CAN11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CAN11_HUMAN
• UniProt AC: Q9UMQ6
• Protein Name: Calpain-11
• Gene Name: CAPN11
• Organism: Homo sapiens (Human).
• Sequence Length: 739
• Subcellular Localization: Cytoplasmic vesicle, secretory vesicle, acrosome.
• Protein Description: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction..
• Protein Sequence: MLYSPGPSLPESAESLDGSQEDKPRGSCAEPTFTDTGMVAHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTDKMLVRGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEVASDIQMQLLHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDYKSYWHTTFYEGSWRRGSSAGGCRNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAVPKEFQNIQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLLRVFTEKHSESWELDEVNYAEQLQEEKVSEDDMDQDFLHLFKIVAGEGKEIGVYELQRLLNRMAIKFKSFKTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWMDIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMFTFFLTMDPKNTGHICLSLEQWLQMTMWG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	Phosphorylation	AQNFGNQSFEELRAA CHHHCCCCHHHHHHH	38.33	23186163
314	Phosphorylation	HYRGKMETLIRVRNP EECCEEEEEEEEECC	24.80	20071362
361	Phosphorylation	EDGEFWMSYQDFLNN CCCCEEECHHHHHHC	15.39	25954137
362	Phosphorylation	DGEFWMSYQDFLNNF CCCEEECHHHHHHCC	8.94	25954137
378	Phosphorylation	LLEICNLTPDTLSGD CHHHHCCCCCCCCCC	12.72	25954137
381	Phosphorylation	ICNLTPDTLSGDYKS HHCCCCCCCCCCCCC	24.83	25954137
404	Phosphorylation	GSWRRGSSAGGCRNH CCCCCCCCCCCCCCC	33.48	-
493	Phosphorylation	KKEFFTKYQDHGFSE CHHHHHHHCCCCCCH	19.00	-
499	Phosphorylation	KYQDHGFSEIFTNSR HHCCCCCCHHCCCCC	34.08	-
509	Phosphorylation	FTNSREVSSQLRLPP CCCCCHHHHCCCCCC	13.96	-
510	Phosphorylation	TNSREVSSQLRLPPG CCCCHHHHCCCCCCC	38.11	-
679	Acetylation	AGIKLNNKVMQVLVA HCCCCCHHHHHHHHH	37.70	7378787
709	Phosphorylation	SCFLRLKTMFTFFLT HHHHHHHHHHHEEEE	23.31	27135362
712	Phosphorylation	LRLKTMFTFFLTMDP HHHHHHHHEEEECCC	11.58	27135362
716	Phosphorylation	TMFTFFLTMDPKNTG HHHHEEEECCCCCCC	17.86	27135362

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CAN11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CAN11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CAN11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
XRCC6_HUMAN	XRCC6	physical	21988832
KAP0_HUMAN	PRKAR1A	physical	21988832
UNG_HUMAN	UNG	physical	21988832
SK2L2_HUMAN	SKIV2L2	physical	26344197

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.