dbPTM

MK06_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	MK06_HUMAN
UniProt AC	Q16659
Protein Name	Mitogen-activated protein kinase 6
Gene Name	MAPK6
Organism	Homo sapiens (Human).
Sequence Length	721
Subcellular Localization	Cytoplasm. Nucleus. Translocates to the cytoplasm following interaction with MAPKAPK5..
Protein Description	Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity)..
Protein Sequence	MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPMDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPVHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTNYSTEPCWQYSDHHENKYCDLECSHTCNYKTRSSSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKEKSDKKGKSKCERNGLVKAQIALEEASQQLAGKEREKNQGFDFDSFIAGTIQLSSQHEPTDVVDKLNDLNSSVSQLELKSLISKSVSQEKQEKGMANLAQLEALYQSSWDSQFVSGGEDCFFINQFCEVRKDEQVEKENTYTSYLDKFFSRKEDTEMLETEPVEDGKLGERGHEEGFLNNSGEFLFNKQLESIGIPQFHSPVGSPLKSIQATLTPSAMKSSPQIPHQTYSSILKHLN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Ubiquitination	----MAEKFESLMNI ----CHHHHHHHHHH	44.91	21890473
4	Ubiquitination	----MAEKFESLMNI ----CHHHHHHHHHH	44.91	21890473
4	Ubiquitination	----MAEKFESLMNI ----CHHHHHHHHHH	44.91	21890473
7	Phosphorylation	-MAEKFESLMNIHGF -CHHHHHHHHHHCCC	35.73	28555341
18	Phosphorylation	IHGFDLGSRYMDLKP HCCCCCCCCCCCCCC	27.77	28509920
54	Phosphorylation	AIKKIVLTDPQSVKH EEEEEEECCHHHHHH	34.44	-
58	Phosphorylation	IVLTDPQSVKHALRE EEECCHHHHHHHHHH	38.22	22985185
60	Ubiquitination	LTDPQSVKHALREIK ECCHHHHHHHHHHCH	28.54	29967540
141	Ubiquitination	YQLLRGLKYIHSANV HHHHHHHHHHHHCCE	45.01	-
145	Phosphorylation	RGLKYIHSANVLHRD HHHHHHHHCCEECCC	16.39	-
154	Ubiquitination	NVLHRDLKPANLFIN CEECCCCCCCCEEEC	46.50	21890473
182	Phosphorylation	ARIMDPHYSHKGHLS HHHCCCCCCCCCCCC	20.19	-
189	Phosphorylation	YSHKGHLSEGLVTKW CCCCCCCCCCCCCCC	24.76	29255136
194	Phosphorylation	HLSEGLVTKWYRSPR CCCCCCCCCCCCCCC	22.39	23403867
195	Ubiquitination	LSEGLVTKWYRSPRL CCCCCCCCCCCCCCE	34.45	-
199	Phosphorylation	LVTKWYRSPRLLLSP CCCCCCCCCCEEECC	9.93	1319925
209	Phosphorylation	LLLSPNNYTKAIDMW EEECCCCHHHHHHHH	19.09	25690035
210	Phosphorylation	LLSPNNYTKAIDMWA EECCCCHHHHHHHHH	19.00	25690035
276	Ubiquitination	NDMTEPHKPLTQLLP CCCCCCCCCHHHHCC	53.06	21890473
357	Phosphorylation	HIYNWERYHDCQFSE CCCCCHHHCCCCCCC	7.18	-
363	Phosphorylation	RYHDCQFSEHDWPVH HHCCCCCCCCCCCCC	14.24	22322096
386	Phosphorylation	QLDPRALSDVTDEEE ECCHHHHCCCCCHHH	29.11	19664994
389	Phosphorylation	PRALSDVTDEEEVQV HHHHCCCCCHHHCCC	42.56	25159151
408	Ubiquitination	YLDGDREKYLEDPAF HCCCCHHHHCCCCCC	56.90	29967540
