dbPTM

CBL_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	CBL_HUMAN
UniProt AC	P22681
Protein Name	E3 ubiquitin-protein ligase CBL
Gene Name	CBL
Organism	Homo sapiens (Human).
Sequence Length	906
Subcellular Localization	Cytoplasm. Cell membrane. Colocalizes with FGFR2 in lipid rafts at the cell membrane.
Protein Description	Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3..
Protein Sequence	MAGNVKKSSGAGGGSGSGGSGSGGLIGLMKDAFQPHHHHHHHLSPHPPGTVDKKMVEKCWKLMDKVVRLCQNPKLALKNSPPYILDLLPDTYQHLRTILSRYEGKMETLGENEYFRVFMENLMKKTKQTISLFKEGKERMYEENSQPRRNLTKLSLIFSHMLAELKGIFPSGLFQGDTFRITKADAAEFWRKAFGEKTIVPWKSFRQALHEVHPISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWSSLLRNWNSLAVTHPGYMAFLTYDEVKARLQKFIHKPGSYIFRLSCTRLGQWAIGYVTADGNILQTIPHNKPLFQALIDGFREGFYLFPDGRNQNPDLTGLCEPTPQDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTSWQESEGQGCPFCRCEIKGTEPIVVDPFDPRGSGSLLRQGAEGAPSPNYDDDDDERADDTLFMMKELAGAKVERPPSPFSMAPQASLPPVPPRLDLLPQRVCVPSSASALGTASKAASGSLHKDKPLPVPPTLRDLPPPPPPDRPYSVGAESRPQRRPLPCTPGDCPSRDKLPPVPSSRLGDSWLPRPIPKVPVSAPSSSDPWTGRELTNRHSLPFSLPSQMEPRPDVPRLGSTFSLDTSMSMNSSPLVGPECDHPKIKPSSSANAIYSLAARPLPVPKLPPGEQCEGEEDTEYMTPSSRPLRPLDTSQSSRACDCDQQIDSCTYEAMYNIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSERKAGSCQQGSGPAASAATASPQLSSEIENLMSQGYSYQDIQKALVIAQNNIEMAKNILREFVSISSPAHVAT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Ubiquitination	-MAGNVKKSSGAGGG -CCCCCCCCCCCCCC	45.64	-
8	Phosphorylation	MAGNVKKSSGAGGGS CCCCCCCCCCCCCCC	28.43	25262027
9	Phosphorylation	AGNVKKSSGAGGGSG CCCCCCCCCCCCCCC	41.35	25262027
15	Phosphorylation	SSGAGGGSGSGGSGS CCCCCCCCCCCCCCC	32.82	25627689
17	Phosphorylation	GAGGGSGSGGSGSGG CCCCCCCCCCCCCCC	41.50	25262027
20	Phosphorylation	GGSGSGGSGSGGLIG CCCCCCCCCCCCHHH	33.05	25262027
22	Phosphorylation	SGSGGSGSGGLIGLM CCCCCCCCCCHHHHH	31.24	25627689
43	Ubiquitination	HHHHHHHLSPHPPGT CCCCCCCCCCCCCCC	8.07	22505724
58	Ubiquitination	VDKKMVEKCWKLMDK CCHHHHHHHHHHHHH	33.70	29967540
61	Acetylation	KMVEKCWKLMDKVVR HHHHHHHHHHHHHHH	43.32	25953088
65	Acetylation	KCWKLMDKVVRLCQN HHHHHHHHHHHHHCC	28.76	25953088
74	Ubiquitination	VRLCQNPKLALKNSP HHHHCCHHHHHCCCC	54.67	29967540
74	Acetylation	VRLCQNPKLALKNSP HHHHCCHHHHHCCCC	54.67	25953088
105	Ubiquitination	ILSRYEGKMETLGEN HHHHHCCCCCCCCCC	22.94	24816145
126	Phosphorylation	MENLMKKTKQTISLF HHHHHHHHHHHHHHH	23.90	30576142
129	Phosphorylation	LMKKTKQTISLFKEG HHHHHHHHHHHHHHH	17.68	21406692
131	Phosphorylation	KKTKQTISLFKEGKE HHHHHHHHHHHHHHH	31.01	24719451
134	Acetylation	KQTISLFKEGKERMY HHHHHHHHHHHHHHH	71.50	25953088
141	Phosphorylation	KEGKERMYEENSQPR HHHHHHHHHCCCCCC	26.72	19534553
183	Ubiquitination	GDTFRITKADAAEFW CCEEEEEHHHHHHHH	41.73	-
197	Acetylation	WRKAFGEKTIVPWKS HHHHHCCCCEECHHH	43.88	19608861
203	Ubiquitination	EKTIVPWKSFRQALH CCCEECHHHHHHHHH	33.38	22505724
203	Acetylation	EKTIVPWKSFRQALH CCCEECHHHHHHHHH	33.38	25953088
216	Phosphorylation	LHEVHPISSGLEAMA HHHHCCCCCHHHHHH	23.86	28857561
217	Phosphorylation	HEVHPISSGLEAMAL HHHCCCCCHHHHHHH	48.38	28857561
245	O-linked_Glycosylation	VFEFDIFTRLFQPWS EEEHHHHHHHHHHHH	27.14	30059200
253	Phosphorylation	RLFQPWSSLLRNWNS HHHHHHHHHHHHHHH	27.79	24719451
337	Phosphorylation	DGFREGFYLFPDGRN HHHHCEEEECCCCCC	20.49	10608804
364	Phosphorylation	PQDHIKVTQEQYELY CCHHEEECHHHHHHH	22.76	28442448
368	Phosphorylation	IKVTQEQYELYCEMG EEECHHHHHHHHHCC	13.72	24927040
370	Phosphorylation	VTQEQYELYCEMGST ECHHHHHHHHHCCCH	5.16	17016520
371	Phosphorylation	TQEQYELYCEMGSTF CHHHHHHHHHCCCHH	3.71	10635327
376	Phosphorylation	ELYCEMGSTFQLCKI HHHHHCCCHHHHHHH	25.41	28442448
377	Phosphorylation	LYCEMGSTFQLCKIC HHHHCCCHHHHHHHH	15.07	28442448
389	Acetylation	KICAENDKDVKIEPC HHHHCCCCCCEEEEC	75.82	25953088
424	Ubiquitination	PFCRCEIKGTEPIVV CCCEEEECCCCCEEE	37.17	29967540
439	Phosphorylation	DPFDPRGSGSLLRQG CCCCCCCCCHHHCCC	26.87	25159151
