dbPTM

CDC27_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CDC27_HUMAN
UniProt AC	P30260
Protein Name	Cell division cycle protein 27 homolog
Gene Name	CDC27
Organism	Homo sapiens (Human).
Sequence Length	824
Subcellular Localization	Nucleus.
Protein Description	Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains..
Protein Sequence	MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEVHSEEALFLLATCYYRSGKAYKAYRLLKGHSCTTPQCKYLLAKCCVDLSKLAEGEQILSGGVFNKQKSHDDIVTEFGDSACFTLSLLGHVYCKTDRLAKGSECYQKSLSLNPFLWSPFESLCEIGEKPDPDQTFKFTSLQNFSNCLPNSCTTQVPNHSLSHRQPETVLTETPQDTIELNRLNLESSNSKYSLNTDSSVSYIDSAVISPDTVPLGTGTSILSKQVQNKPKTGRSLLGGPAALSPLTPSFGILPLETPSPGDGSYLQNYTNTPPVIDVPSTGAPSKKSVARIGQTGTKSVFSQSGNSREVTPILAQTQSSGPQTSTTPQVLSPTITSPPNALPRRSSRLFTSDSSTTKENSKKLKMKFPPKIPNRKTKSKTNKGGITQPNINDSLEITKLDSSIISEGKISTITPQIQAFNLQKAAAEGLMSLLREMGKGYLALCSYNCKEAINILSHLPSHHYNTGWVLCQIGRAYFELSEYMQAERIFSEVRRIENYRVEGMEIYSTTLWHLQKDVALSVLSKDLTDMDKNSPEAWCAAGNCFSLQREHDIAIKFFQRAIQVDPNYAYAYTLLGHEFVLTEELDKALACFRNAIRVNPRHYNAWYGLGMIYYKQEKFSLAEMHFQKALDINPQSSVLLCHIGVVQHALKKSEKALDTLNKAIVIDPKNPLCKFHRASVLFANEKYKSALQELEELKQIVPKESLVYFLIGKVYKKLGQTHLALMNFSWAMDLDPKGANNQIKEAIDKRYLPDDEEPITQEEQIMGTDESQESSMTDADDTQLHAAESDEF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
62	Ubiquitination	YKAYRLLKGHSCTTP HHHHHHHCCCCCCCH	60.20	-
68	Phosphorylation	LKGHSCTTPQCKYLL HCCCCCCCHHHHHHH	18.71	-
72	Ubiquitination	SCTTPQCKYLLAKCC CCCCHHHHHHHHHHH	33.41	-
77	Acetylation	QCKYLLAKCCVDLSK HHHHHHHHHHCCHHH	28.30	7226429
77	Ubiquitination	QCKYLLAKCCVDLSK HHHHHHHHHHCCHHH	28.30	-
84	Ubiquitination	KCCVDLSKLAEGEQI HHHCCHHHHHCCCCH	60.04	-
99	Acetylation	LSGGVFNKQKSHDDI HCCCCCCCCCCCCHH	47.87	25953088
99	Ubiquitination	LSGGVFNKQKSHDDI HCCCCCCCCCCCCHH	47.87	21890473
133	Ubiquitination	CKTDRLAKGSECYQK ECCCHHCCCCHHHHH	68.51	-
154	Phosphorylation	FLWSPFESLCEIGEK HHCCCHHHHHHCCCC	38.40	21209074
177	Phosphorylation	FTSLQNFSNCLPNSC EEECCCHHCCCCCCC	33.90	21712546
183	Phosphorylation	FSNCLPNSCTTQVPN HHCCCCCCCCCCCCC	15.76	29214152
185	Phosphorylation	NCLPNSCTTQVPNHS CCCCCCCCCCCCCCC	21.78	21712546
186	Phosphorylation	CLPNSCTTQVPNHSL CCCCCCCCCCCCCCC	31.71	21712546
192	Phosphorylation	TTQVPNHSLSHRQPE CCCCCCCCCCCCCCC	37.90	25159151
194	Phosphorylation	QVPNHSLSHRQPETV CCCCCCCCCCCCCCE	21.46	21712546
200	Phosphorylation	LSHRQPETVLTETPQ CCCCCCCCEEECCCC	27.74	21815630
203	Phosphorylation	RQPETVLTETPQDTI CCCCCEEECCCCCCE	33.21	30266825
205	Phosphorylation	PETVLTETPQDTIEL CCCEEECCCCCCEEE	22.48	30266825
209	Phosphorylation	LTETPQDTIELNRLN EECCCCCCEEECCCC	15.88	30266825