435	Phosphorylation	SDHHENKYCDLECSH CCCCCCCEEEEECCC	11.63	27642862
441	Phosphorylation	KYCDLECSHTCNYKT CEEEEECCCCCCCCC	16.68	28555341
447	Ubiquitination	CSHTCNYKTRSSSYL CCCCCCCCCCCCHHH	24.38	32015554
448	Phosphorylation	SHTCNYKTRSSSYLD CCCCCCCCCCCHHHH	25.98	23186163
450	Phosphorylation	TCNYKTRSSSYLDNL CCCCCCCCCHHHHHC	28.94	30108239
451	Phosphorylation	CNYKTRSSSYLDNLV CCCCCCCCHHHHHCE	21.51	22617229
452	Phosphorylation	NYKTRSSSYLDNLVW CCCCCCCHHHHHCEE	30.84	22617229
453	Phosphorylation	YKTRSSSYLDNLVWR CCCCCCHHHHHCEEE	21.74	30108239
462	Phosphorylation	DNLVWRESEVNHYYE HHCEEEHHHCCCCCC	37.97	28796482
467	Phosphorylation	RESEVNHYYEPKLII EHHHCCCCCCCEEEE	12.34	28796482
468	Phosphorylation	ESEVNHYYEPKLIID HHHCCCCCCCEEEEE	20.43	28796482
471	Ubiquitination	VNHYYEPKLIIDLSN CCCCCCCEEEEECCC	40.14	21890473
471	Ubiquitination	VNHYYEPKLIIDLSN CCCCCCCEEEEECCC	40.14	21890473
471	Ubiquitination	VNHYYEPKLIIDLSN CCCCCCCEEEEECCC	40.14	21890473
477	Phosphorylation	PKLIIDLSNWKEQSK CEEEEECCCHHHHHH	36.58	28122231
480	Ubiquitination	IIDLSNWKEQSKEKS EEECCCHHHHHHHHC	50.56	21890473
480	Ubiquitination	IIDLSNWKEQSKEKS EEECCCHHHHHHHHC	50.56	21906983
480	Ubiquitination	IIDLSNWKEQSKEKS EEECCCHHHHHHHHC	50.56	21890473
483	Phosphorylation	LSNWKEQSKEKSDKK CCCHHHHHHHHCCCC	43.82	-
484	Ubiquitination	SNWKEQSKEKSDKKG CCHHHHHHHHCCCCC	69.70	23503661
486	Ubiquitination	WKEQSKEKSDKKGKS HHHHHHHHCCCCCCC	68.63	23503661
502	Ubiquitination	CERNGLVKAQIALEE HHHHHHHHHHHHHHH	39.35	21906983
511	Phosphorylation	QIALEEASQQLAGKE HHHHHHHHHHHCCCH	23.03	25159151
517	Ubiquitination	ASQQLAGKEREKNQG HHHHHCCCHHHHHCC	48.25	21906983
521	Ubiquitination	LAGKEREKNQGFDFD HCCCHHHHHCCCCHH	61.87	23503661
529	Phosphorylation	NQGFDFDSFIAGTIQ HCCCCHHHHHHHHEE	20.67	28387310
538	Phosphorylation	IAGTIQLSSQHEPTD HHHHEECCCCCCCCC	16.15	28387310
544	Phosphorylation	LSSQHEPTDVVDKLN CCCCCCCCCHHHHHH	38.14	28387310
555	Phosphorylation	DKLNDLNSSVSQLEL HHHHHHCCHHHHHHH	39.14	27050516
556	Phosphorylation	KLNDLNSSVSQLELK HHHHHCCHHHHHHHH	25.39	30576142
558	Phosphorylation	NDLNSSVSQLELKSL HHHCCHHHHHHHHHH	30.88	25159151
563	Ubiquitination	SVSQLELKSLISKSV HHHHHHHHHHHHHHC	33.56	21890473
563	Ubiquitination	SVSQLELKSLISKSV HHHHHHHHHHHHHHC	33.56	33845483
563	Neddylation	SVSQLELKSLISKSV HHHHHHHHHHHHHHC	33.56	32015554
563	Ubiquitination	SVSQLELKSLISKSV HHHHHHHHHHHHHHC	33.56	21890473
564	Phosphorylation	VSQLELKSLISKSVS HHHHHHHHHHHHHCC	43.49	24719451
568	Ubiquitination	ELKSLISKSVSQEKQ HHHHHHHHHCCHHHH	48.13	21906983
621	Ubiquitination	RKDEQVEKENTYTSY CCHHHHHCHHCCHHH	58.36	29967540
624	Phosphorylation	EQVEKENTYTSYLDK HHHHCHHCCHHHHHH	29.30	28796482