441	Phosphorylation	FDPRGSGSLLRQGAE CCCCCCCHHHCCCCC	26.40	25159151
452	Phosphorylation	QGAEGAPSPNYDDDD CCCCCCCCCCCCCCC	25.83	23927012
454	Phosphorylation	AEGAPSPNYDDDDDE CCCCCCCCCCCCCCH	58.15	17016520
455	Phosphorylation	EGAPSPNYDDDDDER CCCCCCCCCCCCCHH	24.92	23927012
466	Phosphorylation	DDERADDTLFMMKEL CCHHHHHHHHHHHHH	23.57	23403867
483	Phosphorylation	AKVERPPSPFSMAPQ CCCCCCCCCCCCCCC	41.06	29255136
486	Phosphorylation	ERPPSPFSMAPQASL CCCCCCCCCCCCCCC	19.88	30266825
492	Phosphorylation	FSMAPQASLPPVPPR CCCCCCCCCCCCCCC	35.84	23927012
511	Phosphorylation	PQRVCVPSSASALGT CCCEECCCCCHHHHH	20.38	28555341
512	Phosphorylation	QRVCVPSSASALGTA CCEECCCCCHHHHHC	21.85	28555341
514	Phosphorylation	VCVPSSASALGTASK EECCCCCHHHHHCCH	26.44	-
518	Phosphorylation	SSASALGTASKAASG CCCHHHHHCCHHHCC	28.71	28555341
520	Phosphorylation	ASALGTASKAASGSL CHHHHHCCHHHCCCC	23.75	-
521	Ubiquitination	SALGTASKAASGSLH HHHHHCCHHHCCCCC	45.57	29967540
524	Phosphorylation	GTASKAASGSLHKDK HHCCHHHCCCCCCCC	33.50	24719451
526	Phosphorylation	ASKAASGSLHKDKPL CCHHHCCCCCCCCCC	25.46	28348404
531	Ubiquitination	SGSLHKDKPLPVPPT CCCCCCCCCCCCCCC	53.94	29967540
538	Phosphorylation	KPLPVPPTLRDLPPP CCCCCCCCCCCCCCC	28.49	29978859
551	Phosphorylation	PPPPPDRPYSVGAES CCCCCCCCCCCCCCC	32.88	17016520
552	Phosphorylation	PPPPDRPYSVGAESR CCCCCCCCCCCCCCC	19.51	28064214
553	Phosphorylation	PPPDRPYSVGAESRP CCCCCCCCCCCCCCC	19.43	30257219
558	Phosphorylation	PYSVGAESRPQRRPL CCCCCCCCCCCCCCC	49.04	30257219
568	Phosphorylation	QRRPLPCTPGDCPSR CCCCCCCCCCCCCCC	28.50	28985074
574	Phosphorylation	CTPGDCPSRDKLPPV CCCCCCCCCCCCCCC	60.48	27251275
577	Ubiquitination	GDCPSRDKLPPVPSS CCCCCCCCCCCCCHH	62.88	29967540
583	Phosphorylation	DKLPPVPSSRLGDSW CCCCCCCHHHCCCCC	28.46	24275569
584	Phosphorylation	KLPPVPSSRLGDSWL CCCCCCHHHCCCCCC	26.00	24275569
589	Phosphorylation	PSSRLGDSWLPRPIP CHHHCCCCCCCCCCC	28.81	27251275
589	O-linked_Glycosylation	PSSRLGDSWLPRPIP CHHHCCCCCCCCCCC	28.81	30059200
601	Phosphorylation	PIPKVPVSAPSSSDP CCCCCCCCCCCCCCC	28.52	-
601	O-linked_Glycosylation	PIPKVPVSAPSSSDP CCCCCCCCCCCCCCC	28.52	30059200
604	O-linked_Glycosylation	KVPVSAPSSSDPWTG CCCCCCCCCCCCCCC	42.04	30059200
604	Phosphorylation	KVPVSAPSSSDPWTG CCCCCCCCCCCCCCC	42.04	29978859
605	O-linked_Glycosylation	VPVSAPSSSDPWTGR CCCCCCCCCCCCCCC	37.39	30059200
605	Phosphorylation	VPVSAPSSSDPWTGR CCCCCCCCCCCCCCC	37.39	29978859
606	O-linked_Glycosylation	PVSAPSSSDPWTGRE CCCCCCCCCCCCCCC	52.62	30059200
606	Phosphorylation	PVSAPSSSDPWTGRE CCCCCCCCCCCCCCC	52.62	29978859
610	O-linked_Glycosylation	PSSSDPWTGRELTNR CCCCCCCCCCCCCCC	31.58	30059200
610	Phosphorylation	PSSSDPWTGRELTNR CCCCCCCCCCCCCCC	31.58	29978859
615	Phosphorylation	PWTGRELTNRHSLPF CCCCCCCCCCCCCCC	26.00	23401153
619	Phosphorylation	RELTNRHSLPFSLPS CCCCCCCCCCCCCCC	34.20	23401153
623	Phosphorylation	NRHSLPFSLPSQMEP CCCCCCCCCCCCCCC	37.11	29255136
626	O-linked_Glycosylation	SLPFSLPSQMEPRPD CCCCCCCCCCCCCCC	47.67	30059200
626	Phosphorylation	SLPFSLPSQMEPRPD CCCCCCCCCCCCCCC	47.67	28450419
639	Phosphorylation	PDVPRLGSTFSLDTS CCCCCCCCCEEECCC	30.76	11024037
640	Phosphorylation	DVPRLGSTFSLDTSM CCCCCCCCEEECCCC	18.55	28464451
642	Phosphorylation	PRLGSTFSLDTSMSM CCCCCCEEECCCCCC	25.98	21712546
645	Phosphorylation	GSTFSLDTSMSMNSS CCCEEECCCCCCCCC	31.46	28450419
646	Phosphorylation	STFSLDTSMSMNSSP CCEEECCCCCCCCCC	14.45	28450419
648	Phosphorylation	FSLDTSMSMNSSPLV EEECCCCCCCCCCCC	17.99	28464451
651	Phosphorylation	DTSMSMNSSPLVGPE CCCCCCCCCCCCCCC	25.37	28450419
652	Phosphorylation	TSMSMNSSPLVGPEC CCCCCCCCCCCCCCC	19.76	28464451
667	Phosphorylation	DHPKIKPSSSANAIY CCCCCCCCCHHHHHH	31.74	23401153
668	Phosphorylation	HPKIKPSSSANAIYS CCCCCCCCHHHHHHH	41.83	21945579
669	Phosphorylation	PKIKPSSSANAIYSL CCCCCCCHHHHHHHH	29.85	25159151
674	Phosphorylation	SSSANAIYSLAARPL CCHHHHHHHHHCCCC	8.67	25159151
