dbPTM

TTK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TTK_HUMAN
UniProt AC	P33981
Protein Name	Dual specificity protein kinase TTK
Gene Name	TTK
Organism	Homo sapiens (Human).
Sequence Length	857
Subcellular Localization
Protein Description	Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint..
Protein Sequence	MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMANNPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARFLYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKRGKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MESEDLSG -------CCCCCCCC	13.27	19369195
3	Phosphorylation	-----MESEDLSGRE -----CCCCCCCCCC	34.80	19369195
7	Phosphorylation	-MESEDLSGRELTID -CCCCCCCCCCCCHH	48.39	25159151
12	Phosphorylation	DLSGRELTIDSIMNK CCCCCCCCHHHHHHH	20.27	18923149
15	Phosphorylation	GRELTIDSIMNKVRD CCCCCHHHHHHHHHH	21.64	18923149
17	Phosphorylation	ELTIDSIMNKVRDIK CCCHHHHHHHHHHHH	4.62	18669648
19	Methylation	TIDSIMNKVRDIKNK CHHHHHHHHHHHHHH	22.67	23644510
19	Ubiquitination	TIDSIMNKVRDIKNK CHHHHHHHHHHHHHH	22.67	29967540
26	Ubiquitination	KVRDIKNKFKNEDLT HHHHHHHHHCCCCCC	53.35	-
28	Sumoylation	RDIKNKFKNEDLTDE HHHHHHHCCCCCCCC	62.12	-
28	Sumoylation	RDIKNKFKNEDLTDE HHHHHHHCCCCCCCC	62.12	-
28	Ubiquitination	RDIKNKFKNEDLTDE HHHHHHHCCCCCCCC	62.12	29967540
31	Ubiquitination	KNKFKNEDLTDELSL HHHHCCCCCCCCCCC	65.35	21890473
33	Phosphorylation	KFKNEDLTDELSLNK HHCCCCCCCCCCCCC	39.49	22167270
37	Phosphorylation	EDLTDELSLNKISAD CCCCCCCCCCCCCCC	28.05	25159151
46	Phosphorylation	NKISADTTDNSGTVN CCCCCCCCCCCCCHH	33.46	20068231
49	Phosphorylation	SADTTDNSGTVNQIM CCCCCCCCCCHHHHH	38.35	17192257
51	Phosphorylation	DTTDNSGTVNQIMMM CCCCCCCCHHHHHHH	18.99	25627689
71	Sumoylation	DWLSLLLKLEKNSVP HHHHHHHHHHHCCCC	55.35	-
71	Sumoylation	DWLSLLLKLEKNSVP HHHHHHHHHHHCCCC	55.35	-
74	Ubiquitination	SLLLKLEKNSVPLSD HHHHHHHHCCCCHHH	66.03	29967540
80	Phosphorylation	EKNSVPLSDALLNKL HHCCCCHHHHHHHHH	18.11	25159151
86	Ubiquitination	LSDALLNKLIGRYSQ HHHHHHHHHHHHHHH	41.26	21890473
86	Ubiquitination	LSDALLNKLIGRYSQ HHHHHHHHHHHHHHH	41.26	22817900
102	Ubiquitination	IEALPPDKYGQNESF HHHCCCCCCCCCCCC	57.99	29967540
108	Phosphorylation	DKYGQNESFARIQVR CCCCCCCCCHHHHHH	31.58	-
120	Ubiquitination	QVRFAELKAIQEPDD HHHHHHHHHCCCCCC	34.64	29967540
131	Phosphorylation	EPDDARDYFQMARAN CCCCHHHHHHHHHHH	7.08	-
136	Ubiquitination	RDYFQMARANCKKFA HHHHHHHHHHCCCEE	22.46	27667366
140	Ubiquitination	QMARANCKKFAFVHI HHHHHHCCCEEEEEE	51.22	29967540