219	Phosphorylation	LNRLNLESSNSKYSL ECCCCCCCCCCCEEC	37.68	23663014
220	Phosphorylation	NRLNLESSNSKYSLN CCCCCCCCCCCEECC	35.43	30266825
222	Phosphorylation	LNLESSNSKYSLNTD CCCCCCCCCEECCCC	34.61	23663014
224	Phosphorylation	LESSNSKYSLNTDSS CCCCCCCEECCCCCC	20.43	29978859
225	Phosphorylation	ESSNSKYSLNTDSSV CCCCCCEECCCCCCC	20.91	29978859
228	Phosphorylation	NSKYSLNTDSSVSYI CCCEECCCCCCCEEE	42.42	29978859
230	Phosphorylation	KYSLNTDSSVSYIDS CEECCCCCCCEEEEE	30.51	29978859
231	Phosphorylation	YSLNTDSSVSYIDSA EECCCCCCCEEEEEE	20.21	29978859
233	Phosphorylation	LNTDSSVSYIDSAVI CCCCCCCEEEEEEEE	20.51	28348404
234	Phosphorylation	NTDSSVSYIDSAVIS CCCCCCEEEEEEEEC	13.44	28348404
237	Phosphorylation	SSVSYIDSAVISPDT CCCEEEEEEEECCCC	18.19	28348404
241	Phosphorylation	YIDSAVISPDTVPLG EEEEEEECCCCCCCC	15.32	26074081
244	Phosphorylation	SAVISPDTVPLGTGT EEEECCCCCCCCCCH	27.66	26074081
252	Phosphorylation	VPLGTGTSILSKQVQ CCCCCCHHHHHHHHH	23.91	24719451
264	Phosphorylation	QVQNKPKTGRSLLGG HHHCCCCCCCCCCCC	46.48	22817900
276	Phosphorylation	LGGPAALSPLTPSFG CCCCCCCCCCCCCCC	17.09	27251275
279	Phosphorylation	PAALSPLTPSFGILP CCCCCCCCCCCCEEE	21.92	27251275
289	Phosphorylation	FGILPLETPSPGDGS CCEEECCCCCCCCCC	36.43	22817900
291	Phosphorylation	ILPLETPSPGDGSYL EEECCCCCCCCCCCC	49.27	22817900
296	Phosphorylation	TPSPGDGSYLQNYTN CCCCCCCCCCCCCCC	27.66	22817900
297	Phosphorylation	PSPGDGSYLQNYTNT CCCCCCCCCCCCCCC	20.17	27251275
301	Phosphorylation	DGSYLQNYTNTPPVI CCCCCCCCCCCCCEE	6.60	27251275
302	Phosphorylation	GSYLQNYTNTPPVID CCCCCCCCCCCCEEC	39.92	27251275
304	Phosphorylation	YLQNYTNTPPVIDVP CCCCCCCCCCEECCC	22.59	22067460
312	Phosphorylation	PPVIDVPSTGAPSKK CCEECCCCCCCCCHH	39.04	22817900
313	Phosphorylation	PVIDVPSTGAPSKKS CEECCCCCCCCCHHH	31.15	22817900
313 (in isoform 2)	Phosphorylation	-	31.15	-
319	Ubiquitination	STGAPSKKSVARIGQ CCCCCCHHHHEECCC	55.27	-
320	Phosphorylation	TGAPSKKSVARIGQT CCCCCHHHHEECCCC	25.42	22067460
320 (in isoform 2)	Phosphorylation	-	25.42	-
326	Phosphorylation	KSVARIGQTGTKSVF HHHEECCCCCCCHHH	34.09	-
326 (in isoform 2)	Phosphorylation	-	34.09	-
327	Phosphorylation	SVARIGQTGTKSVFS HHEECCCCCCCHHHC	41.42	-
329	Phosphorylation	ARIGQTGTKSVFSQS EECCCCCCCHHHCCC	24.43	22817900
330	Acetylation	RIGQTGTKSVFSQSG ECCCCCCCHHHCCCC	46.06	26051181
330	Ubiquitination	RIGQTGTKSVFSQSG ECCCCCCCHHHCCCC	46.06	21906983
333	Phosphorylation	QTGTKSVFSQSGNSR CCCCCHHHCCCCCCC	7.69	-
334	O-linked_Glycosylation	TGTKSVFSQSGNSRE CCCCHHHCCCCCCCE	22.68	23301498