675	Phosphorylation	SSANAIYSLAARPLP CHHHHHHHHHCCCCC	12.86	21945579
698	Phosphorylation	QCEGEEDTEYMTPSS CCCCCCCCCCCCCCC	32.09	30576142
699	Phosphorylation	CEGEEDTEYMTPSSR CCCCCCCCCCCCCCC	45.70	17016520
700	Phosphorylation	EGEEDTEYMTPSSRP CCCCCCCCCCCCCCC	14.37	9525940
702	Phosphorylation	EEDTEYMTPSSRPLR CCCCCCCCCCCCCCC	21.08	30576142
704	Phosphorylation	DTEYMTPSSRPLRPL CCCCCCCCCCCCCCC	29.79	30576142
705	Phosphorylation	TEYMTPSSRPLRPLD CCCCCCCCCCCCCCC	38.84	30576142
713	Phosphorylation	RPLRPLDTSQSSRAC CCCCCCCCCCCCCCC	36.03	26552605
714	Phosphorylation	PLRPLDTSQSSRACD CCCCCCCCCCCCCCC	27.94	25159151
716	Phosphorylation	RPLDTSQSSRACDCD CCCCCCCCCCCCCCC	22.89	27050516
717	Phosphorylation	PLDTSQSSRACDCDQ CCCCCCCCCCCCCCH	19.09	26552605
731	Phosphorylation	QQIDSCTYEAMYNIQ HHHHHHHHHHHHHHH	13.15	9525940
735	Phosphorylation	SCTYEAMYNIQSQAP HHHHHHHHHHHHCCC	19.03	22817900
762	Phosphorylation	LAAAHANTGPEESEN CHHHHCCCCCCCCCC	55.70	26074081
767	Phosphorylation	ANTGPEESENEDDGY CCCCCCCCCCCCCCC	44.02	26657352
774	Phosphorylation	SENEDDGYDVPKPPV CCCCCCCCCCCCCCC	22.29	9525940
789	Phosphorylation	PAVLARRTLSDISNA CHHHHHCCHHHHCCC	25.67	26074081
791	Phosphorylation	VLARRTLSDISNASS HHHHCCHHHHCCCCC	32.08	28464451
794	Phosphorylation	RRTLSDISNASSSFG HCCHHHHCCCCCCCC	31.19	26074081
797	Phosphorylation	LSDISNASSSFGWLS HHHHCCCCCCCCCEE	30.66	26074081
798	Phosphorylation	SDISNASSSFGWLSL HHHCCCCCCCCCEEC	27.55	26074081
799	Phosphorylation	DISNASSSFGWLSLD HHCCCCCCCCCEECC	25.86	26074081
804	Phosphorylation	SSSFGWLSLDGDPTT CCCCCCEECCCCCCC	20.22	28270605
833	Phosphorylation	PFPRRINSERKAGSC CCCCCCCCCCCCCCC	36.09	28102081
866	Phosphorylation	SEIENLMSQGYSYQD HHHHHHHHCCCCHHH	24.50	-
887	Sulfoxidation	IAQNNIEMAKNILRE HHHHHHHHHHHHHHH	5.95	21406390
897	Phosphorylation	NILREFVSISSPAHV HHHHHHHHCCCCCCC	23.29	22199227
899	Phosphorylation	LREFVSISSPAHVAT HHHHHHCCCCCCCCC	23.82	25159151
900	Phosphorylation	REFVSISSPAHVAT- HHHHHCCCCCCCCC-	25.16	25159151
906	Phosphorylation	SSPAHVAT------- CCCCCCCC-------	37.75	22199227

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
371	Y	Phosphorylation	Kinase	EGFR	Q01279	PSP
371	Y	Phosphorylation	Kinase	LYN	P07948	PSP
371	Y	Phosphorylation	Kinase	INSR	P06213	Uniprot
371	Y	Phosphorylation	Kinase	INSR	P15127	PSP
700	Y	Phosphorylation	Kinase	ABL1	P00520	GPS
700	Y	Phosphorylation	Kinase	FYN	P06241	PSP
700	Y	Phosphorylation	Kinase	INSR	P06213	PhosphoELM
700	Y	Phosphorylation	Kinase	INSR	P15127	PSP
700	Y	Phosphorylation	Kinase	YES1	P07947	GPS
700	Y	Phosphorylation	Kinase	SYK	P43405	PSP
700	Y	Phosphorylation	Kinase	ABL1	P00519	Uniprot
700	Y	Phosphorylation	Kinase	LCK	P06239	PSP
700	Y	Phosphorylation	Kinase	SYK	Q15046	PhosphoELM
731	Y	Phosphorylation	Kinase	SYK	Q15046	PhosphoELM
731	Y	Phosphorylation	Kinase	SRC	P12931	Uniprot
731	Y	Phosphorylation	Kinase	LCK	P06239	PSP
731	Y	Phosphorylation	Kinase	SYK	P43405	PSP
731	Y	Phosphorylation	Kinase	FYN	P06241	PSP
731	Y	Phosphorylation	Kinase	YES1	P07947	GPS
774	Y	Phosphorylation	Kinase	YES1	P07947	GPS
774	Y	Phosphorylation	Kinase	SYK	P43405	PSP
774	Y	Phosphorylation	Kinase	SYK	Q15046	PhosphoELM
774	Y	Phosphorylation	Kinase	SRC	P12931	PSP
774	Y	Phosphorylation	Kinase	LCK	P06239	PSP
774	Y	Phosphorylation	Kinase	INSR	P15127	PSP
774	Y	Phosphorylation	Kinase	FYN	P06241	PSP
774	Y	Phosphorylation	Kinase	ABL1	P00520	GPS
-	K	Ubiquitination	E3 ubiquitin ligase	ITCH	Q96J02	PMID:12226085

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of CBL_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of CBL_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ZAP70_HUMAN	ZAP70	physical	8798643
PGFRA_HUMAN	PDGFRA	physical	9234717
CRKL_HUMAN	CRKL	physical	10907644
P85A_MOUSE	Pik3r1	physical	9174058
GRB2_HUMAN	GRB2	physical	9174058
HCK_HUMAN	HCK	physical	11896602
FAK2_HUMAN	PTK2B	physical	15128873
SRBS2_HUMAN	SORBS2	physical	15128873
