dbPTM

UBS3B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	UBS3B_HUMAN
UniProt AC	Q8TF42
Protein Name	Ubiquitin-associated and SH3 domain-containing protein B
Gene Name	UBASH3B
Organism	Homo sapiens (Human).
Sequence Length	649
Subcellular Localization	Cytoplasm. Nucleus .
Protein Description	Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination..
Protein Sequence	MAQYGHPSPLGMAAREELYSKVTPRRNRQQRPGTIKHGSALDVLLSMGFPRARAQKALASTGGRSVQAACDWLFSHVGDPFLDDPLPREYVLYLRPTGPLAQKLSDFWQQSKQICGKNKAHNIFPHITLCQFFMCEDSKVDALGEALQTTVSRWKCKFSAPLPLELYTSSNFIGLFVKEDSAEVLKKFAADFAAEAASKTEVHVEPHKKQLHVTLAYHFQASHLPTLEKLAQNIDVKLGCDWVATIFSRDIRFANHETLQVIYPYTPQNDDELELVPGDFIFMSPMEQTSTSEGWIYGTSLTTGCSGLLPENYITKADECSTWIFHGSYSILNTSSSNSLTFGDGVLERRPYEDQGLGETTPLTIICQPMQPLRVNSQPGPQKRCLFVCRHGERMDVVFGKYWLSQCFDAKGRYIRTNLNMPHSLPQRSGGFRDYEKDAPITVFGCMQARLVGEALLESNTIIDHVYCSPSLRCVQTAHNILKGLQQENHLKIRVEPGLFEWTKWVAGSTLPAWIPPSELAAANLSVDTTYRPHIPISKLVVSESYDTYISRSFQVTKEIISECKSKGNNILIVAHASSLEACTCQLQGLSPQNSKDFVQMVRKIPYLGFCSCEELGETGIWQLTDPPILPLTHGPTGGFNWRETLLQE

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MAQYGHPSPLG ----CCCCCCCCHHH	14.09	27642862
8	Phosphorylation	MAQYGHPSPLGMAAR CCCCCCCCHHHHHHH	27.38	22199227
8	O-linked_Glycosylation	MAQYGHPSPLGMAAR CCCCCCCCHHHHHHH	27.38	29237092
19	Phosphorylation	MAAREELYSKVTPRR HHHHHHHHHHCCCCC	15.10	19605366
20	Phosphorylation	AAREELYSKVTPRRN HHHHHHHHHCCCCCC	33.02	28152594
21	Acetylation	AREELYSKVTPRRNR HHHHHHHHCCCCCCC	36.25	25953088
21	Ubiquitination	AREELYSKVTPRRNR HHHHHHHHCCCCCCC	36.25	21906983
23	Phosphorylation	EELYSKVTPRRNRQQ HHHHHHCCCCCCCCC	18.14	27134283
34	Phosphorylation	NRQQRPGTIKHGSAL CCCCCCCCCCCCCHH	29.54	28060719
46	Phosphorylation	SALDVLLSMGFPRAR CHHHHHHHCCCCHHH	16.82	19413330
56	Ubiquitination	FPRARAQKALASTGG CCHHHHHHHHHHCCC	44.37	27667366
77	Ubiquitination	CDWLFSHVGDPFLDD HHHHHHCCCCCCCCC	10.10	21963094
82	Ubiquitination	SHVGDPFLDDPLPRE HCCCCCCCCCCCCCE	9.93	22817900
93	Ubiquitination	LPREYVLYLRPTGPL CCCEEEEEEECCCHH	7.22	21963094
98	Ubiquitination	VLYLRPTGPLAQKLS EEEEECCCHHHHHHH	20.22	22817900
112	Ubiquitination	SDFWQQSKQICGKNK HHHHHHHHHHHCCCC	39.07	21963094
117	Ubiquitination	QSKQICGKNKAHNIF HHHHHHCCCCCCCCC	51.36	22817900
140	Ubiquitination	FMCEDSKVDALGEAL EECCCHHHHHHHHHH	6.36	21963094
145	Ubiquitination	SKVDALGEALQTTVS HHHHHHHHHHHHHHH	47.24	22817900
152	Ubiquitination	EALQTTVSRWKCKFS HHHHHHHHHCCCEEC	30.26	29901268
157	Ubiquitination	TVSRWKCKFSAPLPL HHHHCCCEECCCCCE	38.33	-
187	Ubiquitination	DSAEVLKKFAADFAA CHHHHHHHHHHHHHH	35.75	29901268
208	Ubiquitination	EVHVEPHKKQLHVTL EEEEECCCCCEEEEE	53.59	29967540
226	Phosphorylation	FQASHLPTLEKLAQN HHHHCCCHHHHHHHC	54.64	24173317