334	Phosphorylation	TGTKSVFSQSGNSRE CCCCHHHCCCCCCCE	22.68	26055452
335	Phosphorylation	GTKSVFSQSGNSREV CCCHHHCCCCCCCEE	43.84	-
336	Phosphorylation	TKSVFSQSGNSREVT CCHHHCCCCCCCEEC	38.45	25159151
339	Phosphorylation	VFSQSGNSREVTPIL HHCCCCCCCEECCEE	33.09	25159151
342	Phosphorylation	QSGNSREVTPILAQT CCCCCCEECCEEEEC	8.19	27251275
343	Phosphorylation	SGNSREVTPILAQTQ CCCCCEECCEEEECC	10.39	14657031
349	Phosphorylation	VTPILAQTQSSGPQT ECCEEEECCCCCCCC	25.47	29632367
351	Phosphorylation	PILAQTQSSGPQTST CEEEECCCCCCCCCC	40.42	29632367
352	Phosphorylation	ILAQTQSSGPQTSTT EEEECCCCCCCCCCC	44.68	29632367
356	Phosphorylation	TQSSGPQTSTTPQVL CCCCCCCCCCCCCCC	31.04	29632367
357	Phosphorylation	QSSGPQTSTTPQVLS CCCCCCCCCCCCCCC	25.65	29632367
358	Phosphorylation	SSGPQTSTTPQVLSP CCCCCCCCCCCCCCC	45.97	25022875
359	Phosphorylation	SGPQTSTTPQVLSPT CCCCCCCCCCCCCCC	16.10	25022875
364	Phosphorylation	STTPQVLSPTITSPP CCCCCCCCCCCCCCC	22.57	25159151
366	Phosphorylation	TPQVLSPTITSPPNA CCCCCCCCCCCCCCC	33.25	14657031
368	Phosphorylation	QVLSPTITSPPNALP CCCCCCCCCCCCCCC	37.34	30175587
369	Phosphorylation	VLSPTITSPPNALPR CCCCCCCCCCCCCCC	34.21	26055452
370	Phosphorylation	LSPTITSPPNALPRR CCCCCCCCCCCCCCC	19.95	24719451
378	Phosphorylation	PNALPRRSSRLFTSD CCCCCCCCCCCCCCC	22.53	25159151
379	Phosphorylation	NALPRRSSRLFTSDS CCCCCCCCCCCCCCC	31.06	27273156
383	Phosphorylation	RRSSRLFTSDSSTTK CCCCCCCCCCCCCCH	35.89	25159151
384	Phosphorylation	RSSRLFTSDSSTTKE CCCCCCCCCCCCCHH	28.32	25159151
386	Phosphorylation	SRLFTSDSSTTKENS CCCCCCCCCCCHHHH	29.38	25159151
387	Phosphorylation	RLFTSDSSTTKENSK CCCCCCCCCCHHHHH	45.12	25159151
388	Phosphorylation	LFTSDSSTTKENSKK CCCCCCCCCHHHHHH	45.93	25159151
389	Phosphorylation	FTSDSSTTKENSKKL CCCCCCCCHHHHHHC	38.01	25159151
390	Ubiquitination	TSDSSTTKENSKKLK CCCCCCCHHHHHHCC	55.79	-
393	Phosphorylation	SSTTKENSKKLKMKF CCCCHHHHHHCCCCC	32.05	26055452
415	Ubiquitination	KTKSKTNKGGITQPN CCCCCCCCCCCCCCC	64.84	21906983
419	Phosphorylation	KTNKGGITQPNINDS CCCCCCCCCCCCCCC	41.05	22210691
426	Phosphorylation	TQPNINDSLEITKLD CCCCCCCCEEEEECC	24.34	30266825
430	Phosphorylation	INDSLEITKLDSSII CCCCEEEEECCHHHH	19.04	30266825
431	Ubiquitination	NDSLEITKLDSSIIS CCCEEEEECCHHHHC	56.83	21906983
432	Phosphorylation	DSLEITKLDSSIISE CCEEEEECCHHHHCC	6.05	27251275
434	Phosphorylation	LEITKLDSSIISEGK EEEEECCHHHHCCCC	33.60	30266825
435	Phosphorylation	EITKLDSSIISEGKI EEEECCHHHHCCCCC	24.49	30266825
438	Phosphorylation	KLDSSIISEGKISTI ECCHHHHCCCCCCCC	38.33	30266825
441	Ubiquitination	SSIISEGKISTITPQ HHHHCCCCCCCCCHH	29.45	21890473