SRBS1_HUMAN	SORBS1	physical	15128873
CD2AP_HUMAN	CD2AP	physical	15128873
CRKL_HUMAN	CRKL	physical	9820532
SH3K1_HUMAN	SH3KBP1	physical	11071869
P85B_HUMAN	PIK3R2	physical	11133830
CRKL_HUMAN	CRKL	physical	11133830
SLAP1_HUMAN	SLA	physical	10449770
CRKL_HUMAN	CRKL	physical	9590251
GRB2_HUMAN	GRB2	physical	10086340
PTN6_HUMAN	PTPN6	physical	12176909
HCK_HUMAN	HCK	physical	10092522
SPY2_HUMAN	SPRY2	physical	11053437
CSF1R_HUMAN	CSF1R	physical	11847211
ZAP70_HUMAN	ZAP70	physical	10078535
SH3G3_HUMAN	SH3GL3	physical	11894096
SH3K1_HUMAN	SH3KBP1	physical	11894096
MET_HUMAN	MET	physical	11894096
KSYK_HUMAN	SYK	physical	9857068
GRB2_HUMAN	GRB2	physical	11997436
FRS2_HUMAN	FRS2	physical	11997436
UB2L3_HUMAN	UBE2L3	physical	10531381
CRKL_HUMAN	CRKL	physical	12244174
GRB2_HUMAN	GRB2	physical	9367879
1433B_HUMAN	YWHAB	physical	9367879
1433Z_HUMAN	YWHAZ	physical	9367879
VAV_HUMAN	VAV1	physical	9200440
LCP2_HUMAN	LCP2	physical	10477741
VAV_HUMAN	VAV1	physical	11331248
KSYK_HUMAN	SYK	physical	11331248
SRBS2_HUMAN	SORBS2	physical	12475393
ABL1_HUMAN	ABL1	physical	12475393
SLAP2_HUMAN	SLA2	physical	11891219
SHIP2_HUMAN	INPPL1	physical	12504111
SRBS1_HUMAN	SORBS1	physical	12504111
GRB2_HUMAN	GRB2	physical	10570290
SHC1_HUMAN	SHC1	physical	10570290
CRKL_HUMAN	CRKL	physical	10204582
NCK1_HUMAN	NCK1	physical	10204582
GRB2_HUMAN	GRB2	physical	10204582
PLCG1_HUMAN	PLCG1	physical	12061819
SH3K1_HUMAN	SH3KBP1	physical	11894095
SPY2_HUMAN	SPRY2	physical	12234920
UB2L3_HUMAN	UBE2L3	physical	12234920
SHC1_HUMAN	SHC1	physical	9461587
GRB2_HUMAN	GRB2	physical	9461587
P85A_HUMAN	PIK3R1	physical	9461587
P85A_HUMAN	PIK3R1	physical	9918857
SH3K1_HUMAN	SH3KBP1	physical	12177062
SH3K1_HUMAN	SH3KBP1	physical	11152963
FAK2_HUMAN	PTK2B	physical	11149930
CSK_HUMAN	CSK	physical	11149930
ABL1_HUMAN	ABL1	physical	11494134
1433T_HUMAN	YWHAQ	physical	8663231
IGF1R_HUMAN	IGF1R	physical	18632619
ARHG7_HUMAN	ARHGEF7	physical	12935897
PTN11_HUMAN	PTPN11	physical	18519587
UB2D1_HUMAN	UBE2D1	physical	18508924
SPY4_HUMAN	SPRY4	physical	18273061
UBC_HUMAN	UBC	physical	17679095
CBL_HUMAN	CBL	physical	17679095
CBL_HUMAN	CBL	physical	17635922
PLCG1_HUMAN	PLCG1	physical	17372230
VGFR2_HUMAN	KDR	physical	17372230
ITSN1_HUMAN	ITSN1	physical	16914641
RON_HUMAN	MST1R	physical	16740632
UB2L3_HUMAN	UBE2L3	physical	16735510
UBC12_HUMAN	UBE2M	physical	16735510
ARHG7_HUMAN	ARHGEF7	physical	16407834
SH3K1_HUMAN	SH3KBP1	physical	16407834
MET_HUMAN	MET	physical	16397241
SLAP1_HUMAN	SLA	physical	16327786
SPY2_HUMAN	SPRY2	physical	16246327
UFO_HUMAN	AXL	physical	15958209
SH2B2_HUMAN	SH2B2	physical	15737992
ITA5_HUMAN	ITGA5	physical	15728256
KSYK_HUMAN	SYK	physical	15577829
SH3K1_HUMAN	SH3KBP1	physical	15456872
TNR16_RAT	Ngfr	physical	15337528
SH3K1_HUMAN	SH3KBP1	physical	12135478
UBS3A_HUMAN	UBASH3A	physical	15159412
MET_HUMAN	MET	physical	15123609
SH3K1_HUMAN	SH3KBP1	physical	15107835
UBS3A_HUMAN	UBASH3A	physical	15107835
G3P_HUMAN	GAPDH	physical	15107835
CRKL_HUMAN	CRKL	physical	15107835
P85B_HUMAN	PIK3R2	physical	15107835
P85A_HUMAN	PIK3R1	physical	15107835
EF1A1_HUMAN	EEF1A1	physical	15107835
RON_HUMAN	MST1R	physical	12802274
SPY2_HUMAN	SPRY2	physical	12593796
SPY2_HUMAN	SPRY2	physical	12593795
SRC_HUMAN	SRC	physical	11994282
P85A_HUMAN	PIK3R1	physical	11994282
SPY2_HUMAN	SPRY2	physical	11983899
CSF1R_HUMAN	CSF1R	physical	11850825
GRB2_HUMAN	GRB2	physical	11823423
KSYK_HUMAN	SYK	physical	11742985
CD3Z_HUMAN	CD247	physical	11353765
ZAP70_HUMAN	ZAP70	physical	11353765
P85A_HUMAN	PIK3R1	physical	11087752
PGFRB_MOUSE	Pdgfrb	physical	10347229
P85A_HUMAN	PIK3R1	physical	21203488
MYH9_HUMAN	MYH9	physical	21203488
ACTS_HUMAN	ACTA1	physical	21203488
ACTB_HUMAN	ACTB	physical	21203488
ACTH_HUMAN	ACTG2	physical	21203488
VIME_HUMAN	VIM	physical	21203488
HSP74_HUMAN	HSPA4	physical	21203488
