LRP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: LRP5_HUMAN
• UniProt AC: O75197
• Protein Name: Low-density lipoprotein receptor-related protein 5
• Gene Name: LRP5
• Organism: Homo sapiens (Human).
• Sequence Length: 1615
• Subcellular Localization: Membrane; Single-pass type I membrane protein. Endoplasmic reticulum. Chaperoned to the plasma membrane by MESD..
• Protein Description: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. Plays a role in norrin (NDP) signal transduction. [PubMed: 27228167 The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Appears be required for postnatal control of vascular regression in the eye (By similarity Required for posterior patterning of the epiblast during gastrulation (By similarity]
• Protein Sequence: MEAAPPGPPWPLLLLLLLLLALCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDWGENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASRDVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTLVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITKPPSDDSPAHSSAIGPVIGIILSLFVMGGVYFVCQRVVCQRYAGANGPFPHEYVSGTPHVPLNFIAPGGSQHGPFTGIACGKSMMSSVSLMGGRGGVPLYDRNHVTGASSSSSSSTKATLYPPILNPPPSPATDPSLYNMDMFYSSNIPATARPYRPYIIRGMAPPTTPCSTDVCDSDYSASRWKASKYYLDLNSDSDPYPPPPTPHSQYLSAEDSCPPSPATERSYFHLFPPPPSPCTDSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	N-linked_Glycosylation	AIKQTYLNQTGAAVQ HHHHHHHCCCCCCCE	27.27	UniProtKB CARBOHYD
121	Ubiquitination	ACDWVGKKLYWTDSE CCCCCCCEEEECCCC	40.66	29967540
138	N-linked_Glycosylation	RIEVANLNGTSRKVL EEEEEECCCCCCEEE	52.05	UniProtKB CARBOHYD
143	Ubiquitination	NLNGTSRKVLFWQDL ECCCCCCEEEEEECC	42.95	-
184	Phosphorylation	ERAGMDGSTRKIIVD EECCCCCCCCEEEEC	22.30	24275569
185	Phosphorylation	RAGMDGSTRKIIVDS ECCCCCCCCEEEECC	41.32	-
399	Ubiquitination	DEVRAIRRAYLDGSG HHHHHHHHHHHCCCC	22.82	29967540
411	Ubiquitination	GSGAQTLVNTEINDP CCCCCEEEECCCCCC	10.66	21963094
446	N-linked_Glycosylation	RIEVTRLNGTSRKIL EEEEEEECCCCCEEE	48.70	UniProtKB CARBOHYD
499	N-linked_Glycosylation	QERRVLVNASLGWPN CCEEEEEEEECCCCC	21.46	UniProtKB CARBOHYD
535	Phosphorylation	EVINVDGTKRRTLLE EEEECCCCCCEEHHH	19.53	29396449
592	Ubiquitination	LPDLMGLKAVNVAKV CCCCCCCEEEEEEEE	44.55	22817900
601	Ubiquitination	VNVAKVVGTNPCADR EEEEEEECCCCCCCC	23.82	22817900
650	Ubiquitination	PEAFLVFTSRAAIHR CCHHHHHHCCCEEEE	15.15	21963094
705	N-linked_Glycosylation	TISRAFMNGSSVEHV HHHHHHHCCCCCEEE	40.52	UniProtKB CARBOHYD
802	Ubiquitination	NCMTLVDKVGRANDL CHHHHHHHHCCCCCE	38.83	-
878	N-linked_Glycosylation	ADKTSGRNRTLIQGH CHHCCCCCCEECCHH	44.83	UniProtKB CARBOHYD
980	Ubiquitination	LHGLRNVKAIDYDPL CCCCCCCCCCCCCCC	43.08	29967540
1008	Phosphorylation	KRAKDDGTQPFVLTS CCCCCCCCCCEEEEE	39.81	24114839
1012	Phosphorylation	DDGTQPFVLTSLSQG CCCCCCEEEEECCCC	7.88	33259812
1014	Phosphorylation	GTQPFVLTSLSQGQN CCCCEEEEECCCCCC	23.48	24114839
1017	Phosphorylation	PFVLTSLSQGQNPDR CEEEEECCCCCCCCC	31.84	24114839
