K2C73_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: K2C73_HUMAN
• UniProt AC: Q86Y46
• Protein Name: Keratin, type II cytoskeletal 73
• Gene Name: KRT73
• Organism: Homo sapiens (Human).
• Sequence Length: 540
• Protein Description: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable)..
• Protein Sequence: MSRQFTYKSGAAAKGGFSGCSAVLSGGSSSSYRAGGKGLSGGFSSRSLYSLGGARSISFNVASGSGWAGGYGFGRGRASGFAGSMFGSVALGSVCPSLCPPGGIHQVTINKSLLAPLNVELDPEIQKVRAQEREQIKVLNNKFASFIDKVRFLEQQNQVLETKWELLQQLDLNNCKNNLEPILEGYISNLRKQLETLSGDRVRLDSELRSVREVVEDYKKRYEEEINKRTTAENEFVVLKKDVDAAYTSKVELQAKVDALDGEIKFFKCLYEGETAQIQSHISDTSIILSMDNNRNLDLDSIIAEVRAQYEEIARKSKAEAEALYQTKFQELQLAAGRHGDDLKHTKNEISELTRLIQRLRSEIESVKKQCANLETAIADAEQRGDCALKDARAKLDELEGALQQAKEELARMLREYQELLSVKLSLDIEIATYRKLLEGEECRMSGEYTNSVSISVINSSMAGMAGTGAGFGFSNAGTYGYWPSSVSGGYSMLPGGCVTGSGNCSPRGEARTRLGSASEFRDSQGKTLALSSPTKKTMR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	AAAKGGFSGCSAVLS CCCCCCCCCCCEEEC	42.01	-
21	Phosphorylation	KGGFSGCSAVLSGGS CCCCCCCCEEECCCC	25.57	-
142	Acetylation	QIKVLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	133003
142	Ubiquitination	QIKVLNNKFASFIDK HHHHHHHHHHHHHHH	41.03	33845483
145	Phosphorylation	VLNNKFASFIDKVRF HHHHHHHHHHHHHHH	26.35	28355574
149 (in isoform 2)	Ubiquitination	-	30.41	21906983
149 (in isoform 1)	Ubiquitination	-	30.41	21906983
149	Acetylation	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	7706051
149	Ubiquitination	KFASFIDKVRFLEQQ HHHHHHHHHHHHHHH	30.41	21963094
188	Phosphorylation	PILEGYISNLRKQLE HHHHHHHHHHHHHHH	22.71	24719451
206	Phosphorylation	GDRVRLDSELRSVRE CCCCHHCHHHHHHHH	43.02	28355574
222	Phosphorylation	VEDYKKRYEEEINKR HHHHHHHHHHHHHHC	36.25	24670416
230	Phosphorylation	EEEINKRTTAENEFV HHHHHHCCCCCCEEE	31.78	-
240	Ubiquitination	ENEFVVLKKDVDAAY CCEEEEEECCCCHHH	35.00	23503661
241	Ubiquitination	NEFVVLKKDVDAAYT CEEEEEECCCCHHHC	59.84	23503661
249	Phosphorylation	DVDAAYTSKVELQAK CCCHHHCCCEEEEHH	23.25	23532336
301	Phosphorylation	NRNLDLDSIIAEVRA CCCCCHHHHHHHHHH	24.16	27966365
317	Phosphorylation	YEEIARKSKAEAEAL HHHHHHHHHHHHHHH	31.38	22210691
325	Phosphorylation	KAEAEALYQTKFQEL HHHHHHHHHHHHHHH	22.60	18083107
327	Phosphorylation	EAEALYQTKFQELQL HHHHHHHHHHHHHHH	21.92	-
344	Acetylation	GRHGDDLKHTKNEIS CCCCCCCHHCHHHHH	57.11	7695417
404	Ubiquitination	DELEGALQQAKEELA HHHHHHHHHHHHHHH	40.42	22817900
417	Phosphorylation	LARMLREYQELLSVK HHHHHHHHHHHHHHH	10.80	19664994
422	Phosphorylation	REYQELLSVKLSLDI HHHHHHHHHHHHCHH	29.81	20068231
434	Phosphorylation	LDIEIATYRKLLEGE CHHHHHHHHHHHCCC	9.20	18083107
436	Ubiquitination	IEIATYRKLLEGEEC HHHHHHHHHHCCCCC	47.19	22817900
444	Methylation	LLEGEECRMSGEYTN HHCCCCCCCCCCCCC	26.11	-
500	Phosphorylation	MLPGGCVTGSGNCSP CCCCCCEECCCCCCC	29.70	-
502	Phosphorylation	PGGCVTGSGNCSPRG CCCCEECCCCCCCCC	19.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of K2C73_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of K2C73_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of K2C73_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of K2C73_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.