237	Ubiquitination	LAQNIDVKLGCDWVA HHHCCCCCCCCCHHH	35.10	-
348	Ubiquitination	TFGDGVLERRPYEDQ EECCCEEECCCCCCC	44.21	27667366
352	Phosphorylation	GVLERRPYEDQGLGE CEEECCCCCCCCCCC	30.26	-
360	Phosphorylation	EDQGLGETTPLTIIC CCCCCCCCCCEEEEE	31.73	28464451
364	Ubiquitination	LGETTPLTIICQPMQ CCCCCCEEEEEEECC	14.97	27667366
366	Ubiquitination	ETTPLTIICQPMQPL CCCCEEEEEEECCCC	1.18	22817900
376	Ubiquitination	PMQPLRVNSQPGPQK ECCCCCCCCCCCCCC	28.61	23000965
377	Phosphorylation	MQPLRVNSQPGPQKR CCCCCCCCCCCCCCE	34.59	21712546
382	Ubiquitination	VNSQPGPQKRCLFVC CCCCCCCCCEEEEEE	52.30	22817900
383	Ubiquitination	NSQPGPQKRCLFVCR CCCCCCCCEEEEEEE	48.49	27667366
392	Ubiquitination	CLFVCRHGERMDVVF EEEEEECCCCEEEEE	12.59	23000965
401	Ubiquitination	RMDVVFGKYWLSQCF CEEEEEEHHHHHHHH	23.07	22817900
402	Phosphorylation	MDVVFGKYWLSQCFD EEEEEEHHHHHHHHC	16.38	22817900
411	Ubiquitination	LSQCFDAKGRYIRTN HHHHHCCCCCEEEEC	45.85	23000965
429	Ubiquitination	PHSLPQRSGGFRDYE CCCCCCCCCCCCCCC	37.71	22817900
439	Ubiquitination	FRDYEKDAPITVFGC CCCCCCCCCEEEEEE	14.41	23000965
457	Ubiquitination	RLVGEALLESNTIID HHHHHHHHHCCCEEE	9.76	27667366
473	Ubiquitination	VYCSPSLRCVQTAHN EEECCHHHHHHHHHH	23.93	27667366
483	Ubiquitination	QTAHNILKGLQQENH HHHHHHHHHHHHCCC	54.50	29967540
492	Ubiquitination	LQQENHLKIRVEPGL HHHCCCEEEEECCCC	22.40	27667366
520	Ubiquitination	AWIPPSELAAANLSV CCCCHHHHHHCCCCC	4.63	27667366
558	Ubiquitination	SRSFQVTKEIISECK HHHHHHHHHHHHHHH	48.32	29967540
561	Ubiquitination	FQVTKEIISECKSKG HHHHHHHHHHHHHCC	2.73	21963094
577	Ubiquitination	NILIVAHASSLEACT EEEEEEECCHHHHHH	7.35	21963094
596	Ubiquitination	GLSPQNSKDFVQMVR CCCCCCHHHHHHHHH	63.84	21963094
624	Ubiquitination	GETGIWQLTDPPILP CCCCCEEECCCCCCC	3.35	21963094

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of UBS3B_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of UBS3B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of UBS3B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CBL_HUMAN	CBL	physical	15159412
SHIP1_HUMAN	INPP5D	physical	22267732
NCK1_HUMAN	NCK1	physical	22267732
GRB2_HUMAN	GRB2	physical	22267732
EGFR_HUMAN	EGFR	physical	17880946
CBL_HUMAN	CBL	physical	17880946
CBL_HUMAN	CBL	physical	16429130
K1C10_HUMAN	KRT10	physical	19380743
K2C1_HUMAN	KRT1	physical	19380743
K22E_HUMAN	KRT2	physical	19380743
CSK_HUMAN	CSK	physical	19380743
K1C9_HUMAN	KRT9	physical	19380743
SPTB2_HUMAN	SPTBN1	physical	19380743
K2C5_HUMAN	KRT5	physical	19380743
K1C14_HUMAN	KRT14	physical	19380743
K2C6B_HUMAN	KRT6B	physical	19380743
HSP7C_HUMAN	HSPA8	physical	19380743
K2C6A_HUMAN	KRT6A	physical	19380743
ACTB_HUMAN	ACTB	physical	19380743
ARAP1_HUMAN	ARAP1	physical	19380743
TBB5_HUMAN	TUBB	physical	19380743
K1C16_HUMAN	KRT16	physical	19380743