163	Ubiquitination	QGNVKKSKQLLQKAV CCCHHHHHHHHHHHH	54.57	29967540
168	Ubiquitination	KSKQLLQKAVERGAV HHHHHHHHHHHCCCC	55.13	29967540
191	Ubiquitination	LRNLNLQKKQLLSEE HHHCCHHHHHHCCHH	45.73	27667366
192	Ubiquitination	RNLNLQKKQLLSEEE HHCCHHHHHHCCHHH	32.97	29967540
200	Ubiquitination	QLLSEEEKKNLSAST HHCCHHHHHCCCHHH	50.68	-
201	Ubiquitination	LLSEEEKKNLSASTV HCCHHHHHCCCHHHH	67.41	29967540
210	Phosphorylation	LSASTVLTAQESFSG CCHHHHHEEHHHHHC	23.20	22210691
214	Phosphorylation	TVLTAQESFSGSLGH HHHEEHHHHHCHHHH	16.78	22817900
216	Phosphorylation	LTAQESFSGSLGHLQ HEEHHHHHCHHHHHC	36.43	22817900
218	Phosphorylation	AQESFSGSLGHLQNR EHHHHHCHHHHHCCC	29.94	22817900
242	Phosphorylation	TTKARFLYGENMPPQ CCHHHHHCCCCCCHH	21.49	26074081
255	Phosphorylation	PQDAEIGYRNSLRQT HHHCHHCCHHCHHCC	16.57	26074081
258	Phosphorylation	AEIGYRNSLRQTNKT CHHCCHHCHHCCCCC	18.87	26074081
265	Phosphorylation	SLRQTNKTKQSCPFG CHHCCCCCCCCCCCC	36.06	18669648
266	Ubiquitination	LRQTNKTKQSCPFGR HHCCCCCCCCCCCCC	41.65	32015554
281	Phosphorylation	VPVNLLNSPDCDVKT CCCHHHCCCCCCCCC	23.29	19664994
287	Sumoylation	NSPDCDVKTDDSVVP CCCCCCCCCCCCCHH	32.74	-
287	Sumoylation	NSPDCDVKTDDSVVP CCCCCCCCCCCCCHH	32.74	-
287	Ubiquitination	NSPDCDVKTDDSVVP CCCCCCCCCCCCCHH	32.74	-
288	Phosphorylation	SPDCDVKTDDSVVPC CCCCCCCCCCCCHHH	44.91	18923149
291	Phosphorylation	CDVKTDDSVVPCFMK CCCCCCCCCHHHHHC	28.02	21712546
298	Ubiquitination	SVVPCFMKRQTSRSE CCHHHHHCCCCCHHH	22.54	32015554
301	Phosphorylation	PCFMKRQTSRSECRD HHHHCCCCCHHHHCC	30.09	24719451
304	Phosphorylation	MKRQTSRSECRDLVV HCCCCCHHHHCCCCC	40.59	29214152
305	Phosphorylation	KRQTSRSECRDLVVP CCCCCHHHHCCCCCC	32.25	18669648
312	Ubiquitination	ECRDLVVPGSKPSGN HHCCCCCCCCCCCCC	33.58	22817900
314	Phosphorylation	RDLVVPGSKPSGNDS CCCCCCCCCCCCCCC	35.01	22199227
315	Ubiquitination	DLVVPGSKPSGNDSC CCCCCCCCCCCCCCH	49.47	33845483
317	Phosphorylation	VVPGSKPSGNDSCEL CCCCCCCCCCCCHHH	54.70	21712546
317	Ubiquitination	VVPGSKPSGNDSCEL CCCCCCCCCCCCHHH	54.70	22817900
321	Phosphorylation	SKPSGNDSCELRNLK CCCCCCCCHHHCCHH	17.31	25159151
328	Ubiquitination	SCELRNLKSVQNSHF CHHHCCHHHHCCCCC	52.72	29967540
329	Phosphorylation	CELRNLKSVQNSHFK HHHCCHHHHCCCCCC	31.91	30576142
330	Ubiquitination	ELRNLKSVQNSHFKE HHCCHHHHCCCCCCC	6.29	22817900
333	Phosphorylation	NLKSVQNSHFKEPLV CHHHHCCCCCCCCCC	17.14	30576142
335	Ubiquitination	KSVQNSHFKEPLVSD HHHCCCCCCCCCCCC	10.86	22817900
