APC11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: APC11_HUMAN
• UniProt AC: Q9NYG5
• Protein Name: Anaphase-promoting complex subunit 11
• Gene Name: ANAPC11
• Organism: Homo sapiens (Human).
• Sequence Length: 84
• Subcellular Localization: Cytoplasm . Nucleus .
• Protein Description: Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex..
• Protein Sequence: MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCILKWLHAQQVQQHCPMCRQEWKFKE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MKVKIKCWNGVAT --CCEEEEEECCEEE	27.72	-
81	Ubiquitination	PMCRQEWKFKE---- HHHCHHHCCCC----	45.89	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of APC11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of APC11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of APC11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
APC10_HUMAN	ANAPC10	physical	11739784
ANC2_HUMAN	ANAPC2	physical	11739784
CUL5_HUMAN	CUL5	physical	10230407
ANC2_HUMAN	ANAPC2	physical	10230407
UBE2C_HUMAN	UBE2C	physical	20080579
UB2D1_HUMAN	UBE2D1	physical	20080579
UBE2C_HUMAN	UBE2C	physical	17227951
UBE2C_HUMAN	UBE2C	physical	21937719
UBE2C_HUMAN	UBE2C	physical	17360335
UBE2C_HUMAN	UBE2C	physical	20733055
UBE2C_HUMAN	UBE2C	physical	16455800
UBE2C_HUMAN	UBE2C	physical	22580460
UB2D2_HUMAN	UBE2D2	physical	15256223
UB2D2_HUMAN	UBE2D2	physical	19826003
UB2D1_HUMAN	UBE2D1	physical	19826003
UBE2C_HUMAN	UBE2C	physical	19826003
UBE2S_HUMAN	UBE2S	physical	22529100
UBE2C_HUMAN	UBE2C	physical	22529100
UBE2C_HUMAN	UBE2C	physical	21874044
UBE2C_HUMAN	UBE2C	physical	23078409
UBE2K_HUMAN	UBE2K	physical	18662541
UBE2C_HUMAN	UBE2C	physical	18662541
UBE2C_HUMAN	UBE2C	physical	23708001
UBE2S_HUMAN	UBE2S	physical	23708001
UBE2C_HUMAN	UBE2C	physical	23708605
UBE2S_HUMAN	UBE2S	physical	23708605
CCNB1_HUMAN	CCNB1	physical	23708605
UBE2C_HUMAN	UBE2C	physical	23791783
RN111_HUMAN	RNF111	physical	22493164
TRI65_HUMAN	TRIM65	physical	22493164
MAK_HUMAN	MAK	physical	21988832
ZAP70_HUMAN	ZAP70	physical	21988832
CAN11_HUMAN	CAPN11	physical	21988832
NKD2_HUMAN	NKD2	physical	21988832
MLKL_HUMAN	MLKL	physical	21988832
CDC27_HUMAN	CDC27	physical	24163370
ANC2_HUMAN	ANAPC2	physical	24163370
CDC23_HUMAN	CDC23	physical	24163370
CDC16_HUMAN	CDC16	physical	24163370
UBE2C_HUMAN	UBE2C	physical	25043029
UBE2S_HUMAN	UBE2S	physical	25043029
CCNA2_HUMAN	CCNA2	physical	24302728
APC11_HUMAN	ANAPC11	physical	10922056
UBE2S_HUMAN	UBE2S	physical	20080579
UB2D1_HUMAN	UBE2D1	physical	19475398
UBE2C_HUMAN	UBE2C	physical	22193957
UBE2C_HUMAN	UBE2C	physical	23707760
UBE2K_HUMAN	UBE2K	physical	17632060
UBE2C_HUMAN	UBE2C	physical	23670162
UBE2K_HUMAN	UBE2K	physical	24930963
UB2D2_HUMAN	UBE2D2	physical	24930963
UBE2C_HUMAN	UBE2C	physical	25246557
PTTG1_HUMAN	PTTG1	physical	10922056
UBE2S_HUMAN	UBE2S	physical	23288039
UBE2C_HUMAN	UBE2C	physical	23288039
UBE2C_HUMAN	UBE2C	physical	22205987
UB2D2_HUMAN	UBE2D2	physical	20383333
E2F1_HUMAN	E2F1	physical	25368385
PTTG1_HUMAN	PTTG1	physical	11739784
UBE2C_HUMAN	UBE2C	physical	11739784
UB2D2_HUMAN	UBE2D2	physical	11739784
APC11_HUMAN	ANAPC11	physical	11739784
PTTG1_HUMAN	PTTG1	physical	12956947
UB2D2_HUMAN	UBE2D2	physical	12956947
UBE2C_HUMAN	UBE2C	physical	25161877
UB2D2_HUMAN	UBE2D2	physical	25161877
UBE2C_HUMAN	UBE2C	physical	23972993
UBE2S_HUMAN	UBE2S	physical	23972993
UBE2S_HUMAN	UBE2S	physical	25490258
UBE2C_HUMAN	UBE2C	physical	25490258
UBE2C_HUMAN	UBE2C	physical	25959309
UBE2C_HUMAN	UBE2C	physical	25825779
UBE2S_HUMAN	UBE2S	physical	25825779
UBE2S_HUMAN	UBE2S	physical	25306923
UB2D2_HUMAN	UBE2D2	physical	25306923
UBE2C_HUMAN	UBE2C	physical	25306923
UBE2C_HUMAN	UBE2C	physical	26329581
UB2D1_HUMAN	UBE2D1	physical	26329581
UBE2S_HUMAN	UBE2S	physical	25306918
UBE2S_HUMAN	UBE2S	physical	26811472
UBE2C_HUMAN	UBE2C	physical	27120157
UBE2S_HUMAN	UBE2S	physical	27120157
UBE2C_HUMAN	UBE2C	physical	21700221
UBE2S_HUMAN	UBE2S	physical	21700221
UBE2C_HUMAN	UBE2C	physical	27114510
UBE2S_HUMAN	UBE2S	physical	27114510
UBE2C_HUMAN	UBE2C	physical	27509861
CDC20_HUMAN	CDC20	physical	27509861
UBE2C_HUMAN	UBE2C	physical	27259151
UBE2S_HUMAN	UBE2S	physical	27259151
UBC_HUMAN	UBC	physical	27259151
UBE2C_HUMAN	UBE2C	physical	27601667
UBE2S_HUMAN	UBE2S	physical	27601667
UB2D2_HUMAN	UBE2D2	physical	25825779
UBE2C_HUMAN	UBE2C	physical	23007648
UB2D3_HUMAN	UBE2D3	physical	27653696

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.