RN111_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN111_HUMAN
• UniProt AC: Q6ZNA4
• Protein Name: E3 ubiquitin-protein ligase Arkadia {ECO:0000305|PubMed:14657019}
• Gene Name: RNF111 {ECO:0000312|HGNC:HGNC:17384}
• Organism: Homo sapiens (Human).
• Sequence Length: 994
• Subcellular Localization: Nucleus . Cytoplasm . Nucleus, PML body . Upon TGF-beta treatment, translocates from nucleus to cytosol.
• Protein Description: E3 ubiquitin-protein ligase. [PubMed: 26656854 Required for mesoderm patterning during embryonic development (By similarity Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP]
• Protein Sequence: MSQWTPEYNELYTLKVDMKSEIPSDAPKTQESLKGILLHPEPIGAAKSFPAGVEMINSKVGNEFSHLCDDSQKQEKEMNGNQQEQEKSLVVRKKRKSQQAGPSYVQNCVKENQGILGLRQHLGTPSDEDNDSSFSDCLSSPSSSLHFGDSDTVTSDEDKEVSVRHSQTILNAKSRSHSARSHKWPRTETESVSGLLMKRPCLHGSSLRRLPCRKRFVKNNSSQRTQKQKERILMQRKKREVLARRKYALLPSSSSSSENDLSSESSSSSSTEGEEDLFVSASENHQNNPAVPSGSIDEDVVVIEASSTPQVTANEEINVTSTDSEVEIVTVGESYRSRSTLGHSRSHWSQGSSSHASRPQEPRNRSRISTVIQPLRQNAAEVVDLTVDEDEPTVVPTTSARMESQATSASINNSNPSTSEQASDTASAVTSSQPSTVSETSATLTSNSTTGTSIGDDSRRTTSSAVTETGPPAMPRLPSCCPQHSPCGGSSQNHHALGHPHTSCFQQHGHHFQHHHHHHHTPHPAVPVSPSFSDPACPVERPPQVQAPCGANSSSGTSYHEQQALPVDLSNSGIRSHGSGSFHGASAFDPCCPVSSSRAAIFGHQAAAAAPSQPLSSIDGYGSSMVAQPQPQPPPQPSLSSCRHYMPPPYASLTRPLHHQASACPHSHGNPPPQTQPPPQVDYVIPHPVHAFHSQISSHATSHPVAPPPPTHLASTAAPIPQHLPPTHQPISHHIPATAPPAQRLHPHEVMQRMEVQRRRMMQHPTRAHERPPPHPHRMHPNYGHGHHIHVPQTMSSHPRQAPERSAWELGIEAGVTAATYTPGALHPHLAHYHAPPRLHHLQLGALPLMVPDMAGYPHIRYISSGLDGTSFRGPFRGNFEELIHLEERLGNVNRGASQGTIERCTYPHKYKKVTTDWFSQRKLHCKQDGEEGTEEDTEEKCTICLSILEEGEDVRRLPCMHLFHQVCVDQWLITNKKCPICRVDIEAQLPSES

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MSQWTPEYNELY ---CCCCCCCCCEEE	9.90	28555341
19	Sumoylation	YTLKVDMKSEIPSDA EEEECCCCCCCCCCC	40.24	-
19	Sumoylation	YTLKVDMKSEIPSDA EEEECCCCCCCCCCC	40.24	28112733
20	Phosphorylation	TLKVDMKSEIPSDAP EEECCCCCCCCCCCC	33.83	-
24 (in isoform 2)	Phosphorylation	-	52.66	24719451
24	Phosphorylation	DMKSEIPSDAPKTQE CCCCCCCCCCCCCHH	52.66	24719451
28	Ubiquitination	EIPSDAPKTQESLKG CCCCCCCCCHHHHCC	65.64	-
28	Sumoylation	EIPSDAPKTQESLKG CCCCCCCCCHHHHCC	65.64	28112733
34	Sumoylation	PKTQESLKGILLHPE CCCHHHHCCEECCCC	53.86	-
34 (in isoform 3)	Ubiquitination	-	53.86	-
34	Ubiquitination	PKTQESLKGILLHPE CCCHHHHCCEECCCC	53.86	-
34	Sumoylation	PKTQESLKGILLHPE CCCHHHHCCEECCCC	53.86	28112733
47	Sumoylation	PEPIGAAKSFPAGVE CCCCCCCCCCCCCCE	52.69	-
47	Sumoylation	PEPIGAAKSFPAGVE CCCCCCCCCCCCCCE	52.69	28112733
47	Acetylation	PEPIGAAKSFPAGVE CCCCCCCCCCCCCCE	52.69	25953088