336	Ubiquitination	SVQNSHFKEPLVSDE HHCCCCCCCCCCCCC	53.66	29967540
345	Phosphorylation	PLVSDEKSSELIITD CCCCCCCCCCEEEEC	27.31	18691976
351	Phosphorylation	KSSELIITDSITLKN CCCCEEEECCEECCC	19.39	17192257
353	Phosphorylation	SELIITDSITLKNKT CCEEEECCEECCCCC	14.60	17192257
359	Ubiquitination	DSITLKNKTESSLLA CCEECCCCCHHHHHH	52.67	29967540
360	Phosphorylation	SITLKNKTESSLLAK CEECCCCCHHHHHHH	50.96	18923149
362	Phosphorylation	TLKNKTESSLLAKLE ECCCCCHHHHHHHHH	31.36	18923149
363	Phosphorylation	LKNKTESSLLAKLEE CCCCCHHHHHHHHHH	22.59	18923149
367	Sumoylation	TESSLLAKLEETKEY CHHHHHHHHHHHHCC	57.30	-
367	Sumoylation	TESSLLAKLEETKEY CHHHHHHHHHHHHCC	57.30	-
367	Ubiquitination	TESSLLAKLEETKEY CHHHHHHHHHHHHCC	57.30	22817900
371	Phosphorylation	LLAKLEETKEYQEPE HHHHHHHHHCCCCCC	21.57	29978859
372	Ubiquitination	LAKLEETKEYQEPEV HHHHHHHHCCCCCCC	58.67	21906983
374	Phosphorylation	KLEETKEYQEPEVPE HHHHHHCCCCCCCCH	21.52	22322096
382	Phosphorylation	QEPEVPESNQKQWQS CCCCCCHHHHHHHHH	38.19	21815630
385	Methylation	EVPESNQKQWQSKRK CCCHHHHHHHHHHHH	58.72	-
385	Ubiquitination	EVPESNQKQWQSKRK CCCHHHHHHHHHHHH	58.72	21906983
388	Ubiquitination	ESNQKQWQSKRKSEC HHHHHHHHHHHHHHH	36.26	27667366
390	Ubiquitination	NQKQWQSKRKSECIN HHHHHHHHHHHHHHH	49.06	22817900
392	Ubiquitination	KQWQSKRKSECINQN HHHHHHHHHHHHHCC	55.10	29967540
393	Phosphorylation	QWQSKRKSECINQNP HHHHHHHHHHHHCCC	41.56	23927012
397	Ubiquitination	KRKSECINQNPAASS HHHHHHHHCCCCCCC	47.43	22505724
403	Phosphorylation	INQNPAASSNHWQIP HHCCCCCCCCCCCHH	33.50	23927012
404	Phosphorylation	NQNPAASSNHWQIPE HCCCCCCCCCCCHHH	28.17	23312004
415	Ubiquitination	QIPELARKVNTEQKH CHHHHHHHCCCCCCC	33.94	29967540
421	Ubiquitination	RKVNTEQKHTTFEQP HHCCCCCCCCCCCCC	36.36	-
423	Phosphorylation	VNTEQKHTTFEQPVF CCCCCCCCCCCCCCE	39.97	23403867
424	Phosphorylation	NTEQKHTTFEQPVFS CCCCCCCCCCCCCEE	25.54	23403867
430 (in isoform 2)	Phosphorylation	-	8.31	27762562
431	Phosphorylation	TFEQPVFSVSKQSPP CCCCCCEECCCCCCC	26.22	23927012
432 (in isoform 2)	Phosphorylation	-	5.87	27762562
433	Phosphorylation	EQPVFSVSKQSPPIS CCCCEECCCCCCCCC	24.63	23401153
434	Ubiquitination	QPVFSVSKQSPPIST CCCEECCCCCCCCCC	53.27	29967540
436	Phosphorylation	VFSVSKQSPPISTSK CEECCCCCCCCCCCC	36.06	25159151
439	Phosphorylation	VSKQSPPISTSKWFD CCCCCCCCCCCCCCC	8.78	18669648
440	Phosphorylation	SKQSPPISTSKWFDP CCCCCCCCCCCCCCH	32.19	23927012
441	Phosphorylation	KQSPPISTSKWFDPK CCCCCCCCCCCCCHH	34.74	23927012