BCR_HUMAN	BCR	physical	19380743
ABL1_HUMAN	ABL1	physical	19380743
HS90B_HUMAN	HSP90AB1	physical	19380743
CRK_HUMAN	CRK	physical	19380743
IQGA1_HUMAN	IQGAP1	physical	19380743
K1C17_HUMAN	KRT17	physical	19380743
SHIP2_HUMAN	INPPL1	physical	19380743
TBA1B_HUMAN	TUBA1B	physical	19380743
MYH10_HUMAN	MYH10	physical	19380743
HS90A_HUMAN	HSP90AA1	physical	19380743
MYO1D_HUMAN	MYO1D	physical	19380743
SPTA1_HUMAN	SPTA1	physical	19380743
SPTN1_HUMAN	SPTAN1	physical	19380743
K2C79_HUMAN	KRT79	physical	19380743
TCPG_HUMAN	CCT3	physical	19380743
ACTN4_HUMAN	ACTN4	physical	19380743
TCPQ_HUMAN	CCT8	physical	19380743
K2C8_HUMAN	KRT8	physical	19380743
HS71L_HUMAN	HSPA1L	physical	19380743
UBC_HUMAN	UBC	physical	19380743
K2C73_HUMAN	KRT73	physical	19380743
ACACA_HUMAN	ACACA	physical	19380743
GRP78_HUMAN	HSPA5	physical	19380743
DSC1_HUMAN	DSC1	physical	19380743
TCPH_HUMAN	CCT7	physical	19380743
COR1C_HUMAN	CORO1C	physical	19380743
DDX6_HUMAN	DDX6	physical	19380743
TCPA_HUMAN	TCP1	physical	19380743
UBS3A_HUMAN	UBASH3A	physical	19380743
DCD_HUMAN	DCD	physical	19380743
TCPZ_HUMAN	CCT6A	physical	19380743
CBL_HUMAN	CBL	physical	19380743
MCCB_HUMAN	MCCC2	physical	19380743
DNJA1_HUMAN	DNAJA1	physical	19380743
MYH9_HUMAN	MYH9	physical	19380743
TCPW_HUMAN	CCT6B	physical	19380743
KSYK_HUMAN	SYK	physical	20585042
ACTB_HUMAN	ACTB	physical	24189400
ACTG_HUMAN	ACTG1	physical	24189400
EGFR_HUMAN	EGFR	physical	24189400
ERRFI_HUMAN	ERRFI1	physical	24189400
GFAP_HUMAN	GFAP	physical	24189400
GRB2_HUMAN	GRB2	physical	24189400
HNRH1_HUMAN	HNRNPH1	physical	24189400
HNRH2_HUMAN	HNRNPH2	physical	24189400
HNRPF_HUMAN	HNRNPF	physical	24189400
HNRPU_HUMAN	HNRNPU	physical	24189400
ROA2_HUMAN	HNRNPA2B1	physical	24189400
RS27A_HUMAN	RPS27A	physical	24189400
S10A8_HUMAN	S100A8	physical	24189400
UBS3B_HUMAN	UBASH3B	physical	24189400
UBS3B_HUMAN	UBASH3B	physical	25416956
S2548_HUMAN	SLC25A48	physical	25416956
TAU_HUMAN	MAPT	physical	16364302
PKP4_HUMAN	PKP4	physical	21516116
AURKB_HUMAN	AURKB	physical	26766443
CUL3_HUMAN	CUL3	physical	26766443
KI20A_HUMAN	KIF20A	physical	26766443
EWS_HUMAN	EWSR1	physical	24189400
H11_HUMAN	HIST1H1A	physical	24189400
H12_HUMAN	HIST1H1C	physical	24189400
H13_HUMAN	HIST1H1D	physical	24189400
H14_HUMAN	HIST1H1E	physical	24189400
H1T_HUMAN	HIST1H1T	physical	24189400
HSP7C_HUMAN	HSPA8	physical	24189400
LG3BP_HUMAN	LGALS3BP	physical	24189400
MYH9_HUMAN	MYH9	physical	24189400

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of UBS3B_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-20 AND THR-23, AND MASSSPECTROMETRY.	18669648 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-19, AND MASSSPECTROMETRY.	19534553 [Abstract]