GRP78_HUMAN	HSPA5	physical	21203488
EPHB1_HUMAN	EPHB1	physical	18034775
IL7RA_HUMAN	IL7R	physical	20404156
CD33_HUMAN	CD33	physical	18062779
EGFR_HUMAN	EGFR	physical	20124286
SHIP2_HUMAN	INPPL1	physical	19880507
CFTR_HUMAN	CFTR	physical	20525683
PRS8_HUMAN	PSMC5	physical	20479273
TIE2_HUMAN	TEK	physical	19689429
BAG1_HUMAN	BAG1	physical	20675402
SPY2_HUMAN	SPRY2	physical	20877636
EGFR_HUMAN	EGFR	physical	20877636
SPY2_HUMAN	SPRY2	physical	21596750
FAK1_HUMAN	PTK2	physical	22203672
PAXI_HUMAN	PXN	physical	22203672
EGFR_HUMAN	EGFR	physical	22203672
SRC_HUMAN	SRC	physical	22203672
UBC_HUMAN	UBC	physical	15273720
GRB2_HUMAN	GRB2	physical	15210722
VAV2_HUMAN	VAV2	physical	20940296
EGFR_HUMAN	EGFR	physical	20940296
EGFR_HUMAN	EGFR	physical	14627991
RET_HUMAN	RET	physical	12727845
IRS1_HUMAN	IRS1	physical	10854852
CFTR_HUMAN	CFTR	physical	22467879
SH3K1_HUMAN	SH3KBP1	physical	21830225
SH3K1_HUMAN	SH3KBP1	physical	19417776
SH3K1_HUMAN	SH3KBP1	physical	12874286
CBL_HUMAN	CBL	physical	12874286
SH3K1_HUMAN	SH3KBP1	physical	12618476
SH3K1_HUMAN	SH3KBP1	physical	10679202
CRK_HUMAN	CRK	physical	8943292
GRB2_HUMAN	GRB2	physical	8943292
SHC1_HUMAN	SHC1	physical	9434624
MK14_HUMAN	MAPK14	physical	9434624
GRB2_HUMAN	GRB2	physical	9434624
PLCG1_HUMAN	PLCG1	physical	12941616
NCK1_HUMAN	NCK1	physical	9851874
CRKL_HUMAN	CRKL	physical	9851874
GRB2_HUMAN	GRB2	physical	9851874
MK08_HUMAN	MAPK8	physical	11944898
P85A_HUMAN	PIK3R1	physical	11944898
BLNK_HUMAN	BLNK	physical	10684856
P85A_HUMAN	PIK3R1	physical	9414268
TBB5_HUMAN	TUBB	physical	15878338
CSF1R_HUMAN	CSF1R	physical	10025673
SOS1_HUMAN	SOS1	physical	10025673
P85A_HUMAN	PIK3R1	physical	10025673
SHC1_HUMAN	SHC1	physical	10025673
GRB2_HUMAN	GRB2	physical	10025673
GRB2_HUMAN	GRB2	physical	9716598
KSYK_HUMAN	SYK	physical	10570266
1433T_HUMAN	YWHAQ	physical	15094368
NCK1_HUMAN	NCK1	physical	10372803
P85A_HUMAN	PIK3R1	physical	11042121
KSYK_HUMAN	SYK	physical	11042121
CRK_HUMAN	CRK	physical	12393469
SRBS1_HUMAN	SORBS1	physical	17548467
KSYK_HUMAN	SYK	physical	15536084
P85A_HUMAN	PIK3R1	physical	8941725
SMAD3_HUMAN	SMAD3	physical	22310290
CRK_HUMAN	CRK	physical	10962563
ZAP70_HUMAN	ZAP70	physical	10779765
GRB2_HUMAN	GRB2	physical	9311917
CRKL_HUMAN	CRKL	physical	9311917
P85A_HUMAN	PIK3R1	physical	7791764
GRB2_HUMAN	GRB2	physical	9129019
P85A_HUMAN	PIK3R1	physical	9890943
LYN_HUMAN	LYN	physical	9160881
ABL1_HUMAN	ABL1	physical	19823681
ARHG7_HUMAN	ARHGEF7	physical	22588125
P85A_HUMAN	PIK3R1	physical	8896416
SH2B2_HUMAN	SH2B2	physical	9989826
FYN_HUMAN	FYN	physical	10629042
ABL1_HUMAN	ABL1	physical	10829062
SRC_HUMAN	SRC	physical	10829062
PTN11_HUMAN	PTPN11	physical	17330819
EGFR_HUMAN	EGFR	physical	11239464
EPHA2_HUMAN	EPHA2	physical	12147253
P85A_HUMAN	PIK3R1	physical	8702998
RPGF1_HUMAN	RAPGEF1	physical	10608804
CBL_HUMAN	CBL	physical	10521482
IF_HUMAN	GIF	physical	11788601
TCO1_HUMAN	TCN1	physical	11788601
TCO2_HUMAN	TCN2	physical	11788601
SLAP2_HUMAN	SLA2	physical	12527895
EPHA2_HUMAN	EPHA2	physical	22509030
MYH2_HUMAN	MYH2	physical	22509030
ZAP70_HUMAN	ZAP70	physical	16503409
NCK1_HUMAN	NCK1	physical	16503409
CRKL_HUMAN	CRKL	physical	16503409
PLCG1_HUMAN	PLCG1	physical	16503409
FYB1_HUMAN	FYB	physical	16503409
UBS3A_HUMAN	UBASH3A	physical	16429130
SRC_HUMAN	SRC	physical	17094785
UBC_HUMAN	UBC	physical	15117950
EGFR_HUMAN	EGFR	physical	15117950
GRB2_HUMAN	GRB2	physical	17944804
SPY2_HUMAN	SPRY2	physical	17255109
SH3K1_HUMAN	SH3KBP1	physical	22833562
STAP2_HUMAN	STAP2	physical	17675501
FAK1_HUMAN	PTK2	physical	17675501
CRKL_HUMAN	CRKL	physical	10657627
EGFR_HUMAN	EGFR	physical	12803489
P85A_HUMAN	PIK3R1	physical	10620516
VGFR2_HUMAN	KDR	physical	20011623
MK14_HUMAN	MAPK14	physical	19635790
CD38_HUMAN	CD38	physical	19635790
VAV_HUMAN	VAV1	physical	19635790
LCP2_HUMAN	LCP2	physical	19635790
