dbPTM

TRAF2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	TRAF2_HUMAN
UniProt AC	Q12933
Protein Name	TNF receptor-associated factor 2
Gene Name	TRAF2
Organism	Homo sapiens (Human).
Sequence Length	501
Subcellular Localization	Cytoplasm .
Protein Description	Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR. In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE..
Protein Sequence	MAAASVTPPGSLELLQPGFSKTLLGTKLEAKYLCSACRNVLRRPFQAQCGHRYCSFCLASILSSGPQNCAACVHEGIYEEGISILESSSAFPDNAARREVESLPAVCPSDGCTWKGTLKEYESCHEGRCPLMLTECPACKGLVRLGEKERHLEHECPERSLSCRHCRAPCCGADVKAHHEVCPKFPLTCDGCGKKKIPREKFQDHVKTCGKCRVPCRFHAIGCLETVEGEKQQEHEVQWLREHLAMLLSSVLEAKPLLGDQSHAGSELLQRCESLEKKTATFENIVCVLNREVERVAMTAEACSRQHRLDQDKIEALSSKVQQLERSIGLKDLAMADLEQKVLEMEASTYDGVFIWKISDFARKRQEAVAGRIPAIFSPAFYTSRYGYKMCLRIYLNGDGTGRGTHLSLFFVVMKGPNDALLRWPFNQKVTLMLLDQNNREHVIDAFRPDVTSSSFQRPVNDMNIASGCPLFCPVSKMEAKNSYVRDDAIFIKAIVDLTGL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAAASVTPP ------CCCCCCCCC	16.25	21406692
5	Phosphorylation	---MAAASVTPPGSL ---CCCCCCCCCCCC	23.07	29255136
5 (in isoform 2)	Phosphorylation	-	23.07	21406692
7 (in isoform 2)	Phosphorylation	-	22.67	21406692
7	Phosphorylation	-MAAASVTPPGSLEL -CCCCCCCCCCCCHH	22.67	29255136
11	Phosphorylation	ASVTPPGSLELLQPG CCCCCCCCCHHCCCC	25.17	29255136
11 (in isoform 2)	Phosphorylation	-	25.17	21406692
20	Phosphorylation	ELLQPGFSKTLLGTK HHCCCCCCCHHCCCH	30.55	20068231
21	Ubiquitination	LLQPGFSKTLLGTKL HCCCCCCCHHCCCHH	40.71	21890473
21	Ubiquitination	LLQPGFSKTLLGTKL HCCCCCCCHHCCCHH	40.71	21890473
21	Ubiquitination	LLQPGFSKTLLGTKL HCCCCCCCHHCCCHH	40.71	21890473
21 (in isoform 1)	Ubiquitination	-	40.71	21890473
21 (in isoform 2)	Ubiquitination	-	40.71	21890473
21	Ubiquitination	LLQPGFSKTLLGTKL HCCCCCCCHHCCCHH	40.71	11907583
22 (in isoform 2)	Phosphorylation	-	26.47	21406692
22	Phosphorylation	LQPGFSKTLLGTKLE CCCCCCCHHCCCHHH	26.47	20068231
26	Phosphorylation	FSKTLLGTKLEAKYL CCCHHCCCHHHHHHH	32.21	20068231
26 (in isoform 2)	Phosphorylation	-	32.21	21406692
27 (in isoform 1)	Ubiquitination	-	42.40	21890473
27	Ubiquitination	SKTLLGTKLEAKYLC CCHHCCCHHHHHHHH	42.40	19150425
27 (in isoform 2)	Ubiquitination	-	42.40	21890473
31	Acetylation	LGTKLEAKYLCSACR CCCHHHHHHHHHHHH	29.40	27452117
31	Ubiquitination	LGTKLEAKYLCSACR CCCHHHHHHHHHHHH	29.40	19150425
32	Phosphorylation	GTKLEAKYLCSACRN CCHHHHHHHHHHHHH	21.71	28152594
55	Phosphorylation	QCGHRYCSFCLASIL HCCCCCHHHHHHHHH	15.29	22817900
102	Phosphorylation	AARREVESLPAVCPS HHHHHHHCCCEECCC	44.84	30108239
117	Phosphorylation	DGCTWKGTLKEYESC CCCCEECCHHHHHHC	30.81	18981220
119	Ubiquitination	CTWKGTLKEYESCHE CCEECCHHHHHHCCC	59.07	-
121	Phosphorylation	WKGTLKEYESCHEGR EECCHHHHHHCCCCC	16.14	-
123	Phosphorylation	GTLKEYESCHEGRCP CCHHHHHHCCCCCCC	21.63	27251275
140	Ubiquitination	LTECPACKGLVRLGE EEECCCCCHHHHCCH	58.34	21890473
140	Ubiquitination	LTECPACKGLVRLGE EEECCCCCHHHHCCH	58.34	21890473
140	Ubiquitination	LTECPACKGLVRLGE EEECCCCCHHHHCCH	58.34	21890473
140 (in isoform 1)	Ubiquitination	-	58.34	21890473
140	Ubiquitination	LTECPACKGLVRLGE EEECCCCCHHHHCCH	58.34	21890473
160	Phosphorylation	EHECPERSLSCRHCR CCCCCCCCCCCCCCC	23.99	29214152