442	Phosphorylation	QSPPISTSKWFDPKS CCCCCCCCCCCCHHH	22.54	23927012
442	Ubiquitination	QSPPISTSKWFDPKS CCCCCCCCCCCCHHH	22.54	27667366
443	Ubiquitination	SPPISTSKWFDPKSI CCCCCCCCCCCHHHH	52.55	27667366
447	Ubiquitination	STSKWFDPKSICKTP CCCCCCCHHHHCCCC	23.87	29967540
448	Ubiquitination	TSKWFDPKSICKTPS CCCCCCHHHHCCCCC	55.06	29967540
451	Ubiquitination	WFDPKSICKTPSSNT CCCHHHHCCCCCCCC	5.32	22505724
452	Ubiquitination	FDPKSICKTPSSNTL CCHHHHCCCCCCCCH	62.90	22505724
453	Phosphorylation	DPKSICKTPSSNTLD CHHHHCCCCCCCCHH	24.80	25159151
455	Phosphorylation	KSICKTPSSNTLDDY HHHCCCCCCCCHHHH	41.26	25159151
456	Phosphorylation	SICKTPSSNTLDDYM HHCCCCCCCCHHHHH	34.73	25159151
458	Phosphorylation	CKTPSSNTLDDYMSC CCCCCCCCHHHHHHH	33.25	25159151
462	Phosphorylation	SSNTLDDYMSCFRTP CCCCHHHHHHHHCCC	7.21	22322096
464	Phosphorylation	NTLDDYMSCFRTPVV CCHHHHHHHHCCCCC	12.13	28796482
467	Dimethylation	DDYMSCFRTPVVKND HHHHHHHCCCCCCCC	42.31	-
467	Methylation	DDYMSCFRTPVVKND HHHHHHHCCCCCCCC	42.31	5172503
468	Phosphorylation	DYMSCFRTPVVKNDF HHHHHHCCCCCCCCC	10.53	25159151
468 (in isoform 1)	Phosphorylation	-	10.53	17804818
472	Sumoylation	CFRTPVVKNDFPPAC HHCCCCCCCCCCCCC	51.54	-
472	Sumoylation	CFRTPVVKNDFPPAC HHCCCCCCCCCCCCC	51.54	-
483	Ubiquitination	PPACQLSTPYGQPAC CCCCCCCCCCCCCCH	29.17	21890473
491	Ubiquitination	PYGQPACFQQQQHQI CCCCCCHHHHHHHHH	8.80	22817900
492	Ubiquitination	YGQPACFQQQQHQIL CCCCCHHHHHHHHHH	39.80	22817900
525	Phosphorylation	ISVKGRIYSILKQIG EECCHHHHHHHHHHC	6.57	28152594
526	Phosphorylation	SVKGRIYSILKQIGS ECCHHHHHHHHHHCC	21.05	24719451
528	Ubiquitination	KGRIYSILKQIGSGG CHHHHHHHHHHCCCC	2.48	29967540
529	Ubiquitination	GRIYSILKQIGSGGS HHHHHHHHHHCCCCC	37.89	29967540
537	Ubiquitination	QIGSGGSSKVFQVLN HHCCCCCHHHHHHHC	35.79	21890473
537	Ubiquitination	QIGSGGSSKVFQVLN HHCCCCCHHHHHHHC	35.79	21890473
538	Ubiquitination	IGSGGSSKVFQVLNE HCCCCCHHHHHHHCH	49.09	21906983
545	Ubiquitination	KVFQVLNEKKQIYAI HHHHHHCHHCCEEEE	58.43	32015554
546	Ubiquitination	VFQVLNEKKQIYAIK HHHHHCHHCCEEEEE	49.24	21906983
547	Ubiquitination	FQVLNEKKQIYAIKY HHHHCHHCCEEEEEE	35.43	22817900
550	Phosphorylation	LNEKKQIYAIKYVNL HCHHCCEEEEEEECH	10.36	29496907
552	Ubiquitination	EKKQIYAIKYVNLEE HHCCEEEEEEECHHH	1.53	29967540
553	Ubiquitination	KKQIYAIKYVNLEEA HCCEEEEEEECHHHH	34.67	29967540
564	Phosphorylation	LEEADNQTLDSYRNE HHHHCCCCHHHHHHH	38.49	18680479
574	Phosphorylation	SYRNEIAYLNKLQQH HHHHHHHHHHHHHHC	19.23	22985185
