TNR16_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TNR16_RAT
• UniProt AC: P07174
• Protein Name: Tumor necrosis factor receptor superfamily member 16
• Gene Name: Ngfr
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 425
• Subcellular Localization: Membrane; Single-pass type I membrane protein.
• Protein Description: Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake. Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells. Necessary for the circadian oscillation of the clock genes ARNTL/BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver..
• Protein Sequence: MRRAGAACSAMDRLRLLLLLILGVSSGGAKETCSTGLYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDNVTFSDVVSATEPCKPCTECLGLQSMSAPCVEADDAVCRCAYGYYQDEETGHCEACSVCEVGSGLVFSCQDKQNTVCEECPEGTYSDEANHVDPCLPCTVCEDTERQLRECTPWADAECEEIPGRWIPRSTPPEGSDSTAPSTQEPEVPPEQDLVPSTVADMVTTVMGSSQPVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQTHTQTASGQALKGDGNLYSSLPLTKREEVEKLLNGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWGAQDSATLDALLAALRRIQRADIVESLCSESTATSPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
61	N-linked_Glycosylation	VAQPCGANQTVCEPC CCCCCCCCCCCCCCC	24.28	20036257
71	N-linked_Glycosylation	VCEPCLDNVTFSDVV CCCCCCCCCCHHHHC	23.06	-
278	Phosphorylation	IAFKRWNSCKQNKQG HHHHHHHHHHCCCCC	18.74	19710323
279	S-palmitoylation	AFKRWNSCKQNKQGA HHHHHHHHHCCCCCC	4.80	7982984
288	Phosphorylation	QNKQGANSRPVNQTP CCCCCCCCCCCCCCC	37.11	30240740
294	Phosphorylation	NSRPVNQTPPPEGEK CCCCCCCCCCCCCCC	32.34	28432305
304	Phosphorylation	PEGEKLHSDSGISVD CCCCCCCCCCCCCCC	43.86	28432305
306	Phosphorylation	GEKLHSDSGISVDSQ CCCCCCCCCCCCCCC	40.83	28432305
309	Phosphorylation	LHSDSGISVDSQSLH CCCCCCCCCCCCCCC	24.32	28432305
312	Phosphorylation	DSGISVDSQSLHDQQ CCCCCCCCCCCCCCC	21.36	28432305
314	Phosphorylation	GISVDSQSLHDQQTH CCCCCCCCCCCCCCC	31.46	28432305
320	Phosphorylation	QSLHDQQTHTQTASG CCCCCCCCCCCCCCC	22.66	28432305
337	Phosphorylation	LKGDGNLYSSLPLTK CCCCCCCCCCCCCCC	10.54	15337528

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TNR16_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TNR16_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TNR16_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MAGD1_MOUSE	Maged1	physical	10985348
BEX3_RAT	Ngfrap1	physical	17355907
NTRK1_RAT	Ntrk1	physical	19549834
PSN1_RAT	Psen1	physical	19549834

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.