162	Phosphorylation	ECPERSLSCRHCRAP CCCCCCCCCCCCCCC	15.45	28555341
176	Ubiquitination	PCCGADVKAHHEVCP CCCCCCHHHHHCCCC	42.42	-
184	Ubiquitination	AHHEVCPKFPLTCDG HHHCCCCCCCCCCCC	55.26	-
192 (in isoform 2)	Ubiquitination	-	4.63	21890473
201	Ubiquitination	KKKIPREKFQDHVKT CCCCCHHHHHHHHHH	49.99	-
207	Ubiquitination	EKFQDHVKTCGKCRV HHHHHHHHHCCCCCC	34.38	-
231	Ubiquitination	LETVEGEKQQEHEVQ EEEECCHHHHHHHHH	69.04	-
255	Ubiquitination	LSSVLEAKPLLGDQS HHHHHHHHHCCCCCC	27.16	21890473
255	Ubiquitination	LSSVLEAKPLLGDQS HHHHHHHHHCCCCCC	27.16	21890473
255 (in isoform 1)	Ubiquitination	-	27.16	21890473
255	Ubiquitination	LSSVLEAKPLLGDQS HHHHHHHHHCCCCCC	27.16	19150425
259 (in isoform 2)	Ubiquitination	-	38.30	-
262	Phosphorylation	KPLLGDQSHAGSELL HHCCCCCCHHHHHHH	21.75	23312004
274	Phosphorylation	ELLQRCESLEKKTAT HHHHHHHHHHHHHCC	45.51	-
277	Ubiquitination	QRCESLEKKTATFEN HHHHHHHHHHCCHHH	61.80	-
278	Ubiquitination	RCESLEKKTATFENI HHHHHHHHHCCHHHE	33.73	-
287	Glutathionylation	ATFENIVCVLNREVE CCHHHEEEHHCHHHH	2.26	22555962
307 (in isoform 2)	Ubiquitination	-	31.03	21890473
313	Ubiquitination	QHRLDQDKIEALSSK HHCCCHHHHHHHHHH	36.49	21890473
313	Ubiquitination	QHRLDQDKIEALSSK HHCCCHHHHHHHHHH	36.49	21890473
313 (in isoform 1)	Ubiquitination	-	36.49	21890473
313	2-Hydroxyisobutyrylation	QHRLDQDKIEALSSK HHCCCHHHHHHHHHH	36.49	-
313	Ubiquitination	QHRLDQDKIEALSSK HHCCCHHHHHHHHHH	36.49	21890473
320	Ubiquitination	KIEALSSKVQQLERS HHHHHHHHHHHHHHH	40.46	21890473
320	Ubiquitination	KIEALSSKVQQLERS HHHHHHHHHHHHHHH	40.46	21890473
320 (in isoform 1)	Ubiquitination	-	40.46	21890473
320	Ubiquitination	KIEALSSKVQQLERS HHHHHHHHHHHHHHH	40.46	21890473
331	Ubiquitination	LERSIGLKDLAMADL HHHHHCHHHHHHHHH	45.54	21890473
331	Ubiquitination	LERSIGLKDLAMADL HHHHHCHHHHHHHHH	45.54	21890473
331 (in isoform 1)	Ubiquitination	-	45.54	21890473
331	Ubiquitination	LERSIGLKDLAMADL HHHHHCHHHHHHHHH	45.54	21890473
335	Sulfoxidation	IGLKDLAMADLEQKV HCHHHHHHHHHHHHH	3.76	21406390
365 (in isoform 2)	Ubiquitination	-	33.74	21890473
372 (in isoform 2)	Ubiquitination	-	23.21	21890473
383 (in isoform 2)	Ubiquitination	-	10.56	21890473
401	Phosphorylation	IYLNGDGTGRGTHLS EEECCCCCCCCCCEE	28.57	-
431	Phosphorylation	WPFNQKVTLMLLDQN CCCCCCEEEEEECCC	17.31	-
477	Ubiquitination	PLFCPVSKMEAKNSY CCEEECHHHCCCCCC	40.78	-
481	Ubiquitination	PVSKMEAKNSYVRDD ECHHHCCCCCCCCCC	32.87	21890473
481	Ubiquitination	PVSKMEAKNSYVRDD ECHHHCCCCCCCCCC	32.87	21890473
481 (in isoform 1)	Ubiquitination	-	32.87	21890473
481	Ubiquitination	PVSKMEAKNSYVRDD ECHHHCCCCCCCCCC	32.87	19150425
533 (in isoform 2)	Ubiquitination	-		21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
11	S	Phosphorylation	Kinase	IKKE	Q14164	PSP
55	S	Phosphorylation	Kinase	PRKCZ	Q05513	GPS
117	T	Phosphorylation	Kinase	PKC-FAMILY	-	GPS
117	T	Phosphorylation	Kinase	PKC	-	Uniprot
-	K	Ubiquitination	E3 ubiquitin ligase	BIRC2	Q13490	PMID:11907583
-	K	Ubiquitination	E3 ubiquitin ligase	TRAF2	Q12933	PMID:20876871
-	K	Ubiquitination	E3 ubiquitin ligase	STUB1	Q9UNE7	PMID:21793045

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Reference
117	T	Phosphorylation	19150425
Phosphorylated at Thr-117 in response to signaling via TNF and TNFRSF1A.