GRB2_HUMAN	GRB2	physical	8824292
GRB2_HUMAN	GRB2	physical	14725908
ABL1_HUMAN	ABL1	physical	14725908
BCR_HUMAN	BCR	physical	14725908
FYN_HUMAN	FYN	physical	8900205
GRB2_HUMAN	GRB2	physical	8900205
LCK_HUMAN	LCK	physical	8900205
GRB2_HUMAN	GRB2	physical	9259313
P85A_HUMAN	PIK3R1	physical	9259313
P85A_HUMAN	PIK3R1	physical	9174058
P85A_HUMAN	PIK3R1	physical	17237826
SLAP1_HUMAN	SLA	physical	17237826
CRK_HUMAN	CRK	physical	9988765
CRKL_HUMAN	CRKL	physical	9988765
GRB2_HUMAN	GRB2	physical	8649804
P85A_HUMAN	PIK3R1	physical	19190244
P85B_HUMAN	PIK3R2	physical	19190244
UBS3B_HUMAN	UBASH3B	physical	17675467
1433T_HUMAN	YWHAQ	physical	9092538
GRB2_HUMAN	GRB2	physical	9092538
P85A_HUMAN	PIK3R1	physical	9092538
CBL_HUMAN	CBL	physical	22301280
SRC_HUMAN	SRC	physical	7782294
ZAP70_HUMAN	ZAP70	physical	9988730
P85A_HUMAN	PIK3R1	physical	8612729
SRBS1_MOUSE	Sorbs1	physical	9447983
OSTF1_HUMAN	OSTF1	physical	15135048
CRK_HUMAN	CRK	physical	16289966
VAV_HUMAN	VAV1	physical	16289966
EPHA2_HUMAN	EPHA2	physical	12496371
GRB2_HUMAN	GRB2	physical	7537740
EGFR_HUMAN	EGFR	physical	7592693
GRB2_HUMAN	GRB2	physical	7592693
P85A_HUMAN	PIK3R1	physical	8695807
ABL1_HUMAN	ABL1	physical	9195915
CRKL_HUMAN	CRKL	physical	9195915
P85A_HUMAN	PIK3R1	physical	8995243
CD38_HUMAN	CD38	physical	18974118
PK3CA_HUMAN	PIK3CA	physical	9119889
PTN11_HUMAN	PTPN11	physical	11157475
PK3CA_HUMAN	PIK3CA	physical	11157475
CRKL_HUMAN	CRKL	physical	11157475
1433B_HUMAN	YWHAB	physical	11157475
CRKL_HUMAN	CRKL	physical	15556646
P85A_HUMAN	PIK3R1	physical	15556646
KSYK_HUMAN	SYK	physical	10617633
BLK_HUMAN	BLK	physical	8621719
KSYK_HUMAN	SYK	physical	8621719
FYN_HUMAN	FYN	physical	8621719
GRB2_HUMAN	GRB2	physical	8621719
P85A_HUMAN	PIK3R1	physical	8621719
P85A_HUMAN	PIK3R1	physical	11157475
GRB2_HUMAN	GRB2	physical	8695851
CUBN_HUMAN	CUBN	physical	15736970
EGFR_HUMAN	EGFR	physical	22394513
CD2AP_HUMAN	CD2AP	physical	17072306
SH3K1_HUMAN	SH3KBP1	physical	17072306
GRB2_HUMAN	GRB2	physical	17072306
SNX18_HUMAN	SNX18	physical	17072306
K1C10_HUMAN	KRT10	physical	19380743
K2C1_HUMAN	KRT1	physical	19380743
K22E_HUMAN	KRT2	physical	19380743
HSP7C_HUMAN	HSPA8	physical	19380743
P85B_HUMAN	PIK3R2	physical	19380743
PK3CB_HUMAN	PIK3CB	physical	19380743
SHIP2_HUMAN	INPPL1	physical	19380743
SPTB2_HUMAN	SPTBN1	physical	19380743
K2C6C_HUMAN	KRT6C	physical	19380743
K2C6B_HUMAN	KRT6B	physical	19380743
K1C9_HUMAN	KRT9	physical	19380743
K1C14_HUMAN	KRT14	physical	19380743
TBB5_HUMAN	TUBB	physical	19380743
K2C5_HUMAN	KRT5	physical	19380743
ACACA_HUMAN	ACACA	physical	19380743
K1C16_HUMAN	KRT16	physical	19380743
BCR_HUMAN	BCR	physical	19380743
P85A_HUMAN	PIK3R1	physical	19380743
TBB4B_HUMAN	TUBB4B	physical	19380743
K2C6A_HUMAN	KRT6A	physical	19380743
ACTB_HUMAN	ACTB	physical	19380743
CRK_HUMAN	CRK	physical	19380743
TBA1C_HUMAN	TUBA1C	physical	19380743
GRB2_HUMAN	GRB2	physical	19380743
PK3CA_HUMAN	PIK3CA	physical	19380743
GRP75_HUMAN	HSPA9	physical	19380743
GRP78_HUMAN	HSPA5	physical	19380743
HS71L_HUMAN	HSPA1L	physical	19380743
MYH10_HUMAN	MYH10	physical	19380743
IQGA1_HUMAN	IQGAP1	physical	19380743
K1C17_HUMAN	KRT17	physical	19380743
SPTA1_HUMAN	SPTA1	physical	19380743
ABL1_HUMAN	ABL1	physical	19380743
SHC1_HUMAN	SHC1	physical	19380743
SPTN1_HUMAN	SPTAN1	physical	19380743
HSP76_HUMAN	HSPA6	physical	19380743
TCPQ_HUMAN	CCT8	physical	19380743
K2C79_HUMAN	KRT79	physical	19380743
CSK_HUMAN	CSK	physical	19380743
RS19_HUMAN	RPS19	physical	19380743
CBLB_HUMAN	CBLB	physical	19380743
KRT84_HUMAN	KRT84	physical	19380743
COR1C_HUMAN	CORO1C	physical	19380743
RO52_HUMAN	TRIM21	physical	19380743
K2C3_HUMAN	KRT3	physical	19380743
PYR1_HUMAN	CAD	physical	19380743
1433B_HUMAN	YWHAB	physical	19380743
ACTN1_HUMAN	ACTN1	physical	19380743
MYO1C_HUMAN	MYO1C	physical	19380743
MYH9_HUMAN	MYH9	physical	19380743