625	Phosphorylation	QVEKENTYTSYLDKF HHHCHHCCHHHHHHH	12.79	28796482
626	Phosphorylation	VEKENTYTSYLDKFF HHCHHCCHHHHHHHH	14.62	28796482
627	Phosphorylation	EKENTYTSYLDKFFS HCHHCCHHHHHHHHC	17.18	28796482
628	Phosphorylation	KENTYTSYLDKFFSR CHHCCHHHHHHHHCC	15.89	28796482
631	Ubiquitination	TYTSYLDKFFSRKED CCHHHHHHHHCCCCC	45.79	21890473
631	Ubiquitination	TYTSYLDKFFSRKED CCHHHHHHHHCCCCC	45.79	21890473
631	Ubiquitination	TYTSYLDKFFSRKED CCHHHHHHHHCCCCC	45.79	21906983
634	Phosphorylation	SYLDKFFSRKEDTEM HHHHHHHCCCCCCCC	45.64	25394399
636	Ubiquitination	LDKFFSRKEDTEMLE HHHHHCCCCCCCCEE	59.76	21890473
636	Ubiquitination	LDKFFSRKEDTEMLE HHHHHCCCCCCCCEE	59.76	21906983
644	Phosphorylation	EDTEMLETEPVEDGK CCCCCEECCCCCCCC	41.44	-
651	Ubiquitination	TEPVEDGKLGERGHE CCCCCCCCCCCCCCC	66.69	21906983
651	Ubiquitination	TEPVEDGKLGERGHE CCCCCCCCCCCCCCC	66.69	21890473
665	Phosphorylation	EEGFLNNSGEFLFNK CCCCCCCCCCEEECH	38.33	30266825
672	Ubiquitination	SGEFLFNKQLESIGI CCCEEECHHHHHCCC	49.26	32015554
676	Phosphorylation	LFNKQLESIGIPQFH EECHHHHHCCCCCCC	34.41	22199227
684	Phosphorylation	IGIPQFHSPVGSPLK CCCCCCCCCCCCCCH	23.67	25159151
688	Phosphorylation	QFHSPVGSPLKSIQA CCCCCCCCCCHHCEE	27.56	25159151
691	Ubiquitination	SPVGSPLKSIQATLT CCCCCCCHHCEEEEC	49.23	29967540
698	Phosphorylation	KSIQATLTPSAMKSS HHCEEEECHHHHHCC	15.73	25159151
703	Ubiquitination	TLTPSAMKSSPQIPH EECHHHHHCCCCCCC	47.72	32015554
704	Phosphorylation	LTPSAMKSSPQIPHQ ECHHHHHCCCCCCCC	33.88	25159151
705	Phosphorylation	TPSAMKSSPQIPHQT CHHHHHCCCCCCCCH	18.46	25159151
712	Phosphorylation	SPQIPHQTYSSILKH CCCCCCCHHHHHHHH	23.49	28796482
713	Phosphorylation	PQIPHQTYSSILKHL CCCCCCHHHHHHHHC	8.21	28796482
714	Phosphorylation	QIPHQTYSSILKHLN CCCCCHHHHHHHHCC	17.81	28796482
715	Phosphorylation	IPHQTYSSILKHLN- CCCCHHHHHHHHCC-	22.87	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
189	S	Phosphorylation	Kinase	MAPK6	Q16659	GPS
189	S	Phosphorylation	Kinase	PAK1	Q13153	Uniprot
189	S	Phosphorylation	Kinase	PAK2	Q13177	Uniprot
189	S	Phosphorylation	Kinase	PAK3	O75914	Uniprot
189	S	Phosphorylation	Kinase	MAPK-FAMILY	-	GPS
189	S	Phosphorylation	Kinase	PAK-SUBFAMILY	-	GPS
189	S	Phosphorylation	Kinase	MAPK_GROUP	-	PhosphoELM
684	S	Phosphorylation	Kinase	CDK1	P06493	PSP
688	S	Phosphorylation	Kinase	CDK1	P06493	PSP
698	T	Phosphorylation	Kinase	CDK1	P06493	PSP
705	S	Phosphorylation	Kinase	CDK1	P06493	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
1	M	ubiquitylation	15226418
Ubiquitination at Met-1 leads to degradation by the proteasome pathway.