117	T	Phosphorylation	19150425
Phosphorylation at Thr-117 is important for interaction with IKKA and IKKB, activation of IKK and subsequent activation of NF-kappa-B.
117	T	Phosphorylation	19150425
Phosphorylation at Thr-117 is required for 'Lys-63'-linked polyubiquitination, but not for 'Lys-48'-linked polyubiquitination.
117	T	Phosphorylation	19150425
Polyubiquitinated via 'Lys-63'-linked ubiquitin in response to TNF signaling; this requires prior phosphorylation at Thr-117.
117	T	ubiquitylation	19150425
Phosphorylation at Thr-117 is required for 'Lys-63'-linked polyubiquitination, but not for 'Lys-48'-linked polyubiquitination.
117	T	ubiquitylation	19150425
Polyubiquitinated via 'Lys-63'-linked ubiquitin in response to TNF signaling; this requires prior phosphorylation at Thr-117.

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of TRAF2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CDCA3_HUMAN	CDCA3	physical	16189514
F120B_HUMAN	FAM120B	physical	16189514
ZBT25_HUMAN	ZBTB25	physical	16189514
FBX28_HUMAN	FBXO28	physical	16189514
UBP53_HUMAN	USP53	physical	16189514
NECP2_HUMAN	NECAP2	physical	16189514
APEX2_HUMAN	APEX2	physical	16189514
ZBT16_HUMAN	ZBTB16	physical	16189514
FXR2_HUMAN	FXR2	physical	16189514
ELOA2_HUMAN	TCEB3B	physical	16189514
SPAT2_HUMAN	SPATA2	physical	16189514
TEANC_HUMAN	TCEANC	physical	16189514
PSMF1_HUMAN	PSMF1	physical	16189514
ENKD1_HUMAN	ENKD1	physical	16189514
SPG21_HUMAN	SPG21	physical	16189514
BANP_HUMAN	BANP	physical	16189514
CIKS_HUMAN	TRAF3IP2	physical	16189514
NIF3L_HUMAN	NIF3L1	physical	16189514
K0408_HUMAN	KIAA0408	physical	16189514
SOX30_HUMAN	SOX30	physical	16189514
LNX1_HUMAN	LNX1	physical	16189514
AFF4_HUMAN	AFF4	physical	16189514
ZN646_HUMAN	ZNF646	physical	16189514
UBX11_HUMAN	UBXN11	physical	16189514
ADPPT_HUMAN	AASDHPPT	physical	16189514
THAP7_HUMAN	THAP7	physical	16189514
CCD33_HUMAN	CCDC33	physical	16189514
TRPT1_HUMAN	TRPT1	physical	16189514
ZBT43_HUMAN	ZBTB43	physical	16189514
SPY2_HUMAN	SPRY2	physical	16189514
DP13A_HUMAN	APPL1	physical	16189514
GORS2_HUMAN	GORASP2	physical	16189514
TRAF6_HUMAN	TRAF6	physical	16189514
TRI31_HUMAN	TRIM31	physical	16189514
RIBC2_HUMAN	RIBC2	physical	16189514
DLGP5_HUMAN	DLGAP5	physical	16189514
CHM2B_HUMAN	CHMP2B	physical	16189514
ZFAN6_HUMAN	ZFAND6	physical	16189514
IPO11_HUMAN	IPO11	physical	16189514
KANL1_HUMAN	KANSL1	physical	16189514
HINFP_HUMAN	HINFP	physical	16189514
UBP2_HUMAN	USP2	physical	16189514
SETD5_HUMAN	SETD5	physical	16189514
FATE1_HUMAN	FATE1	physical	16189514
EXAS1_HUMAN	EXOC3-AS1	physical	16189514
BAHD1_HUMAN	BAHD1	physical	16189514
LZTS2_HUMAN	LZTS2	physical	16189514
RGS14_HUMAN	RGS14	physical	16189514
CACO2_HUMAN	CALCOCO2	physical	16189514