576	Ubiquitination	RNEIAYLNKLQQHSD HHHHHHHHHHHHCCC	30.25	29967540
577	Ubiquitination	NEIAYLNKLQQHSDK HHHHHHHHHHHCCCC	45.11	29967540
582	Phosphorylation	LNKLQQHSDKIIRLY HHHHHHCCCCEEHHC	35.94	18680479
584	Ubiquitination	KLQQHSDKIIRLYDY HHHHCCCCEEHHCCC	42.94	-
594	Phosphorylation	RLYDYEITDQYIYMV HHCCCCCCCCEEEEE	12.71	-
615	Ubiquitination	DLNSWLKKKKSIDPW CHHHHHHHCCCCCHH	64.36	29967540
616	Ubiquitination	LNSWLKKKKSIDPWE HHHHHHHCCCCCHHH	50.60	29967540
617	Ubiquitination	NSWLKKKKSIDPWER HHHHHHCCCCCHHHH	62.62	29967540
618	Phosphorylation	SWLKKKKSIDPWERK HHHHHCCCCCHHHHH	40.89	-
624	Ubiquitination	KSIDPWERKSYWKNM CCCCHHHHHHHHHHH	29.38	29967540
625	Ubiquitination	SIDPWERKSYWKNML CCCHHHHHHHHHHHH	36.06	29967540
641	Ubiquitination	AVHTIHQHGIVHSDL HHHHHHHCCCCCCCC	17.49	22817900
649	Ubiquitination	GIVHSDLKPANFLIV CCCCCCCCCCCEEEE	47.26	-
655	Ubiquitination	LKPANFLIVDGMLKL CCCCCEEEEECCHHH	2.02	27667366
675	Phosphorylation	ANQMQPDTTSVVKDS CCCCCCCCCCEEECC	27.88	18923149
676	Phosphorylation	NQMQPDTTSVVKDSQ CCCCCCCCCEEECCC	27.23	18680479
676 (in isoform 1)	Phosphorylation	-	27.23	18545697
677	Phosphorylation	QMQPDTTSVVKDSQV CCCCCCCCEEECCCC	27.31	18923149
679	Ubiquitination	QPDTTSVVKDSQVGT CCCCCCEEECCCCCE	5.97	29967540
680	Ubiquitination	PDTTSVVKDSQVGTV CCCCCEEECCCCCEE	49.89	29967540
686	Phosphorylation	VKDSQVGTVNYMPPE EECCCCCEEEECCHH	13.51	18923149
686 (in isoform 1)	Phosphorylation	-	13.51	18680479
689	Phosphorylation	SQVGTVNYMPPEAIK CCCCEEEECCHHHHH	13.48	21945579
695	Ubiquitination	NYMPPEAIKDMSSSR EECCHHHHHHCHHHC	3.56	22817900
696	Ubiquitination	YMPPEAIKDMSSSRE ECCHHHHHHCHHHCC	55.19	21906983
699	O-linked_Glycosylation	PEAIKDMSSSRENGK HHHHHHCHHHCCCCC	34.98	23301498
700	O-linked_Glycosylation	EAIKDMSSSRENGKS HHHHHCHHHCCCCCC	27.12	23301498
701	O-linked_Glycosylation	AIKDMSSSRENGKSK HHHHCHHHCCCCCCC	35.99	23301498
708	Methylation	SRENGKSKSKISPKS HCCCCCCCCCCCCHH	60.29	117956023
709	Ubiquitination	RENGKSKSKISPKSD CCCCCCCCCCCCHHH	42.17	27667366
710	Ubiquitination	ENGKSKSKISPKSDV CCCCCCCCCCCHHHH	51.44	27667366
742	Phosphorylation	QQIINQISKLHAIID HHHHHHHHHHCCCCC	21.28	18680479
761	Ubiquitination	IEFPDIPEKDLQDVL CCCCCCCHHHHHHHH	60.58	29967540
762	Ubiquitination	EFPDIPEKDLQDVLK CCCCCCHHHHHHHHH	59.38	29967540
768	Ubiquitination	EKDLQDVLKCCLKRD HHHHHHHHHHHHCCC	4.77	32015554
769	Ubiquitination	KDLQDVLKCCLKRDP HHHHHHHHHHHCCCH	23.81	32015554
772	Ubiquitination	QDVLKCCLKRDPKQR HHHHHHHHCCCHHHC	7.75	21890473
