NTRK1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: NTRK1_RAT
• UniProt AC: P35739
• Protein Name: High affinity nerve growth factor receptor
• Gene Name: Ntrk1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 799
• Subcellular Localization: Cell membrane ; Single-pass type I membrane protein . Early endosome membrane ; Single-pass type I membrane protein . Late endosome membrane ; Single-pass type I membrane protein . Internalized to endosomes upon binding of NGF or NTF3 and further tra
• Protein Description: Receptor tyrosine kinase involved in the development and the maturation of the central and peripheral nervous systems through regulation of proliferation, differentiation and survival of sympathetic and nervous neurons. High affinity receptor for NGF which is its primary ligand. [PubMed: 1312719]
• Protein Sequence: MLRGQRHGQLGWHRPAAGLGGLVTSLMLACACAASCRETCCPVGPSGLRCTRAGTLNTLRGLRGAGNLTELYVENQRDLQRLEFEDLQGLGELRSLTIVKSGLRFVAPDAFHFTPRLSHLNLSSNALESLSWKTVQGLSLQDLTLSGNPLHCSCALLWLQRWEQEDLCGVYTQKLQGSGSGDQFLPLGHNNSCGVPSVKIQMPNDSVEVGDDVFLQCQVEGQALQQADWILTELEGTATMKKSGDLPSLGLTLVNVTSDLNKKNVTCWAENDVGRAEVSVQVSVSFPASVHLGKAVEQHHWCIPFSVDGQPAPSLRWFFNGSVLNETSFIFTQFLESALTNETMRHGCLRLNQPTHVNNGNYTLLAANPYGQAAASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSRDPVEKKDETPFGVSVAVGLAVSAALFLSALLLVLNKCGQRSKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIMENPQYFSDTCVHHIKRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGRELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQALAQAPPSYLDVLG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
67	N-linked_Glycosylation	RGLRGAGNLTELYVE HCCCCCCCCEEEEEC	43.16	-
97	Phosphorylation	LGELRSLTIVKSGLR CHHHHHHEEEECCCE	25.60	26022182
121	N-linked_Glycosylation	TPRLSHLNLSSNALE CCCCCCCCCCCHHHH	32.24	-
190	N-linked_Glycosylation	QFLPLGHNNSCGVPS CEEECCCCCCCCCCE	40.07	-
204	N-linked_Glycosylation	SVKIQMPNDSVEVGD EEEEECCCCCEEECC	49.17	-
255	N-linked_Glycosylation	SLGLTLVNVTSDLNK CCCEEEEEECCCCCC	34.17	-
264	N-linked_Glycosylation	TSDLNKKNVTCWAEN CCCCCCCCCEEEEEC	35.62	-
320	N-linked_Glycosylation	PSLRWFFNGSVLNET CCEEEEECCCCCCCC	32.15	-
325	N-linked_Glycosylation	FFNGSVLNETSFIFT EECCCCCCCCHHHHH	48.63	-
341	N-linked_Glycosylation	FLESALTNETMRHGC HHHHHHCCHHHHCCE	43.52	-
361	N-linked_Glycosylation	PTHVNNGNYTLLAAN CCEEECCCEEEEEEC	28.83	-
404	N-linked_Glycosylation	SFSPVDTNSTSRDPV CCCCCCCCCCCCCCC	38.53	-
485	Ubiquitination	SLSPTEGKGSGLQGH CCCCCCCCCCCCCCC	43.61	-
499	Phosphorylation	HIMENPQYFSDTCVH CCCCCCCCCCCCHHH	13.30	12067229
679	Phosphorylation	FGMSRDIYSTDYYRV CCCCCCCEECCCEEE	15.14	22817900
683	Phosphorylation	RDIYSTDYYRVGGRT CCCEECCCEEECCEE	8.02	15753086
684	Phosphorylation	DIYSTDYYRVGGRTM CCEECCCEEECCEEE	11.13	15753086
760	Phosphorylation	RACPPDVYAIMRGCW CCCCHHHHHHHCCHH	9.59	8156997
794	Phosphorylation	LAQAPPSYLDVLG-- HHHCCCHHHHCCC--	16.82	8156997

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	Nedd4	Q62940	PMID:22199232

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of NTRK1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of NTRK1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SQSTM_RAT	Sqstm1	physical	18174161
CYLD_RAT	Cyld	physical	18174161
UBC_RAT	Ubc	physical	18419753
PRS7_RAT	Psmc2	physical	18419753
RAB7A_RAT	Rab7a	physical	18419753
PSB10_RAT	Psmb10	physical	18419753
TNR16_RAT	Ngfr	physical	16246731
TRAF6_RAT	Traf6	physical	16246731
SQSTM_RAT	Sqstm1	physical	16246731
SHC1_RAT	Shc1	physical	16246731
GIPC1_RAT	Gipc1	physical	16819522
MP2K2_RAT	Map2k2	physical	17380122
RASH_RAT	Hras	physical	17380122
RGS12_RAT	Rgs12	physical	17380122
TNR16_RAT	Ngfr	physical	19549834
TNR16_RAT	Ngfr	physical	25708205
SQSTM_RAT	Sqstm1	physical	25708205
TRAF6_RAT	Traf6	physical	25708205
SH2B3_RAT	Sh2b3	physical	22028877
SH2B1_RAT	Sh2b1	physical	22028877

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.