| UniProt ID | TNR4_HUMAN | |
|---|---|---|
| UniProt AC | P43489 | |
| Protein Name | Tumor necrosis factor receptor superfamily member 4 | |
| Gene Name | TNFRSF4 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 277 | |
| Subcellular Localization |
Membrane Single-pass type I membrane protein. |
|
| Protein Description | Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.; (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.. | |
| Protein Sequence | MCVGARRLGRGPCAALLLLGLGLSTVTGLHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQNTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRDPPATQPQETQGPPARPITVQPTEAWPRTSQGPSTRPVEVPGGRAVAAILGLGLVLGLLGPLAILLALYLLRRDQRLPPDAHKPPGGGSFRTPIQEEQADAHSTLAKI | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 146 | N-linked_Glycosylation | QACKPWTNCTLAGKH CCCCCCCCCCCCCCC | 16.95 | UniProtKB CARBOHYD | |
| 160 | N-linked_Glycosylation | HTLQPASNSSDAICE CCCCCCCCCCCCCCC | 47.87 | UniProtKB CARBOHYD | |
| 174 | O-linked_Glycosylation | EDRDPPATQPQETQG CCCCCCCCCCCCCCC | 46.70 | OGP | |
| 179 | O-linked_Glycosylation | PATQPQETQGPPARP CCCCCCCCCCCCCCC | 33.31 | OGP | |
| 199 | O-linked_Glycosylation | TEAWPRTSQGPSTRP CCCCCCCCCCCCCCC | 34.13 | 29351928 | |
| 258 | Phosphorylation | HKPPGGGSFRTPIQE CCCCCCCCCCCCCHH | 18.15 | 23684312 | |
| 261 | Phosphorylation | PGGGSFRTPIQEEQA CCCCCCCCCCHHHHH | 23.80 | 26074081 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of TNR4_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of TNR4_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of TNR4_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| TRAF5_HUMAN | TRAF5 | physical | 9488716 | |
| TRAF2_HUMAN | TRAF2 | physical | 9418902 | |
| TNR9_HUMAN | TNFRSF9 | physical | 15941918 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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