775	Ubiquitination	LKCCLKRDPKQRISI HHHHHCCCHHHCCCH	53.84	22817900
793	Ubiquitination	LAHPYVQIQTHPVNQ HHCCEEEEECCCCCH	3.49	22817900
795	Phosphorylation	HPYVQIQTHPVNQMA CCEEEEECCCCCHHC	29.76	18680479
797	Ubiquitination	YVQIQTHPVNQMAKG EEEEECCCCCHHCCC	30.09	22817900
798	Ubiquitination	VQIQTHPVNQMAKGT EEEECCCCCHHCCCC	6.36	22817900
802	Ubiquitination	THPVNQMAKGTTEEM CCCCCHHCCCCHHHH	9.43	29967540
803	Ubiquitination	HPVNQMAKGTTEEMK CCCCHHCCCCHHHHH	51.99	29967540
805	Phosphorylation	VNQMAKGTTEEMKYV CCHHCCCCHHHHHHH	30.26	18680479
806	Phosphorylation	NQMAKGTTEEMKYVL CHHCCCCHHHHHHHH	38.32	18680479
808	Phosphorylation	MAKGTTEEMKYVLGQ HCCCCHHHHHHHHHH	38.59	18669648
809	Ubiquitination	AKGTTEEMKYVLGQL CCCCHHHHHHHHHHH	2.86	29967540
810	Ubiquitination	KGTTEEMKYVLGQLV CCCHHHHHHHHHHHH	35.17	29967540
811	Phosphorylation	GTTEEMKYVLGQLVG CCHHHHHHHHHHHHC	10.29	18680479
820	Phosphorylation	LGQLVGLNSPNSILK HHHHHCCCCHHHHHH	49.87	32142685
821	Phosphorylation	GQLVGLNSPNSILKA HHHHCCCCHHHHHHH	30.42	18680479
824	Phosphorylation	VGLNSPNSILKAAKT HCCCCHHHHHHHHHH	32.45	18680479
826	Ubiquitination	LNSPNSILKAAKTLY CCCHHHHHHHHHHHH	2.87	21890473
826	Ubiquitination	LNSPNSILKAAKTLY CCCHHHHHHHHHHHH	2.87	21890473
827	Ubiquitination	NSPNSILKAAKTLYE CCHHHHHHHHHHHHH	44.63	21906983
829	Ubiquitination	PNSILKAAKTLYEHY HHHHHHHHHHHHHHH	12.09	22817900
830	Ubiquitination	NSILKAAKTLYEHYS HHHHHHHHHHHHHHC	43.87	22817900
831	Phosphorylation	SILKAAKTLYEHYSG HHHHHHHHHHHHHCC	29.82	28796482
833	Phosphorylation	LKAAKTLYEHYSGGE HHHHHHHHHHHCCCC	13.09	22322096
836	Phosphorylation	AKTLYEHYSGGESHN HHHHHHHHCCCCCCC	9.32	22322096
837	Phosphorylation	KTLYEHYSGGESHNS HHHHHHHCCCCCCCC	42.08	28796482
844	Phosphorylation	SGGESHNSSSSKTFE CCCCCCCCCCCCCCH	26.61	28555341
845	Phosphorylation	GGESHNSSSSKTFEK CCCCCCCCCCCCCHH	43.90	18680479
847	Phosphorylation	ESHNSSSSKTFEKKR CCCCCCCCCCCHHHC	37.35	18680479
847	Ubiquitination	ESHNSSSSKTFEKKR CCCCCCCCCCCHHHC	37.35	22817900
848	Ubiquitination	SHNSSSSKTFEKKRG CCCCCCCCCCHHHCC	60.21	21906983
849	Phosphorylation	HNSSSSKTFEKKRGK CCCCCCCCCHHHCCC	38.69	18680479
851	Ubiquitination	SSSSKTFEKKRGKK- CCCCCCCHHHCCCC-	64.00	22817900
852	Acetylation	SSSKTFEKKRGKK-- CCCCCCHHHCCCC--	43.51	7491843
852	Ubiquitination	SSSKTFEKKRGKK-- CCCCCCHHHCCCC--	43.51	22817900
853	Acetylation	SSKTFEKKRGKK--- CCCCCHHHCCCC---	60.22	7491851
853	Ubiquitination	SSKTFEKKRGKK--- CCCCCHHHCCCC---	60.22	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