POP1_HUMAN	POP1	physical	19380743
1433T_HUMAN	YWHAQ	physical	19380743
FYN_HUMAN	FYN	physical	7642581
GRB2_HUMAN	GRB2	physical	7642581
P85A_HUMAN	PIK3R1	physical	7642581
CRK_HUMAN	CRK	physical	9617486
FYN_HUMAN	FYN	physical	12231245
KPCT_HUMAN	PRKCQ	physical	10358153
P85A_HUMAN	PIK3R1	physical	10358153
M3K11_HUMAN	MAP3K11	physical	19546888
P85A_HUMAN	PIK3R1	physical	9541596
GRB2_HUMAN	GRB2	physical	9541596
GRB2_HUMAN	GRB2	physical	8995358
CSF1R_HUMAN	CSF1R	physical	10648820
ABL1_HUMAN	ABL1	physical	14604282
VAV_HUMAN	VAV1	physical	18835194
CRK_HUMAN	CRK	physical	18835194
CRKL_HUMAN	CRKL	physical	18835194
RPGF1_HUMAN	RAPGEF1	physical	18835194
UB2D2_HUMAN	UBE2D2	physical	22266821
ZAP70_HUMAN	ZAP70	physical	22266821
CBL_HUMAN	CBL	physical	22266821
EGFR_HUMAN	EGFR	physical	22266821
UB2D1_HUMAN	UBE2D1	physical	18632619
UB2D2_HUMAN	UBE2D2	physical	18632619
UB2D2_HUMAN	UBE2D2	physical	15117950
UB2D2_HUMAN	UBE2D2	physical	22301280
UB2D1_HUMAN	UBE2D1	physical	20675402
UB2D2_HUMAN	UBE2D2	physical	20675402
UB2D3_HUMAN	UBE2D3	physical	20675402
KIT_HUMAN	KIT	physical	8950973
GRB2_HUMAN	GRB2	physical	8950973
SHC1_HUMAN	SHC1	physical	8950973
MET_HUMAN	MET	physical	21222362
PAXI_HUMAN	PXN	physical	8641358
EGFR_HUMAN	EGFR	physical	10635327
CRK_HUMAN	CRK	physical	22974441
HCK_HUMAN	HCK	physical	22974441
EGFR_HUMAN	EGFR	physical	23153581
EGFR_HUMAN	EGFR	physical	23175185
CD5_HUMAN	CD5	physical	23376399
EGFR_HUMAN	EGFR	physical	23418353
PLCG1_HUMAN	PLCG1	physical	16467851
RET_HUMAN	RET	physical	15677445
EGFR_HUMAN	EGFR	physical	15677445
GRB2_HUMAN	GRB2	physical	15677445
MET_HUMAN	MET	physical	21163258
EGFR_HUMAN	EGFR	physical	8662998
SHC1_HUMAN	SHC1	physical	8662998
GRB2_HUMAN	GRB2	physical	8662998
P85A_HUMAN	PIK3R1	physical	8662998
PTEN_HUMAN	PTEN	physical	23118026
EPHB1_HUMAN	EPHB1	physical	23118026
CTNB1_HUMAN	CTNNB1	physical	23744067
CBL_HUMAN	CBL	physical	23744067
EGFR_HUMAN	EGFR	physical	23799367
UB2D3_HUMAN	UBE2D3	physical	23799367
EGFR_HUMAN	EGFR	physical	9121472
EGFR_HUMAN	EGFR	physical	23897813
TRAF4_HUMAN	TRAF4	physical	22493164
TRIM8_HUMAN	TRIM8	physical	22493164
FLT3_HUMAN	FLT3	physical	17446348
P85A_HUMAN	PIK3R1	physical	24113870
UB2D2_HUMAN	UBE2D2	physical	24113870
NCK1_HUMAN	NCK1	physical	24287595
NCK2_HUMAN	NCK2	physical	24287595
ERBB2_HUMAN	ERBB2	physical	12574167
UBC_HUMAN	UBC	physical	14661060
GRB2_HUMAN	GRB2	physical	25036637
SH3K1_HUMAN	SH3KBP1	physical	25036637
1433E_HUMAN	YWHAE	physical	25036637
CAZA1_HUMAN	CAPZA1	physical	25036637
CD2AP_HUMAN	CD2AP	physical	25036637
KPRB_HUMAN	PRPSAP2	physical	25036637
1433F_HUMAN	YWHAH	physical	25036637
SIR2_HUMAN	SIRT2	physical	25285640
ABL1_HUMAN	ABL1	physical	20675402
BCR_HUMAN	BCR	physical	20675402
TGFR2_HUMAN	TGFBR2	physical	23290524
UBC12_HUMAN	UBE2M	physical	23290524
UBC_HUMAN	UBC	physical	23851457
EGFR_HUMAN	EGFR	physical	10428778
PGFRA_MOUSE	Pdgfra	physical	10347229
SMAD7_HUMAN	SMAD7	physical	26055326
P85A_HUMAN	PIK3R1	physical	25814554
P55G_HUMAN	PIK3R3	physical	25814554
CRKL_HUMAN	CRKL	physical	25814554
FYN_HUMAN	FYN	physical	25814554
MZF1_HUMAN	MZF1	physical	25814554
KPCA_HUMAN	PRKCA	physical	25814554
IPSP_HUMAN	SERPINA5	physical	25814554
CBL_HUMAN	CBL	physical	25814554
PLCG1_HUMAN	PLCG1	physical	25241761
MET_HUMAN	MET	physical	25241761
SP7_HUMAN	SP7	physical	25744063
CTNB1_HUMAN	CTNNB1	physical	25784557
CBL_HUMAN	CBL	physical	25784557
ARHG6_HUMAN	ARHGEF6	physical	26177020
UBC_HUMAN	UBC	physical	26548852
DOK3_MOUSE	Dok3	physical	26548852
CBLB_HUMAN	CBLB	physical	27048651
TGM2_HUMAN	TGM2	physical	23770238
EGFR_HUMAN	EGFR	physical	27059931
UB2D2_HUMAN	UBE2D2	physical	27609087
UBC_HUMAN	UBC	physical	27609087
EPS8_HUMAN	EPS8	physical	27629044
IRF3_HUMAN	IRF3	physical	27503123
TR10B_HUMAN	TNFRSF10B	physical	28972304
TRAF2_HUMAN	TRAF2	physical	28972304