47	Ubiquitination	PEPIGAAKSFPAGVE CCCCCCCCCCCCCCE	52.69	-
59	Sumoylation	GVEMINSKVGNEFSH CCEEHHHHCCCHHHH	50.07	28112733
73	Sumoylation	HLCDDSQKQEKEMNG HHCCHHHHHHHHHCC	65.46	-
73	Ubiquitination	HLCDDSQKQEKEMNG HHCCHHHHHHHHHCC	65.46	-
73	Sumoylation	HLCDDSQKQEKEMNG HHCCHHHHHHHHHCC	65.46	28112733
87	Ubiquitination	GNQQEQEKSLVVRKK CCHHHHHHHHHHHHH	49.11	-
87 (in isoform 3)	Ubiquitination	-	49.11	-
87	Sumoylation	GNQQEQEKSLVVRKK CCHHHHHHHHHHHHH	49.11	28112733
96	Sumoylation	LVVRKKRKSQQAGPS HHHHHHHHHHHCCHH	62.59	28112733
97	Phosphorylation	VVRKKRKSQQAGPSY HHHHHHHHHHCCHHH	31.40	25159151
110	Sumoylation	SYVQNCVKENQGILG HHHHHHHHHCCCEEC	53.82	28112733
162	Phosphorylation	SDEDKEVSVRHSQTI CCCCCCEEEEHHHHH	17.96	29496963
173	Ubiquitination	SQTILNAKSRSHSAR HHHHHHHHCCCCCCC	45.38	-
173	Sumoylation	SQTILNAKSRSHSAR HHHHHHHHCCCCCCC	45.38	-
173 (in isoform 3)	Ubiquitination	-	45.38	-
173	Sumoylation	SQTILNAKSRSHSAR HHHHHHHHCCCCCCC	45.38	28112733
178	Phosphorylation	NAKSRSHSARSHKWP HHHCCCCCCCCCCCC	26.99	26329039
198	Sumoylation	SVSGLLMKRPCLHGS CCCHHHHCCCCCCCC	53.83	28112733
205	Phosphorylation	KRPCLHGSSLRRLPC CCCCCCCCHHCCCCC	18.56	28555341
206	Phosphorylation	RPCLHGSSLRRLPCR CCCCCCCHHCCCCCH	30.41	28555341
218	Ubiquitination	PCRKRFVKNNSSQRT CCHHHHHHCCCCHHH	47.93	-
218	Sumoylation	PCRKRFVKNNSSQRT CCHHHHHHCCCCHHH	47.93	28112733
221	Phosphorylation	KRFVKNNSSQRTQKQ HHHHHCCCCHHHHHH	36.92	29759185
222	Phosphorylation	RFVKNNSSQRTQKQK HHHHCCCCHHHHHHH	26.29	29759185
339	Phosphorylation	GESYRSRSTLGHSRS CCCCCCCCCCCCCCC	29.27	-
349	Phosphorylation	GHSRSHWSQGSSSHA CCCCCCCCCCCCCCC	21.17	28348404
352	Phosphorylation	RSHWSQGSSSHASRP CCCCCCCCCCCCCCC	22.49	28348404
353	Phosphorylation	SHWSQGSSSHASRPQ CCCCCCCCCCCCCCC	32.73	28348404
354	Phosphorylation	HWSQGSSSHASRPQE CCCCCCCCCCCCCCC	25.44	28348404
369	Phosphorylation	PRNRSRISTVIQPLR CCCHHHHHHHHHHHH	18.60	28555341
370	Phosphorylation	RNRSRISTVIQPLRQ CCHHHHHHHHHHHHH	21.18	28555341
461	Phosphorylation	IGDDSRRTTSSAVTE CCCCCCCCCCCCCCC	29.89	22210691
576	Phosphorylation	LSNSGIRSHGSGSFH CCCCCCCCCCCCCCC	30.22	27080861
579	Phosphorylation	SGIRSHGSGSFHGAS CCCCCCCCCCCCCCC	26.32	27080861
581	Phosphorylation	IRSHGSGSFHGASAF CCCCCCCCCCCCCCC	18.77	27080861
586	Phosphorylation	SGSFHGASAFDPCCP CCCCCCCCCCCCCCC	33.78	27080861
783	Phosphorylation	PHRMHPNYGHGHHIH CCCCCCCCCCCCCCC	18.23	-
861	Dimethylation	MAGYPHIRYISSGLD CCCCCCEEEEECCCC	21.50	-
861	Methylation	MAGYPHIRYISSGLD CCCCCCEEEEECCCC	21.50	54561739
895	Methylation	ERLGNVNRGASQGTI HHHCCCCCCCCCCHH	37.46	115491367
898	Phosphorylation	GNVNRGASQGTIERC CCCCCCCCCCHHCCC	31.78	-