7	S	Phosphorylation	Kinase	TTK	P33981	PSP
12	T	Phosphorylation	Kinase	TTK	P33981	PSP
12	T	Phosphorylation	Kinase	PLK1	P53350	PSP
15	S	Phosphorylation	Kinase	TTK	P33981	PSP
33	T	Phosphorylation	Kinase	TTK	P33981	PSP
33	T	Phosphorylation	Kinase	PLK1	P53350	PSP
37	S	Phosphorylation	Kinase	TTK	P33981	PSP
37	S	Phosphorylation	Kinase	PLK1	P53350	PSP
46	T	Phosphorylation	Kinase	PLK1	P53350	PSP
80	S	Phosphorylation	Kinase	TTK	P33981	PSP
108	S	Phosphorylation	Kinase	PLK1	P53350	PSP
210	T	Phosphorylation	Kinase	PLK1	P53350	PSP
214	S	Phosphorylation	Kinase	PLK1	P53350	PSP
281	S	Phosphorylation	Kinase	BRAF	P15056	PSP
288	T	Phosphorylation	Kinase	TTK	P33981	PSP
288	T	Phosphorylation	Kinase	CHEK2	O96017	GPS
291	S	Phosphorylation	Kinase	PLK1	P53350	PSP
321	S	Phosphorylation	Kinase	PLK1	P53350	PSP
321	S	Phosphorylation	Kinase	TTK	P33981	PSP
333	S	Phosphorylation	Kinase	PLK1	P53350	PSP
345	S	Phosphorylation	Kinase	PLK1	P53350	PSP
360	T	Phosphorylation	Kinase	TTK	P33981	PSP
362	S	Phosphorylation	Kinase	PLK1	P53350	PSP
362	S	Phosphorylation	Kinase	TTK	P33981	PSP
363	S	Phosphorylation	Kinase	TTK	P33981	PSP
363	S	Phosphorylation	Kinase	PLK1	P53350	PSP
371	T	Phosphorylation	Kinase	PLK1	P53350	PSP
371	T	Phosphorylation	Kinase	TTK	P33981	PSP
436	S	Phosphorylation	Kinase	TTK	P33981	PSP
436	S	Phosphorylation	Kinase	BRAF	P15056	PSP
436	S	Phosphorylation	Kinase	CDK2	P24941	PSP
453	T	Phosphorylation	Kinase	CDK2	P24941	PSP
458	T	Phosphorylation	Kinase	PLK1	P53350	PSP
468	T	Phosphorylation	Kinase	CDK2	P24941	PSP
468	T	Phosphorylation	Kinase	CDK2	P24941	PhosphoELM
564	T	Phosphorylation	Kinase	PLK1	P53350	PSP
564	T	Phosphorylation	Kinase	TTK	P33981	PSP
582	S	Phosphorylation	Kinase	TTK	P33981	PSP
594	T	Phosphorylation	Kinase	PLK1	P53350	PSP
675	T	Phosphorylation	Kinase	TTK	P33981	PSP
676	T	Phosphorylation	Kinase	TTK	P33981	PSP
676	T	Phosphorylation	Kinase	TTK	P33981	PhosphoELM
676	T	Phosphorylation	Kinase	PLK1	P53350	PSP
677	S	Phosphorylation	Kinase	TTK	P33981	PSP
686	T	Phosphorylation	Kinase	TTK	P33981	PhosphoELM
686	T	Phosphorylation	Kinase	TTK	P33981	PSP
742	S	Phosphorylation	Kinase	TTK	P33981	PSP
795	T	Phosphorylation	Kinase	TTK	P33981	PSP
805	T	Phosphorylation	Kinase	TTK	P33981	PSP
806	T	Phosphorylation	Kinase	TTK	P33981	PSP
811	Y	Phosphorylation	Kinase	TTK	P33981	PSP
821	S	Phosphorylation	Kinase	MAPK1	P28482	GPS
821	S	Phosphorylation	Kinase	MAPK3	P27361	GPS