UBC_HUMAN	UBC	physical	28319114
CBL_HUMAN	CBL	physical	29053960
ZAP70_HUMAN	ZAP70	physical	29053960

Drug and Disease Associations

Kegg Disease
H00523	Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noona
OMIM Disease
613563	Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia (NSLL)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of CBL_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-197, AND MASS SPECTROMETRY.	19608861 [Abstract]
Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-452, AND MASSSPECTROMETRY.	19690332 [Abstract]
"A probability-based approach for high-throughput proteinphosphorylation analysis and site localization."; Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; Nat. Biotechnol. 24:1285-1292(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-900, AND MASSSPECTROMETRY.	16964243 [Abstract]
"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry."; Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.; Nat. Methods 2:591-598(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-667 AND SER-675, ANDMASS SPECTROMETRY.	16094384 [Abstract]
"Profiling of tyrosine phosphorylation pathways in human cells usingmass spectrometry."; Salomon A.R., Ficarro S.B., Brill L.M., Brinker A., Phung Q.T.,Ericson C., Sauer K., Brock A., Horn D.M., Schultz P.G., Peters E.C.; Proc. Natl. Acad. Sci. U.S.A. 100:443-448(2003). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-669 AND TYR-674, ANDMASS SPECTROMETRY.	12522270 [Abstract]
"An extensive survey of tyrosine phosphorylation revealing new sitesin human mammary epithelial cells."; Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A.,Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D.,Wiley H.S., Qian W.-J.; J. Proteome Res. 8:3852-3861(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-141; TYR-674 ANDTYR-774, AND MASS SPECTROMETRY.	19534553 [Abstract]
"Multiple reaction monitoring for robust quantitative proteomicanalysis of cellular signaling networks."; Wolf-Yadlin A., Hautaniemi S., Lauffenburger D.A., White F.M.; Proc. Natl. Acad. Sci. U.S.A. 104:5860-5865(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-455; TYR-552 ANDTYR-700, AND MASS SPECTROMETRY.	17389395 [Abstract]
"Immunoaffinity profiling of tyrosine phosphorylation in cancercells."; Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H.,Zha X.-M., Polakiewicz R.D., Comb M.J.; Nat. Biotechnol. 23:94-101(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-674, AND MASSSPECTROMETRY.	15592455 [Abstract]
"Time-resolved mass spectrometry of tyrosine phosphorylation sites inthe epidermal growth factor receptor signaling network reveals dynamicmodules."; Zhang Y., Wolf-Yadlin A., Ross P.L., Pappin D.J., Rush J.,Lauffenburger D.A., White F.M.; Mol. Cell. Proteomics 4:1240-1250(2005). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-371 AND TYR-552, ANDMASS SPECTROMETRY.	15951569 [Abstract]
"Src kinase activity is essential for osteoclast function."; Miyazaki T., Sanjay A., Neff L., Tanaka S., Horne W.C., Baron R.; J. Biol. Chem. 279:17660-17666(2004). Cited for: FUNCTION, PHOSPHORYLATION AT TYR-731, AND MUTAGENESIS OF TYR-731.	14739300 [Abstract]
"Catalytic domains of tyrosine kinases determine the phosphorylationsites within c-Cbl."; Grossmann A.H., Kolibaba K.S., Willis S.G., Corbin A.S., Langdon W.S.,Deininger M.W., Druker B.J.; FEBS Lett. 577:555-562(2004). Cited for: PHOSPHORYLATION AT TYR-700.	15556646 [Abstract]
"APS facilitates c-Cbl tyrosine phosphorylation and GLUT4translocation in response to insulin in 3T3-L1 adipocytes."; Liu J., Kimura A., Baumann C.A., Saltiel A.R.; Mol. Cell. Biol. 22:3599-3609(2002). Cited for: INTERACTION WITH SH2B2, MUTAGENESIS OF TYR-371; TYR-700; TYR-731 ANDTYR-774, AND PHOSPHORYLATION AT TYR-371; TYR-700 AND TYR-774.	11997497 [Abstract]