923	Sumoylation	TDWFSQRKLHCKQDG CCHHHHCCEECCCCC	34.64	28112733
923	Ubiquitination	TDWFSQRKLHCKQDG CCHHHHCCEECCCCC	34.64	-
927	Ubiquitination	SQRKLHCKQDGEEGT HHCCEECCCCCCCCC	40.45	-
927	Sumoylation	SQRKLHCKQDGEEGT HHCCEECCCCCCCCC	40.45	-
927	Sumoylation	SQRKLHCKQDGEEGT HHCCEECCCCCCCCC	40.45	28112733
932 (in isoform 3)	Ubiquitination	-	76.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RN111_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN111_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN111_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SMAD3_HUMAN	SMAD3	physical	14657019
SMAD6_HUMAN	SMAD6	physical	14657019
SMAD7_HUMAN	SMAD7	physical	14657019
SMAD3_HUMAN	SMAD3	physical	18950738
SKIL_HUMAN	SKIL	physical	17591695
SMAD2_HUMAN	SMAD2	physical	17591695
SMAD3_HUMAN	SMAD3	physical	17591695
SKI_HUMAN	SKI	physical	17510063
SKI_HUMAN	SKI	physical	18451154
SUMO2_HUMAN	SUMO2	physical	23086935
SUMO1_HUMAN	SUMO1	physical	23086935
FHL2_HUMAN	FHL2	physical	23212909
RN111_HUMAN	RNF111	physical	23212909
SKI_HUMAN	SKI	physical	23530056
SKIL_HUMAN	SKIL	physical	23530056
SMAD2_HUMAN	SMAD2	physical	23530056
SMAD3_HUMAN	SMAD3	physical	23530056
SMAD7_HUMAN	SMAD7	physical	23530056
SUMO2_HUMAN	SUMO2	physical	23530056
UB2D2_HUMAN	UBE2D2	physical	23530056
UB2D3_HUMAN	UBE2D3	physical	23530056
PML_HUMAN	PML	physical	23530056
SUMO2_HUMAN	SUMO2	physical	23751493
UBC13_YEAST	UBC13	physical	23751493
MMS2_YEAST	MMS2	physical	23751493
XPC_HUMAN	XPC	physical	23751493
PML_HUMAN	PML	physical	22493164
MARH7_HUMAN	MARCH7	physical	22493164
TRAF5_HUMAN	TRAF5	physical	22493164
RN111_HUMAN	RNF111	physical	22493164
RN111_HUMAN	RNF111	physical	25416956
EDAD_HUMAN	EDARADD	physical	25416956
LCE4A_HUMAN	LCE4A	physical	25416956
RN111_HUMAN	RNF111	physical	23751493
SMAD2_HUMAN	SMAD2	physical	18451154
SMAD3_HUMAN	SMAD3	physical	18451154
UBC_HUMAN	UBC	physical	26656854
UBE2N_HUMAN	UBE2N	physical	26656854
UB2D2_HUMAN	UBE2D2	physical	26656854
ESRP2_HUMAN	ESRP2	physical	26522722
ESRP1_HUMAN	ESRP1	physical	26522722
UBXN7_HUMAN	UBXN7	physical	28514442
TPX2_HUMAN	TPX2	physical	28514442
DCNL5_HUMAN	DCUN1D5	physical	28514442
TTC9C_HUMAN	TTC9C	physical	28514442
SUGP1_HUMAN	SUGP1	physical	28514442
CGBP1_HUMAN	CGGBP1	physical	28514442
RBM27_HUMAN	RBM27	physical	28514442
GNAQ_HUMAN	GNAQ	physical	28514442
ADDG_HUMAN	ADD3	physical	28514442
CU059_HUMAN	C21orf59	physical	28514442
SPAST_HUMAN	SPAST	physical	28514442
UB2D2_HUMAN	UBE2D2	physical	28647409

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.