NRIP1_HUMAN	NRIP1	physical	16189514
ZN205_HUMAN	ZNF205	physical	16189514
CC130_HUMAN	CCDC130	physical	16189514
F107A_HUMAN	FAM107A	physical	16189514
FBF1_HUMAN	FBF1	physical	16189514
NUD18_HUMAN	NUDT18	physical	16189514
TIFA_HUMAN	TIFA	physical	16189514
TRAF2_HUMAN	TRAF2	physical	16189514
M3K7_HUMAN	MAP3K7	physical	14633987
ERN1_HUMAN	ERN1	physical	12843613
SIAH2_HUMAN	SIAH2	physical	12411493
CFLAR_HUMAN	CFLAR	physical	9208847
M3K5_HUMAN	MAP3K5	physical	9774977
TRADD_HUMAN	TRADD	physical	8702708
RIPK1_HUMAN	RIPK1	physical	8702708
TRAF1_HUMAN	TRAF1	physical	8702708
TNR1B_HUMAN	TNFRSF1B	physical	8702708
TRAF2_HUMAN	TRAF2	physical	8702708
TRAF2_HUMAN	TRAF2	physical	10411888
TNR5_HUMAN	CD40	physical	10411888
CAV1_HUMAN	CAV1	physical	11112773
SPHK1_HUMAN	SPHK1	physical	11777919
TANK_HUMAN	TANK	physical	8710854
TNR1B_HUMAN	TNFRSF1B	physical	8710854
TNR9_HUMAN	TNFRSF9	physical	9464265
TYDP2_HUMAN	TDP2	physical	10764746
M3K5_HUMAN	MAP3K5	physical	17015619
RBCC1_HUMAN	RB1CC1	physical	17015619
FLNA_HUMAN	FLNA	physical	10617615
IKKA_HUMAN	CHUK	physical	11359906
IKKB_HUMAN	IKBKB	physical	11359906
I15RA_HUMAN	IL15RA	physical	11064452
TBK1_HUMAN	TBK1	physical	10990461
RIPK1_HUMAN	RIPK1	physical	11479302
TRADD_HUMAN	TRADD	physical	11479302
CFLAR_HUMAN	CFLAR	physical	10837247
C8AP2_HUMAN	CASP8AP2	physical	11340079
CASPC_HUMAN	CASP12	physical	11278723
TANK_HUMAN	TANK	physical	10759890
TNR9_HUMAN	TNFRSF9	physical	9418902
TNR4_HUMAN	TNFRSF4	physical	9418902
TNR17_HUMAN	TNFRSF17	physical	10903733
EDAD_HUMAN	EDARADD	physical	11882293
RIPK3_HUMAN	RIPK3	physical	10339433
RIPK1_HUMAN	RIPK1	physical	8612133
TRADD_HUMAN	TRADD	physical	8565075
BIRC2_HUMAN	BIRC2	physical	8943045
M3K1_HUMAN	MAP3K1	physical	10346818
M4K5_HUMAN	MAP4K5	physical	10477597
ERN2_MOUSE	Ern2	physical	10650002
TR13B_HUMAN	TNFRSF13B	physical	10880535
BCL10_HUMAN	BCL10	physical	10753917
BIRC2_HUMAN	BIRC2	physical	10753917
BIRC3_HUMAN	BIRC3	physical	10753917
M3K14_HUMAN	MAP3K14	physical	11278268
TRAF2_HUMAN	TRAF2	physical	9020361
M3K14_HUMAN	MAP3K14	physical	9020361
UBE2N_HUMAN	UBE2N	genetic	11057907
UBE2N_HUMAN	UBE2N	physical	11057907
UB2V1_HUMAN	UBE2V1	physical	11057907
IKKA_HUMAN	CHUK	physical	19150425
IKKB_HUMAN	IKBKB	physical	19150425
TAB2_HUMAN	TAB2	physical	19150425
HSPB2_HUMAN	HSPB2	physical	18950704
CSN5_HUMAN	COPS5	physical	16936264
GSK3B_HUMAN	GSK3B	physical	20562859
BIRC2_HUMAN	BIRC2	physical	20562859
TANK_HUMAN	TANK	physical	20562859
BIRC3_HUMAN	BIRC3	physical	20562859
TBK1_HUMAN	TBK1	physical	20562859
DBLOH_HUMAN	DIABLO	physical	20562859
HTRA2_HUMAN	HTRA2	physical	20562859
GOGA3_HUMAN	GOLGA3	physical	20562859
BIRC2_HUMAN	BIRC2	physical	16282325
CYLD_HUMAN	CYLD	physical	12917691
NEMO_HUMAN	IKBKG	physical	12867425
