CAH1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAH1_HUMAN
• UniProt AC: P00915
• Protein Name: Carbonic anhydrase 1
• Gene Name: CA1
• Organism: Homo sapiens (Human).
• Sequence Length: 261
• Subcellular Localization: Cytoplasm.
• Protein Description: Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea..
• Protein Sequence: MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MASPDWGYD ------CCCCCCCCC	29.76	4217196
30	Phosphorylation	IANGNNQSPVDIKTS CCCCCCCCCCCCCCC	29.07	27251275
36	Phosphorylation	QSPVDIKTSETKHDT CCCCCCCCCCCCCCC	31.93	30576142
43	Phosphorylation	TSETKHDTSLKPISV CCCCCCCCCCCEEEE	35.36	30576142
49	Phosphorylation	DTSLKPISVSYNPAT CCCCCEEEEECCHHC	17.34	23312004
51	Phosphorylation	SLKPISVSYNPATAK CCCEEEEECCHHCHH	16.64	28857561
56	Phosphorylation	SVSYNPATAKEIINV EEECCHHCHHHHEEE	39.25	30576142
78	Phosphorylation	FEDNDNRSVLKGGPF CCCCCCCEEEECCCC	37.75	27251275
86	Phosphorylation	VLKGGPFSDSYRLFQ EEECCCCCCCEEEEE	28.87	23025827
88	Phosphorylation	KGGPFSDSYRLFQFH ECCCCCCCEEEEEEE	15.79	22673903
89	Phosphorylation	GGPFSDSYRLFQFHF CCCCCCCEEEEEEEE	19.14	-
130	Phosphorylation	HWNSAKYSSLAEAAS ECCCHHHHHHHHHHH	20.40	-
130	O-linked_Glycosylation	HWNSAKYSSLAEAAS ECCCHHHHHHHHHHH	20.40	24126823
131	Phosphorylation	WNSAKYSSLAEAASK CCCHHHHHHHHHHHH	28.63	28857561
137	Phosphorylation	SSLAEAASKADGLAV HHHHHHHHHCCCEEH	35.11	27251275
218	O-linked_Glycosylation	IICKESISVSSEQLA EEECCCCCCCHHHHH	25.81	12556433
220	Phosphorylation	CKESISVSSEQLAQF ECCCCCCCHHHHHHH	22.74	27251275
221	Phosphorylation	KESISVSSEQLAQFR CCCCCCCHHHHHHHH	27.49	28857561
229	Phosphorylation	EQLAQFRSLLSNVEG HHHHHHHHHHHCCCC	34.64	27251275
232	Phosphorylation	AQFRSLLSNVEGDNA HHHHHHHHCCCCCCC	44.09	27251275
260	Phosphorylation	KGRTVRASF------ CCCEEEECC------	22.41	23025827

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAH1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAH1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAH1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DHB7_HUMAN	HSD17B7	physical	21988832
TFCP2_HUMAN	TFCP2	physical	25416956

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00819: Acetazolamide
• DB00381: Amlodipine
• DB00436: Bendroflumethiazide
• DB00562: Benzthiazide
• DB01194: Brinzolamide
• DB00880: Chlorothiazide
• DB00606: Cyclothiazide
• DB01119: Diazoxide
• DB01144: Diclofenamide
• DB00869: Dorzolamide
• DB01031: Ethinamate
• DB00999: Hydrochlorothiazide
• DB00774: Hydroflumethiazide
• DB00703: Methazolamide
• DB00423: Methocarbamol
• DB00232: Methyclothiazide
• DB01325: Quinethazone
• DB01021: Trichlormethiazide
• DB00909: Zonisamide

Related Literatures of Post-Translational Modification

Acetylation

"Human carbonic anhydrases. XII. The complete primary structure of theC isozyme.";
Lin K.-T.D., Deutsch H.F.;
J. Biol. Chem. 249:2329-2337(1974).
Cited for: SEQUENCE REVISION.
PubMed: 4207120