CCHL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCHL_HUMAN
• UniProt AC: P53701
• Protein Name: Cytochrome c-type heme lyase
• Gene Name: HCCS
• Organism: Homo sapiens (Human).
• Sequence Length: 268
• Subcellular Localization: Mitochondrion inner membrane . Membrane ; Lipid-anchor .
• Protein Description: Links covalently the heme group to the apoprotein of cytochrome c..
• Protein Sequence: MGLSPSAPAVAVQASNASASPPSGCPMHEGKMKGCPVNTEPSGPTCEKKTYSVPAHQERAYEYVECPIRGTAAENKENLDPSNLMPPPNQTPAPDQPFALSTVREESSIPRADSEKKWVYPSEQMFWNAMLKKGWKWKDEDISQKDMYNIIRIHNQNNEQAWKEILKWEALHAAECPCGPSLIRFGGKAKEYSPRARIRSWMGYELPFDRHDWIINRCGTEVRYVIDYYDGGEVNKDYQFTILDVRPALDSLSAVWDRMKVAWWRWTS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Myristoylation	------MGLSPSAPA ------CCCCCCCCE	34.56	25807930
33	Acetylation	PMHEGKMKGCPVNTE CCCCCCCCCCCCCCC	61.93	26051181
35	S-palmitoylation	HEGKMKGCPVNTEPS CCCCCCCCCCCCCCC	2.58	21044946
39	Phosphorylation	MKGCPVNTEPSGPTC CCCCCCCCCCCCCCC	49.89	29759185
45	Phosphorylation	NTEPSGPTCEKKTYS CCCCCCCCCCCEEEE	36.50	29759185
46	S-palmitoylation	TEPSGPTCEKKTYSV CCCCCCCCCCEEEEC	8.98	21044946
48	Acetylation	PSGPTCEKKTYSVPA CCCCCCCCEEEECCC	53.19	26051181
48	2-Hydroxyisobutyrylation	PSGPTCEKKTYSVPA CCCCCCCCEEEECCC	53.19	-
49	Acetylation	SGPTCEKKTYSVPAH CCCCCCCEEEECCCC	30.33	26051181
49	Ubiquitination	SGPTCEKKTYSVPAH CCCCCCCEEEECCCC	30.33	-
50	Phosphorylation	GPTCEKKTYSVPAHQ CCCCCCEEEECCCCH	31.90	30108239
51	Phosphorylation	PTCEKKTYSVPAHQE CCCCCEEEECCCCHH	19.29	30108239
52	Phosphorylation	TCEKKTYSVPAHQER CCCCEEEECCCCHHH	27.19	30108239
61	Phosphorylation	PAHQERAYEYVECPI CCCHHHHHHHCCCCC	17.64	25884760
63	Phosphorylation	HQERAYEYVECPIRG CHHHHHHHCCCCCCC	6.72	28796482
66	Glutathionylation	RAYEYVECPIRGTAA HHHHHCCCCCCCCCH	2.12	22555962
76	Ubiquitination	RGTAAENKENLDPSN CCCCHHCCCCCCHHH	39.21	-
132	Acetylation	MFWNAMLKKGWKWKD HHHHHHHHHCCCCCC	35.83	26051181
136	Ubiquitination	AMLKKGWKWKDEDIS HHHHHCCCCCCCCCC	53.70	-
138	2-Hydroxyisobutyrylation	LKKGWKWKDEDISQK HHHCCCCCCCCCCHH	47.73	-
138	Acetylation	LKKGWKWKDEDISQK HHHCCCCCCCCCCHH	47.73	26051181
138	Ubiquitination	LKKGWKWKDEDISQK HHHCCCCCCCCCCHH	47.73	-
145	Ubiquitination	KDEDISQKDMYNIIR CCCCCCHHHHHHHEE	37.36	21906983
145	Sumoylation	KDEDISQKDMYNIIR CCCCCCHHHHHHHEE	37.36	-
148	Phosphorylation	DISQKDMYNIIRIHN CCCHHHHHHHEEHHH	17.22	27642862
163	Ubiquitination	QNNEQAWKEILKWEA CCCHHHHHHHHHHHH	37.58	-
167	Ubiquitination	QAWKEILKWEALHAA HHHHHHHHHHHHHHC	48.96	-
200	Phosphorylation	SPRARIRSWMGYELP CCHHHHHHHCCCCCC	21.02	28348404
224	Phosphorylation	RCGTEVRYVIDYYDG CCCCEEEEEEEECCC	13.61	-
228	Phosphorylation	EVRYVIDYYDGGEVN EEEEEEEECCCCCCC	7.73	29052541
229	Phosphorylation	VRYVIDYYDGGEVNK EEEEEEECCCCCCCC	12.36	29052541
241	Phosphorylation	VNKDYQFTILDVRPA CCCCEEEEEEECHHH	12.71	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCHL_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCHL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCHL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
FZR1_HUMAN	FZR1	physical	26186194
ARMX3_HUMAN	ARMCX3	physical	26186194
PHF23_HUMAN	PHF23	physical	26186194
NPAT_HUMAN	NPAT	physical	26186194
CY1_HUMAN	CYC1	physical	26186194
KCNQ5_HUMAN	KCNQ5	physical	26186194
MTCH2_HUMAN	MTCH2	physical	26186194
GPTC8_HUMAN	GPATCH8	physical	26186194
M1IP1_HUMAN	MID1IP1	physical	26186194
RRFM_HUMAN	MRRF	physical	26186194
MPZL1_HUMAN	MPZL1	physical	26186194
MET16_HUMAN	METTL16	physical	26186194
MARH7_HUMAN	MARCH7	physical	26186194
RM17_HUMAN	MRPL17	physical	26496610
CRTC3_HUMAN	CRTC3	physical	26496610
MROH1_HUMAN	MROH1	physical	26496610
NPAT_HUMAN	NPAT	physical	28514442
PHF23_HUMAN	PHF23	physical	28514442
CY1_HUMAN	CYC1	physical	28514442
AGK_HUMAN	AGK	physical	28514442
FZR1_HUMAN	FZR1	physical	28514442
MET16_HUMAN	METTL16	physical	28514442
RRFM_HUMAN	MRRF	physical	28514442
KCNQ5_HUMAN	KCNQ5	physical	28514442
ARMX3_HUMAN	ARMCX3	physical	28514442
MPZL1_HUMAN	MPZL1	physical	28514442
MARH7_HUMAN	MARCH7	physical	28514442
GPTC8_HUMAN	GPATCH8	physical	28514442
COMT_HUMAN	COMT	physical	27173435
ESYT1_HUMAN	ESYT1	physical	27173435
TMX1_HUMAN	TMX1	physical	27173435
SG196_HUMAN	POMK	physical	27173435
ARL8B_HUMAN	ARL8B	physical	27173435
ATLA2_HUMAN	ATL2	physical	27173435

Drug and Disease Associations

• Kegg Disease
• H01027: Anophthalmia and microphthalmia (A/M)
• OMIM Disease
• 309801: Linear skin defects with multiple congenital anomalies 1 (LSDMCA1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.