| UniProt ID | SG196_HUMAN | |
|---|---|---|
| UniProt AC | Q9H5K3 | |
| Protein Name | Protein O-mannose kinase | |
| Gene Name | POMK | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 350 | |
| Subcellular Localization |
Endoplasmic reticulum membrane Single-pass type II membrane protein . |
|
| Protein Description | Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.. | |
| Protein Sequence | MEKQPQNSRRGLAPREVPPAVGLLLIMALMNTLLYLCLDHFFIAPRQSTVDPTHCPYGHFRIGQMKNCSPWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHKVALSQLTSLEMKDDFLHGLQMLKSLQGTHVVTLLGYCEDDNTMLTEYHPLGSLSNLEETLNLSKYQNVNTWQHRLELAMDYVSIINYLHHSPVGTRVMCDSNDLPKTLSQYLLTSNFSILANDLDALPLVNHSSGMLVKCGHRELHGDFVAPEQLWPYGEDVPFHDDLMPSYDEKIDIWKIPDISSFLLGHIEGSDMVRFHLFDIHKACKSQTPSERPTAQDVLETYQKVLDTLRDAMMSQAREML | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 1 | Acetylation | -------MEKQPQNS -------CCCCCCCC | 15.21 | 22814378 | |
| 3 | Ubiquitination | -----MEKQPQNSRR -----CCCCCCCCCC | 67.01 | 33845483 | |
| 93 | Ubiquitination | RVGEGAVKRVFLSEW HHCCHHHHHHHHHHH | 42.16 | 29967540 | |
| 101 | Ubiquitination | RVFLSEWKEHKVALS HHHHHHHHHHHHHHH | 45.98 | 29967540 | |
| 104 | Ubiquitination | LSEWKEHKVALSQLT HHHHHHHHHHHHHHC | 30.23 | 29967540 | |
| 108 | Phosphorylation | KEHKVALSQLTSLEM HHHHHHHHHHCCHHC | 17.26 | 28450419 | |
| 116 | Ubiquitination | QLTSLEMKDDFLHGL HHCCHHCHHCHHHHH | 44.78 | - | |
| 165 | N-linked_Glycosylation | SNLEETLNLSKYQNV CCHHHHHCCHHCCCC | 50.08 | UniProtKB CARBOHYD | |
| 220 | N-linked_Glycosylation | SQYLLTSNFSILAND HHHHHHCCCHHHCCC | 29.46 | UniProtKB CARBOHYD | |
| 235 | N-linked_Glycosylation | LDALPLVNHSSGMLV CCCCCCCCCCCCCEE | 36.69 | UniProtKB CARBOHYD | |
| 311 | Ubiquitination | FHLFDIHKACKSQTP EEEEEHHHHHHCCCC | 56.67 | - | |
| 314 | Ubiquitination | FDIHKACKSQTPSER EEHHHHHHCCCCCCC | 50.92 | 29967540 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of SG196_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of SG196_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of SG196_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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