SHC1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SHC1_RAT
• UniProt AC: Q5M824
• Protein Name: SHC-transforming protein 1
• Gene Name: Shc1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 469
• Subcellular Localization: Cytoplasm.
• Protein Description: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity)..
• Protein Sequence: MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGAMRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEELPDHQYYNDFPGKEPPLGGVVDMRLREGAARPTLPSTQMPSHLGATLPIGQHVTGDHEVRKQMLPPPPCPGRELFDDPSYVNIQNLDKARQAGGGAGPPNPSVNGSAPRDLFDMKPFEDALRVPPAPQSMSMAEQLQGESWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVDRKV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
29	Phosphorylation	EEWTRHGSFVNKPTR CCCCCCCCCCCCCCC	21.64	29779826
35	Phosphorylation	GSFVNKPTRGWLHPN CCCCCCCCCCCCCCC	43.34	23984901
44	Acetylation	GWLHPNDKVMGPGVS CCCCCCCCCCCCCHH	40.54	-
214	Phosphorylation	RNPPKLVTPHDRMAG HCCCCCCCCCHHHCC	25.91	-
239	Phosphorylation	EELPDHQYYNDFPGK HHCCCCCCCCCCCCC	10.79	-
240	Phosphorylation	ELPDHQYYNDFPGKE HCCCCCCCCCCCCCC	11.16	-
266	Phosphorylation	REGAARPTLPSTQMP CCCCCCCCCCCCCCC	45.83	28432305
269	Phosphorylation	AARPTLPSTQMPSHL CCCCCCCCCCCCCCC	34.09	28432305
270	Phosphorylation	ARPTLPSTQMPSHLG CCCCCCCCCCCCCCC	27.26	28432305
274	Phosphorylation	LPSTQMPSHLGATLP CCCCCCCCCCCCCCC	26.46	28432305
279	Phosphorylation	MPSHLGATLPIGQHV CCCCCCCCCCCCCCC	31.13	28432305
287	Phosphorylation	LPIGQHVTGDHEVRK CCCCCCCCCCHHHHH	34.46	28432305
312	Phosphorylation	RELFDDPSYVNIQNL CCCCCCCCCCEEECH	49.02	27097102
313	Phosphorylation	ELFDDPSYVNIQNLD CCCCCCCCCEEECHH	11.69	27097102
335	Phosphorylation	GAGPPNPSVNGSAPR CCCCCCCCCCCCCCH	34.55	28432305
339	Phosphorylation	PNPSVNGSAPRDLFD CCCCCCCCCCHHHCC	29.87	28432305
399	Phosphorylation	GDFLVRESTTTPGQY CCEEEEECCCCCCEE	22.08	28432305
400	Phosphorylation	DFLVRESTTTPGQYV CEEEEECCCCCCEEE	29.90	28432305
401	Phosphorylation	FLVRESTTTPGQYVL EEEEECCCCCCEEEE	40.03	28432305
402	Phosphorylation	LVRESTTTPGQYVLT EEEECCCCCCEEEEE	26.05	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SHC1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SHC1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SHC1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GRB2_RAT	Grb2	physical	12167719
GRB2_RAT	Grb2	physical	9722539
GRB2_RAT	Grb2	physical	9918770
SHIP1_RAT	Inpp5d	physical	11970986
SHIP1_RAT	Inpp5d	physical	12008030
INSR_HUMAN	INSR	physical	25667086

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.