443	Phosphorylation	IISEGKISTITPQIQ HHCCCCCCCCCHHHH	19.76	21815630
444	Phosphorylation	ISEGKISTITPQIQA HCCCCCCCCCHHHHH	32.13	25159151
446	Phosphorylation	EGKISTITPQIQAFN CCCCCCCCHHHHHHH	14.83	25159151
452	Phosphorylation	ITPQIQAFNLQKAAA CCHHHHHHHHHHHHH	5.55	24719451
523	Phosphorylation	MQAERIFSEVRRIEN HHHHHHHHHHHCHHC	32.58	24719451
553	Phosphorylation	LQKDVALSVLSKDLT HHHHHHHHHHCCCCC	15.98	22817900
557	Ubiquitination	VALSVLSKDLTDMDK HHHHHHCCCCCCCCC	53.23	21906983
564	Ubiquitination	KDLTDMDKNSPEAWC CCCCCCCCCCHHHHH	53.33	-
578	Phosphorylation	CAAGNCFSLQREHDI HHHHCCHHCCCHHHH	26.28	-
588	Ubiquitination	REHDIAIKFFQRAIQ CHHHHHHHHHHHHHC	30.98	21890473
685	O-linked_Glycosylation	VQHALKKSEKALDTL HHHHHHHCHHHHHHC	42.62	23301498
687	Ubiquitination	HALKKSEKALDTLNK HHHHHCHHHHHHCCC	62.43	-
691	O-linked_Glycosylation	KSEKALDTLNKAIVI HCHHHHHHCCCCEEE	32.83	23301498
691	Phosphorylation	KSEKALDTLNKAIVI HCHHHHHHCCCCEEE	32.83	22817900
694	Ubiquitination	KALDTLNKAIVIDPK HHHHHCCCCEEECCC	42.47	21890473
701	Acetylation	KAIVIDPKNPLCKFH CCEEECCCCCCCHHH	68.40	26051181
701	Ubiquitination	KAIVIDPKNPLCKFH CCEEECCCCCCCHHH	68.40	-
706	Ubiquitination	DPKNPLCKFHRASVL CCCCCCCHHHHHHHH	52.46	-
718	Ubiquitination	SVLFANEKYKSALQE HHHHCCHHHHHHHHH	58.76	21906983
720	Ubiquitination	LFANEKYKSALQELE HHCCHHHHHHHHHHH	40.08	21906983
721	Phosphorylation	FANEKYKSALQELEE HCCHHHHHHHHHHHH	30.99	28060719
730	Ubiquitination	LQELEELKQIVPKES HHHHHHHHCCCCHHH	41.06	21906983
735	Ubiquitination	ELKQIVPKESLVYFL HHHCCCCHHHHHHHH	49.38	21890473
740	Phosphorylation	VPKESLVYFLIGKVY CCHHHHHHHHHHHHH	9.65	25147952
753	Phosphorylation	VYKKLGQTHLALMNF HHHHHCCCEEEEEEC	19.63	28111955
761	Phosphorylation	HLALMNFSWAMDLDP EEEEEECHHHCCCCC	14.66	28111955
776	Ubiquitination	KGANNQIKEAIDKRY CCCCHHHHHHHHHHC	31.18	-
809	Phosphorylation	ESQESSMTDADDTQL CCHHCCCCCCCCCHH	29.95	30576142
821	Phosphorylation	TQLHAAESDEF---- CHHHHHHCCCC----	37.40	22139841

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
154	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
205	T	Phosphorylation	Kinase	PLK1	P53350	PSP
205	T	Phosphorylation	Kinase	CDK1	P06493	PSP
209	T	Phosphorylation	Kinase	CDK1	P06493	PSP
209	T	Phosphorylation	Kinase	PLK1	P53350	PSP
222	S	Phosphorylation	Kinase	CDK1	P06493	PSP
289	T	Phosphorylation	Kinase	CDK1	P06493	PSP
312	S	Phosphorylation	Kinase	CDK1	P06493	PSP
329	T	Phosphorylation	Kinase	CDK1	P06493	PSP
343	T	Phosphorylation	Kinase	CDK1	P06493	PSP
364	S	Phosphorylation	Kinase	CDK1	P06493	PhosphoELM
