TYW1B_HUMAN - dbPTM
TYW1B_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TYW1B_HUMAN
UniProt AC Q6NUM6
Protein Name S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase
Gene Name TYW1B
Organism Homo sapiens (Human).
Sequence Length 668
Subcellular Localization
Protein Description Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis (By similarity)..
Protein Sequence MDPSADTWDLSSPLISLWINRFYIYLGFAVSISLWICVQIVIEMQGFATVLAEAVTSLDLPVAIINLKEYDPDDHLIEEVTSKNVCVFLVATYTDGLPTESAEWFCKWLEEASIDFRFGKTYLKGMRDAVFGLGNSAYASHFNKVGKNVDKWLWMLGVHRVMSRGEGDCDVVKSKHGSIEANFRAWKTKFISQLQALQKGERKKSCGGHCKKGKCESHQHGSEEREEGSQEQDELHHRDTKEEEPFESSSEEEFGGEDHQSLNSIVDVEDLGKIMDHVKKEKREKEQQEEKSGLFRNMGRNEDGERRAMITPALREALTKQVDAPRERSLLQTHILWNESHRCMETTPSLACANKCVFCWWHHNNPVGTEWLWKMDQPEMILKEAIENHQNMIKQFKGVPGVKAERFEEGMTVKHCALSLVGEPIMYPEINRFLKLLHQCKISSFLVTNAQFPAEIRNLEPVTQLYVSVDASTKDSLKKIDRPLFKDFWQQFLDSLKALAVKQQRTVYRLMLVKAWNVDELQAYAQLVSLGNPDFIEVKGVTYCRESSASSLTMAHVPWHEEVVQFVRELVDLIPEYEIACEHEHSNCLLIAHRKFKIGGEWWTWIDYNRFQELIQEYEDSGGSKTFSAKDYMARTPHWALFGANERSFDPKDTRHQRKNKSKAISGC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
20UbiquitinationPLISLWINRFYIYLG
HHHHHHHHHHHHHHH		19.2021890473
97UbiquitinationVATYTDGLPTESAEW
EEEECCCCCHHCHHH		5.4421890473
120UbiquitinationSIDFRFGKTYLKGMR
CCCEECCHHHHHHHH		31.14-
124MethylationRFGKTYLKGMRDAVF
ECCHHHHHHHHHHHH		40.00-
136PhosphorylationAVFGLGNSAYASHFN
HHHCCCHHHHHHHHH		22.36-
138PhosphorylationFGLGNSAYASHFNKV
HCCCHHHHHHHHHHH		14.41-
140PhosphorylationLGNSAYASHFNKVGK
CCHHHHHHHHHHHCC		18.88-
173UbiquitinationEGDCDVVKSKHGSIE
CCCCCEEECCCCCHH		54.3527667366
189UbiquitinationNFRAWKTKFISQLQA
HHHHHHHHHHHHHHH		36.6527667366
199UbiquitinationSQLQALQKGERKKSC
HHHHHHHHCCCCCCC		64.6929967540
205UbiquitinationQKGERKKSCGGHCKK
HHCCCCCCCCCCCCC		22.4927667366
229PhosphorylationSEEREEGSQEQDELH
CHHCCCCCHHHHHHC		33.5529255136
251UbiquitinationEPFESSSEEEFGGED
CCCCCCCCCHHCCCC		64.5921890473
291UbiquitinationEKEQQEEKSGLFRNM
HHHHHHHHCCCCHHC		49.4229967540
292PhosphorylationKEQQEEKSGLFRNMG
HHHHHHHCCCCHHCC		43.9726074081
333UbiquitinationRERSLLQTHILWNES
HHHHHHHHHHHHCCC		15.7422505724
374UbiquitinationVGTEWLWKMDQPEMI
CCCHHHHHCCCHHHH		30.35-
383UbiquitinationDQPEMILKEAIENHQ
CCHHHHHHHHHHHHH		33.89-
394UbiquitinationENHQNMIKQFKGVPG
HHHHHHHHHHCCCCC		38.6221890473
397UbiquitinationQNMIKQFKGVPGVKA
HHHHHHHCCCCCCCC		57.41-
403UbiquitinationFKGVPGVKAERFEEG
HCCCCCCCCHHHCCC		50.9029967540
419PhosphorylationTVKHCALSLVGEPIM
CHHHHHHHHHCCCCH		11.5025850435
426UbiquitinationSLVGEPIMYPEINRF
HHHCCCCHHHHHHHH		7.1727667366
435UbiquitinationPEINRFLKLLHQCKI
HHHHHHHHHHHHCCC		46.41-
441UbiquitinationLKLLHQCKISSFLVT
HHHHHHCCCCEEEEC		38.77-
479UbiquitinationSTKDSLKKIDRPLFK
CCHHHHHHCCCHHHH		55.95-
497UbiquitinationQQFLDSLKALAVKQQ
HHHHHHHHHHHHHHH		45.35-
502UbiquitinationSLKALAVKQQRTVYR
HHHHHHHHHHHHHHH		34.8027667366
554UbiquitinationSSASSLTMAHVPWHE
CCCCCCEECCCCCHH		2.7022505724
618PhosphorylationFQELIQEYEDSGGSK
HHHHHHHHHHCCCCE		14.5228796482
621PhosphorylationLIQEYEDSGGSKTFS
HHHHHHHCCCCEEEC		32.8728796482
624PhosphorylationEYEDSGGSKTFSAKD
HHHHCCCCEEECHHH		31.8628796482
625UbiquitinationYEDSGGSKTFSAKDY
HHHCCCCEEECHHHH		57.7921890473
628PhosphorylationSGGSKTFSAKDYMAR
CCCCEEECHHHHHHC		39.3721712546
630UbiquitinationGSKTFSAKDYMARTP
CCEEECHHHHHHCCC		48.4722505724
636PhosphorylationAKDYMARTPHWALFG
HHHHHHCCCCCCCCC		15.23-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of TYW1B_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TYW1B_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TYW1B_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TYW1B_HUMAN !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TYW1B_HUMAN

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Related Literatures of Post-Translational Modification

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