TRAF2_HUMAN	TRAF2	physical	12591926
GCKR_HUMAN	GCKR	physical	12591926
SMUF1_HUMAN	SMURF1	genetic	19937093
RIPK1_HUMAN	RIPK1	physical	16603398
TRAF2_HUMAN	TRAF2	physical	19810754
PRKN_HUMAN	PARK2	physical	17314283
ZFAN6_HUMAN	ZFAND6	physical	21810480
RIPK1_HUMAN	RIPK1	physical	21810480
BIRC2_HUMAN	BIRC2	physical	19815541
RIPK1_HUMAN	RIPK1	physical	19815541
TRADD_HUMAN	TRADD	physical	19815541
BIRC3_HUMAN	BIRC3	physical	19815541
XIAP_HUMAN	XIAP	physical	19815541
TRAF2_HUMAN	TRAF2	physical	20577214
RIPK1_HUMAN	RIPK1	physical	20577214
M3K11_HUMAN	MAP3K11	physical	19586614
TCAM1_HUMAN	TICAM1	physical	20047764
KHDR1_MOUSE	Khdrbs1	physical	21620750
UBP4_HUMAN	USP4	physical	22029577
BIRC2_HUMAN	BIRC2	physical	21903422
DBLOH_HUMAN	DIABLO	physical	21903422
TANK_HUMAN	TANK	physical	21903422
TBK1_HUMAN	TBK1	physical	21903422
TRAF1_HUMAN	TRAF1	physical	21903422
TRAF3_HUMAN	TRAF3	physical	21903422
UBP2_HUMAN	USP2	physical	22179575
UBC_HUMAN	UBC	physical	22184250
PIAS2_HUMAN	PIAS2	physical	22184250
UBE2N_HUMAN	UBE2N	physical	22184250
FBX7_HUMAN	FBXO7	physical	22212761
SH3K1_HUMAN	SH3KBP1	physical	15707590
TNR3_HUMAN	LTBR	physical	20348096
BIRC2_HUMAN	BIRC2	physical	20348096
M3K14_HUMAN	MAP3K14	physical	20348096
M3K5_HUMAN	MAP3K5	physical	18776134
AIMP2_HUMAN	AIMP2	physical	19584093
BIRC2_HUMAN	BIRC2	physical	19584093
BIRC2_HUMAN	BIRC2	physical	20184394
TR13B_HUMAN	TNFRSF13B	physical	20184394
KS6A3_HUMAN	RPS6KA3	physical	22685297
TRAF2_HUMAN	TRAF2	physical	15383523
TRAF3_HUMAN	TRAF3	physical	15383523
TRAF6_HUMAN	TRAF6	physical	16260598
CYTSB_HUMAN	SPECC1	physical	22170762
TRAF2_HUMAN	TRAF2	physical	20385093
BIRC3_HUMAN	BIRC3	physical	20385093
TRAF1_HUMAN	TRAF1	physical	20385093
M3K5_HUMAN	MAP3K5	physical	17724081
PEG3_HUMAN	PEG3	physical	9500555
TRAF1_HUMAN	TRAF1	physical	9500555
TRAF2_HUMAN	TRAF2	physical	11181075
TRADD_HUMAN	TRADD	physical	11181075
TRAF1_HUMAN	TRAF1	physical	11181075
RIPK1_HUMAN	RIPK1	physical	11181075
BIRC2_HUMAN	BIRC2	physical	11181075
M3K14_HUMAN	MAP3K14	physical	9275204
M3K7_HUMAN	MAP3K7	physical	17384642
PDLI7_HUMAN	PDLIM7	physical	21864338
BRRF1_EBVB9	BRRF1	physical	21325409
BRRF1_EBVG	BRRF1	physical	21325409
BIRC2_HUMAN	BIRC2	physical	8548810
BIRC3_HUMAN	BIRC3	physical	8548810
TNR1B_HUMAN	TNFRSF1B	physical	8548810
TRAF3_HUMAN	TRAF3	physical	9718306
TRAF2_HUMAN	TRAF2	physical	9718306
DAB2P_HUMAN	DAB2IP	physical	17389591
VFLIP_HHV8P	HHV8GK18_gp80	physical	16311516
TNR9_HUMAN	TNFRSF9	physical	15941918
TNR4_HUMAN	TNFRSF4	physical	15941918
IF4G1_HUMAN	EIF4G1	physical	15743837
TRAF2_HUMAN	TRAF2	physical	10206649
TNR1B_HUMAN	TNFRSF1B	physical	10206649
JUN_HUMAN	JUN	physical	12796506
TP4AP_HUMAN	TRPC4AP	physical	16876162
DAB2P_HUMAN	DAB2IP	physical	15310755
