TRAF5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRAF5_HUMAN
• UniProt AC: O00463
• Protein Name: TNF receptor-associated factor 5
• Gene Name: TRAF5
• Organism: Homo sapiens (Human).
• Sequence Length: 557
• Subcellular Localization: Cytoplasm . Cytoplasm, cytosol .
• Protein Description: Adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases. Mediates activation of NF-kappa-B and probably JNK. Seems to be involved in apoptosis. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR..
• Protein Sequence: MAYSEEHKGMPCGFIRQNSGNSISLDFEPSIEYQFVERLEERYKCAFCHSVLHNPHQTGCGHRFCQHCILSLRELNTVPICPVDKEVIKSQEVFKDNCCKREVLNLYVYCSNAPGCNAKVILGRYQDHLQQCLFQPVQCSNEKCREPVLRKDLKEHLSASCQFRKEKCLYCKKDVVVINLQNHEENLCPEYPVFCPNNCAKIILKTEVDEHLAVCPEAEQDCPFKHYGCAVTDKRRNLQQHEHSALREHMRLVLEKNVQLEEQISDLHKSLEQKESKIQQLAETIKKLEKEFKQFAQLFGKNGSFLPNIQVFASHIDKSAWLEAQVHQLLQMVNQQQNKFDLRPLMEAVDTVKQKITLLENNDQRLAVLEEETNKHDTHINIHKAQLSKNEERFKLLEGTCYNGKLIWKVTDYKMKKREAVDGHTVSIFSQSFYTSRCGYRLCARAYLNGDGSGRGSHLSLYFVVMRGEFDSLLQWPFRQRVTLMLLDQSGKKNIMETFKPDPNSSSFKRPDGEMNIASGCPRFVAHSVLENAKNAYIKDDTLFLKVAVDLTDLEDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Ubiquitination	MAYSEEHKGMPCGFI CCCCCCCCCCCCEEE	61.25	-
19	Phosphorylation	CGFIRQNSGNSISLD CEEEECCCCCCEEEC	30.89	26074081
22	Phosphorylation	IRQNSGNSISLDFEP EECCCCCCEEECCCC	19.65	26074081
24	Phosphorylation	QNSGNSISLDFEPSI CCCCCCEEECCCCCH	23.00	26074081
85	Ubiquitination	VPICPVDKEVIKSQE CCCCCCCHHHHCCCH	54.86	29967540
89	Ubiquitination	PVDKEVIKSQEVFKD CCCHHHHCCCHHHCC	51.79	29967540
95	Ubiquitination	IKSQEVFKDNCCKRE HCCCHHHCCCCCCCC	53.89	-
100	Ubiquitination	VFKDNCCKREVLNLY HHCCCCCCCCCCCEE	54.52	-
143	Ubiquitination	PVQCSNEKCREPVLR CCCCCCHHCCCCHHH	42.73	29967540
154	Ubiquitination	PVLRKDLKEHLSASC CHHHHHHHHHHHHHC	53.90	29967540
158	Phosphorylation	KDLKEHLSASCQFRK HHHHHHHHHHCHHCC	21.75	29449344
160	Phosphorylation	LKEHLSASCQFRKEK HHHHHHHHCHHCCCC	12.69	29449344
161	S-nitrosylation	KEHLSASCQFRKEKC HHHHHHHCHHCCCCC	4.42	24105792
225	Ubiquitination	AEQDCPFKHYGCAVT CCCCCCCCCCEEECC	22.51	29967540
234	Ubiquitination	YGCAVTDKRRNLQQH CEEECCCCCHHHHHH	43.84	29967540
256	Ubiquitination	HMRLVLEKNVQLEEQ HHHHHHHHCCCHHHH	59.25	29967540
269	Ubiquitination	EQISDLHKSLEQKES HHHHHHHHHHHHHHH	65.12	29967540
277	Ubiquitination	SLEQKESKIQQLAET HHHHHHHHHHHHHHH	45.70	29967540
286	Ubiquitination	QQLAETIKKLEKEFK HHHHHHHHHHHHHHH	59.74	29967540
293	Ubiquitination	KKLEKEFKQFAQLFG HHHHHHHHHHHHHHC	45.67	29967540
319	Phosphorylation	FASHIDKSAWLEAQV HHHHCCHHHHHHHHH	22.41	24043423
353	Ubiquitination	MEAVDTVKQKITLLE HHHHHHHHHHEEEEE	48.22	-