189	S	Phosphorylation	18669648
Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of MK06_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ANK3_HUMAN	ANK3	physical	20936779
DYST_HUMAN	DST	physical	20936779
XPO2_HUMAN	CSE1L	physical	20936779
HS90B_HUMAN	HSP90AB1	physical	20936779
CH60_HUMAN	HSPD1	physical	20936779
ENPL_HUMAN	HSP90B1	physical	20936779
TCPG_HUMAN	CCT3	physical	20936779
MAPK5_HUMAN	MAPKAPK5	physical	20936779
CNTRL_HUMAN	CNTRL	physical	20936779
ZN600_HUMAN	ZNF600	physical	20936779
PHAR3_HUMAN	PHACTR3	physical	21900206
HACL1_HUMAN	HACL1	physical	21900206
NAT9_HUMAN	NAT9	physical	21900206
PDC6I_HUMAN	PDCD6IP	physical	21900206
EIF3C_HUMAN	EIF3C	physical	21900206
ACTG_HUMAN	ACTG1	physical	21900206
STX7_HUMAN	STX7	physical	21900206
RAB2A_HUMAN	RAB2A	physical	21900206
BBS10_HUMAN	BBS10	physical	21900206
ZN133_HUMAN	ZNF133	physical	21900206
ATP5J_HUMAN	ATP5J	physical	21900206
SNPC4_HUMAN	SNAPC4	physical	21900206
MOK_HUMAN	MOK	physical	21900206
RL10_HUMAN	RPL10	physical	21900206
THAP4_HUMAN	THAP4	physical	21900206
SPR2D_HUMAN	SPRR2D	physical	21900206
MZB1_HUMAN	MZB1	physical	21900206
ITSN1_HUMAN	ITSN1	physical	21900206
ELOF1_HUMAN	ELOF1	physical	21900206
PLK1_HUMAN	PLK1	physical	21900206
DREB_HUMAN	DBN1	physical	21900206
FXL16_HUMAN	FBXL16	physical	21900206
RL40_HUMAN	UBA52	physical	21900206
ATG9A_HUMAN	ATG9A	physical	21900206
RGS19_HUMAN	RGS19	physical	21900206
MAPK5_HUMAN	MAPKAPK5	physical	21900206
TYDP2_HUMAN	TDP2	physical	21900206
MBOA7_HUMAN	MBOAT7	physical	21900206
NRX2B_HUMAN	NRXN2	physical	21900206
NRX2A_HUMAN	NRXN2	physical	21900206
ARPC3_HUMAN	ARPC3	physical	21900206
MK_HUMAN	MDK	physical	21900206
CU059_HUMAN	C21orf59	physical	21900206
CSN6_HUMAN	COPS6	physical	21900206
CYH2_HUMAN	CYTH2	physical	21900206
APBA2_HUMAN	APBA2	physical	21900206
RPGP1_HUMAN	RAP1GAP	physical	21900206
MASP1_HUMAN	MASP1	physical	21900206
MTG2_HUMAN	MTG2	physical	21900206
APC5_HUMAN	ANAPC5	physical	21900206
ACTY_HUMAN	ACTR1B	physical	21900206
GORS1_HUMAN	GORASP1	physical	21900206
FXYD3_HUMAN	FXYD3	physical	21900206
NDUS6_HUMAN	NDUFS6	physical	21900206
PP1R7_HUMAN	PPP1R7	physical	21900206
CAH12_HUMAN	CA12	physical	21900206
ROA0_HUMAN	HNRNPA0	physical	21900206
KLC1_HUMAN	KLC1	physical	21900206
S41A3_HUMAN	SLC41A3	physical	21900206
MET17_HUMAN	METTL17	physical	21900206
ZN671_HUMAN	ZNF671	physical	21900206
MYOZ3_HUMAN	MYOZ3	physical	21900206
SERA_HUMAN	PHGDH	physical	21900206
PSIP1_HUMAN	PSIP1	physical	21900206
HAUS2_HUMAN	HAUS2	physical	21900206
CALR_HUMAN	CALR	physical	21900206
EMD_HUMAN	EMD	physical	21900206