GSTP1_HUMAN	GSTP1	physical	16636664
M3K5_HUMAN	MAP3K5	physical	16636664
M3K1_HUMAN	MAP3K1	physical	16636664
MAVS_HUMAN	MAVS	physical	16153868
APEX1_HUMAN	APEX1	physical	17599408
TRAF1_HUMAN	TRAF1	physical	8069916
TRAF2_HUMAN	TRAF2	physical	8069916
TNR1B_HUMAN	TNFRSF1B	physical	8069916
BIRC2_HUMAN	BIRC2	physical	16891304
TNR5_HUMAN	CD40	physical	12220533
IKKE_HUMAN	IKBKE	physical	23007157
TBK1_HUMAN	TBK1	physical	23007157
BIRC2_HUMAN	BIRC2	physical	23007157
TANK_HUMAN	TANK	physical	23007157
IKKA_HUMAN	CHUK	physical	23007157
IKKB_HUMAN	IKBKB	physical	23007157
NEMO_HUMAN	IKBKG	physical	23007157
RIPK1_HUMAN	RIPK1	physical	23007157
IKKA_HUMAN	CHUK	physical	20449947
IKKB_HUMAN	IKBKB	physical	20449947
IKKE_HUMAN	IKBKE	physical	20449947
TBK1_HUMAN	TBK1	physical	20449947
NF2IP_HUMAN	NFATC2IP	physical	11435475
ZMY11_HUMAN	ZMYND11	physical	20138174
PTN2_HUMAN	PTPN2	physical	15696169
UBE2N_HUMAN	UBE2N	physical	20577214
UB2D1_HUMAN	UBE2D1	physical	20577214
UB2V2_HUMAN	UBE2V2	physical	20047764
UBE2N_HUMAN	UBE2N	physical	20047764
FADD_HUMAN	FADD	physical	23142077
CASP8_HUMAN	CASP8	physical	23142077
RD23A_HUMAN	RAD23A	physical	23357418
UBE2O_HUMAN	UBE2O	physical	23381138
CYLD_HUMAN	CYLD	physical	23405219
IKKE_HUMAN	IKBKE	physical	23453969
UBE2N_HUMAN	UBE2N	physical	23453969
BIRC3_HUMAN	BIRC3	physical	23543740
M3K14_HUMAN	MAP3K14	physical	23543740
RIPK1_HUMAN	RIPK1	physical	23972990
EGFR_HUMAN	EGFR	physical	23972990
SIVA_HUMAN	SIVA1	physical	22343716
RIPK1_HUMAN	RIPK1	physical	24735611
MUL1_HUMAN	MUL1	physical	24841215
RS3_HUMAN	RPS3	physical	23188828
E2AK2_HUMAN	EIF2AK2	physical	15121867
DAB2P_HUMAN	DAB2IP	physical	24912918
TRAF4_HUMAN	TRAF4	physical	23743189
FBX7_HUMAN	FBXO7	physical	25029497
TRAF2_HUMAN	TRAF2	physical	20447407
PP4R1_HUMAN	PPP4R1	physical	25134449
ELAV1_HUMAN	ELAVL1	physical	23772036
TRAF2_HUMAN	TRAF2	physical	25416956
TRAF6_HUMAN	TRAF6	physical	25416956
USF1_HUMAN	USF1	physical	25416956
YES_HUMAN	YES1	physical	25416956
ZBT25_HUMAN	ZBTB25	physical	25416956
RIPK1_HUMAN	RIPK1	physical	25416956
BCL10_HUMAN	BCL10	physical	25416956
M3K14_HUMAN	MAP3K14	physical	25416956
UBP2_HUMAN	USP2	physical	25416956
CREB5_HUMAN	CREB5	physical	25416956
TROAP_HUMAN	TROAP	physical	25416956
TSSC4_HUMAN	TSSC4	physical	25416956
NEBL_HUMAN	NEBL	physical	25416956
GORS2_HUMAN	GORASP2	physical	25416956
AFF4_HUMAN	AFF4	physical	25416956
GPKOW_HUMAN	GPKOW	physical	25416956
ZN544_HUMAN	ZNF544	physical	25416956
ASCC1_HUMAN	ASCC1	physical	25416956
KLF3_HUMAN	KLF3	physical	25416956
SPG21_HUMAN	SPG21	physical	25416956
AMOL2_HUMAN	AMOTL2	physical	25416956
NB5R2_HUMAN	CYB5R2	physical	25416956
SYT17_HUMAN	SYT17	physical	25416956
CCHCR_HUMAN	CCHCR1	physical	25416956
ZSC32_HUMAN	ZSCAN32	physical	25416956
