GRB2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GRB2_RAT
• UniProt AC: P62994
• Protein Name: Growth factor receptor-bound protein 2
• Gene Name: Grb2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 217
• Subcellular Localization: Nucleus. Cytoplasm. Endosome. Golgi apparatus.
• Protein Description: Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway..
• Protein Sequence: MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
1	Acetylation	-------MEAIAKYD -------CCCCCCCC	7.67	-
6	Acetylation	--MEAIAKYDFKATA --CCCCCCCCCCCCC	38.96	22902405
18	Phosphorylation	ATADDELSFKRGDIL CCCCCCCCCCCCCHH	27.03	30181290
50	Acetylation	GKDGFIPKNYIEMKP CCCCCCCHHHEECCC	58.53	-
88	Phosphorylation	GAFLIRESESAPGDF CEEEEEECCCCCCCE	27.31	25575281
90	Phosphorylation	FLIRESESAPGDFSL EEEEECCCCCCCEEE	49.39	25575281
96	Phosphorylation	ESAPGDFSLSVKFGN CCCCCCEEEEEEECC	25.19	25575281
109	Acetylation	GNDVQHFKVLRDGAG CCCCEEEEEEECCCC	37.93	-
109	Ubiquitination	GNDVQHFKVLRDGAG CCCCEEEEEEECCCC	37.93	-
160	Phosphorylation	QVPQQPTYVQALFDF HCCCCCCEEEEEECC	9.39	22276854
211	Phosphorylation	MFPRNYVTPVNRNV- CCCCHHCCCCCCCC-	15.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GRB2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GRB2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GRB2_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DYN1_HUMAN	DNM1	physical	9259551
IRS1_RAT	Irs1	physical	12960006

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.