379	S	Phosphorylation	Kinase	PRKAA2	P54646	GPS
426	S	Phosphorylation	Kinase	PLK1	P53350	PSP
426	S	Phosphorylation	Kinase	CDK1	P06493	PSP
430	T	Phosphorylation	Kinase	PLK1	P53350	PSP
430	T	Phosphorylation	Kinase	CDK1	P06493	PSP
434	S	Phosphorylation	Kinase	CDK1	P06493	PSP
434	S	Phosphorylation	Kinase	PLK1	P53350	PSP
435	S	Phosphorylation	Kinase	PLK1	P53350	PSP
435	S	Phosphorylation	Kinase	CDK1	P06493	PSP
446	T	Phosphorylation	Kinase	CDK1	P06493	PSP
446	T	Phosphorylation	Kinase	PLK1	P53350	PSP

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
426	S	Phosphorylation	14657031
Phosphorylation on Ser-426 and Thr-446 occurs specifically during mitosis.
446	T	Phosphorylation	14657031
Phosphorylation on Ser-426 and Thr-446 occurs specifically during mitosis.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CDC27_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APC1_HUMAN	ANAPC1	physical	12956947
APC10_HUMAN	ANAPC10	physical	12956947
APC11_HUMAN	ANAPC11	physical	12956947
APC4_HUMAN	ANAPC4	physical	12956947
APC5_HUMAN	ANAPC5	physical	12956947
CDC16_HUMAN	CDC16	physical	12956947
APC7_HUMAN	ANAPC7	physical	12956947
CDC23_HUMAN	CDC23	physical	12956947
PPP5_MOUSE	Ppp5c	physical	9405394
PPP5_HUMAN	PPP5C	physical	9405394
PIN1_HUMAN	PIN1	physical	9499405
MD2L1_HUMAN	MAD2L1	physical	9736712
CDC20_HUMAN	CDC20	physical	9736712
CDC20_HUMAN	CDC20	physical	9811605
FZR1_HUMAN	FZR1	physical	9811605
CDC20_HUMAN	CDC20	physical	9628895
CDC16_HUMAN	CDC16	physical	9628895
MD2L1_HUMAN	MAD2L1	physical	9628895
APC4_HUMAN	ANAPC4	physical	10922056
APC5_HUMAN	ANAPC5	physical	10922056
CDC16_HUMAN	CDC16	physical	10922056
CDC23_HUMAN	CDC23	physical	10922056
APC10_HUMAN	ANAPC10	physical	10922056
CDC26_HUMAN	CDC26	physical	10922056
APC11_HUMAN	ANAPC11	physical	10922056
APC7_HUMAN	ANAPC7	physical	10922056
CDN1A_HUMAN	CDKN1A	physical	17679094
CTNB1_HUMAN	CTNNB1	physical	16510875
ANC2_HUMAN	ANAPC2	physical	14657031
APC4_HUMAN	ANAPC4	physical	14657031
APC5_HUMAN	ANAPC5	physical	14657031
CDC16_HUMAN	CDC16	physical	14657031
APC7_HUMAN	ANAPC7	physical	14657031
CDC23_HUMAN	CDC23	physical	14657031
APC10_HUMAN	ANAPC10	physical	14657031
CDC26_HUMAN	CDC26	physical	14657031
APC11_HUMAN	ANAPC11	physical	14657031
CDC16_HUMAN	CDC16	physical	9356466
MD2L1_HUMAN	MAD2L1	physical	9356466
CBP_HUMAN	CREBBP	physical	21454660
CDC20_HUMAN	CDC20	physical	21454660
HSF2_HUMAN	HSF2	physical	20937767
TTK_HUMAN	TTK	physical	20729194
APC1_HUMAN	ANAPC1	physical	22193957
ANC2_HUMAN	ANAPC2	physical	22193957