AMPH_HUMAN	AMPH	physical	21900206
PIHD1_HUMAN	PIH1D1	physical	21900206
KAIN_HUMAN	SERPINA4	physical	21900206
TTK_HUMAN	TTK	physical	21900206
OSTF1_HUMAN	OSTF1	physical	21900206
M3K12_HUMAN	MAP3K12	physical	21900206
BARX1_HUMAN	BARX1	physical	21900206
CXCL7_HUMAN	PPBP	physical	21900206
SPSY_HUMAN	SMS	physical	21900206
MYBB_HUMAN	MYBL2	physical	21900206
HIP1_HUMAN	HIP1	physical	21900206
KIBRA_HUMAN	WWC1	physical	21900206
SRSF5_HUMAN	SRSF5	physical	21900206
RANB9_HUMAN	RANBP9	physical	21900206
CENPR_HUMAN	ITGB3BP	physical	21900206
PDLI1_HUMAN	PDLIM1	physical	21900206
NECT2_HUMAN	PVRL2	physical	21900206
RAB31_HUMAN	RAB31	physical	21900206
APOA1_HUMAN	APOA1	physical	21900206
DPPA4_HUMAN	DPPA4	physical	21900206
AAKB1_HUMAN	PRKAB1	physical	21900206
RRP7A_HUMAN	RRP7A	physical	21900206
HDA11_HUMAN	HDAC11	physical	21900206
WDR34_HUMAN	WDR34	physical	21900206
GLRX3_HUMAN	GLRX3	physical	21900206
DDR1_HUMAN	DDR1	physical	21900206
NPA1P_HUMAN	URB1	physical	21900206
PHC2_HUMAN	PHC2	physical	21900206
ZN775_HUMAN	ZNF775	physical	21900206
SHC1_HUMAN	SHC1	physical	21900206
2AAA_HUMAN	PPP2R1A	physical	21900206
CAD13_HUMAN	CDH13	physical	21900206
BAG6_HUMAN	BAG6	physical	21900206
COF1_HUMAN	CFL1	physical	21900206
NELFB_HUMAN	NELFB	physical	21900206
SKAP_HUMAN	KNSTRN	physical	21900206
GATA1_HUMAN	GATA1	physical	21900206
RARA_HUMAN	RARA	physical	21900206
TBA1A_HUMAN	TUBA1A	physical	21900206
ZN579_HUMAN	ZNF579	physical	21900206
MET2A_HUMAN	METTL2A	physical	21900206
EDF1_HUMAN	EDF1	physical	21900206
DKC1_HUMAN	DKC1	physical	21900206
INS_HUMAN	INS	physical	21900206
SOCS3_HUMAN	SOCS3	physical	21900206
OST48_HUMAN	DDOST	physical	21900206
DJC28_HUMAN	DNAJC28	physical	21900206
DSCR3_HUMAN	DSCR3	physical	21900206
MIPEP_HUMAN	MIPEP	physical	21900206
RBL1_HUMAN	RBL1	physical	21900206
WFS1_HUMAN	WFS1	physical	21900206
GDIR1_HUMAN	ARHGDIA	physical	21900206
SEPT5_HUMAN	SEPT5	physical	21900206
MCM3_HUMAN	MCM3	physical	21900206
TPIS_HUMAN	TPI1	physical	21900206
KAP0_HUMAN	PRKAR1A	physical	21900206
CNTN1_HUMAN	CNTN1	physical	21900206
NOL4_HUMAN	NOL4	physical	21900206
DGKZ_HUMAN	DGKZ	physical	21900206
PR38A_HUMAN	PRPF38A	physical	21900206
CASP6_HUMAN	CASP6	physical	21900206
DCTN2_HUMAN	DCTN2	physical	21900206
WDR26_HUMAN	WDR26	physical	21900206
FOXO3_HUMAN	FOXO3	physical	21900206
ZN205_HUMAN	ZNF205	physical	21900206
LPXN_HUMAN	LPXN	physical	21900206
SNW1_HUMAN	SNW1	physical	21900206
MGAT1_HUMAN	MGAT1	physical	21900206
EIF1_HUMAN	EIF1	physical	21900206
EF1A2_HUMAN	EEF1A2	physical	21900206
HNRPD_HUMAN	HNRNPD	physical	21900206