821	S	Phosphorylation	Kinase	TTK	P33981	PSP
824	S	Phosphorylation	Kinase	TTK	P33981	PSP
845	S	Phosphorylation	Kinase	TTK	P33981	PSP
847	S	Phosphorylation	Kinase	TTK	P33981	PSP
849	T	Phosphorylation	Kinase	TTK	P33981	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of TTK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TTK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDC27_HUMAN	CDC27	physical	12686615
CDC16_HUMAN	CDC16	physical	12686615
P53_HUMAN	TP53	physical	19332559
TTK_HUMAN	TTK	physical	20360068
CDC27_HUMAN	CDC27	physical	20729194
KNL1_HUMAN	CASC5	physical	22660415
CDK2_HUMAN	CDK2	physical	9311822
A4_HUMAN	APP	physical	21832049
VIGLN_HUMAN	HDLBP	physical	22939629
WDR5_HUMAN	WDR5	physical	22939629
UBE4B_HUMAN	UBE4B	physical	22045814
CDC27_HUMAN	CDC27	physical	22045814
TACC2_HUMAN	TACC2	physical	15304323
BOREA_HUMAN	CDCA8	physical	18243099
TTK_HUMAN	TTK	physical	18082144
RPB1_HUMAN	POLR2A	physical	9311822
KIF2A_HUMAN	KIF2A	physical	26496610
RL7A_HUMAN	RPL7A	physical	26496610
UTRO_HUMAN	UTRN	physical	26496610
ESPL1_HUMAN	ESPL1	physical	26496610
GEMI5_HUMAN	GEMIN5	physical	26496610
IBTK_HUMAN	IBTK	physical	26496610
HERC5_HUMAN	HERC5	physical	26496610
NAA50_HUMAN	NAA50	physical	26496610
HS90A_HUMAN	HSP90AA1	physical	26804907
RAD52_YEAST	RAD52	physical	29078282
RAD52_HUMAN	RAD52	physical	29078282
UBP16_HUMAN	USP16	physical	28380042

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TTK_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216 AND SER-218, ANDMASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; SER-7; THR-33;SER-49; SER-80; SER-281; SER-317; SER-321; SER-431; SER-436; THR-453;SER-455 AND SER-821, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-281 AND SER-821, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-33; SER-281; SER-321;SER-393 AND SER-821, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-7; THR-33; SER-37;SER-80; SER-281; SER-317; SER-393; SER-436 AND SER-821, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-436, AND MASSSPECTROMETRY.	19007248 [Abstract]
"Improved titanium dioxide enrichment of phosphopeptides from HeLacells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."; Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D.; J. Proteome Res. 6:4150-4162(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-821 AND SER-824, ANDMASS SPECTROMETRY.	17924679 [Abstract]