BANP_HUMAN	BANP	physical	25416956
KI26B_HUMAN	KIF26B	physical	25416956
F90A1_HUMAN	FAM90A1	physical	25416956
CN105_HUMAN	C14orf105	physical	25416956
RBM41_HUMAN	RBM41	physical	25416956
RCOR3_HUMAN	RCOR3	physical	25416956
SMG9_HUMAN	SMG9	physical	25416956
NMUR2_HUMAN	NMUR2	physical	25416956
CBX8_HUMAN	CBX8	physical	25416956
TSH3_HUMAN	TSHZ3	physical	25416956
ZN410_HUMAN	ZNF410	physical	25416956
ADPPT_HUMAN	AASDHPPT	physical	25416956
SH24A_HUMAN	SH2D4A	physical	25416956
TEKT3_HUMAN	TEKT3	physical	25416956
FND3B_HUMAN	FNDC3B	physical	25416956
ZN655_HUMAN	ZNF655	physical	25416956
CCNJL_HUMAN	CCNJL	physical	25416956
SNR25_HUMAN	SNRNP25	physical	25416956
ARSJ_HUMAN	ARSJ	physical	25416956
ZC21C_HUMAN	ZC2HC1C	physical	25416956
PKRI1_HUMAN	PRKRIP1	physical	25416956
F192A_HUMAN	FAM192A	physical	25416956
THAP7_HUMAN	THAP7	physical	25416956
RN146_HUMAN	RNF146	physical	25416956
GSG1_HUMAN	GSG1	physical	25416956
CDCA3_HUMAN	CDCA3	physical	25416956
RASF5_HUMAN	RASSF5	physical	25416956
ENKD1_HUMAN	ENKD1	physical	25416956
TIRR_HUMAN	NUDT16L1	physical	25416956
PCGF5_HUMAN	PCGF5	physical	25416956
PGBD1_HUMAN	PGBD1	physical	25416956
BEX2_HUMAN	BEX2	physical	25416956
UBX11_HUMAN	UBXN11	physical	25416956
FDXA1_HUMAN	FDXACB1	physical	25416956
RIPP1_HUMAN	RIPPLY1	physical	25416956
TIFA_HUMAN	TIFA	physical	25416956
HENMT_HUMAN	HENMT1	physical	25416956
EXAS1_HUMAN	EXOC3-AS1	physical	25416956
CTSR1_HUMAN	CATSPER1	physical	25416956
ZN488_HUMAN	ZNF488	physical	25416956
EDAD_HUMAN	EDARADD	physical	25416956
ZMAT2_HUMAN	ZMAT2	physical	25416956
IQUB_HUMAN	IQUB	physical	25416956
ZBT49_HUMAN	ZBTB49	physical	25416956
CD20B_HUMAN	CDC20B	physical	25416956
PPR18_HUMAN	PPP1R18	physical	25416956
NATD1_HUMAN	NATD1	physical	25416956
MORN3_HUMAN	MORN3	physical	25416956
CE57L_HUMAN	CEP57L1	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
VWA2_HUMAN	VWA2	physical	25416956
CQ082_HUMAN	C17orf82	physical	25416956
ZN662_HUMAN	ZNF662	physical	25416956
GSTP1_HUMAN	GSTP1	physical	24457959
TRAF2_HUMAN	TRAF2	physical	23007157
UBC_HUMAN	UBC	physical	15327770
IFIT3_HUMAN	IFIT3	physical	21813773
SRSF1_MOUSE	Srsf1	physical	21822258
CIKS_HUMAN	TRAF3IP2	physical	21822258
SRSF1_HUMAN	SRSF1	physical	21822258
TRAIP_HUMAN	TRAIP	physical	25716317
RIPK1_HUMAN	RIPK1	physical	25716317
BIRC2_HUMAN	BIRC2	physical	25716317
SPHK1_HUMAN	SPHK1	physical	25716317
M3K5_HUMAN	MAP3K5	physical	15310755
TRAF6_HUMAN	TRAF6	physical	21516116
FND11_HUMAN	C20orf195	physical	21516116
UBX11_HUMAN	UBXN11	physical	21516116
TIFA_HUMAN	TIFA	physical	21516116
M3K1_HUMAN	MAP3K1	physical	25241761
ERN1_HUMAN	ERN1	physical	25241761
ACTG_HUMAN	ACTG1	physical	25241761
TRAF1_HUMAN	TRAF1	physical	25241761
HS71L_HUMAN	HSPA1L	physical	25241761
ZBT16_HUMAN	ZBTB16	physical	25241761