NUDT5_HUMAN	NUDT5	physical	21900206
M3K7_HUMAN	MAP3K7	physical	21900206
SMAD6_HUMAN	SMAD6	physical	21900206
SEPT3_HUMAN	SEPT3	physical	21900206
SPTN1_HUMAN	SPTAN1	physical	21900206
PLS1_HUMAN	PLSCR1	physical	21900206
FA49B_HUMAN	FAM49B	physical	21900206
SERC_HUMAN	PSAT1	physical	21900206
MON1A_HUMAN	MON1A	physical	21900206
UB2L3_HUMAN	UBE2L3	physical	21900206
IF4A1_HUMAN	EIF4A1	physical	21900206
CAH1_HUMAN	CA1	physical	21900206
RACK1_HUMAN	GNB2L1	physical	21900206
ZN331_HUMAN	ZNF331	physical	21900206
PTPM1_HUMAN	PTPMT1	physical	21900206
SPG7_HUMAN	SPG7	physical	21900206
HNRH3_HUMAN	HNRNPH3	physical	21900206
NNRE_HUMAN	APOA1BP	physical	21900206
PKHM1_HUMAN	PLEKHM1	physical	21900206
CERS1_HUMAN	CERS1	physical	21900206
IDH3B_HUMAN	IDH3B	physical	21900206
GPX1_HUMAN	GPX1	physical	21900206
MBIP1_HUMAN	MBIP	physical	21988832
S20A1_HUMAN	SLC20A1	physical	21988832
IF2G_HUMAN	EIF2S3	physical	23602568
A2MG_HUMAN	A2M	physical	23602568
MK06_HUMAN	MAPK6	physical	23602568
HERC2_HUMAN	HERC2	physical	23602568
MAPK5_HUMAN	MAPKAPK5	physical	23602568
NEUL4_HUMAN	NEURL4	physical	23602568
PSA7_HUMAN	PSMA7	physical	23602568
MAPK5_HUMAN	MAPKAPK5	physical	25416956
MAPK5_HUMAN	MAPKAPK5	physical	28514442
APOA1_HUMAN	APOA1	physical	28514442
ZNF7_HUMAN	ZNF7	physical	28514442
A1AT_HUMAN	SERPINA1	physical	28514442
FIBB_HUMAN	FGB	physical	28514442
HPT_HUMAN	HP	physical	28514442
HBB_HUMAN	HBB	physical	28514442
FIBG_HUMAN	FGG	physical	28514442
FIBA_HUMAN	FGA	physical	28514442
NEUL4_HUMAN	NEURL4	physical	28514442
HERC2_HUMAN	HERC2	physical	28514442
CO3_HUMAN	C3	physical	28514442
A1AG1_HUMAN	ORM1	physical	28514442
ALBU_HUMAN	ALB	physical	28514442
TRFE_HUMAN	TF	physical	28514442
ZNF28_HUMAN	ZNF28	physical	28514442
FETUA_HUMAN	AHSG	physical	28514442
ZNF92_HUMAN	ZNF92	physical	28514442
ZN813_HUMAN	ZNF813	physical	28514442
SPB4_HUMAN	SERPINB4	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of MK06_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Activation loop phosphorylation of ERK3/ERK4 by group I p21-activatedkinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated proteinkinase 5 signaling pathway."; Deleris P., Trost M., Topisirovic I., Tanguay P.L., Borden K.L.,Thibault P., Meloche S.; J. Biol. Chem. 286:6470-6478(2011). Cited for: PHOSPHORYLATION AT SER-189.	21177870 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189, AND MASSSPECTROMETRY.	19369195 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-189; SER-386; THR-389AND SER-665, AND MASS SPECTROMETRY.	18669648 [Abstract]

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