CCD33_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CCD33_HUMAN
• UniProt AC: Q8N5R6
• Protein Name: Coiled-coil domain-containing protein 33
• Gene Name: CCDC33
• Organism: Homo sapiens (Human).
• Sequence Length: 958
• Protein Sequence: MAFRGPEPWVSASLLRQRLKAEEKTLDLEFEVLSVGFNEAGRYALRLSAENPLQVGSGAGVQLQVNDGDPFPACSAITDVIEQQEPGQSLTLTRSKFIFTLPKGFCKNDGQHDAQLHVEALRLDEPLGRAAQRVGEAIFPIYPRPDQPRMNPKAQDHEDLYRYCGNLALLRASTDPTARHCGSLAYSVAFHVHRGPQPPVSDSPPRAGQPELMSPEEPLIASQSTEPEIGHLSPSKKETIMVTLHGATNLPACKDGSEPWPYVVVKSTSEEKNNQSSKAVTSVTSEPTRAPIWGDTVNVEIQAEDAGQEDVILKVVDNRKKQELLSYKIPIKYLRVFHPYHFELVKPTESGKADEATAKTQLYATVVRKSSFIPRYIGCNHMALEIFLRGVNEPLANNPNPIVVIARVVPNYKEFKVSQANRDLASVGLPITPLSFPIPSMMNFDVPRVSQNGCPQLSKPGGPPEQPLWNQSFLFQGRDGATSFSEDTALVLEYYSSTSMKGSQPWTLNQPLGISVLPLKSRLYQKMLTGKGLDGLHVERLPIMDTSLKTINDEAPTVALSFQLLSSERPENFLTPNNSKALPTLDPKILDKKLRTIQESWSKDTVSSTMDLSTSTPREAEEEPLVPEMSHDTEMNNYRRAMQKMAEDILSLRRQASILEGENRILRSRLAQQEEEEGQGKASEAQNTVSMKQKLLLSELDMKKLRDRVQHLQNELIRKNDREKELLLLYQAQQPQAALLKQYQGKLQKMKALEETVRHQEKVIEKMERVLEDRLQDRSKPPPLNRQQGKPYTGFPMLSASGLPLGSMGENLPVELYSVLLAENAKLRTELDKNRHQQAPIILQQQALPDLLSGTSDKFNLLAKLEHAQSRILSLESQLEDSARRWGREKQDLATRLQEQEKGFRHPSNSIIIEQPSALTHSMDLKQPSELEPLLPSSDSKLNKPLSPQKETANSQQT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
214	Phosphorylation	AGQPELMSPEEPLIA CCCCCCCCCCCCCCC	41.61	24043423
222	Phosphorylation	PEEPLIASQSTEPEI CCCCCCCCCCCCCCC	20.05	24043423
223	Phosphorylation	EEPLIASQSTEPEIG CCCCCCCCCCCCCCC	45.40	24719451
224	Phosphorylation	EPLIASQSTEPEIGH CCCCCCCCCCCCCCC	32.04	24043423
225	Phosphorylation	PLIASQSTEPEIGHL CCCCCCCCCCCCCCC	48.17	24043423
229	Phosphorylation	SQSTEPEIGHLSPSK CCCCCCCCCCCCCCC	6.53	24719451
233	Phosphorylation	EPEIGHLSPSKKETI CCCCCCCCCCCCCEE	22.81	24719451
235	Phosphorylation	EIGHLSPSKKETIMV CCCCCCCCCCCEEEE	53.64	24043423
248	Phosphorylation	MVTLHGATNLPACKD EEEEECCCCCCCCCC	41.71	-
284	Phosphorylation	SKAVTSVTSEPTRAP CCCEEECCCCCCCCC	27.43	29759185
285	Phosphorylation	KAVTSVTSEPTRAPI CCEEECCCCCCCCCC	39.15	29759185
288	Phosphorylation	TSVTSEPTRAPIWGD EECCCCCCCCCCCCC	35.10	21712546
327	Phosphorylation	KKQELLSYKIPIKYL HHHHHHCEECCEEEE	16.95	-
369	Methylation	LYATVVRKSSFIPRY HHEEHHHCCCCCCCC	38.55	23644510
369	"N6,N6-dimethyllysine"	LYATVVRKSSFIPRY HHEEHHHCCCCCCCC	38.55	-
426	Phosphorylation	QANRDLASVGLPITP CCCHHHHHCCCCCCC	24.82	24719451
