTSIESLPEL CCCCCCCCHHHHHHH	24.01	24961811
2011	Phosphorylation	GGKDHVFSSMVESEL CCCCHHHHHHHHHHH	19.21	20873877
2012	Phosphorylation	GKDHVFSSMVESELH CCCHHHHHHHHHHHH	18.51	20873877
2016	Phosphorylation	VFSSMVESELHAAKT HHHHHHHHHHHHHHH	33.76	20873877
2022	Ubiquitination	ESELHAAKTKQAWNF HHHHHHHHHHHHHHH	57.97	-
2065	Ubiquitination	VSTLTADKRDDNKWI EEEEECCCCCCCCEE	56.09	-
2070	Ubiquitination	ADKRDDNKWIKLHAD CCCCCCCCEEEEECC	58.24	-
2097	Ubiquitination	HFGFHKGKPESCAVT EECCCCCCCHHCEEC	50.87	-
2104	Phosphorylation	KPESCAVTPRFPKSK CCHHCEECCCCCCCC	7.10	24719451
2111	Ubiquitination	TPRFPKSKDEGWFLI CCCCCCCCCCCEEEE	66.96	-
2193	Phosphorylation	AQVNTKVSDSLTDLA HHCCCHHHHHHHHHH	24.04	30266825
2195	Phosphorylation	VNTKVSDSLTDLALK CCCHHHHHHHHHHCC	26.18	19664994
2197	Phosphorylation	TKVSDSLTDLALK-- CHHHHHHHHHHCC--	32.68	30266825

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ASCC3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ASCC3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ASCC3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CCHL_HUMAN	HCCS	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Acetylation

"Lysine acetylation targets protein complexes and co-regulates majorcellular functions.";
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.;
Science 325:834-840(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-572, AND MASS SPECTROMETRY.
PubMed: 19608861

Phosphorylation

"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-234, AND MASSSPECTROMETRY.
PubMed: 19413330