KDSR_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KDSR_HUMAN
• UniProt AC: Q06136
• Protein Name: 3-ketodihydrosphingosine reductase
• Gene Name: KDSR
• Organism: Homo sapiens (Human).
• Sequence Length: 332
• Subcellular Localization: Endoplasmic reticulum membrane ; Multi-pass membrane protein .
• Protein Description: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS)..
• Protein Sequence: MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLISETTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQVVTMGLFRTIALFYLGSFDSIVRRCMMQREKSENADKTA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
60	Phosphorylation	YKQGAFITLVARNED ECCCCEEEEEEECHH	14.55	24702127
68	Ubiquitination	LVARNEDKLLQAKKE EEEECHHHHHHHHHE	44.94	-
74	Ubiquitination	DKLLQAKKEIEMHSI HHHHHHHHEEEECCC	67.92	-
74	Ubiquitination	DKLLQAKKEIEMHSI HHHHHHHHEEEECCC	67.92	-
80	Phosphorylation	KKEIEMHSINDKQVV HHEEEECCCCCCEEE	23.06	28509920
136	Phosphorylation	KFEDLEVSTFERLMS CCCCCCCHHHHHHHC	20.29	28270605
137	Phosphorylation	FEDLEVSTFERLMSI CCCCCCHHHHHHHCH	34.39	28270605
143	Phosphorylation	STFERLMSINYLGSV HHHHHHHCHHCCCCC	16.57	28270605
146	Phosphorylation	ERLMSINYLGSVYPS HHHHCHHCCCCCCCC	15.69	28270605
149	Phosphorylation	MSINYLGSVYPSRAV HCHHCCCCCCCCCCE	18.84	28270605
151	Phosphorylation	INYLGSVYPSRAVIT HHCCCCCCCCCCEEE	9.37	28270605
153	Phosphorylation	YLGSVYPSRAVITTM CCCCCCCCCCEEEEC	18.38	28270605
172	Phosphorylation	VGRIVFVSSQAGQLG CCEEEEEECCCCCCC	12.79	-
173	Phosphorylation	GRIVFVSSQAGQLGL CEEEEEECCCCCCCC	20.81	-
182	Ubiquitination	AGQLGLFGFTAYSAS CCCCCCCCEEHHHHH	24.84	-
186	Phosphorylation	GLFGFTAYSASKFAI CCCCEEHHHHHHHHH	11.17	22210691
207	Phosphorylation	LQMEVKPYNVYITVA HCCCCCCEEEEEEEE	16.14	-
210	Phosphorylation	EVKPYNVYITVAYPP CCCCEEEEEEEEECC	6.29	-
215	Phosphorylation	NVYITVAYPPDTDTP EEEEEEEECCCCCCC	15.80	-
246	Ubiquitination	SETTSVCKPEQVAKQ ECCCCCCCHHHHHHH	49.81	-
252	Ubiquitination	CKPEQVAKQIVKDAI CCHHHHHHHHHHHHH	41.52	-
307	Phosphorylation	FRTIALFYLGSFDSI HHHHHHHHHHCHHHH	15.82	24719451
310	Phosphorylation	IALFYLGSFDSIVRR HHHHHHHCHHHHHHH	24.24	24719451
313	Phosphorylation	FYLGSFDSIVRRCMM HHHHCHHHHHHHHHH	22.44	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of KDSR_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KDSR_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KDSR_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MK06_HUMAN	MAPK6	physical	21988832
RPN1_HUMAN	RPN1	physical	26344197
TERA_HUMAN	VCP	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.