APC4_HUMAN	ANAPC4	physical	22193957
APC5_HUMAN	ANAPC5	physical	22193957
CDC16_HUMAN	CDC16	physical	22193957
APC7_HUMAN	ANAPC7	physical	22193957
CDC23_HUMAN	CDC23	physical	22193957
APC10_HUMAN	ANAPC10	physical	22193957
APC16_HUMAN	ANAPC16	physical	22193957
BUB1B_HUMAN	BUB1B	physical	22193957
BUB3_HUMAN	BUB3	physical	22193957
CDC20_HUMAN	CDC20	physical	22193957
MD2L1_HUMAN	MAD2L1	physical	22193957
APC4_HUMAN	ANAPC4	physical	21926987
CDC20_HUMAN	CDC20	physical	21926987
BUB1B_HUMAN	BUB1B	physical	21926987
BUB3_HUMAN	BUB3	physical	21926987
MD2L1_HUMAN	MAD2L1	physical	21926987
FZR1_HUMAN	FZR1	physical	11340163
CDC16_HUMAN	CDC16	physical	17187060
FZR1_HUMAN	FZR1	physical	17187060
FZR1_HUMAN	FZR1	physical	17942546
CDC23_HUMAN	CDC23	physical	17942546
APC7_HUMAN	ANAPC7	physical	17942546
APC1_HUMAN	ANAPC1	physical	17942546
FOXM1_HUMAN	FOXM1	physical	18573889
MD2L1_HUMAN	MAD2L1	physical	20081372
CDC20_HUMAN	CDC20	physical	20081372
FZR1_HUMAN	FZR1	physical	21986944
MD2L1_HUMAN	MAD2L1	physical	21335556
CDC27_HUMAN	CDC27	physical	21335556
APC4_HUMAN	ANAPC4	physical	21335556
ANC2_HUMAN	ANAPC2	physical	16364912
APC1_HUMAN	ANAPC1	physical	16364912
APC4_HUMAN	ANAPC4	physical	16364912
APC5_HUMAN	ANAPC5	physical	16364912
APC7_HUMAN	ANAPC7	physical	16364912
APC11_HUMAN	ANAPC11	physical	16364912
CDC16_HUMAN	CDC16	physical	16364912
CDC23_HUMAN	CDC23	physical	16364912
CDC26_HUMAN	CDC26	physical	16364912
APC10_HUMAN	ANAPC10	physical	16364912
CDC23_HUMAN	CDC23	physical	22792066
UL21A_HCMVM	UL21A	physical	22792066
UL21A_HCMVA	UL21A	physical	22792066
APC5_HUMAN	ANAPC5	physical	22792066
APC10_HUMAN	ANAPC10	physical	22792066
MDC1_HUMAN	MDC1	physical	19826003
APC1_HUMAN	ANAPC1	physical	21043528
ANC2_HUMAN	ANAPC2	physical	21043528
APC4_HUMAN	ANAPC4	physical	21043528
APC5_HUMAN	ANAPC5	physical	21043528
CDC16_HUMAN	CDC16	physical	21043528
APC7_HUMAN	ANAPC7	physical	21043528
CDC23_HUMAN	CDC23	physical	21043528
APC10_HUMAN	ANAPC10	physical	21043528
CDC26_HUMAN	CDC26	physical	21043528
APC13_HUMAN	ANAPC13	physical	21043528
APC16_HUMAN	ANAPC16	physical	21043528
CDC20_HUMAN	CDC20	physical	14561775
APC10_HUMAN	ANAPC10	physical	10498862
ANC2_HUMAN	ANAPC2	physical	22280307
CDC23_HUMAN	CDC23	physical	22280307
CDC20_HUMAN	CDC20	physical	22280307
CDC20_HUMAN	CDC20	physical	9734353
FZR1_HUMAN	FZR1	physical	17609108
CDC20_HUMAN	CDC20	physical	17609108
MD2L1_HUMAN	MAD2L1	physical	11707408
MCPH1_HUMAN	MCPH1	physical	22139841
BUB1B_HUMAN	BUB1B	physical	21525009
CDC20_HUMAN	CDC20	physical	21525009