355	Ubiquitination	AVDTVKQKITLLENN HHHHHHHHEEEEECC	31.76	29967540
375	Ubiquitination	VLEEETNKHDTHINI EEEHHHCCCCCCCEE	50.72	29967540
384	Ubiquitination	DTHINIHKAQLSKNE CCCCEEEHHHHCCCH	33.75	29967540
389	Ubiquitination	IHKAQLSKNEERFKL EEHHHHCCCHHHHHH	76.58	29967540
405	Ubiquitination	EGTCYNGKLIWKVTD CCEEECCEEEEEEEE	32.91	29967540
414	Ubiquitination	IWKVTDYKMKKREAV EEEEEECCCCCCCCC	47.23	29967540
457	Phosphorylation	GDGSGRGSHLSLYFV CCCCCCCCCEEEEEE	21.64	20049867
462	Phosphorylation	RGSHLSLYFVVMRGE CCCCEEEEEEEECCC	7.31	20049867
493	Ubiquitination	LLDQSGKKNIMETFK EECCCCCCCHHHHCC	56.05	29967540
500	Ubiquitination	KNIMETFKPDPNSSS CCHHHHCCCCCCCCC	56.80	29967540
509	Ubiquitination	DPNSSSFKRPDGEMN CCCCCCCCCCCCCCC	66.04	29967540
534	Ubiquitination	HSVLENAKNAYIKDD HHHHHHHHHCEECCC	54.41	29967540
539	Ubiquitination	NAKNAYIKDDTLFLK HHHHCEECCCCEEEE	36.55	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRAF5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRAF5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRAF5_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
M3K5_HUMAN	MAP3K5	physical	9774977
TYDP2_HUMAN	TDP2	physical	10764746
TR13B_HUMAN	TNFRSF13B	physical	10880535
SMUF1_HUMAN	SMURF1	genetic	19937093
COG5_HUMAN	COG5	physical	21903422
COG7_HUMAN	COG7	physical	21903422
TRAF2_HUMAN	TRAF2	physical	21903422
TRAF3_HUMAN	TRAF3	physical	21903422
M3K14_HUMAN	MAP3K14	physical	9275204
TRAF2_HUMAN	TRAF2	physical	9718306
TRAF5_HUMAN	TRAF5	physical	9718306
TNR9_HUMAN	TNFRSF9	physical	15941918
TNR4_HUMAN	TNFRSF4	physical	15941918
TNR5_HUMAN	CD40	physical	12220533
NF2IP_HUMAN	NFATC2IP	physical	11435475
ZMY11_HUMAN	ZMYND11	physical	20138174
NUMBL_HUMAN	NUMBL	physical	22593207
UBE2O_HUMAN	UBE2O	physical	23381138
TRAF5_HUMAN	TRAF5	physical	22493164
TRI27_HUMAN	TRIM27	physical	22493164
E2AK2_HUMAN	EIF2AK2	physical	15121867
ELAV1_HUMAN	ELAVL1	physical	23772036
TRAF5_HUMAN	TRAF5	physical	25416956
TRAF6_HUMAN	TRAF6	physical	25416956
NMI_HUMAN	NMI	physical	25416956
ENOX2_HUMAN	ENOX2	physical	25416956
GORS2_HUMAN	GORASP2	physical	25416956
ZFAN6_HUMAN	ZFAND6	physical	25416956
THAP1_HUMAN	THAP1	physical	25416956
CC184_HUMAN	CCDC184	physical	25416956
SRSF1_MOUSE	Srsf1	physical	21822258
CIKS_HUMAN	TRAF3IP2	physical	21822258
SRSF1_HUMAN	SRSF1	physical	21822258
TRAF6_HUMAN	TRAF6	physical	21516116
NMI_HUMAN	NMI	physical	21516116
TRAF3_HUMAN	TRAF3	physical	25241761
RORG_HUMAN	RORC	physical	26453305
UBC_HUMAN	UBC	physical	29176576
TRAF6_HUMAN	TRAF6	physical	29176576
TBK1_HUMAN	TBK1	physical	29125880

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.