432	Phosphorylation	ASVGLPITPLSFPIP HHCCCCCCCCCCCCC	19.08	24719451
450	Phosphorylation	NFDVPRVSQNGCPQL CCCCCCCCCCCCCCC	21.14	27732954
458	Phosphorylation	QNGCPQLSKPGGPPE CCCCCCCCCCCCCCC	31.40	27732954
524	Phosphorylation	LPLKSRLYQKMLTGK EECCHHHHHHHHHCC	12.65	-
575	Phosphorylation	ERPENFLTPNNSKAL CCCCCCCCCCCCCCC	21.60	28450419
579	Phosphorylation	NFLTPNNSKALPTLD CCCCCCCCCCCCCCC	26.41	28450419
600	O-linked_Glycosylation	KLRTIQESWSKDTVS HHHHHHHHHCCCCHH	21.92	30379171
602	O-linked_Glycosylation	RTIQESWSKDTVSST HHHHHHHCCCCHHHC	29.90	30379171
609	Phosphorylation	SKDTVSSTMDLSTST CCCCHHHCEECCCCC	13.75	22210691
613	Phosphorylation	VSSTMDLSTSTPREA HHHCEECCCCCCCHH	18.95	26699800
614	Phosphorylation	SSTMDLSTSTPREAE HHCEECCCCCCCHHH	43.87	26699800
615	Phosphorylation	STMDLSTSTPREAEE HCEECCCCCCCHHHC	32.79	26699800
616	Phosphorylation	TMDLSTSTPREAEEE CEECCCCCCCHHHCC	26.84	22210691
651	Phosphorylation	KMAEDILSLRRQASI HHHHHHHHHHHHHHH	21.84	20736484
657	Phosphorylation	LSLRRQASILEGENR HHHHHHHHHHHHHHH	21.26	20736484
690	Phosphorylation	SEAQNTVSMKQKLLL CHHHHHHCHHHHHHH	20.44	-
741	Ubiquitination	QPQAALLKQYQGKLQ CHHHHHHHHHHHHHH	48.05	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CCD33_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CCD33_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CCD33_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
USBP1_HUMAN	USHBP1	physical	16189514
T22D4_HUMAN	TSC22D4	physical	16189514
ZBT8A_HUMAN	ZBTB8A	physical	16189514
A4_HUMAN	APP	physical	21832049
KHDR3_HUMAN	KHDRBS3	physical	19447967
RHXF2_HUMAN	RHOXF2	physical	19447967
MDFI_HUMAN	MDFI	physical	19447967
TRI37_HUMAN	TRIM37	physical	19447967
TSG10_HUMAN	TSGA10	physical	25416956
F161A_HUMAN	FAM161A	physical	25416956
ING5_HUMAN	ING5	physical	25416956
ZGPAT_HUMAN	ZGPAT	physical	25416956
ZN572_HUMAN	ZNF572	physical	25416956
MIPO1_HUMAN	MIPOL1	physical	25416956
KCD19_HUMAN	KCTD19	physical	25416956
F124A_HUMAN	FAM124A	physical	25416956
TRI42_HUMAN	TRIM42	physical	25416956
CENPP_HUMAN	CENPP	physical	25416956
ZBT8A_HUMAN	ZBTB8A	physical	25416956
EAF1_HUMAN	EAF1	physical	21516116
STK16_HUMAN	STK16	physical	21516116
CENPF_HUMAN	CENPF	physical	28514442
UBS3B_HUMAN	UBASH3B	physical	28514442
ATS4_HUMAN	ADAMTS4	physical	28514442
ANM5_HUMAN	PRMT5	physical	28514442
UBE2O_HUMAN	UBE2O	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.