MD2L1_HUMAN	MAD2L1	physical	21525009
ANC2_HUMAN	ANAPC2	physical	16648845
CDC27_HUMAN	CDC27	physical	16648845
CDC16_HUMAN	CDC16	physical	16648845
CDC23_HUMAN	CDC23	physical	16648845
NEK2_HUMAN	NEK2	physical	16648845
MD1L1_HUMAN	MAD1L1	physical	22100920
MD2BP_HUMAN	MAD2L1BP	physical	22100920
CDC20_HUMAN	CDC20	physical	22100920
MD2L1_HUMAN	MAD2L1	physical	22100920
BUB1B_HUMAN	BUB1B	physical	22100920
CDC27_HUMAN	CDC27	physical	22100920
RB_HUMAN	RB1	physical	7756179
CDC16_HUMAN	CDC16	physical	7736578
FBX5_HUMAN	FBXO5	physical	16921029
APC15_HUMAN	ANAPC15	physical	23007861
BUB1B_HUMAN	BUB1B	physical	23007861
CDC20_HUMAN	CDC20	physical	23007861
MD2L2_HUMAN	MAD2L2	physical	23007861
APC4_HUMAN	ANAPC4	physical	23007861
TRI33_HUMAN	TRIM33	physical	23160376
PTEN_HUMAN	PTEN	physical	21241890
APC4_HUMAN	ANAPC4	physical	21241890
APC5_HUMAN	ANAPC5	physical	21241890
APC7_HUMAN	ANAPC7	physical	21241890
BUB1B_HUMAN	BUB1B	physical	23754430
CDC20_HUMAN	CDC20	physical	23754430
MD2L1_HUMAN	MAD2L1	physical	23754430
GKN1_HUMAN	GKN1	physical	21988832
DCPS_HUMAN	DCPS	physical	21988832
FZR1_HUMAN	FZR1	physical	23670162
CDC20_HUMAN	CDC20	physical	25156254
CDC20_HUMAN	CDC20	physical	25246557
BUB1B_HUMAN	BUB1B	physical	25246557
COMT_HUMAN	COMT	physical	25416956
E2F1_HUMAN	E2F1	physical	25368385
TFDP1_HUMAN	TFDP1	physical	25368385
CADH1_HUMAN	CDH1	physical	22539978
FZR1_HUMAN	FZR1	physical	21768287
FZR1_HUMAN	FZR1	physical	12956947
ANC2_HUMAN	ANAPC2	physical	12956947
CDC26_HUMAN	CDC26	physical	12956947
ANC2_HUMAN	ANAPC2	physical	10922056
FZR1_HUMAN	FZR1	physical	9734353
APC1_HUMAN	ANAPC1	physical	20686030
APC7_HUMAN	ANAPC7	physical	20686030
CDC23_HUMAN	CDC23	physical	20686030
CADH1_HUMAN	CDH1	physical	20686030
APC5_HUMAN	ANAPC5	physical	20686030
APC4_HUMAN	ANAPC4	physical	20686030
APC16_HUMAN	ANAPC16	physical	25490258
CDC27_HUMAN	CDC27	physical	25490258
APC10_HUMAN	ANAPC10	physical	26344197
APC16_HUMAN	ANAPC16	physical	26344197
APC4_HUMAN	ANAPC4	physical	26344197
APC7_HUMAN	ANAPC7	physical	26344197
CDC16_HUMAN	CDC16	physical	26344197
CDC23_HUMAN	CDC23	physical	26344197
NUCL_HUMAN	NCL	physical	26344197
RL5_HUMAN	RPL5	physical	26344197
TAF4_HUMAN	TAF4	physical	26344197
TAF5_HUMAN	TAF5	physical	26344197
APC4_HUMAN	ANAPC4	physical	26496610
APC10_HUMAN	ANAPC10	physical	26496610
CFA97_HUMAN	CFAP97	physical	26496610
ANC2_HUMAN	ANAPC2	physical	25306918
APC5_HUMAN	ANAPC5	physical	25306918
APC7_HUMAN	ANAPC7	physical	25306918
CDC20_HUMAN	CDC20	physical	25306918
BUB1B_HUMAN	BUB1B	physical	25306918