CDN1B_HUMAN	CDKN1B	physical	25241761
MK09_HUMAN	MAPK9	physical	25241761
MTOR_HUMAN	MTOR	physical	25241761
FLNA_HUMAN	FLNA	physical	25241761
IKKA_HUMAN	CHUK	physical	25241761
DUS14_HUMAN	DUSP14	physical	26521044
TRAF2_HUMAN	TRAF2	physical	26390021
M3K7_HUMAN	MAP3K7	physical	26299341
PRKN_HUMAN	PARK2	physical	25963095
RXRA_HUMAN	RXRA	physical	25795708
RACK1_HUMAN	GNB2L1	physical	26038599
MLKL_HUMAN	MLKL	physical	25882049
TRAF4_HUMAN	TRAF4	physical	25738361
UBP2_HUMAN	USP2	physical	22659130
TRAF1_HUMAN	TRAF1	physical	28514442
BIRC2_HUMAN	BIRC2	physical	28514442
TANK_HUMAN	TANK	physical	28514442
FBXW7_HUMAN	FBXW7	physical	28514442
TM102_HUMAN	TMEM102	physical	28514442
TBK1_HUMAN	TBK1	physical	28514442
RAB3I_HUMAN	RAB3IP	physical	28514442
FBX28_HUMAN	FBXO28	physical	28514442
TRAF6_HUMAN	TRAF6	physical	28514442
ISCA1_HUMAN	ISCA1	physical	28514442
GSK3B_HUMAN	GSK3B	physical	28514442
FBX7_HUMAN	FBXO7	physical	28514442
RIPK1_HUMAN	RIPK1	physical	27768232
TRADD_HUMAN	TRADD	physical	27768232
CASP8_HUMAN	CASP8	physical	28972304
BECN1_HUMAN	BECN1	physical	28521610
SPHK1_HUMAN	SPHK1	physical	28521610
CYLD_HUMAN	CYLD	physical	28900035
MAVS_HUMAN	MAVS	physical	29125880
TBK1_HUMAN	TBK1	physical	29125880
IKKE_HUMAN	IKBKE	physical	29125880
M3K5_HUMAN	MAP3K5	physical	19805025
BIRC2_HUMAN	BIRC2	physical	27534557
BIRC3_HUMAN	BIRC3	physical	27534557
RD23A_HUMAN	RAD23A	physical	27534557

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of TRAF2_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-7 AND SER-11, AND MASSSPECTROMETRY.	19369195 [Abstract]
"TRAF2 phosphorylation modulates tumor necrosis factor alpha-inducedgene expression and cell resistance to apoptosis."; Blackwell K., Zhang L., Thomas G.S., Sun S., Nakano H., Habelhah H.; Mol. Cell. Biol. 29:303-314(2009). Cited for: FUNCTION, IDENTIFICATION IN A COMPLEX WITH TNFRSF1A; RIPK1 AND IKKB,MUTAGENESIS OF SER-11, AND PHOSPHORYLATION AT SER-11.	18981220 [Abstract]
"PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment andK63-linked polyubiquitination."; Li S., Wang L., Dorf M.E.; Mol. Cell 33:30-42(2009). Cited for: FUNCTION, INTERACTION WITH IKKA; IKKB; TAB2 AND TAB3, UBIQUITINATIONAT LYS-31, PHOSPHORYLATION AT THR-117, MUTAGENESIS OF THR-117,UBIQUITINATION, AND SUBCELLULAR LOCATION.	19150425 [Abstract]
Ubiquitylation
Reference	PubMed
"PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment andK63-linked polyubiquitination."; Li S., Wang L., Dorf M.E.; Mol. Cell 33:30-42(2009). Cited for: FUNCTION, INTERACTION WITH IKKA; IKKB; TAB2 AND TAB3, UBIQUITINATIONAT LYS-31, PHOSPHORYLATION AT THR-117, MUTAGENESIS OF THR-117,UBIQUITINATION, AND SUBCELLULAR LOCATION.	19150425 [Abstract]

show

show

show

show

show

show