1034	Phosphorylation	HDLSIDIYSRTLFWT CCEEEEEEECEEEEE	6.58	24043423
1035	Phosphorylation	DLSIDIYSRTLFWTC CEEEEEEECEEEEEE	21.08	24719451
1054	Phosphorylation	TINVHRLSGEAMGVV EEEEEECCCCCCEEE	34.25	22210691
1138	Phosphorylation	ADLKRIESCDLSGAN CCCCCHHCCCCCCCC	15.57	-
1142	Phosphorylation	RIESCDLSGANRLTL CHHCCCCCCCCCCCC	23.70	-
1231	Ubiquitination	CSHICIAKGDGTPRC CCEEEEEECCCCCCC	37.31	21963094
1240	Ubiquitination	DGTPRCSCPVHLVLL CCCCCCCCCHHHHHH	4.70	21963094
1459	Phosphorylation	ACGKSMMSSVSLMGG ECCCHHHHCHHCCCC	20.95	23186163
1460	Phosphorylation	CGKSMMSSVSLMGGR CCCHHHHCHHCCCCC	9.60	23186163
1462	Phosphorylation	KSMMSSVSLMGGRGG CHHHHCHHCCCCCCC	18.00	23186163
1473	Phosphorylation	GRGGVPLYDRNHVTG CCCCCCCCCCCCCCC	13.54	25884760
1483	Phosphorylation	NHVTGASSSSSSSTK CCCCCCCCCCCCCCC	33.43	22210691
1485	Phosphorylation	VTGASSSSSSSTKAT CCCCCCCCCCCCCEE	35.87	22210691
1487	Phosphorylation	GASSSSSSSTKATLY CCCCCCCCCCCEEEC	43.93	22210691
1492	Phosphorylation	SSSSTKATLYPPILN CCCCCCEEECCCCCC	28.51	-
1494	Phosphorylation	SSTKATLYPPILNPP CCCCEEECCCCCCCC	11.56	-
1503	Phosphorylation	PILNPPPSPATDPSL CCCCCCCCCCCCHHH	32.70	-
1528	Phosphorylation	IPATARPYRPYIIRG CCCCCCCCCCEEEEC	20.75	25884760
1531	Phosphorylation	TARPYRPYIIRGMAP CCCCCCCEEEECCCC	10.44	25884760
1552	Phosphorylation	TDVCDSDYSASRWKA CCCCCCCCCCHHHEE	15.30	25884760
1589	Phosphorylation	QYLSAEDSCPPSPAT HCCCCHHCCCCCCCC	21.74	-
1593	Phosphorylation	AEDSCPPSPATERSY CHHCCCCCCCCCCCC	16.59	33259812
1609	Phosphorylation	HLFPPPPSPCTDSS- CCCCCCCCCCCCCC-	38.08	25159151
1612	Phosphorylation	PPPPSPCTDSS---- CCCCCCCCCCC----	42.15	23312004
1614	Phosphorylation	PPSPCTDSS------ CCCCCCCCC------	21.57	23312004
1615	Phosphorylation	PSPCTDSS------- CCCCCCCC-------	47.23	23312004

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of LRP5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of LRP5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of LRP5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AXIN1_HUMAN	AXIN1	physical	11336703
CAPR2_HUMAN	CAPRIN2	physical	18762581
AXIN1_HUMAN	AXIN1	physical	18762581
DKK1_HUMAN	DKK1	physical	15035989

Drug and Disease Associations

• Kegg Disease
• H00436: Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermed
• H00450: Sclerosing bone dysplasias, including: Endosteal hyperostosis; Van Buchem disease, type 2; Osteopetr
• H00451: Osteoporosis-pseudoglioma syndrome (OPPG)
• H00589: Familial exudative vitreoretinopathy (FEVR), including: Exudative vitreoretinopathy 1 (EVR1); Exudat
• OMIM Disease
• 601813: Vitreoretinopathy, exudative 4 (EVR4)
• 166710: Osteoporosis (OSTEOP)
• 259770: Osteoporosis-pseudoglioma syndrome (OPPG)
• 601884: High bone mass trait (HBM)
• 144750: Endosteal hyperostosis, Worth type (WENHY)
• 607634: Osteopetrosis, autosomal dominant 1 (OPTA1)
• 607636: Van Buchem disease 2 (VBCH2)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.