UBE2S_HUMAN	UBE2S	physical	25306918
CDC16_HUMAN	CDC16	physical	25306918
FZR1_HUMAN	FZR1	physical	25306918
APC4_HUMAN	ANAPC4	physical	26811472
APC7_HUMAN	ANAPC7	physical	26811472
CDC20_HUMAN	CDC20	physical	26811472
UBE2S_HUMAN	UBE2S	physical	26811472
BUB1B_HUMAN	BUB1B	physical	26811472
MD2L1_HUMAN	MAD2L1	physical	26811472
2A5A_HUMAN	PPP2R5A	physical	26811472
PP2AA_HUMAN	PPP2CA	physical	26811472
ANC2_HUMAN	ANAPC2	physical	26811472
APC11_HUMAN	ANAPC11	physical	26811472
APC5_HUMAN	ANAPC5	physical	26811472
FZR1_HUMAN	FZR1	physical	24100295
PCNA_HUMAN	PCNA	physical	21700221
APC1_HUMAN	ANAPC1	physical	27114510
ANC2_HUMAN	ANAPC2	physical	27114510
BUB1B_HUMAN	BUB1B	physical	27114510
APC4_HUMAN	ANAPC4	physical	27114510
APC5_HUMAN	ANAPC5	physical	27114510
CDC16_HUMAN	CDC16	physical	27114510
APC7_HUMAN	ANAPC7	physical	27114510
CDC23_HUMAN	CDC23	physical	27114510
CDC20_HUMAN	CDC20	physical	27114510
BUB3_HUMAN	BUB3	physical	27114510
PTTG1_HUMAN	PTTG1	physical	27114510
CCND1_HUMAN	CCND1	physical	20439707
CDC23_HUMAN	CDC23	physical	27173435
NUP98_HUMAN	NUP98	physical	27097363
HXD13_HUMAN	HOXD13	physical	27097363
LNP1_HUMAN	LNP1	physical	27097363
HHEX_HUMAN	HHEX	physical	27097363

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CDC27_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-426 AND THR-446, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-205; SER-339; SER-426;SER-435; SER-438 AND THR-446, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Evaluation of the low-specificity protease elastase for large-scalephosphoproteome analysis."; Wang B., Malik R., Nigg E.A., Korner R.; Anal. Chem. 80:9526-9533(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-339; SER-435 ANDSER-438, AND MASS SPECTROMETRY.	19007248 [Abstract]
"Phosphoproteome analysis of the human mitotic spindle."; Nousiainen M., Sillje H.H.W., Sauer G., Nigg E.A., Koerner R.; Proc. Natl. Acad. Sci. U.S.A. 103:5391-5396(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-435 AND SER-438, ANDMASS SPECTROMETRY.	16565220 [Abstract]
"Mitotic regulation of the human anaphase-promoting complex byphosphorylation."; Kraft C., Herzog F., Gieffers C., Mechtler K., Hagting A., Pines J.,Peters J.-M.; EMBO J. 22:6598-6609(2003). Cited for: PHOSPHORYLATION AT THR-205; THR-209; THR-244; SER-291; THR-313;SER-426; THR-430; SER-435 AND THR-446.	14657031 [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-366, AND MASSSPECTROMETRY.	19690332 [Abstract]

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